Notes

Primary High Grade Non-Anaplastic Thyroid gland Carcinoma: Any Retrospective Study associated with 364 Instances.
commended.Three patients developed recurrent corneal erosions (RCEs) over their cataract surgery corneal incisions. These cataract incision-related corneal erosions (CIRCEs) resulted in pain after cataract surgery. None had any physical findings for corneal erosion; thus, a new technique called the corneal sweep test was developed to identify the erosion. To the authors' knowledge, this is the first time this association between the clear corneal cataract incision and RCEs has been reported. Considering the high number of cataract surgeries performed around the world, it is important for ophthalmologists to recognize CIRCEs as a potential cause of ocular discomfort after clear corneal cataract surgery.
To evaluate the ease of replacement and capsular stability of a new fluid-filled, modular, accommodating intraocular lens (IOL) system composed of a monofocal base lens with a fluid lens clipped inside of it.

John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.

Experimental study.

Five New Zealand rabbits underwent bilateral phacoemulsification with implantation of the test lens (Juvene, LensGen) in both eyes (4 rabbits), or a control IOL in 1 eye (AcrySof, Alcon) and the test IOL in the other (1 rabbit). At 2 weeks, the 4 rabbits with bilateral Juvene IOLs had the clipped-in fluid lens exchanged for a new fluid lens in 1 eye, and the base and fluid lenses exchanged for a control lens in the contralateral eye. Slitlamp exams were performed weekly for 4 weeks. The globes were enucleated and evaluated with ultrasound biomicroscopy (UBM), grossly from the posterior Miyake-Apple view, and histopathologically.

Explantation/exchange of the fluid lens was considered straightforward by the surgeon. Explantation of the base lens was also safely performed, albeit more demanding, without any signs of damage to the capsular bag under clinical, ultrasound biomicroscopy, and pathological examination in the exchanged eyes. Less capsular bag opacification was observed with the Juvene lens system.

Explantation/exchange of the fluid lens component, or both fluid and base lenses, of this new lens system can be safely accomplished if necessary, owing to its modular design and the relative lack of postoperative capsular bag opacification associated with it.
Explantation/exchange of the fluid lens component, or both fluid and base lenses, of this new lens system can be safely accomplished if necessary, owing to its modular design and the relative lack of postoperative capsular bag opacification associated with it.
To determine any changes in macular or choroidal thickness associated with the use of intracameral moxifloxacin as post-cataract endophthalmitis prophylaxis.

University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.

Prospective, randomized, partially masked, single-site clinical trial.

Phacoemulsification surgery patients in the experimental group (Group A) received a 0.03 mL intracameral injection of undiluted moxifloxacin from a sealed bottle immediately following phacoemulsification surgery (150 µg in 0.03 mL - Vigamox solution), while the control group (Group B) did not. Investigators evaluated in masked fashion macular and choroidal thickness using spectral domain optical coherence tomography before and after surgery.

A total of 93 patients were included (48 in Group A and 45 in Group B). Baseline parameters were similar between the groups. Either of the 2 parameters assessed differed statistically between the groups or preoperatively vs postoperatively. On postoperative day 30, central macular thickness was 8.85 ± 14.78 μm in Group A and 10.26 ± 22.44 μm in Group B (p=0.7232); choroidal thickness as measured by enhanced depth imaging (EDI) was 1.45 ± 16.13 μm in Group A and 3.74 ± 16.15 in Group B (p=0.5017). On postoperative day 60, central macular thickness was 19.53 ± 39.28 μm in Group A and 17.14 ± 53.68 μm in Group B (p=0.8363); EDI was 5.08 ± 21.96 μm in Group A and 5.24 ± 15.8 in Group B (p=0.9752).

The application of intracameral injection of 0.03 mL of undiluted 0.5% moxifloxacin during phacoemulsification surgery as endophthalmitis prophylaxis induced no changes in macular or choroidal thickness.
The application of intracameral injection of 0.03 mL of undiluted 0.5% moxifloxacin during phacoemulsification surgery as endophthalmitis prophylaxis induced no changes in macular or choroidal thickness.
To develop a mesoporous silica drug delivery system and target drop-free care after cataract surgery with a single subconjunctival injection.

Laboratory.

Experimental animal study.

Ketorolac was infiltration-loaded into sol-gel mesoporous silica particles encapsulated with poly(allylamine hydrochloride) and poly(sodium 4-styrenesulfonate) using a layer-by-layer adsorption technique (SG-Ket-LBL). The formulation was subjected to an in vitro and in vivo drug release study in addition to ocular toxicology evaluation.

Thermogravimetric analysis revealed that the drug loading efficiency was 4.4% for the SG-Ket-LBL particles. The in vivo safety study demonstrated that the formulation was well tolerated after subconjunctival injection and aqueous humor pharmacokinetics showed sustained therapeutic drug release for the targeted time window of 6 to 8 weeks.

Findings indicated that sol-gel mesoporous silica could be used as a drug carrier for subconjunctival administration. The tested formulation, SG-Ket-LBL, provided therapeutic ketorolac for 6 to 8 weeks, which might be used for a single subconjunctival injection to replace nonsteroidal anti-inflammatory drug eyedrops after cataract surgery.
Findings indicated that sol-gel mesoporous silica could be used as a drug carrier for subconjunctival administration. The tested formulation, SG-Ket-LBL, provided therapeutic ketorolac for 6 to 8 weeks, which might be used for a single subconjunctival injection to replace nonsteroidal anti-inflammatory drug eyedrops after cataract surgery.A 50-year-old woman with cornea plana had reduced visual acuity due to development of lenticular changes. selleck chemicals llc Flat keratometry with high astigmatism, shallow anterior chamber depth and short axial length made it challenging both for intraocular lens (IOL) power calculation and cataract surgery. Surgery was planned for the right eye, as the left eye was densely amblyopic. IOL power required was beyond the commercially available lenses, hence a customised toric IOL was obtained. Phacoemulsification was successfully performed along with-in-the bag implantation of the toric IOL, which resulted in improved visual acuity with satisfactory refractive outcome. Cataract surgery with a customised IOL improved visual acuity in an eye with cornea plana.Oscillopsia associated with near fixation after multifocal intraocular lens (IOL) implantation has not been fully recognized. A 46-year-old woman presented with shaking of vision in both eyes during near fixation after uneventful implantation of a single-piece multifocal posterior chamber IOL in both eyes. There was no sign of zonular weakness in either eye before or during cataract surgery, and the postoperative course was uneventful. Visual acuity was 20/25 in both eyes without correction. There was no IOL oscillation with distant fixation, however, when she changed her focus from a distant to a near object, the IOLs started to oscillate in both eyes, which was assumed to be the cause of her oscillopsia. On cycloplegia, there was no IOL oscillation either with distant or near fixation. A rare cause of oscillopsia associated with pseudoaccommodation after IOL implantation should be recognized.
To assess the repeatability of keratometric measurements obtained using a reflectance and swept-source based optical coherence tomography (SS-OCT) biometer and to compare these values to those obtained with a dual Scheimpflug-Placido disc based tomographer/topographer.

Department of Ophthalmology, Penn State College of Medicine, Hershey, Pennsylvania, USA.

Prospective consecutive case series.

Patients undergoing cataract evaluation were prospectively enrolled. Surgery-naive eyes without corneal pathology were measured 3 times with the reflectance/SS-OCT biometer and once with the dual Scheimpflug-Placido (S-P) disc tomographer/topographer. Intradevice repeatability for anterior (K), posterior (PK), and total corneal keratometry (TK) readings were evaluated using within-eye standard deviations, test-retest repeatability, coefficients of variance, and intraclass correlation coefficients (ICCs). Bland-Altman analysis was used to assess agreement between devices.

Eighty-two eyes from 48 patients met incf anterior measurements. This may be due to the small index of refraction change at the cornea-aqueous interface. While keratometric indices from the 2 devices are highly correlated, measurements taken using SS-OCT and S-P devices were not interchangeable.The degree of visual disturbance associated with a particular model of intraocular lens (IOL) depends upon several factors, including IOL optic, material, and mechanics. Characterization of visual disturbance profiles is paramount for informing clinical IOL selection. While many studies evaluating presbyopia-correcting IOLs include subjective assessment of visual symptoms, the types of patient-reported outcome measures (PROMs) used to capture these outcomes are inconsistent across studies, complicating data contextualization. Furthermore, some tools produce more meaningful results than others. This review presents a discussion on the scientific literature published on the subjective and semi-objective (halo and glare simulator, light-distortion analyzer, vision monitor, and halometers) methods used to assess visual disturbances in patients implanted with trifocal or extended-depth-of-focus IOLs, highlighting their advantages and limitations. It underscores the importance of between-study comparisons and the need for standardized PROMs in clinical IOL research to provide more accurate information for IOL selection.
To determine the ability to differentiate between normal eyes and clinically unaffected eyes of patients with highly asymmetric keratoconus using a Scheimpflug/Placido device SETTING Tel Aviv Sourasky Medical Center and Enaim Medical Center, Israel.

Retrospective case-control.

Imaging from a combined Scheimpflug/Placido device (Sirius, C.S.O.) was obtained from 26 clinically unaffected eyes of patients with frank keratoconus in the fellow eye, and 166 eyes from 166 patients with bilaterally normal corneal examinations that underwent uneventful corneal refractive surgery with at least 1 year of follow-up. Receiver operating characteristic curves were produced to calculate the area under the curve (AUC), sensitivity, and specificity of 60 metrics, and finally a logistic regression modeling was employed to determine optimal variables to differentiate populations.

The most predictive individual metric was the posterior cornea inferior-superior (I-S) ratio, with an AUC of 0.862. A combination model of 4 metrics (posterior cornea I-S ratio in the central 3 mm, thinnest pachymetry coordinate on the x horizontal axis, posterior asymmetry and asphericity index, corneal volume) yielded an AUC of 0.936, with a sensitivity/specificity pair of 92.3%/87%. Variables related to maximum elevation were not found significant.

Using a combination of metrics from a combined Scheimpflug/Placido device, a practical model for discrimination between clinically normal eyes of patients with highly asymmetric keratoconus and normal eyes was constructed. Variables related to pachymetry and posterior cornea asymmetry were the most impactful.
Using a combination of metrics from a combined Scheimpflug/Placido device, a practical model for discrimination between clinically normal eyes of patients with highly asymmetric keratoconus and normal eyes was constructed. Variables related to pachymetry and posterior cornea asymmetry were the most impactful.
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