Notes

Strong method towards highly emissive nitroaromatics through a weakly electron-deficient central.
In the magnetoencephalogram (MEG), spatial attention to the left versus right side induced lateralization of alpha power in all temporal cueing conditions. Modulation of alpha lateralization at the 0.8 Hz presentation rate of spoken numbers was stronger following instructive compared to neutral temporal cues. Critically, we found stronger modulation of lateralized alpha power specifically at the onsets of temporally cued numbers. These results suggest that the precisely timed hemispheric lateralization of alpha power qualifies as a spatio-temporal attentional filter mechanism susceptible to top-down behavioural goals.Information processing in the brain is mediated by structural white matter pathways and is highly dependent on topological brain properties. Here we combined transcranial magnetic stimulation (TMS) with high-density electroencephalography (EEG) and Diffusion Weighted Imaging (DWI), specifically looking at macroscale connectivity to understand whether regional, network-level or whole-brain structural properties are more responsible for stimulus propagation. Neuronavigated TMS pulses were delivered over two individually defined nodes of the default mode (DMN) and dorsal attention (DAN) networks in a group of healthy subjects, with test-retest reliability assessed 1-month apart. TMS-evoked activity was predicted by the modularity and structural integrity of the stimulated network rather than the targeted region(s) or the whole-brain connectivity, suggesting network-level structural connectivity as more relevant than local and global brain properties in shaping TMS signal propagation. The importance of network structural connectome was unveiled only by evoked activity, but not resting-state data. Future clinicals interventions might enhance target engagement by adopting DWI-guided, network-focused TMS.
In Alzheimer`s disease (AD), regional heterogeneity of β-amyloid burden and microglial activation of individual patients is a well-known phenomenon. Recently, we described a high incidence of inter-individual regional heterogeneity in terms of asymmetry of plaque burden and microglial activation in β-amyloid mouse models of AD as assessed by positron-emission-tomography (PET). We now investigate the regional associations between amyloid plaque burden, microglial activation, and impaired spatial learning performance in transgenic mice in vivo.

In 30 App
mice (15 female, 15 male) we acquired cross-sectional 18 kDa translocator protein (TSPO-PET,
F-GE-180) and β-amyloid-PET (
F-florbetaben) scans at ten months of age. Control data were obtained from age- and sex-matched C57BI/6 wild-type mice. We assessed spatial learning (i.e. Morris water maze) within two weeks of PET scanning and correlated the principal component of spatial learning performance scores with voxel-wise β-amyloid and TSPO tracer uptakee of the global microglial activation and amyloid level. Region-based results for amyloid-PET showed no significant associations with spatial learning.

Elevated microglial activation in the right amygdala-entorhinal-hippocampal complex of App
mice is associated with better spatial learning. Our findings support a protective role of microglia on cognitive function when they highly express TSPO in specific brain regions involved in spatial memory.
Elevated microglial activation in the right amygdala-entorhinal-hippocampal complex of AppNL-G-F mice is associated with better spatial learning. Our findings support a protective role of microglia on cognitive function when they highly express TSPO in specific brain regions involved in spatial memory.Recognising and knowing about conspecifics is vital to human interaction and is served in the brain by a well-characterised cortical network. Understanding the temporal dynamics of this network is critical to gaining insight into both hierarchical organisation and regional coordination. Here, we combine the high spatial resolution of fMRI with a paradigm that permits investigation of differential temporal tuning across cortical regions. We cognitively under- and overload the system using the rapid presentation (100-1200msec) of famous faces and buildings. We observed an increase in activity as presentation rates slowed and a negative deflection when inter-stimulus intervals (ISIs) were extended to longer periods. The primary distinction in tuning patterns was between core (perceptual) and extended (non-perceptual) systems but there was also evidence for nested hierarchies within systems, as well as indications of widespread parallel processing. Extended regions demonstrated common temporal tuning across regions which may indicate coordinated activity as they cooperate to manifest the diverse cognitive representation accomplished by this network. With the support of an additional psychophysical study, we demonstrated that ISIs necessary for different levels of semantic access are consistent with temporal tuning patterns. Collectively, these results show that regions of the person-knowledge network operate over different temporal timescales consistent with hierarchical organisation.The development of the organization of the motor representation areas in children and adolescents is not well-known. This cross-sectional study aimed to provide an understanding for the development of the functional motor areas of the upper extremity muscles by studying healthy right-handed children (6-9 years, n = 10), preadolescents (10-12 years, n = 13), adolescents (15-17 years, n = 12), and adults (22-34 years, n = 12). Sapitinib price The optimal representation site and resting motor threshold (rMT) for the abductor pollicis brevis (APB) were assessed in both hemispheres using navigated transcranial magnetic stimulation (nTMS). Motor mapping was performed at 110% of the rMT while recording the EMG of six upper limb muscles in the hand and forearm. The association between the motor map and manual dexterity (box and block test, BBT) was examined. The mapping was well-tolerated and feasible in all but the youngest participant whose rMT exceeded the maximum stimulator output. The centers-of-gravity (CoG) for individual musyears of age.Understanding others' speech while individuals simultaneously produce speech utterances implies neural competition and requires specific mechanisms for a neural resolution given that previous studies proposed opposing signal dynamics for both processes in the auditory cortex (AC). We here used neuroimaging in humans to investigate this neural competition by lateralized stimulations with other speech samples and ipsilateral or contralateral lateralized feedback of actively produced self speech utterances in the form of various speech vowels. In experiment 1, we show, first, that others' speech classifications during active self speech lead to activity in the planum temporale (PTe) when both self and other speech samples were presented together to only the left or right ear. The contralateral PTe also seemed to indifferently respond to single self and other speech samples. Second, specific activity in the left anterior superior temporal cortex (STC) was found during dichotic stimulations (i.e. self and other spsignment, and unusual lateralization of AC and frontal brain activations.Verbal communication relies heavily upon mutual understanding, or common ground. Inferring the intentional states of our interaction partners is crucial in achieving this, and social neuroscience has begun elucidating the intra- and inter-personal neural processes supporting such inferences. Typically, however, neuroscientific paradigms lack the reciprocal to-and-fro characteristic of social communication, offering little insight into the way these processes operate online during real-world interaction. In the present study, we overcame this by developing a "hyperscanning" paradigm in which pairs of interactants could communicate verbally with one another in a joint-action task whilst both undergoing functional magnetic resonance imaging simultaneously. Successful performance on this task required both interlocutors to predict their partner's upcoming utterance in order to converge on the same word as each other over recursive exchanges, based only on one another's prior verbal expressions. By applying various whilst they establish a common ground.People are capable of rapid improvements in performance when they are offered a reward. The neural mechanism by which this performance enhancement occurs remains unclear. We investigated this phenomenon by offering people monetary reward for successful performance in a sequence production task. We found that people performed actions more quickly and accurately when they were offered large reward. Increasing reward magnitude was associated with elevated activity throughout the brain prior to movement. Multivariate patterns of activity in these reward-responsive regions encoded information about the upcoming action. Follow-up analyses provided evidence that action decoding in pre-SMA and other motor planning areas was improved for large reward trials and successful action decoding in SMA was associated with improved performance. These results suggest that reward may enhance performance by enhancing neural representations of action used in motor planning.In recent years there has been growing interest in measuring time-varying functional connectivity between different brain regions using resting-state functional magnetic resonance imaging (rs-fMRI) data. One way to assess the relationship between signals from different brain regions is to measure their phase synchronization (PS) across time. There are several ways to perform such analyses, and we compare methods that utilize a PS metric together with a sliding window, referred to here as windowed phase synchronization (WPS), with those that directly measure the instantaneous phase synchronization (IPS). In particular, IPS has recently gained popularity as it offers single time-point resolution of time-resolved fMRI connectivity. In this paper, we discuss the underlying assumptions required for performing PS analyses and emphasize the importance of band-pass filtering the data to obtain valid results. Further, we contrast this approach with the use of Empirical Mode Decomposition (EMD) to achieve similar goals. We review various methods for evaluating PS and introduce a new approach within the IPS framework denoted the cosine of the relative phase (CRP). We contrast methods through a series of simulations and application to rs-fMRI data. Our results indicate that CRP outperforms other tested methods and overcomes issues related to undetected temporal transitions from positive to negative associations common in IPS analysis. Further, in contrast to phase coherence, CRP unfolds the distribution of PS measures, which benefits subsequent clustering of PS matrices into recurring brain states.Evidence accrues that readers form multiple hypotheses about upcoming words. The present study investigated the hemodynamic effects of predictive processing during natural reading by means of combining fMRI and eye movement recordings. In particular, we investigated the neural and behavioral correlates of precision-weighted prediction errors, which are thought to be indicative of subsequent belief updating. Participants silently read sentences in which we manipulated the cloze probability and the semantic congruency of the final word that served as an index for precision and prediction error respectively. With respect to the neural correlates, our findings indicate an enhanced activation within the left inferior frontal and middle temporal gyrus suggesting an effect of precision on prediction update in higher (lexico-)semantic levels. Despite being evident at the neural level, we did not observe any evidence that this mechanism resulted in disproportionate reading times on participants' eye movements. The results speak against discrete predictions, but favor the notion that multiple words are activated in parallel during reading.
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