Notes

A manuscript function of HSP90 throughout regulatory osteoclastogenesis simply by abrogating Rab11b-driven transportation.
Reduction pathways were proposed accordingly. Collectively, S(IV)/Fe(III) process is a viable technology for reductively decontaminating realistic waters, especially when applied between the ozone-activated carbon process (i.e., the ozone-S(IV)/Fe(III)-activated carbon process).Estuarine sediments are crucial repositories and incubators of molybdenum (Mo) during its transport from rivers to the ocean. Here, Mo mobility and related processes in estuarine sediments were explored using high-resolution dialysis (HR-Peeper) and diffusive gradients in thin films (DGT) techniques. Better correlations were observed between dissolved Mn and Mo than between dissolved Fe and Mo, implying that Mn geochemistry plays a key role in dissolved Mo mobility via molybdate adsorption onto abundant Mn oxides and its substantial release upon intense Mn reduction. As a result, oxic intertidal sediments functioned as Mo sinks, and anoxic subtidal sediments functioned as Mo sources. Y-27632 The opposite vertical distributions between DGT-Labile S and DGT-Labile Mo indicated that the availability of labile Mo can be blocked by aqueous sulfide. However, the corresponding high concentrations of DGT-Labile S and dissolved Mo at subtidal sites demonstrated that the abundant dissolved Mo remobilized via Mn reduction was not effectively solidified by sulfide. Simulation with the DIFS model further verified that redox conditions and induced physicochemical processes are crucial factors controlling Mo mobility, with relatively low dissolved Mo concentrations but an adequate and steady resupply capacity of the bioavailable molybdate in intertidal sediments.Water pollution caused by industrial oily wastewater, is world-widely concerned by both scientific and practical researches, owing to its catastrophic destruction to natural environment, which highlights the urgency of producing green and advanced separation materials. Herein, a novel approach was proposed to fabricate oil-absorbing and oil/water-separating microcellular polypropylene (PP)/carbon nanotubes (CNTs)/sorbitol nanocomposites using a simple, green, and facile microcellular foaming technology. Owning to the effectively modified crystallization via introducing CNTs/sorbitol derivatives, the ultralight and highly-reticulated PP microcellular foam was prepared with an open-cell content of 99.4% and an expansion ratio of 50, which facilitated the creation of nano-porous structures on cell walls. Hence, the as-prepared PP nanocomposite foam presented pronounced absorption capacity of 40 g/g for applied oils with recovery efficiency of 97.2%, superior thermal-insulating and mechanical performance. Furthermore, the as-achieved unique hierarchical porous structures of the PP/CNT/sorbitol foam contributed to the outstanding oil/water separation capability, separation efficiency of up-to 97.6%, ascribed to its superhydrophobicity, capillary penetration action, high porosity and open-cell content. Therefore, this work provided new insight into the feasibility of advantageous, high-efficiency, environmentally friendly, and profitable PP-based foams as oil absorbents, which, to the best of our knowledge, outperform conventional polymer absorbents in treatment of oily wastewater.As the wide application of carbon nanoparticles (CNPs) and zinc oxide nanoparticles (ZnONPs), as well as ubiquitous chromium (Cr(VI)) pollution in environment, the chance of human exposure to CNPs/ZnONPs and their Cr(VI) adducts is enhanced. We therefore investigated the impacts of nano-cell and nano-Cr(VI) interactions on nanoparticle-Cr(VI) combined cytotoxicity in human lung epithelial (A549) cells. Our results showed that nano-cell and nano-pollutant interactions were the key elements in NP-pollutant combined cytotoxicity, as determined by cell death, oxidative stress and mitochondrial dysfunction. A strong adsorption of Cr(VI) on CNPs and reduction of Cr(VI) to Cr(III) were confirmed, resulting in the reduced cytotoxicity of CNP-Cr(VI) adducts. In contrast, ZnONPs caused the destruction of cell membranes so that more ZnONP-Cr(VI) adducts could enter the cells. Meantime, more Cr contents could be released from ZnONP-Cr(VI) adducts once entering cells and locating in lysosomes than that from CNP-Cr(VI) adducts. These two reasons together caused the enhanced cytotoxicity of ZnONP-Cr(VI) adducts. These findings indicate that the in-depth investigations on the interaction mechanisms are crucial to comprehensively understand the combined cytotoxicity of different NPs and pollutants.The widespread use of selenium (Se) in technological applications (e.g., solar cells and electronic devices) has led to an accumulation of this metalloid in the environment to toxic levels. The newly described bacterial strain Stenotrophomonas bentonitica BII-R7 has been demonstrated to reduce mobile Se(IV) to Se(0)-nanoparticles (Se(0)NPs) and volatile species. Amorphous Se-nanospheres are reported to aggregate to form crystalline nanostructures and trigonal selenium. We investigated the molecular mechanisms underlying the biotransformation of Se(IV) to less toxic forms using differential shotgun proteomics analysis of S. bentonitica BII-R7 grown with or without sodium selenite for three different time-points. Results showed an increase in the abundance of several proteins involved in Se(IV) reduction and stabilization of Se(0)NPs, such as glutathione reductase, in bacteria grown with Se(IV), in addition to many proteins with transport functions, including RND (resistance-nodulation-division) systems, possibly facilitating Se uptake. Notably proteins involved in oxidative stress defense (e.g., catalase/peroxidase HPI) were also induced by Se exposure. Electron microscopy analyses confirmed the biotransformation of amorphous nanospheres to trigonal Se. Overall, our results highlight the potential of S. bentonitica in reducing the bioavailability of Se, which provides a basis both for the development of bioremediation strategies and the eco-friendly synthesis of biotechnological nanomaterials.The wide application of carbon-based nanomaterials (CNMs) has resulted in the ubiquity of CNMs in the natural environment and they potentially impose adverse consequences on ecosystems and human health. In this study, we comprehensively evaluated and compared potential toxicological effects and mechanisms of seven CNMs in three representative types (carbon blacks, graphene nanoplatelets, and fullerenes), to elucidate the correlation between their physicochemical/structural properties and toxicity. We employed a recently-developed quantitative toxicogenomics-based toxicity testing system with GFP-fused yeast reporter library targeting main cellular stress response pathways, as well as conventional phenotype-based bioassays. The results revealed that DNA damage, oxidative stress, and protein stress were the major mechanisms of action for all the CNMs at sub-cytotoxic concentration levels. The molecular toxicity nature were concentration-dependent, and they exhibited both similarity within the same structural group and distinctiveness among different CNMs, evidencing the structure-driven toxicity of CNMs. The toxic potential based on toxicogenomics molecular endpoints revealed the remarkable impact of size and structure on the toxicity. Furthermore, the phenotypic endpoints derived from conventional phenotype-based bioassays correlated with quantitative molecular endpoints derived from the toxicogenomics assay, suggesting that the selected protein biomarkers captured the main cellular effects that are associated with phenotypic adverse outcomes.Despite the progress in explanation of mixture toxicity of rare earth elements (REEs), a large knowledge gap still exists in interpreting their mixed effects from a dynamic perspective. Here, we investigated the effects of La-Ce mixtures in Enchytraeus crypticus at different exposure times. The single and mixture toxicity of La and Ce increased with time, as reflected by the reduced LC50/MT50 values. With concentration addition as the reference model, the interactions between La and Ce were quantified by MIXTOX modelling tool, showing a time-dependent pattern with antagonistic effect after 1 and 2 d but additive effects afterwards. The dynamic accumulation and toxicity of La/Ce in organisms exposed to REE mixtures was fitted using a process-based toxicokinetic and toxicodynamic (TK-TD) model to unravel how the elements interacted. Generally, the estimated uptake, elimination, and damage rate constants of La/Ce declined with increasing level of each other, suggesting inhibited uptake and subsequently reduced toxicity of La/Ce due to competition effect. The interplay of La and Ce in TK and TD processes seemed responsible for the observed antagonism. Our study showed that mixture toxicity and interaction of REEs are time-dependent processes and application of TK-TD model may provide more insight into this dynamic effect.In this work, two-dimensional Bi2O2CO3 disk is synthesized, followed by the growth of Bi2S3 over Bi2O2CO3 via topotactic transformation by controlling the amount of thiourea under hydrothermal conditions. The synthesized composite catalyst is investigated for photocatalytic oxidation and reduction of tetracycline hydrochloride and hexavalent chromium under visible light irradiation. High interfacial contact between the Bi2O2CO3 disk0 and Bi2S3 fiber is confirmed via high-resolution microscopic imaging. Enhanced light absorption and increased charge carrier separation is observed after the formation of the Bi2S3/Bi2O2CO3 composite. The Bi2S3/Bi2O2CO3 composite grown using 1 mmol of thiourea shows approximately 98% degradation of tetracycline hydrochloride after 120 min and 99% Cr(VI) reduction after 90 min of photochemical reaction under visible light irradiation. The charge separation is due to the formed internal electric field at the interface, which upon light irradiation follows a z-scheme charge transfer hindering the recombination at the Bi2S3 and Bi2O2CO3 interface, thereby contributing efficiently to the photochemical process. In addition, the mechanism of the photochemical reaction for the degradation of pollutants is supported using quencher and probe experiments. Furthermore, photoelectrochemical detection of antibiotic in aqueous solution is conducted to understand the sensing feasibility of the synthesized system.Heavy metal ions (HMIs) pollution is always a serious issue worldwide. Therefore, monitoring HMIs in environmental water is an important and challenging step to ensure environmental health and human safety. In this study, we spotlight an effortless, single-step in-situ electrochemical polymerization deposition technique to fabricate a novel, low-cost, efficient, nano-engineered poly(melamine)/graphitic-carbon nitride nanonetwork (PM/g-C3N4) modified screen-printed carbon electrode (SPE) for sensitive, selective, and simultaneous electrochemical monitoring of toxic HMIs in environmental waters. g-C3N4 nanomaterial was prepared using melamine as a precursor via pyrolysis technique. As-prepared g-C3N4 and melamine monomer were electrochemically in-situ polymerized/deposited over pre-anodized SPE (ASPE) using cyclic voltammetry technique. XRD, XPS, and SEM were engaged to characterize the developed electrode. The fabricated PM/g-C3N4/ASPE was applied as an environmental sensor to selective and simultaneous electrochemical detection of Pb2+ and Cd2+ ions using differential pulse voltammetry technique.
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