Notes

Treatment-level impacts regarding microplastic coverage could possibly be mixed up by deviation in individual-level reactions inside juvenile bass.
The region between the pulp and the froth also known as pulp/froth interface in mineral flotation processes separates the pulp from the froth. Various researchers suggest particle detachment occurs around this region significantly affecting mineral recovery and grade. One of the causes pointed out is sudden deceleration of bubble-particle aggregate upon collision with the interface while another theory suggests detachment to be caused by bubble coalescence. A possible cause of divergence in views may be in the different methods of investigation employed. Though, more than several researchers indicate that detachment occurs, it is not conclusive whether kinetic energy changes or bubble coalesce or a combination of the two is responsible for detachment if any. Thus, this review examines and presents work that has been done on the role of the pulp-froth interface on particle detachment and selectivity. The review also considers the behaviour of a bubble with various interface as found in literature with a view of inferring the dominant cause of detachment at the interface.Water is the universal solvent in nature to catalyze the biological transformation processes. However, owing to the immiscibility of many reagents in water, synthesis chemistry relies heavily on organic solvent. Micellar media is a green alternative to traditional petroleum feedstock derived solvents, which is recently attracting increasing research attention. The present review deals with the recent advances in micellar catalysis with an emphasis on the new "tailor-made" surfactants for various reactions. A brief overview of commercial surfactants, including anionic micelles, cationic micelles, and nonionic micelles is presented. TPH104m More importantly, an attempt was made to discuss systematically the recent research progress on new surfactants by introducing structures, micellar effects and recycling process, aiming to serve as the basis for future development of surfactants.
Mental health symptoms are frequent in women with gestational diabetes mellitus (GDM) and may influence glycemic control. We therefore investigated if mental health symptoms (high depression and low well-being scores) predicted a need for glucose-lowering medication and if this use of medication influenced the trajectory of mental health during pregnancy and in the postpartum period.

We included 341 pregnant women from a cohort of GDM women in a Swiss University Hospital. The World Health Organization Well-being Index-Five was collected at the first and last GDM and at the postpartum clinical visits and the Edinburgh Postnatal Depression Scale at the first GDM and the postpartum clinical visits. Medication intake was extracted from participants' medical records. We conducted linear and logistic regressions with depression as an interaction factor.

Mental health symptoms did not predict a need for medication (all p≥0.29). Mental health improved over time (both p≤0.001) and use of medication did not predict this change (all p≥0.40). In women with symptoms of depression, medication was associated with less improvement in well-being at the postpartum clinical visit (p for interaction=0.013).

Mental health and glucose-lowering medication did not influence each other in an unfavourable way in this cohort of women with GDM.
Mental health and glucose-lowering medication did not influence each other in an unfavourable way in this cohort of women with GDM.
Preeclampsia is associated with hypertension in later life, but the underlying pathophysiological mechanisms remain uncertain. We aimed to explore whether the angiogenic markers soluble Fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) measured in women with preeclampsia could be associated with hypertension 1year after delivery.

This is a secondary analysis of a prospective cohort study, originally aimed to evaluate the use of sFlt-1/PlGF ratio to predict adverse outcome in women with (suspected) preeclampsia. Office blood pressure (BP) was evaluated at 1year postpartum in women who had a confirmed diagnosis of preeclampsia within one week of biomarker measurement.

Eighty women were included with a median (interquartile range) gestational age (GA) at biomarker measurement of 30 (27-33) weeks. Twenty-three (29%) women had hypertension 1year postpartum. These women showed higher median SBP during their pregnancy and lower GA at PE diagnosis compared to women without hypertension. Median PlGF levels were lower in women with hypertension 1year postpartum compared to women without hypertension (23 vs. 48pg/mL, p=0.017), while no differences in sFlt-1 or sFlt-1/PlGF ratio were observed. Multivariable analysis adjusted for GA did not show significant association between PlGF (nor sFlt-1, sFlt-1/PlGF ratio) and hypertension 1year postpartum (OR [95% CI] 0.9 [0.2-4.4], p=0.97).

Our data indicate that sFlt-1, PlGF or their ratio measured during pregnancy are not suitable for the prediction of hypertension 1year postpartum and hence guiding follow-up of women with previous preeclampsia.
Our data indicate that sFlt-1, PlGF or their ratio measured during pregnancy are not suitable for the prediction of hypertension 1 year postpartum and hence guiding follow-up of women with previous preeclampsia.HPV-inactive head and neck and cervical cancers contain HPV DNA but do not express HPV E6/E7. HPV-positive primary head and neck tumors usually express E6/E7, however they may produce HPV-inactive metastases. These observations led to our hypothesis that HPV-inactive cancers begin as HPV-active lesions, losing dependence on E6/E7 expression during progression. Because HPV-inactive cervical cancers often have mutated p53, we investigated whether p53 loss may play a role in the genesis of HPV-inactive cancers. p53 knockout (p53-KO) by CRISPR-Cas9 resulted in a 5-fold reduction of E7 mRNA in differentiation-resistant HPV16 immortalized human keratinocytes (HKc/DR). E7 expression was restored by 5-Aza-2 deoxycytidine in p53 KO lines, suggesting a role of DNA methylation in this process. In-situ hybridization showed that p53 KO lines consist of mixed populations of E6/E7-positive and negative cells. Hence, loss of p53 predisposes HPV16 transformed cells to losing dependence on the continuous expression of HPV oncogenes for proliferation.
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