Notes

Spatiotemporal proteomic profiling in the pro-inflammatory response to lipopolysaccharide from the THP-1 man leukaemia cell line.
following the declaration of the COVID-19 pandemic on 11 March 2020, countries started implementing strict control measures, health workers were re-deployed and health facilities re-purposed to assist COVID-19 control efforts. These measures, along with the public concerns of getting COVID-19, led to a decline in the utilization of regular health services including immunization.

we reviewed the administrative routine immunization data from 15 African countries for the period from January 2018 to June 2020 to analyze the trends in the monthly number of children vaccinated with specific antigens, and compare the changes in the first three months of the COVID-19 pandemic.

thirteen of the 15 countries showed a decline in the monthly average number of vaccine doses provided, with 6 countries having more than 10% decline. Nine countries had a lower monthly mean of recipients of first dose measles vaccination in the second quarter of 2020 as compared to the first quarter. Guinea, Nigeria, Ghana, Angola, Gabon,mber of children vaccinated poses a serious risk for outbreaks such as measles. Countries should monitor coverage trends at national and subnational levels, and undertake catch-up vaccination activities to ensure that children who have missed scheduled vaccines receive them at the earliest possible time.We report the case of a 64-year-old patient with a history of coronary artery disease and severe left ventricular dysfunction ischemic requiring medical therapy only admitted for dyspnea. The association of heart failure with COVID-19 pneumonia is discussed. The distinction between these two pathologies is based on a set of clinical, biological and radiological arguments.
Prescription medication use may be associated with phantom odor perception. We evaluated associations between number of prescription medications and their therapeutic class and phantom odor perception among U.S. adults.

Data were collected between 2011-2014 as part of the National Health and Nutrition Examination Survey (NHANES). A complex sampling design resulted in a nationally representative sample of 7,417 adults aged 40 years and older. During an in-home interview, participants were asked whether they had experienced an unpleasant, bad, or burning odor when nothing is there. Prescription medication use was assessed using validation with prescription bottles, when possible.

Almost one quarter (23.3%) of adults uses ≥5 prescription medications. Use of five or more prescription medications is associated with 70% greater odds of phantom odor perception (OR 1.69 (1.09, 2.63)). Among adults 60 years and older, antidiabetic medications, antihyperlipidemic agents, and proton pump inhibitors are associated with 74-88% greater odds of report of phantom odor [OR=1.74 (1.09, 2.77), OR=1.85 (1.22. 2.80), and OR=1.88 (1.15, 3.07)], respectively.

Phantom odor perception may be a side effect of antidiabetic or antihyperlipidemic agents. Among people taking proton pump inhibitors, phantom odors may also be a consequence of gastric gas reflux.

Common prescription medications may be providing an olfactory stimulus.
Common prescription medications may be providing an olfactory stimulus.This paper finds that the Great Chinese Famine of 1959-1961 reduced lifetime educational attainment by up to 3.8 years for people who lived in areas most severely hit by the famine. Using geographical variation in famine intensity, information about place of residence during the famine, and educational attainment recorded in the China Health and Retirement Longitudinal Study, the paper demonstrates that the decline in educational attainment was particularly sharp for women. This decline interrupted substantial gains in schooling achieved in China during the middle part of the twentieth century.TiO2 nanotubular films prepared using the anodic oxidation process applied to various forms of metal titanium are promising materials for photocatalytic applications. However, during successive anodizations in batch-anodization cells, the chemical composition of the NH4F- and water-based ethylene glycol electrolyte changes with each subsequent anodization, which greatly affects the final photocatalytic properties of the annealed TiO2 nanotubular films. In the present study, 20 titanium discs (Φ 90 mm) were sequentially anodized in the same anodization electrolyte. The chemical composition of the electrolyte was measured after each anodization and correlated with the anodization current density, temperature, electrical conductivity, and pH of the electrolyte and with the morphology, structure, composition, and photocatalytic activity of the resulting TiO2 nanotube films. It was found that the length of the TiO2 nanotubes decreased with the age of the electrolyte due to its lower conductivity. The subsurface chemical composition was evaluated by time of flight secondary ion mass spectrometry (ToF SIMS) analyses, and the integrated ToF SIMS signals over a depth of 250 nm for the TiO2 nanotube films showed that the concentration of F- in the annealed TiO2 film increased with each subsequent anodization due to the increased pH value of the electrolyte. As a consequence, the concentration of the OH- and O2- species decreased, which is a major reason for the reduced photocatalytic activity of the TiO2 films. It is proposed that the length of the TiO2 nanotubes does not play a decisive role in determining the photocatalytic activity of the TiO2 nanotube films. Finally, the best measured degradation results of 60% for caffeine were thus achieved for the first anodized titanium discs. After that the efficiency gradually decreased for each subsequent anodized disc.By combining time-correlated single photon counting (TCSPC) measurements, density functional theory (DFT), and time-dependent DFT (TD-DFT) calculations, we herein investigate the role of protons, in solutions and on semiconductor surfaces, for the emission quenching of indoline dyes. JDQ443 in vivo We show that the rhodanine acceptor moieties, and in particular the carbonyl oxygens, undergo protonation, leading to nonradiative excited-state deactivation. The presence of the carboxylic acid anchoring group, close to the rhodanine moiety, further facilitates the emission quenching, by establishing stable H-bond complexes with carboxylic acid quenchers, with high association constants, in both ground and excited states. This complexation favors the proton transfer process, at a low quencher concentration, in two ways bringing close to the rhodanine unit the quencher and assisting the proton release from the acid by a partial-concerted proton donation from the close-by carboxylic group to the deprotonated acid. Esterification of the carboxylic group, indeed, inhibits the ground-state complex formation with carboxylic acids and thus the quenching at a low quencher concentration.
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