Notes

Reaction of nitric oxide supplement substances in transition-metal-doped silver cluster cations: size- as well as dopant-dependent impulse path ways.
SNP rs5746136 may affect m6A modification and regulate SOD2 expression by guiding the binding of hnRNP C to SOD2, which played a critical tumor suppressor role in bladder cancer cells by promoting cell apoptosis and inhibiting proliferation, migration and invasion. In conclusion, our findings suggest the important role of genetic variants in m6A modification. SOD2 polymorphisms may influence the expression of SOD2 via an m6A-hnRNP C-dependent mechanism and be promising predictors of bladder cancer risk.Engaging the public in protecting water resources is a critical yet challenging task. A wealth of social science studies has identified psychological predictors for individual pro-environmental behaviors. These predictors can guide communication in public engagement and inform the allocation of engagement efforts. However, a thorny challenge is to select influential factors among many candidates. This paper addresses this challenge by using social science research to guide the development of strategies to motivate the public to protect the North American Great Lakes. We considered a variable selection technique, the LASSO regression, in the post-hoc analysis of the International Joint Commission's 2018 Binational Great Lakes Binational Poll data. The poll surveyed 4250 Canadian and U.S. residents of the Great Lakes basin. We fit LASSO logistic models to predict respondents' intentions to take three public actions to protect the Great Lakes, including contacting public officials, attending public meetings, and engaging in online forums and groups. find more The models included 41 predictors encompassing demographic characteristics as well as respondents' awareness, beliefs, and values that are pertinent to Great Lakes policy development and management. Results revealed eight variables that consistently predicted the three public actions, including indigenous status, political ideology, impacts of the specific policy issues of nuclear wastes, policy awareness and interests, and the Great Lakes values for personal benefits and wildlife. Based on these findings, we recommend strategies to motivate the public to take public actions to protect the Great Lakes.
The hypoglossal nucleus (HN) controls the movement of the genioglossus (GG) muscle whose dysfunction leads to airway occlusion and occurrence of obstructive sleep apnea (OSA). Histamine produced by the tuberomammillary nucleus (TMN) has a potent excitatory action on GG muscle activity.

The aim of the study was to investigate the role histaminergic neurons play in the regulation of the genioglossus.

C57BL/6 mice were exposed to chronic intermittent hypoxia (CIH) for 3weeks to resemble OSA. The histamine H3 receptor (H3R) antagonist ciproxifan was applied to increase histamine in the brain. Histamine levels and GG activity were measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and electromyogram (EMG) separately. Neuronal activity and repair ability of the HN and TMN and key proteins of histamine were analyzed by immunohistochemistry and western blots.

Significant decline of histamine level and GG activity of the HN and TMN induced by CIH exposure could be ameliorated by ciproxifan. Application of ciproxifan could also partly reverse the decline of the histidine decarboxylase (HDC) by CIH.

This investigation studied the impacts of ciproxifan on the HN and TMN in CIH conditions and revealed that the negative effects on the HN and TMN caused by CIH could be partly ameliorated by ciproxifan, which might open new perspectives for the development of pharmacological treatment for OSA.
This investigation studied the impacts of ciproxifan on the HN and TMN in CIH conditions and revealed that the negative effects on the HN and TMN caused by CIH could be partly ameliorated by ciproxifan, which might open new perspectives for the development of pharmacological treatment for OSA.
Methylphenidate and d-amphetamine, medications used for treatment of attention deficit hyperactivity disorder (ADHD), are used recreationally and self-administered by laboratory animals. Benztropine (BZT) analogs, like those medications, increase synaptic dopamine levels but are less effective in maintaining self-administration, suggesting clinical utility with less abuse liability.

The current study was designed to evaluate potential therapeutic effects of BZT analogs related to ADHD.

Rats responded under a delay-discounting procedure in which responses on one lever produced immediate delivery of a single food pellet and alternative responses produced four food pellets either immediately or with various temporal delays, with those delays arranged in ascending or random orders in different groups of rats. Selection of the smaller more immediate reinforcer has been suggested as an aspect of "impulsivity," a trait with suggested involvement in ADHD. Other rats were studied under fixed-interval (FI) 300-s schedules to assess drug effects on behavior under temporal control.

d-Amphetamine, methylphenidate, and the BZT analog AHN 1-055, but not AHN 2-005 or JHW 007, increased selection of the large, delayed reinforcer with either arrangement of delays. All drugs changed the temporal distribution of responses within the FI from one with responses concentrated at the end to a more uniform distribution. Changes in the temporal distribution of FI responding occurred with drugs that did not affect discounting suggesting that discounting does not arise directly from the same temporal control processes controlling FI responding.

AHN 1-055 may be of clinical utility in the treatment of ADHD.
AHN 1-055 may be of clinical utility in the treatment of ADHD.We report the observation of the soft tissue recurrence of an osteoid osteoma (OO) in a 26-year-old man initially complaining of post-traumatic pain and swelling of the right ankle. A first arthroscopic resection was performed after the misdiagnosis of "bone irregularities" observed on computed tomography (CT) and magnetic resonance imaging (MRI). The diagnosis of OO was made by histological analysis of the resection material. The patient became asymptomatic for 5 years until the symptoms progressively recurred. Follow-up MRI and CT studies demonstrated a nodular bony focus within the periarticular soft tissues of the ankle. The lesion was removed, and histological analysis confirmed the diagnosis of a whole viable OO. This observation likely resulted from the displacement of the initial lesion during the initial arthroscopic procedure. This case report highlights the possibility of recurrence of OO in the soft tissues.
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