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Redox-responsive magnetic nanovectors self-assembled from amphiphilic polymer as well as metal oxide nanoparticles to get a a little bit specific delivery of paclitaxel.
83-9.47) in the group receiving JD Granule and 8 months (95% CI 6.67-9.80) in the group receiving sorafenib, with half-, 1- and 2-year survival rates of 53.6%, 31.2% and 13.2% vs 60.1%, 35.5% and 14.2%, respectively. Even after PSM, the median survival time did not differ between the JD Granule group (9.03 months; 95% CI 6.37-14.2) and the sorafenib group (7.93 months; 95% CI 6.5-9.97), with comparable half-, 1- and 2-year survival rates. The most common adverse events (AEs) were diarrhea (13.7%) and fatigue (5.6%) in the JD Granule group, and hand-foot skin reaction (46.3%) and diarrhea (36.6%) in the sorafenib group. The JD Granule was more cost-effective than sorafenib treatment for advanced HCC. Conclusion Compared to sorafenib, JD Granule was more cost-effective and caused fewer AEs for the treatment of Chinese patients with advanced HCC.Objective To investigate the effects of Aurantii Fructus Immaturus (Zhishi, ZS) and Atractylodis Macrocephalae Rhizoma (Baizhu, BZ)-containing serum on glutamate-induced autophagy in rat colonic interstitial cells of Cajal (ICCs) and to analyze the underlying mechanism. Methods Rat colonic ICCs cultured in vitro were identified by fluorescence and then stimulated with glutamic acid (5 mmol/L) for 24 h to establish a cell model of autophagy. The cells were then treated with different concentrations of ZSBZ-containing serum or rat serum. The viability of the ICCs was detected with cell counting kit-8 assays, and cell apoptosis rates were examined with flow cytometry. The ultrastructure and autophagosomes in the ICCs were observed using transmission electron microscopy. The effects of ZSBZ-containing serum on apoptosis-associated mediators were assessed by Western blotting and real-time quantitative polymerase chain reaction. In addition, microtubule-associated protein light chain 3 (LC3), p-phosphoinositide 3-kinase (p-PI3K), p-Akt and p-mammalian target of rapamycin (p-mTOR) expression was detected via Western blotting analysis. Results Compared to those in the model group, ICC viability and apoptosis rates were significantly increased by ZSBZ-containing serum (P less then 0.05). In addition, the expression levels of Beclin-1, LC3, p-PI3K, p-Akt and p-mTOR were significantly lower (P less then 0.05) and Bcl-2 expression was higher in the ZSBZ-containing serum treatment groups than in the model group (P less then 0.05). Conclusion Our findings demonstrated that ZSBZ protects glutamic acid-stimulated ICCs, and this beneficial effect may be mediated by a reduction in autophagy via inhibition of the PI3K/Akt/mTOR pathway.This is the first study that compared treatment plan quality and planning efficiency for lung stereotactic body radiation therapy (SBRT) using CyberKnife (CK) Multiplan vs Varian Eclipse treatment planning systems, including volumetric modulated arc therapy (VMAT) and knowledge-based VMAT (KBP-VMAT). Thirteen lung SBRT patients treated with 50 to 55 Gy in 3 or 5 fractions were retrospectively included in this study. CK plans created with Multiplan V. 4.6.1 using 2 fixed circular cones were previously approved used for treatment. For the comparison, the computed tomography (CT) data sets and contours from the CK plans were used to generate VMAT and KBP-VMAT plans (University of California San Diego publicly-shared RapidPlan model) using Eclipse V. 13.7. Metrics used for the comparison of CK, VMAT, and KBP-VMAT plans included monitor units (MUs), conformity indices, dose heterogeneity, high-dose spillage, low-dose spillage, adjacent organs at risk (OAR) doses, and treatment planning time. One-way analysis of vaMU requirements. Further improvement for KBP-VMAT is likely achievable by developing site-specific patient models.Sides of ovulation at beginning and end of an interovulatory interval (IOI) were studied for 10 successive ovulations in each of 100 heifers (1000 ovulations, 900 IOI). The frequency of side for 1000 ovulations was less (P less then 0.0002) for the left ovary (LO or L; 44.4 %) than for the right ovary (RO or R; 55.6 %). Number of observed ratios of L to R was determined within each of 100 sets of 10 ovulations per set (eg, L2 to R8, L6 to R4). Expected ratios were calculated by combinatorics using the criterion that side of ovulation was an independent event. Differences in ratios between observed and expected were significant supporting the hypothesis that side of ovulation is dependent on the side of the previous ovulation. Number of pairs of ovulations for each end of the 900 IOI was significantly less for the LL pair (144, 16.0 %) than for the pairs of RR (255, 28.3 %), LR (247, 27.5 %), and RL (254, 28.2 %). The hypothesis was supported that the frequency of the pairs of ovulations at the beginning and end of an IOI differed among LL, RR, LR, and RL pairs. Decursin Novel observations were that frequency was lowest for the LL pair and similar among the the RR, LR, and RL pairs. These observations indicated that the greater frequency of RO ovulation was mathematically and functionally related to lower frequency of LO ovulation. The interpretation was that intraovarianism in the LL pair accounted for the lower frequency of LO than RO ovulation.Introduction We examined patient characteristics, treatments, and outcomes of patients with transformed mycosis fungoides (tMF) from COMPLETE a large, multicenter, prospective cohort study of peripheral T-cell lymphoma patients in the United States. Methods Patients with tMF were enrolled in COMPLETE at the time of transformation. For this analysis, we identified patients with tMF with completed baseline, treatment, and follow-up records. Median survival was assessed using Kaplan-Meier methodology. Results Of the 499 patients enrolled in COMPLETE, 17 had tMF. Median age was 61; 53% were male, 9 had elevated lactate dehydrogenase, and 9 had lymph node involvement. Approximately one-quarter of the patients were African American and 47% had CD30+ disease. Median time to transformation was 53 months. All patients received systemic therapy, with 19% receiving concomitant radiotherapy. Most patients (87%) received single agents, including liposomal doxorubicin, pralatrexate, and gemcitabine. Eight patients (50%) had reported responses to therapy.
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