Notes

Application of K-Means Clustering Formula to Commercial Guidelines associated with Pleurotus spp. Harvested in Representative Garden Waste items from Province of Guayas.
The regularities of changes of the indices of the conducted research discovered in the process of our research allow us to suspect active EBV Infection for the patients with SLE. The ultimate verification of this needs the application of direct serological tests.Rehabilitation ifluences of adaptive physical exercises are based on interrelation of impellent and also vegetative and muscular functions. In particular at corrective picked up physical exercises according to functionalities of an organism muscular and vegetative system causes positive changes in work of internal bodies. The purpose of our experiment was to study the role of physical exertion in the process of comparative restoration of impaired homeostasis of individuals with limited abilities (Down syndrome), along with drug therapies; establishing the form and power of physical impact. Received data of researching and control group, allows conclude, that the complex adaptive exercises and correct by selected power of physical load, with the accounting of time, causes comparative rehabilitation of muscular and vegetative systems for people with congenital aberration of genes, which is very important for their vital activity, from our point of view.Study goal - to study the characteristics of the development of acute reno-cardial syndrome (ARCS) and correlation analysis between clinic-laboratory and instrumental indicators of cardiac involvement in young adults in acute post-streptococcal glomerulonephritis (APSG) with acute nephritic syndrome (ANS) complicated by acute kidney injury (AKI) and without it, to identify the role of the etiological factor on the course of APSG. 220 male patients with APSG with ANS aged 18-20 were examined. The patients were divided into 2 groups based on the functional state of kidneys. The first group included 140 patients with APSG without ANS, the second group included 80 patients with AKI. Impairment of cardiovascular function was observed in all 220 patients. In 71.4% of group I patients bradycardia occurred, in 83.7% of group II patients, in addition to bradycardia, extrasystolic arrhythmia was observed. Lung congestion occurred in 17.8% of patients of group I and in all patients of group II. ECG and Echocardiography previously occurred streptodermа.World Health Organization recognized coronavirus disease 2019 (COVID-19) as a pandemic on 11 March 2020. The first case of COVID-19 in Ukraine was confirmed on 3 March 2020 in Chernivtsi and the first lethal case was reported on 13 March 2020. As of 22 April 2020 6592 cases of COVID-19 have been reported in Ukraine, among these cases 174 caused death (2.64% lethality), 467 patients (7.08% of cases) have recovered. The feature of COVID-19 pandemics in Ukraine is that the age of patients is lower (50-59 years old, 40-49 years old and 30-39 years old) than in China and other European countries. Another feature of COVID-19 epidemiology in Ukraine is that virus cause disease in women (56.0%) more often than in men (44.0%). But there are more male patients in other countries. Although there are more male deaths (51.7%) than female (48.3%) in Ukraine. Deaths have occurred in 30-49 years old patients (14%), in 50-69 years old patients (48%), in 70 years old and older patients (38%). 85% of all deaths were over 50 years of age. 79% of patients who died from COVID-19 had severe cardiovascular diseases, diabetes mellitus, neoplasms, renal diseases, respiratory disorders and obesity. In total, co-morbidities (one or several) have been cardiovascular diseases (74%), diabetes mellitus (22%), lungs diseases (9%), neoplasms (8%), renal diseases (7%). In this article we analyzed epidemiology and causes of negative influence of diabetes mellitus on COVID-19 progress in world and Ukraine. We also made recommendations on prophylaxis and patients treatment in cases of COVID-19 and diabetes mellitus co-morbidity.Joint damage in patients with diabetes mellitus (DM) is a common complication and is associated with the induction of metabolic inflammation against the background of increased catabolic processes in various joint structures. The aim of our work was to study the level of insulin, leptin, osteocalcin, as well as biochemical markers of connective tissue metabolism in patients with diabetes-associated osteoarthritis. We examined 77 patients who were divided into groups by type of diabetes, the presence and severity of diabetic arthropathy. The content of insulin and leptin, osteocalcin in the blood serum was determined by the enzyme immunoassay, the level of glycosaminoglycans, hydroxyproline, hyaluronidase, collagenase according to traditional biochemical methods. Among the examined patients, diabetic arthropathy was diagnosed in more than 70%. Patients with diabetic arthropathy significantly increased levels of insulin (with type 1 diabetes by 38.5%, with type 2 diabetes by 55.6%) and leptin (with type 1 diabemarker for the presence and progression of arthropathy in patients with diabetes. Patients with arthropathies have increased levels of hydroxyproline and collagenase, which reflects an increase in catabolic processes in the connective tissue, which may be one of the mechanisms for the development of joint structures in patients with diabetes.The aim of the study is to improve the results of uncomplicated hypertensive crises treatment at the prehospital stage by studying the state of systemic hemodynamics, determining the balance of the autonomic nervous system, and markers relating to the systemic inflammatory response in patients with hypertension in uncomplicated hypertensive crises. In 2017-2019, an open, prospective and comparative study was conducted and consisted of 206 patients with documented stage II HT, of which 131 patients applied for E.M.S. in the "Municipal Institution Zaporizhzhya Station of Emergency (Ambulance) Medical Assistance of " of the Zaporizhzhia regional Council and 75 people who had a stable course of the disease and were examined on an outpatiently on the basis of the "Primary health care Center No. 10". Almost healthy 31 people were examined on the basis of the MI "Regional medical exercises dispensary" of the Zaporizhzhia regional Council. The indicators of systemic inflammatory response among the examined individuals in the study were analyzed. An increase in the concentration of serum proinflammatory markers was demonstrated depending on the stage and degree of BP increase. Increased concentrations of catecholamines are associated with increased blood levels of proinflammatory cytokines such as IL-6 and TNF-б.the level of CRP may reflect the inflammatory process in the intima of blood vessels. Interleukin-1в (IL-1в), which is considered an "early response" factor, has been proven to be involved in energy homeostasis and inflammation.Age is used in various algorithms to estimate cardiovascular risk. It is known that at the same age the health status of different patients can differ dramatically. The term vascular age (VA) was introduced in order to assess the severity of pathological process in the arterial wall. Arterial stiffness is most commonly used to estimate VA. The aim of our study was to investigate the arterial stiffness, VA in patients with uncontrolled and controlled course of arterial hypertension (AH), as well as to study the relationship between age, VA and markers of hypertension - mediated organ damage (HMOD). We put in our study 140 patients, including 80 patients with controlled course of hypertension (CH), 30 patients with uncontrolled course of hypertension (UH). 30 patients made up the control group. All groups were similar regarding age, sex, duration of hypertension and some biochemical characteristics. For all patients in our study the arterial stiffness, by means of cardio-ankle vascular index (CAVI), and VA werers of HMOD as IMT, ESV, GFR, LVPW thickness, IVS thickness. When VA was used instead of age, it was found that third of patients in CH and UH groups moved to the group of higher risk of cardiovascular (CV) events. The absence of antihypertensive therapy and target blood pressure values in patients lead to the progression of arterial stiffness and acceleration of VA in comparison to patients committed to the therapy. Use of VA in assessing the risk of CV events allows us to identify up to 30% of patients with an underestimated risk level.The study of clinical and biochemical processes in the oral cavity determined changes in the entire biochemical spectrum of the oral cavity in 132 patients aged 20-40 years with various forms of periodontitis. Similar follow-ups were divided into three groups in the main group with mild to moderate severity of periodontitis with a 10-day intake of radon, 43 patients were united into the control group with no pathological changes in periodontal tissue however. Inhalation and rinsing with radon-containing water causes a decrease in LDH levels in the oral cavity. In patients with mild severity it decreased by 1.29 times, and with moderate severity - by 1.16 times in the main group. The difference is statistically significant (p less then 0.01). which leads to a decrease in oxidative processes in the oral fluid and the restoration of the fermentation spectrum. As it is known, lactate hydrogenase is an indicator of anaerobic processes and, amylase change and the oral cavity PH, as well as the development of different forms of severity of periodontitis. In our case, the treatment with Tskaltubo water as an antioxidant medicine levels all these processes. Only in case of rinses with water of Tskaltubo, these changes are less pronounced, and in case of both inhalation and rinses they are more pronounced.The literature review was conducted in order to assess correlations between periodontics and orthodontics, effectiveness of the orthodontic treatment in patients with periodontitis. Also, causative agents of periodontitis, risk factors and its influence on systemic diseases are discussed and analyzed. The literature review was carried out several databases such as PubMed, Google Scholar, Scopus, Web of Science and Medline. The language of publication was limited to English and the year of publication was limited to over the past 5 years. For that healthy oral cavity is the guarantee of the state of the person's general health. There is a correlation between the oral health and systemic diseases. Timely diagnosis and combined treatment is crucial for the successful treatment of the periodontal diseases and stabilization of the condition to achieve the satisfactory results. Orthodontic treatment is a basic component of the combined treatment of periodontitis as the correction of teeth, dental arches and occlusion occurs, gingival architecture improves, the periodontal recovery occurs and accordingly it impacts on the patient's quality of life and self-esteem. Prevention and treatment of periodontitis reduces the increase of several systemic diseases that accordingly reduces the treatment resources and expenses.Periodontal diseases are widespread in children and adolescents. By the information of World Health Organization, 80% of children have different degrees of inflammatory periodontal diseases, that often develop from the ages of 10-11 years. Pathology of periodontal tissues is developed when there is a disproportional growth and development of tissue structure, as within the system, also in the systems and structures that provide entire organism, which itself supplements the development of periodontal diseases in juveniles. Harmonious development of children and adolescents is, on a certain level, dependent on the proper functioning of endocrine system, the functional state of which is judged by the hormones it produces, specifically cortisol. The goal of our study was to determine the level of salivary cortisol in children during puberty, also reveal the connection between the hormonal disbalance and the periodontal tissue pathologies. Gandotinib concentration To achieve this, we have studied 50 students of age 11-16 years. To assess periodontal tissue state we used clinical-instrumental and roentgenologic methods, while the salivary cortisol levels were determined by the enzyme-linked immunosorbent assay (ELISA) method.
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