Notes

Decrease respiratory system contamination hospitalizations among United states Indian/Alaska Native adults, Indian Wellbeing Assistance along with Florida Location, 1998-2014.
The COVID-19 pandemic has had not only a tremendous impact on public health but also on the care of many pre-COVID-19 diseases, such as stroke. The pandemic has tested the robustness of comprehensive stroke care programs. Especially during the months of confinement, an alarming increase in the incidence of several risk factors for cerebrovascular diseases was noticed, without, however, the proportional strengthening of strategies for the prevention and/or control of comorbidities. Patients who had already suffered a stroke were neglected from the secondary prevention routine and neurological rehabilitation therapies. Regarding the acute treatment, the fear of contagion in the hospital environment promoted a significant delay in the time from the onset of symptoms to admission to an emergency department as well as in the door to imaging and door to needle times. Moreover, the pandemic also exposed the enormous inequalities in the approach to cerebrovascular diseases worldwide. Actually, many consequences of COVID-19 in stroke care will persist for months even after pandemic control. Strategies to combat the pandemic must be reconciled with the fight against stroke in a way that does not exclude any patient from access to the best possible care.This paper presents an approach to access real time data from underground mine. Two advance technologies are presented that can improve the adverse environmental effect of underground mine. Visible light communication (VLC) technology is incorporated to estimate the location of miners inside the mine. The distribution of signal to noise ratio (SNR) for VLC system is also studied. In the second part of the paper, long range (LoRa) technology is introduced for transmitting underground information to above the surface control room. This paper also includes details of the LoRa technology, and presents comparison of ranges with existing above the surface technologies.Human respiratory syncytial virus (RSV) is a leading ubiquitous respiratory pathogen in newborn infants, young children, and the elderly, with no vaccine available to date. The viral fusion glycoprotein (RSV F) plays an essential role in the infection process, and it is a primary target of neutralizing antibodies, making it an attractive site for vaccine development. With this in view, there is a persistent need to identify selective antiviral drugs against RSV, targeting the major antigenic sites on the F protein. We aimed to conduct a robust in silico high-throughput drug screening of one million compounds to explore potential inhibitors that bind the major antigenic site Ø and site II on RSV F protein, which are the main target of neutralizing antibodies (NAb). We utilized the three-dimensional crystallographic structure of both antigenic site Ø on pre-F and antigenic II on post-F to screen for potential anti-RSV inhibitors. A library of one million small compounds was docked to explore lead binders in thenline version contains supplementary material available at 10.1007/s42247-021-00213-6.
The online version contains supplementary material available at 10.1007/s42247-021-00213-6.
Since extracorporeal membrane oxygenator (ECMO) has been utilized to save countless lives by providing continuous extracorporeal breathing and circulation to patients with severe cardiopulmonary failure. In particular, it has played an important role during the COVID-19 epidemic. this website One of the important composites of ECMO is membrane oxygenator, and the core composite of the membrane oxygenator is hollow fiber membrane, which is not only a place for blood oxygenation, but also is a barrier between the blood and gas side. However, the formation of blood clots in the oxygenator is a key problem in the using process. According to the study of the mechanism of thrombosis generation, it was found that improving the hemocompatibility is an efficient approach to reduce thrombus formation by modifying the surface of materials. In this review, the corresponding modification methods (surface property regulation, anticoagulant grafting, and bio-interface design) of hollow fiber membranes in ECMO are classified and discussed, and then, the research status and development prospects are summarized.
COVID-19 pneumonia represents a global threatening disease, especially in severe cases. Chest imaging, with X-ray and high-resolution computed tomography (HRCT), plays an important role in the initial evaluation and follow-up of patients with COVID-19 pneumonia. Chest imaging can also help in assessing disease severity and in predicting patient's outcome, either as an independent factor or in combination with clinical and laboratory features. This review highlights the current knowledge of imaging features of COVID-19 pneumonia and their temporal evolution over time, and provides recent evidences on the role of chest imaging in the prognostic assessment of the disease.The effectiveness and safety of venous thromboembolism (VTE) treatment with apixaban, demonstrated in phase III trials, need to be confirmed in daily care. Using data from the prospective, noninterventional cross-indication Dresden NOAC Registry we evaluated rates of VTE recurrence and bleeding complications during apixaban treatment of VTE patients. For this analysis, we only included patients with acute VTE who started apixaban within 14 days after diagnosis and who were enrolled within these 14 days. Patient characteristics, treatment persistence, and clinical outcomes were assessed. Between August 1st, 2014 and October 31, 2018, 352 patients with apixaban treatment for acute VTE were enrolled. During treatment (median exposure 13.7 ± 9.8 months; median follow-up 21.7 ± 6.1 months) rates of recurrent VTE and International Society on Thrombosis and Haemostasis major bleeding were 1.3/100 pt.years (95% confidence interval or CI 0.4-3.0) and 1.5/100 pt.years (0.6-3.3), respectively. At 6 months. 68.6% of patients were still taking apixaban, 23.9% had a scheduled end of treatment, 6.3% were switched to other anticoagulants, and the remaining 2.3% had unplanned complete discontinuation of anticoagulation. Of the 188 patients stopping apixaban, 12 (6.4%) experienced a recurrent VTE (six pulmonary embolisms ± deep vein thrombosis, six deep vein thrombosis; mean time between stopping anticoagulation and VTE recurrence 5.2 ± 4.1 months [range 14-417 days]). Our findings suggest that, in daily care, apixaban demonstrated high effectiveness, safety, and persistence in the treatment of acute VTE with low rates of unplanned discontinuation.
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