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Postponed Intravascular Lithotripsy-Facilitated Stenting throughout ACS: Novel Way of Improve PCI Results within Severe Calcification?
OBJECTIVE In April 2015, the English National Health Service started implementing the first waiting time targets in mental health care. This study aims to investigate the effect of the 14-day waiting time target for early intervention in psychosis (EIP) services after the first six months of its implementation. STUDY DESIGN We analyse a cohort of first-episode psychosis patients from the English administrative Mental Health and Learning Disabilities Dataset 2011 to 2015. We compare patients being treated by EIP services (treatment) with those receiving care from standard community mental health services (control). We combine non-parametric matching with a difference-in-difference approach to account for observed and unobserved group differences. We analyse the probability of waiting below target and look at different percentiles of the waiting time distribution. RESULTS EIP patients had an 11.6-18.4 percentage point higher chance of waiting below target post-policy compared to standard care patients. However, post-policy trends at different percentiles of the waiting time distribution were not different between groups. CONCLUSIONS Mental health providers seem to respond to waiting time targets in a similar way as physical health providers. The increased proportion waiting below target did not, however, result in an overall improvement across the waiting time distribution.The present study investigates predictors of the national resilience (NR) and community resilience (CR) of civilians who live on Israel's northern border, and are facing for years acts of terror and threats of war. A sample of 1515 kibbutz (communal settlement) members who live next to this northern Israeli border has responded to questionnaires pertaining to the investigated resiliencies. Results indicate that under these conditions psychological reactions (trust in community institutes and individual resilience), rather than demographic characteristics, are the best predictors of NR and CR; although NR is further predicted by right-wing political attitudes. Our data suggest that CR and NR are not predicted by objective examinations of the strength of one's community or country. Both of them are perceived as stronger the greater the trust of the respondents in their own ability to cope with adversities, and in the ability of their close community to take care of them and their families in face of terror.Research on Arts on Prescription (AoP) programmes are on the increase and the participants' positive mental health outcomes are well-documented. However, there is insufficient research that considers the participating cultural institutions' perspectives. A qualitative focus group interview was conducted with the participating culture institutions in an AoP project in Denmark. Representatives from seven cultural institutions participated in the interview. The data was transcribed and analysed using Braun and Clark's (Qual Res Psychol 3(77)77-101. https//doi.org/10.1191/1478088706qp063oa, 2006) thematic approach. The cultural institutions were positive about the interdisciplinary collaboration with the Center for Mental Health and benefited from working with groups of people with mental health problems. NSC 27223 clinical trial They considered the collaboration to have encouraged skills development by working with groups that they did not regularly engaged with. If cultural institutions are to engage with the mental health wellbeing agenda then policy-driven initiatives can support collaborations that involve groups of people with mental health problems.This study assessed youth anxiety about political issues and associated characteristics. Caregivers (N = 374) were recruited through Amazon Mechanical Turk and reported on their child's anxiety about 15 voting issues covered in the media since the 2016 presidential election as well as their child's psychological functioning and their own trait anxiety. For the majority of voting issues, over 50% of caregivers indicated that their child experienced at least one related worry; worries about the environment and gun violence were most common. Youth empathy and intolerance of uncertainty were each positively associated with worry about political issues but did not predict such worry after accounting for the effect of youth trait anxiety. Youth with clinical levels of generalized anxiety experienced more severe worry about political issues than did youth with minimal/subthreshold anxiety. Future studies should identify strategies for mitigating the negative impact of political news on youth with anxiety disorders.Population decline and the threat of extinction are realities currently facing many species. Yet, in most cases, the detailed demographic data necessary to identify causes of population decline are unavailable. Using 43 years (1975-2017) of data from a box-nesting population of tree swallows (Tachycineta bicolor), we identified reduced survival of offspring as a probable demographic cause of population decline. Poor fledging success was associated with increased predation and poor weather conditions during early nestling development. Low juvenile survival and subsequent recruitment was linked to poor weather conditions during the post-fledging period and may also be linked to conditions on the wintering grounds. Regional weather conditions during critical stages of breeding (early nestling and post-fledging) have become progressively worse over the 43-year study period. None of the other factors linked to offspring survival have similarly deteriorated. Overall, our results suggest tree swallows should be added to the growing list of species challenged by climate change, and that other species of aerial insect specialists may face similar impacts of climate change.Establishing superior preclinical models is critical for translational cancer research owing to the high failure rates of novel therapeutics in clinical studies. Even though cell line-derived xenograft models are easy to create, they have numerous limitations since these models do not represent the distinctive features of each cancer patient adequately. To circumvent the discrepancies between xenograft models and tumors, patient-derived xenograft (PDX) models have been developed. These models are established through the engraftment of tissue from a patient's tumor into an immune-deficient mouse, which preserves cell-cell interactions and tumor microenvironment. Since PDXs precisely replicate intratumoral heterogeneity, a range of chemotherapeutic agents can be tested on individual tumors. Colorectal cancer represents a unique case to demonstrate clinical perspectives revealed by PDX models since they surmount limitations of conventional ex vivo models. Even though PDX models have been associated with drawbacks with respect to prediction of clinical outcomes, they are currently the model of choice for preclinical investigations in colorectal cancer.
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