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Spot light upon Asteroid Hyalosis: A Medical Viewpoint.
Chondrocytes and osteoblasts were applied each in the shell while the respective differentiation factors (TGF-β3, BMP-2) were provided by a Laponite-supported core serving as central factor depot within the strand, allowing directed differentiation of cells in close contact to the core. Experiments with bi-zonal constructs, comprising an osteogenic and a chondrogenic zone, revealed that the local delivery of the factors from the core reduces effects of these factors on the cells in the other scaffold zone. These observations prove the general suitability of the suggested system for co-differentiation of different cell types within a zonal construct.We study the dynamics of a spin torque nano oscillator that consists of parallelly magnetized free and pinned layers by numerically solving the associated Landau-Lifshitz-Gilbert-Slonczewski equation in the presence of a field-like torque. We observe that an in-plane magnetic field which is applied for a short interval of time ( less then 1 ns) triggers the magnetization to exhibit self-oscillations from low energy initial magnetization state. Also, we confirm that the frequency of oscillations can be tuned over the range ∼25-∼72 GHz by current, even in the absence of field-like torque. We find the frequency enhancement up to 10 GHz by the presence of field-like torque. We determine theQ-factor for different frequencies and show that it increases with frequency. Our analysis with thermal noise confirms that the system is stable against thermal noise and the dynamics is not altered appreciably by it.As the myelin sheath is crucial for neuronal saltatory conduction, loss of myelin in the peripheral nervous system (PNS) leads to demyelinating neuropathies causing muscular atrophy, numbness, foot deformities and paralysis. Unfortunately, few interventions are available for such neuropathies, because previous pharmaceuticals have shown severe side effects and failed in clinical trials. Therefore, exploring new strategies to enhance PNS myelination is critical to provide solution for such intractable diseases. This study aimed to investigate the effectiveness of electrical stimulation (ES) to enhance myelination in the mouse dorsal root ganglion (DRG)-anex vivomodel of the PNS. Mouse embryonic DRGs were extracted at E13 and seeded onto Matrigel-coated surfaces. After sufficient growth and differentiation, screening was carried out by applying ES in the 1-100 Hz range at the beginning of the myelination process. DRG myelination was evaluated via immunostaining at the intermediate (19 daysin vitro(DIV)) and matew way to treat such diseases via electroceuticals.P-type nanostructured photodetectors and phototransistors have been widely used in the field of photodetection due to their excellent electrical and optoelectronic characteristics. However, the large dark current of p-type photodetectors will limit the detectivity. Herein, we synthesized small-diameter single-crystalline p-type SnS nanowires (NWs) and then fabricated single SnS NW photodetectors and phototransistors. The device exhibits low noise and low dark current, and its noise current power is as low as 2.4 × 10-28A2. Under 830 nm illumination and low power density of 0.12 mW cm-2, the photoconductive gain, responsivity and detectivity of the photodetector are as high as 3.9 × 102, 2.6 × 102A W-1and 1.8 × 1013Jones, respectively, at zero gate voltage. The rise and fall time of response are about 9.6 and 14 ms. The experimental results show that the small-diameter p-type SnS NWs have broad application prospects in high-performance and low-power photodetectors with high sensitivity, fast response speed and wide spectrum detection in the future.- Objective the use of motor imagery (MI) in motor rehabilitation protocols has been increasingly investigated as a potential technique for enhancing traditional treatments, yielding better clinical outcomes. However, since MI performance can be challenging, practice is usually required. This demands appropriate training, actively engaging the MI-related brain areas, consequently enabling the user to properly benefit from it. The role of feedback is central for MI practice. Yet, assessing which underlying neural changes are feedback-specific or purely due to MI practice is still a challenging effort, mainly due to the difficulty in isolating their contributions. In this work, we aimed to assess functional connectivity (FC) changes following MI practice that are either extrinsic or specific to feedback.
to achieve this, we investigated FC, using graph theory, in electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) data, during MI performance and at resting-state (rs), respectively. Thedback impacted FC by disrupting common inter-subject patterns, suggesting that subject-specific neural plasticity mechanisms become important. Future studies should consider this when designing experimental NFBT protocols and analyses.Stem cells have been utilized as 'living drugs' in clinics for decades. Their self-renewal, differentiation, and immunomodulating properties provide potential solutions for a variety of malignant diseases and disorders. However, the pathological environment may diminish the therapeutic functions and survival of the transplanted stem cells, causing failure in clinical translation. To overcome these challenges, researchers have developed biomaterial-based strategies that facilitatein vivotracking, functional engineering, and protective delivery of stem cells, paving the way for next-generation stem cell therapies. In this perspective, we briefly overview different types of stem cells and the major clinical challenges and summarize recent progress of biomaterials applied to boost stem cell therapies.The antiferromagnetic topological insulator (AFTI) is topologically protected by the combined time-reversal and translational symmetryTc. In this paper we investigate the effects of thes-wave superconducting pairings on the multilayers of AFTI, which breaksTcsymmetry and can realize quantum anomalous Hall insulator with unit Chern number. For the weakly coupled pairings, the system corresponds to the topological superconductor (TSC) with the Chern numberC= ±2. We answer the following questions whether the local Chern numbers and chiral Majorana edge modes of such a TSC distribute around the surface layers. By the numerical calculations based on a theoretic model of AFTI, we find that when the local Chern numbers are always dominated by the surface layers, the wavefunctions of chiral Majorana edge modes must not localize on the surface layers and show a smooth crossover from spatially occupying all layers to only distributing near the surface layers, similar to the hinge states in a three dimensional second-order topological phases. The latter phase, denoted by the hinged TSC, can be distinguished from the former phase by the measurements of the local density of state. In addition we also study the superconducting vortex phase transition in this system and find that the exchange field in the AFTI not only enlarges the phase space of topological vortex phase but also enhances its topological stability. These conclusions will stimulate the investigations on superconducting effects of AFTI and drive the studies on chiral Majorana edge modes and vortex Majorana zero modes into a new era.Objective. Treatment planning based on computer simulations wasproposed to account for the increased relative biological effectiveness (RBE) of proton radiotherapy beams near to the edges of the irradiated volume. Since silicon detectors could be used to validate the results of these simulations, it is important to explore the limitations of this comparison.Approach. Microdosimetric measurements with a MicroPlus Bridge V2 silicon detector (thickness = 10μm) were performed along the Bragg peak of a clinical proton beam. The lineal energy distributions, the dose-mean values, and the RBE calculated with a biological weighting function were compared with PHITS simulations (microdosimetric target = 1μm water sphere), and published clonogenic survivalin vitroRBE data for the V79 cell line. The effect of the silicon-to-water conversion was also investigated by comparing three different methodologies (conversion based on a single value, novel bin-to-bin conversions based on SRIM and PSTAR).Main results. Mainly due to differences in the microdosimetric targets, the experimental dose-mean lineal energy and RBE values at the distal edge were respectively up to 53% and 28% lower than the simulated ones. Furthermore, the methodology chosen for the silicon-to-water conversion was proven to affect the dose-mean lineal energy and the RBE10up to 32% and 11% respectively. The best methodology to compensate for this underestimation was the bin-to-bin silicon-to-water conversion based on PSTAR.Significance. This work represents the first comparison between PHITS-simulated lineal energy distributions in water targets and corresponding experimental spectra measured with silicon detectors. Furthermore, the effect of the silicon-to-water conversion on the RBE was explored for the first time. The proposed methodology based on the PSTAR bin-to-bin conversion appears to provide superior results with respect to commonly used single scaling factors and is recommended for future studies.Objective. Speed of sound has previously been demonstrated to correlate with fat concentration in the liver. However, estimating speed of sound in the liver noninvasively can be biased by the speed of sound of the tissue layers overlying the liver. Here, we demonstrate a noninvasive local speed of sound estimator, which is based on a layered media assumption, that can accurately capture the speed of sound in the liver. We validate the estimator using an obese Zucker rat model of non-alcoholic fatty liver disease and correlate the local speed of sound with liver steatosis.Approach.We estimated the local and global average speed of sound noninvasively in 4 lean Zucker rats fed a normal diet and 16 obese Zucker rats fed a high fat diet for up to 8 weeks. The ground truth speed of sound and fat concentration were measured from the excised liver using established techniques.Main Results. The noninvasive, local speed of sound estimates of the livers were similar in value to their corresponding 'ground truth' measurn has the potential to be used to predict or assist in the measurement of hepatic fat concentration and that the global average speed of sound should be avoided in hepatic fat estimation due to significant bias in the speed of sound estimate.Flexible conductive thin films have recently become a research area of focus in both academia and industry. In this study, a method of preparing nanofiber conductive films by centrifugal spinning is proposed. find more Polyurethane (PU) nanofiber films were prepared by centrifugal spinning as the flexible substrate film, and carbon nanotubes (CNTs) were used as the conducting medium, to obtain CNTs/PU nanofiber conductive films with good conductivity and elasticity. The effects of different CNT concentrations on the properties of the nanofiber films were investigated. It was found that the conductivity of the nanofiber conductive films was optimal when an impregnation concentration of 9% CNTs was used in the stretching process. Cyclic tensile resistance tests showed that the nanofiber conductive films have good durability and repeatability. Physical and structural property analysis of the CNT/PU conductive films indicate that the adsorption of the CNTs on the PU surface was successful and the CNTs were evenly dispersed on the surface of the matrix.
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