Notes

Effectiveness involving Durability Interventions about Psychosocial Final results regarding People Using Neurocognitive Disorders: A planned out Assessment as well as Meta-Analysis.
To conduct a comprehensive pharmacoeconomic evaluation of lurasidone for the treatment of patients with schizophrenia under Russian healthcare system conditions and inclusion in EDL (Essential Drugs List) and Medication List for the Certain Categories of Citizens.

A retrospective study of lurasidone in the treatment of patients with schizophrenia was performed. Methods of pharmacoeconomic analysis were cost analysis, budget impact analysis and cost-effectiveness analysis.

Use of lurasidone for the treatment of patients with schizophrenia requires 50.04% less costs than the use of paliperidone and 46.69% less costs than the use of sertindole allowing to provide additional therapies to 100.1 and 87.6% of patients, respectively. The cost minimization analysis results are stable when prices fluctuate in the range of ±30%. Considering the current volume of antipsychotic drug supply, replacing 100% of paliperidone with lurasidone from the first year will reduce the cost of antipsychotics for patients who rececompensation for certain categories of citizens.
To determine the frequency of administration, efficacy and safety of long acting antipsychotics in day-to-day psychiatric practice in outpatient clinics.

The study included 90 patients with schizophrenia treated with haloperidol decanoate (
=18), rispolept consta (
=19), clopixol depot (
=25), paliperidone palmitate (
=25). Symptoms of schizophrenia were assessed with PANSS during 12 months.

The use of long acting antipsychotics has proven to be effective and safe to control all symptom clusters in patients regardless of the disease duration.
The use of long acting antipsychotics has proven to be effective and safe to control all symptom clusters in patients regardless of the disease duration.
An analysis of the efficacy and safety of additional therapy of excitement with the injectable form of alimemazine during exacerbations of schizophrenia with psychomotor agitation, impulsivity, including dangerous behavior, irritability, conflict, hostility, aggressiveness, anxiety, sleep disturbances (insomnia).

Thirty patients, aged 18 to 65 years, with a diagnosis of «paranoid schizophrenia», established in accordance with the ICD-10 criteria, were studied. The patients received treatment with a second-generation antipsychotic and alimemazine (intramuscular injection solution) in daily dose from 25 mg to 150 mg during no more than 9 days. The patients were assessed with psychometric scales (PANSS, ABS, HARS and VAS) four times during the observation period.

During therapy with a combination of second-generation antipsychotics and alimemazine solution for intramuscular injection, a reliable (
<0.001) reduction in the severity of psychotic symptoms assessed with PANSS was achieved by 8-9 days (the hen 0.001) reduction in the severity of psychotic symptoms assessed with PANSS was achieved by 8-9 days (the average total score decreased by 30% relative to the initial level) that indicated the improvement in all manifestations of schizophrenia exacerbation. A decrease of 34.8% (p=0.007) in the risk of aggression (PANSS points S1-S3) was established. The level of excitation on the agitation scale (ABS) decreased by 3.6% (p less then 0.001). In 50% of patients, manifestations of anxiety disappeared, and the average HARS score decreased by 2.2 times compared with the initial level (p less then 0.001). Almost half of the patients noted the normalization of sleep, and the average value of sleep disturbance on a visual analogue scale decreased threefold compared with the initial level (p less then 0.001). The observed adverse events were moderate or mild. Alimemazine shows the highest efficacy in the treatment of anxiety arousal in patients with schizophrenia with affective-delusional attacks.
A pharmacoeconomical analysis of the use of prolonged injectable antipsychotics in the treatment of patients with schizophrenia in Moscow over 2015-2019 in the context of the reform of the psychiatric service.

The authors studied the economic costs of treatment of psychiatric patients with prolonged injectable antipsychotics on the pharmaceutical market in Moscow for five years on the example of patients diagnosed with paranoid schizophrenia (ICD-10 F20.0) based on the dynamics of the registered contingent of patients with schizophrenic spectrum disorders over the past fifteen years including the period of active modernization of the psychiatric service.

A constant increase in public spending on treatment, including therapy with prolonged injectable neuroleptics (both first-generation drugs and atypical antipsychotics), was shown. At the same time, the increase in the use of atypical antipsychotics is ahead of schedule. The number of patients receiving treatment with prolonged injectable haloperidol andachievements of psychopharmacology and the development of social support systems for patients with schizophrenia spectrum disorders.
To determine the network connections between clinical, cognitive, speech and oculographic parameters in patients with schizophrenia.

The study included 104 patients with schizophrenia and schizophrenia spectrum disorders and 70 healthy subjects. Clinical assessment of the patients was performed using a number of scales PANSS, CDSS, YMRS, SAS and BAS. Basic cognitive functions were assessed by BACS. Eye movements were recorded using the SMI RED-500 non-invasive eye tracking system. Several experimental paradigms were used - free viewing of animal images with subsequent description of these images, performing progressive saccades in the experimental Go/NoGo scheme, and performing anti-saccades.

The severity of clinical symptoms, cognitive impairments, oculomotor parameters and characteristics of speech structure of written speech are largely independent, although not completely isolated from each other. Cognitive and oculomotor parameters have the largest number of connections. In this case, the results of cognitive tests are the central element of the «network» that connects other groups.

Further development of the approach should be aimed at studying the influence of node changes on the structure of the network that would potentially allows the identification of the most effective points of application of therapeutic and rehabilitation programs.
Further development of the approach should be aimed at studying the influence of node changes on the structure of the network that would potentially allows the identification of the most effective points of application of therapeutic and rehabilitation programs.
An analysis of inflammatory and autoimmune markers in schizophrenic patients with- and without catatonic symptoms in comparison to healthy controls.

A sample of 170 patients with paranoid schizophrenia was stratified by the presence of catatonic symptoms in the structure of psychosis (66 patients with catatonia and 104 patients without catatonia), inclusion threshold was >10 points on the Bush-Francis catatonia scale. The examination was carried out in the early days of inpatient treatment using psychopathological, psychometric and immunological methods.

Quantitative and qualitative differences in the spectrum of immune indicators in both groups of patients are revealed. learn more A higher level of the immune system activation is found in the group with catatonic symptoms that indicates a worsening of the pathological process. A specific feature of the immunological profile of catatonic syndrome in schizophrenia is a decrease in ratio between leukocyte elastase and a1-proteinase inhibitor (leukocyte-inhibitory index) accompanied by the increase of other inflammatory markers that, presumably, indicates the deterioration of the phagocyte component of the inflammatory response.

The results suggest that the decrease in leukocyte-inhibitory index is a potential biomarker of catatonic syndrome in schizophrenia.
The results suggest that the decrease in leukocyte-inhibitory index is a potential biomarker of catatonic syndrome in schizophrenia.
To evaluate the dynamics of clinical-epidemiological and social-demographic characteristics in a continuous sample of patients with newly diagnosed schizophrenia in 2013-2017.

An analysis of the continuous study of medical records of 4708 patients, aged 14 to 77 years, with newly diagnosed schizophrenia, who referred to Moscow psychoneurological dispensaries, was performed.

Patients of young working age prevailed in the sample; the onset of symptoms of the disease in men was noted at an earlier age than in women. The disease at an early stage was accompanied by a professional decline and a significant disability. Schizophrenia was most frequently diagnosed in the first visit. There was a clear correlation between an increase in the number of compliance violations and an increase in the duration of the disease. Assessment of the frequency of visits to primary care psychiatrists and admissions to hospitals and day hospitals indicates the increased effectiveness of outpatient psychiatric services in Moscow.
Patients of young working age prevailed in the sample; the onset of symptoms of the disease in men was noted at an earlier age than in women. The disease at an early stage was accompanied by a professional decline and a significant disability. Schizophrenia was most frequently diagnosed in the first visit. There was a clear correlation between an increase in the number of compliance violations and an increase in the duration of the disease. Assessment of the frequency of visits to primary care psychiatrists and admissions to hospitals and day hospitals indicates the increased effectiveness of outpatient psychiatric services in Moscow.
To determine the frequency of the key psychopathological syndromes, the dynamics and comorbidity of schizophrenia and other psychoses in Russian veterans of local wars receiving hospital treatment.

The study included 685 patients of a psychiatric department of a military hospital, including 264 veterans of the local wars (the main group), 296 people (career military servicemen and retirees), who do not take part in combat actions (the first comparison group) and 125 people matched for the middle age and the age distribution curve with the main group (the second comparison group).

The frequency of psychoses appeared to be slightly less in veterans (7.2%) compared to patients of comparison groups (14.5% and 8.8%, respectively). In all groups, most patients were diagnosed with schizophrenia (ICD-10 F20) 3.8% in the main group, 4.4% in the first comparison group and 4.0% in the second comparison group. Other acute and chronic psychotic disorders (F22-F23) were diagnosed in 0.8, 5.4 and 3.2% patients, respecbat stress, the subsequent development and recurrence of psychotic symptoms happened regardless of the influence of combat stress factors.
To determine the features of the course of young-onset schizophrenia based on the long-term follow-up results (20-25 years).

The results of the long-term follow-up study of 320 patients with young-onset schizophrenia referred for psychiatric care in an outpatient clinic in Moscow from 1990 to 1994 were analyzed. Correlations between typological variants of the patient's condition during the follow-up and features of the dynamics of the schizophrenic process at different stages of the disease were studied. Clinical-psychopathological, clinical follow-up, clinical-epidemiological and a psychometric method were applied.

The severity of symptoms at all stages of the disease correlates with typological variants of conditions at the stage of long-term follow-up. In the first type, there is an accumulation of personality desorders and the most prognostically favorable variants of the initial stage, manifestations of psychotic states, the disease often manifests with only one episode and has a regressive character, the disease process fades quite quickly, mainly high-and medium-quality remissions are formed.
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