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2D materials open the possibility to study Dirac electrons in complex self-similar geometries. The two-dimensional nature of materials like graphene, silicene, phosphorene and transition-metal dichalcogenides allow the nanostructuration of complex geometries through metallic electrodes, interacting substrates, strain, etc. So far, the only 2D material that presents physical properties that directly reflect the characteristics of the complex geometries is monolayer graphene. In the present work, we show that silicene nanostructured in complex fashion also displays self-similar characteristics in physical properties. In particular, we find self-similar patterns in the conductance, spin polarization and thermoelectricity of Cantor-like silicene structures. These complex structures are generated by modulating electrostatically the silicene local bandgap in Cantor-like fashion along the structure. The charge carriers are described quantum relativistically by means of a Dirac-like Hamiltonian. The transfer matrix method, the Landauer-Büttiker formalism and the Cutler-Mott formula are used to obtain the transmission, transport and thermoelectric properties. We numerically derive scaling rules that connect appropriately the self-similar conductance, spin polarization and Seebeck coefficient patterns. The scaling rules are related to the structural parameters that define the Cantor-like structure such as the generation and length of the system as well as the height of the potential barriers. As far as we know this is the first time that a 2D material beyond monolayer graphene shows self-similar quantum transport as well as that transport related properties like spin polarization and thermoelectricity manifest self-similarity.Boson sampling can simulate physical problems for which classical simulations are inefficient. However, not all problems simulated by boson sampling are classically intractable. Selleck Tirzepatide We show explicit classical methods of finding boson sampling distributions when they are known to be highly sparse. In the methods, we first determine a few distributions from restricted number of detectors and then recover the full one using compressive sensing techniques. In general, the latter step could be of high complexity. However, we show that this problem can be reduced to solving an Ising model which under certain conditions can be done in polynomial time. Various extensions are discussed including a version involving quantum annealing. Hence, our results impact the understanding of the class of classically calculable problems. We indicate that boson samplers may be advantageous in dealing with problems which are not highly sparse. Finally, we suggest a hybrid method for problems of intermediate sparsity.Benign prostate hyperplasia is a dysfunctional disease with an elevated prevalence. Despite the accepted impact of aging and testosterone (TES) in its pathophysiology, its aetiology remains unknown. Recent studies described that serotonin (5-HT) inhibits benign prostate growth through the modulation of the androgen receptor, in the presence of TES. Accordingly, this work aimed to determine the impact of castration and TES replacement in plasmatic and prostatic 5-HT regulation. C57BL/6 mice were submitted to surgical castration and divided into three groups, continually exposed to either vehicle or different TES doses for 14 days. Plasmatic 5-HT concentration was measured before and after castration, and after TES reintroduction. Finally, total prostatic weight and intra-prostatic 5-HT were determined in the different groups. Our results demonstrate that mice prostate exhibits high 5-HT tissue levels and that intra-prostatic total 5-HT was independent of castration or TES reintroduction, in all studied groups. Also, 5-HT plasmatic concentration significantly increased after castration and then normalized after TES administration. Our findings revealed that mice prostate has a high 5-HT content and that total prostatic 5-HT levels do not depend on androgens' action. On the other hand, castration induced a significant increase in plasmatic 5-HT concentration, raising the hypothesis that androgens might be regulating the production of extra-prostatic 5-HT.Editor's Note this Article has been retracted; the Retraction Note is available at https//www.nature.com/articles/s41598-020-71843-9.Lipid astaxanthin, a potent antioxidant known as a natural sunscreen, accumulates in eukaryotic microalgae and confers photoprotection. We previously identified a photooxidative stress-inducible water-soluble astaxanthin-binding carotenoprotein (AstaP) in a eukaryotic microalga (Coelastrella astaxanthina Ki-4) isolated from an extreme environment. The distribution in eukaryotic microalgae remains unknown. Here we identified three novel AstaP orthologs in a eukaryotic microalga, Scenedesmus sp. Oki-4N. The purified proteins, named AstaP-orange2, AstaP-pink1, and AstaP-pink2, were identified as secreted fasciclin proteins with potent 1O2 quenching activity in aqueous solution, which are characteristics shared with Ki-4 AstaP. Nonetheless, the absence of glycosylation in the AstaP-pinks, the presence of a glycosylphosphatidylinositol (GPI) anchor motif in AstaP-orange2, and highly acidic isoelectric points (pI = 3.6-4.7), differed significantly from that of AstaP-orange1 (pI = 10.5). These results provide unique examples on the use of water-soluble forms of astaxanthin in photosynthetic organisms as novel strategies for protecting single cells against severe photooxidative stresses.In the phase 3 OPTIMISMM trial, pomalidomide, bortezomib, and dexamethasone (PVd) demonstrated superior efficacy vs bortezomib and dexamethasone (Vd) in patients with relapsed or refractory multiple myeloma previously treated with lenalidomide, including those refractory to lenalidomide. This analysis evaluated outcomes in patients at first relapse (N = 226) by lenalidomide-refractory status, prior bortezomib exposure, and prior stem cell transplant (SCT). Second-line PVd significantly improved PFS vs Vd in lenalidomide-refractory (17.8 vs 9.5 months; P = 0.0276) and lenalidomide-nonrefractory patients (22.0 vs 12.0 months; P = 0.0491), patients with prior bortezomib (17.8 vs 12.0 months; P = 0.0068), and patients with (22.0 vs 13.8 months; P = 0.0241) or without (16.5 vs 9.5 months; P = 0.0454) prior SCT. In patients without prior bortezomib, median PFS was 20.7 vs 9.5 months (P = 0.1055). Significant improvement in overall response rate was also observed with PVd vs Vd in lenalidomide-refractory (85.9% vs 50.
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