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A Tale of Two Assessment Methods: Looking at a great eHealth Reading and writing and User Experience Record together with Heuristic Examination.
High intraocular pressure (IOP) has been regarded as a predominant risk factor for glaucoma. Nitric oxide (NO) is shown to lower IOP, but the magnitude and duration of IOP reduction are not satisfying due to the poor cornea penetration of NO drugs and limited NO generation in the trabecular meshwork (TM)/Schlemm's canal (SC) area. Herein, we introduce deep cornea penetrating biodegradable hollow mesoporous organosilica (HOS) nanocapsules for the efficient co-delivery of hydrophobic JS-K (JR) and hydrophilic l-Arginine (LO). The resulting HOS-JRLO can be reduced and oxidized by the ascorbic acid (AA) and catalysis of endothelial nitric oxide synthase (eNOS) in the TM/SC microenvironment to release NO for inducing appreciable IOP reduction in various glaucoma mouse models. In addition to developing an endogenous stimuli-responsive NO nanotherapeutic, this study is also expected to establish a versatile, non-invasive, and efficacious treatment paradigm for precision glaucoma therapy.Frequent leaks of hazardous chemicals have a huge impact on human lives, property and the ecological environment. Therefore, the three-dimensional functional porous materials with high absorption efficiency and special wettability for the disposal of hazardous chemical spills is an urgent demand. In this work, a series of spherical beads consisting of partially reduced graphene oxide (prGO) and MXene (Ti3C2Tx) nanosheets were constructed by hydrogen bond induced self-assembly along with freeze-drying and thermal treatment. The lightweight and amphipathic prGO/MXene spherical beads (prGMSBDs) had millimeter-level size, spherical morphology and highly porous internal structure, which were especially suitable for eliminating hazardous chemicals. Because of their excellent thermal stability and fire retardance, the prGMSBDs could be used to absorb flammable organic liquids, reducing the fire risk of the flammable hazardous chemical spills. Indeed, the prGMSBDs exhibited outstanding absorption performances for various hazardous chemicals, including organic solvents and water-based concentrated acid and alkali. Moreover, the prGMSBDs showed relatively stable absorption performance after five absorption-drying cycles. Due to meeting the requirements of both amphipathic characteristic and flame retardancy, the prGMSBDs reported in this work may offer a promising strategy for rapidly cleaning up various hazardous chemicals and open a feasible route to protecting the combustible hazardous chemical spills from fire.The great threat of pesticide residues to the environment and human health has drawn widespread interest to explore approaches for pesticide monitoring. Compared to commonly developed single-signal pesticide assays, multi-mode detection with inherent self-validation and self-correction is expected to offer more reliable and anti-interference results. However, how to realize multi-mode analysis of pesticides still remains challenging. Herein, we propose a dual-mode fluorescence and colorimetric method for pesticide determination by integrating stimulus-responsive luminescence with oxidase-mimetic activity into cerium-based coordination polymer nanoparticles (CPNs(Ⅳ)). The CPNs(Ⅳ) exhibit good oxidase-like activity of catalyzing the colorless 3,3',5,5'-tetramethylbenzidine (TMB) oxidation to its blue oxide, offering a visible color signal; by employing acid phosphatase (ACP) to hydrolyze ascorbic acid 2-phosphate (AAP), the generated ascorbic acid (AA) can chemically reduce the CPNs(Ⅳ) to CPNs(Ⅲ), which exhibit a remarkable fluorescence signal but lose the oxidase-mimicking ability to trigger the TMB chromogenic reaction; when pesticides exist, the enzymatic activity of ACP is restrained and the hydrolysis of AAP to AA is blocked, leading to the recovery of the catalytic TMB chromogenic reaction but the suppression of the fluorescence signal of CPNs(Ⅲ). According to this principle, by taking malathion as a pesticide model, dual-mode 'off-on-off' fluorescence and 'on-off-on' colorimetric detection of the pesticide with good sensitivity was realized. Excellent interference-tolerance and reliability were verified by applying it to analyze the target in real sample matrices. With good performance and practicability, the proposed dual-mode approach shows great potential in the facile and reliable monitoring of pesticide residues.In this work, sequential applications of light-emitting diodes (UV-LEDs) with two wavelengths and chlorine (Cl2) were performed for fungal spores disinfection UV-Cl2, Cl2-UV, UV/Cl2-UV, UV-UV/Cl2, Cl2-UV/Cl2-Cl2. Overall comparisons of the sequential processes with respect to the inhibitory effect on photoreactivation were also evaluated. According to the evaluation of culturability and membrane permeability, inactivation of fungal spores by UV was not enhanced by prior or post exposure to Cl2, but in the UV/Cl2 process with pre or post UV treatment, the inactivation efficiency was greatly enhanced. Take P. polonicum for example, pre-treatments by UV265 and UV280 (40 mJ/cm2) caused the log count reduction (LCR) of 1.05 log and 0.95 log, then the followed UV265/Cl2 and UV280/Cl2 at the same UV fluence caused additional LCR of 1.80 log and 2.00 log. The permeabilization of P. polonicum was also accelerated in the processes of UV/Cl2-UV and UV-UV/Cl2, especially at the wavelength of 280 nm. In the sequential processes, especially those containing UV/Cl2 or at the wavelength of 280 nm, could promote the formation of intracellular reactive oxygen species (ROS), thus leading to more severe damage to the spores as reflected in the culturability reduction, membrane permeability and inhibition of photoreactivation.This study evaluated the effectiveness of external electron donors on the bio-reductive degradation enhancement of fluoroglucocorticoids (FGCs) in the groundwater fluctuation zone during the wet season when reverse upward fluctuation of the groundwater table occurs and the dry season after the groundwater table declines. The results showed that the external electron donors, provided by the addition of nano zero-valent iron-modified biochar (nZVI@BC), inhibited the migration and enhanced the reductive defluorination of triamcinolone acetonide (TA), a representative FGC. Bezafibrate concentration The accumulation rate constant with temporal fluctuation depth and the attenuation rate constant with vertical fluctuation depth were -2.55 × 10-3 and 4.20 × 10-2, respectively, in the groundwater of the natural groundwater fluctuation zone (N-FZ). In contrast, the accumulation and attenuation rate constants were, respectively, 35.6% and 2.64 times higher in the groundwater fluctuation zone amended with nZVI@BC (nZVI@BC-FZ) as compared with those observed in the N-FZ. Furthermore, the decay rate constant of the TA residue in the dry season was 0.843 × 10-2 μg/d in N-FZ and was 2.19 times higher in nZVI@BC-FZ. This enhancement effect, caused by the addition of external electrons, was positively correlated with the evolution of the microbial community and the expression of functional genes. The microbes evolved into functional genera with reductive dehalogenation (Xylophilus and Hydrogenophaga) and iron-oxidizing (Lysobacter, Pseudoxanthomonas, and Sphingomonas) abilities in the nZVI@BC-FZ system, which increased dehalogenation and iron oxide genes by a 4-5 order of magnitude. The utilization proportion of external electrons for TA metabolism was 50.04%, of which 30.82%, 10.26%, and 8.96% were utilized for defluorination, hydrogenation, and ring-opening, respectively. This study provides an effective method to reduce pollutant diffusion and enhance the bio-reductive degradation caused by groundwater table fluctuation.Periodate (PI)-based advanced oxidation processes have recently received increasing attentions. Herein, PI was readily activated by nano zero-valent iron (nZVI) and subsequently led to the enhanced oxidation of organic contaminants, with the removal performance of sulfadiazine (SDZ) in the nZVI/PI process even higher than that in the nZVI/peroxydisulfate process under identical conditions. Kinetic experiments indicated that the decay of SDZ was susceptible to the dosage of nZVI and PI, but was barely affected by pH values (4.0-7.0) under buffered conditions, suggesting the promising performance of the nZVI/PI process in a relatively wide pH range. Selective degradation of contaminants and 18O-isotope labeling assays collectively demonstrated that iodate radical (•IO3), high-valent iron-oxo species (Fe(IV)) and hydroxyl radical (•OH) were responsible for the abatement of organic contaminants. More importantly, due to the relatively weak steric hindrance effect of PI, PI easily adsorbed on the surface of nZVI and no iron leaching was detected throughout the reaction, implying that PI activation induced by nZVI was a surface-mediated process. Besides, PI was not transformed into harmful reactive iodine species. This study proposed an environmental-friendly approach for PI activation and shed new lights on the PI-based processes.Polyethylene film is the most widely used plastic film in agricultural production activities, and its depolymerization products are mainly polyethylene-particles (PE-particles) of different molecular weights. However, the impact of the molecular weights of the PE-particles on soil-crop microenvironment has not been elucidated. In this study, a potted microcosmic simulation system was used to evaluate the impact of low, medium and high molecular weight PE-particles on soil metabolism, microbial community structure, and crop growth. There were obvious differences in the shape and surface microstructure of PE-particles with different molecular weights. Soil sucrase and peroxidase had significant responses to PE-particles of different molecular weights. In the rhizosphere, the number of microorganisms and the microbial alpha diversity index increased with increasing PE-particles molecular weight. Rhizobacter, Nitrospira, and Sphingomonas were the dominant microorganisms induced by PE-particles to regulate the metabolism of elements. Carbohydrate and amino acid contents in rhizosphere soils were the key factors affecting the species abundance of Lysobacter, Polyclovorans, Rhizobacter, and Sphingomonas. In plants, PE-particles treatment reduced the plant biomass and photosynthetic rate and disrupted normal mineral nutrient metabolism. Different molecular weight PE-particles may therefore have adverse effects on the soil-plant system.Antibiotic resistant bacteria (ARB) and the antibiotic resistance genes (ARGs) dissemination via plasmid-mediated conjugation have attracted considerable attentions. In this research, sulfidated nanoscale zerovalent iron (S-nZVI)/peroxymonosulfate (PMS) and S-nZVI/peroxydisulfate (PDS) process were investigated to inactivate ARB (Escherichia coli DH5α with RP4 plasmid, Pseudomonas. HLS-6 contains sul1 and intI1 on genome DNA sequence). S-nZVI/PMS system showed higher efficiency than S-nZVI/PDS on ARB inactivation. Thus, the optimal condition 28 mg/L S-nZVI coupled with 153.7 mg/L (0.5 mM) PMS was applied to remove both intracellular ARGs (iARGs) and ARB. The oxidative damage of ARB cell was systemically studied by cell viability, intracellular Mg2+ levels, the changes of extracellular and internal structure, integrity of cell walls and membranes and enzymatic activities. S-nZVI/PMS effectively inactivated ARB (~7.32 log) within 15 min. These effects were greatly higher than those achieved individually. Moreover, removal efficiencies of iARGs sul1, intI1 and tetA were 1.
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