Notes

Antisocial behavior and polymorphisms within the oxytocin receptor gene: studies by 50 % unbiased trials.
of wide application.A 57-year-old man underwent lumbar selective nerve root block (SNRB) for low back pain and lower radiating pain caused by left-sided L4 disc herniation. He presented to the emergency department with fever, headache and aggravated low back pain approximately 3 hours after the procedure. Infection was suspected; hence, blood tests, cerebrospinal fluid (CSF) tests, lumbar magnetic resonance imaging, and brain computed tomography were performed. Imaging findings were not suggestive of infection. The CSF was turbid and yellowish with pleiocytosis; however, the CSF culture was negative. Based on these findings, the patient was diagnosed with acute meningitis. Broad-spectrum antibiotics and steroid therapy were initiated considering the patient's age and general condition. From hospital day (HD) 2, fever and headache were reduced and disappeared completely by HD 5. At the last follow-up, 1 month after discharge, the patient had no symptoms. Acute meningitis is associated with a high mortality and neurologic deficits. Hence, timely tests, diagnosis, and treatment are critical for positive outcomes. Symptoms of meningitis following a nerve block generally occur within 24-48 hours after the procedure. This case is notable, as it involved a quicker and more sudden onset of symptoms; meningitis occurred only a few hours after lumbar selective nerve root block.Heavy menstrual bleeding (HMB) due to primary myelofibrosis (PMF) is secondary to progressive pancytopenia, which is a rare and difficult to treat condition. We report this case with the aim of sharing our experiences and exploring a safe and effective way to treat patients with HMB due to PMF. A 40-year-old woman who had been taking combined oral contraceptives (COCs) for eight years was admitted to our hospital with HMB. A bone marrow biopsy report and genetic testing confirmed the diagnosis of PMF. Norethisterone tablets had an unsatisfactory hemostatic effect. The patient underwent a hysteroscopy and the insertion of a levonorgestrel intrauterine system (LNG-IUS). At the 5-month follow-up, the patient had a lower menstruation bleeding volume. COCs are unsuitable for managing the menstruation of patients with PMF in the long run. Endometrial ablation is the long-term method. However, the patient's fertility requirements should be taken into account. The insertion of an LNG-IUS after hysteroscopic curettage to exclude endometrial malignant lesions is recommended.Epstein-Barr virus (EBV) associated T/NK-cell lymphoproliferative diseases (EBV-T/NK-LPDs) are a cluster of diseases that include chronic active EBV infection (CAEBV) and aggressive NK cell leukemia (ANKL). The pathogenesis of EBV-T/NK-LPDs is largely unclear and the treatment is difficult and in most cases a hematopoietic stem cell transplantation is needed. Hemophagocytic lymphohistiocytosis (HLH) is known to affect the prognosis of patients with EBV-T/NK-LPDs. This study reports a case of a 20-year-old male patient with repeated infectious mononucleosis (IM)-like symptoms such as high fever, splenomegaly, lymphadenopathy for more than two years. The patient had a high EBV-DNA load (NK cells were the main target cells). He was first diagnosed as CAEBV. However, the disease gradually progressed and the patient developed with high ferritin, phagocytosis and monoclonal NK cells in bone marrow, pancytopenia, increased cytokines, and elevated expression of Ki-67. Also, his NK cells had abnormal immunophenotypes and impaired function. The patient had a typical clinical course of progression from CAEBV to ANKL, accompanied by HLH complications and a poor prognosis. Herein, the detailed diagnostic and differential diagnostic process of EBV infection was shown in this report.
In this study, we aim to investigate if there exists some change in the pathogenicity of SARS-CoV-2 by comparing the clinical characteristics between recent imported patients and earlier local patients.

227 local COVID-19 patients diagnosed before February 15, 2020 (local group) and 23 imported COVID-19 patients diagnosed between July 1, 2020, and January 15, 2021 (imported group) were included in this study. Baseline characteristics and characteristics of computed tomography (CT), routine blood test, liver functions, and infectious markers upon admission were collected and compared.

The neutrophil-to-lymphocyte ratio (NLR) of the imported group was 3.21 ± 1.25, which was significantly higher than that of the local group (2.55 ± 1.19) with a
-value of 0.030. The concentration of C-reactive protein of the imported group was 12.34 ± 5.25, which was significantly higher than that of the local group (7.76 ± 6.54 mg/L) with a
-value of 0.0005. No significant difference was observed in the rest characteristics.

The recent imported cases had higher NLR and C-reactive protein levels than the earlier local cases, indicating that the pathogenicity of SARS-CoV-2 is getting worse during the pandemic.
The recent imported cases had higher NLR and C-reactive protein levels than the earlier local cases, indicating that the pathogenicity of SARS-CoV-2 is getting worse during the pandemic.
To investigate the role of comfort care on pain degree and nursing satisfaction in patients undergoing kidney stone surgery.

Altogether 107 patients undergoing kidney stone surgery were obtained as the research participants and randomly grouped into the nursing group (NG, 55 cases) and the control group (CG, 52 cases). MEK inhibitor clinical trial The operation and medication modes of patients in the NG and the CG were the same. Patients in the CG were given routine care, while those in the NG were given comfort care on the basis of the CG. After intervention, the pain, mood, sleep quality, complications and nursing satisfaction of the NG and the CG were compared.

The pain score, SAS and SDS scores of the NG were evidently lower than those of the CG, and the sleep quality was evidently better than that of the CG (P<0.05). The incidence of complications in the NG was 9.0%, which was evidently lower than that in the CG (25.0%), and the nursing satisfaction of the NG was evidently higher than that in the CG (P<0.05).

Comfort care can effectively relieve pain, as well as improve poor moods and the sleep quality of patients with kidney stone surgery, and as such it has a good clinical effect.
Comfort care can effectively relieve pain, as well as improve poor moods and the sleep quality of patients with kidney stone surgery, and as such it has a good clinical effect.
To investigate the expression levels and significance of T lymphocyte subsets, RANTES (regulated on activation, normal T cell expressed and secreted), and inflammatory factors in serum of patients with abdominal aortic aneurysm (AAA).

32 patients each with large (large AAA) and small (small AAA) groups were selected, and 32 normal subjects were selected as control group. Serum C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), RANTES and CD4+ T cells, CD8+ T cells and CD4+/CD8+ expressions in peripheral blood were compared among the three groups.

Compared with control group, CRP, TNF-α, IL-6, RANTES and CD8+ T cells levels were higher in large and small AAA groups, while CD4+ T cells and CD4+/CD8+ levels were lower (P<0.05). Compared with small AAA group, CRP, TNF-α, IL-6, RANTES and CD8+ T cells levels in large AAA group were higher, while CD4+ T cells and CD4+/CD8+ levels were lower (P<0.05). The abdominal aorta diameter was positively correlated with CRP, TNF-α, IL-6, RANTES and CD8+ T cells levels, while negatively correlated with CD4+ T cells and CD4+/CD8+ levels (P<0.001). Receiver operating characteristic curve results showed that the areas under the curve of CRP, TNF-α, IL-6 and RANTES in the diagnosis of AAA were all more than 0.800 (P<0.001).

The serum of patients with AAA was in a state of inflammatory activation, and the expression of T lymphocytes was abnormal. The levels of T lymphocyte subsets, RANTES and inflammatory factors were closely related to abdominal aorta diameter. CRP, TNF-α, IL-6 and RANTES levels could be used as auxiliary indicators for the diagnosis of AAA.
The serum of patients with AAA was in a state of inflammatory activation, and the expression of T lymphocytes was abnormal. The levels of T lymphocyte subsets, RANTES and inflammatory factors were closely related to abdominal aorta diameter. CRP, TNF-α, IL-6 and RANTES levels could be used as auxiliary indicators for the diagnosis of AAA.
This study investigated the correlation between LncRNA-17A expression in peripheral blood mononuclear cells (PBMC) and the Wnt/β-catenin signaling pathway and cognitive function in patients sufferer from Alzheimer disease (AD).

90 cases of AD patients hospitalized during March 2019 to July 2020 were selected into the AD-group, and another 90 healthy volunteers who underwent physical examination during the same period were randomly enrolled as the control-group. The Mini-mental State Examination (MMSE) was applied to measure the cognitive function of the two groups of subjects, and the qRT-PCR was to detect the expressions of LncRNA-17A, Wnt mRNA, Tcf-4 mRNA and β-catenin mRNA in PBMC, and the correlation between LncRNA-17A expression and cognitive function and Wnt/β-catenin signaling pathway was analyzed.

MMSE score in AD-group was remarkably lower than that in control-group (
). The relative LncRNA-17A expression in PBMC of AD patients was evidently higher than that of the control-group (
). LncRNA-1potential molecular markers of AD with diagnostic and prognostic value.
To investigate the effect of high-quality nursing on psychological status and prognosis of patients undergoing brain tumor surgery.

One hundred and ten patients undergoing brain tumor surgery were divided into control group (n=55, receiving routine nursing) and observation group (n=55, receiving high-quality nursing). The psychological status (Hamilton Anxiety Rating Scale (HAMA) and Hamilton Depression Rating Scale (HAMD)), quality of life (Generic Quality of Life Inventory-74 Scale (GQOLI-74)), prognosis (Glasgow Outcome Scale (GOS)), self-efficacy (Strategies Used by People to Promote Health Scale (SUPPH)) and complications of patients in both groups were recorded and compared.

After intervention, scores of HAMA and HAMD in both groups decreased, while scores of GOS, GQOLI-74 and SUPPH in both groups increased (all P<0.05). Compared with the control group, scores of HAMA and HAMD in the observation group were lower after intervention, while scores of GOS, GQOLI-74 and SUPPH were higher (all P<0.05). There was no significant difference in mortality between the two groups (P>0.05). The overall complication rate in the observation group was lower than that in the control group during hospitalization (P<0.05).

Perioperative high-quality nursing for patients undergoing brain tumor surgery can significantly alleviate the adverse psychological states, reduce the complication rate and improve the postoperative self-efficacy and quality of life.
Perioperative high-quality nursing for patients undergoing brain tumor surgery can significantly alleviate the adverse psychological states, reduce the complication rate and improve the postoperative self-efficacy and quality of life.
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