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To determine factors of innate and acquired immunity in adaptation disorders with a predominance of asthenic or anxiety-depressive syndrome.
Twenty-five patients with ICD-10 diagnosis of «Adaptation Disorders» (F43.2), including 9 with asthenic syndrome and 16 with anxiety-depressive syndrome, were examined. The control group consisted of 23 healthy individuals. The relative number of lymphocyte phenotypes was determined by flow cytometry; the concentration of IgM, IgG, IgA, aAB to S100b and MBP - by ELISA; CIC level - by the method of selective precipitation with PEG-6000; phagocytic activity of neutrophils by a test system with melamine-formaldehyde latex; activities of leukocyte elastase (LE) and α1-proteinase inhibitor (α1-PI) by a spectrophotometric method.
There were significant changes in the parameters of acquired immunity in the group with asthenic syndrome and those of innate immunity in the group with anxiety-depressive syndrome. Fluoxetine An increase in α1-PI activity, in the total number of significa the course of adaptation disorders.
To study the diagnostic potential of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGFA) and their high affinity receptors (TrkB, VEGFR2) in the development and progression of diabetic polyneuropathy.
The main group consisted of 65 patients with diabetes mellitus and confirmed DPN. The comparison group included 14 people with diabetes mellitus without DPN. The control group consisted of 15 healthy individuals. Clinical characteristics of DPN were evaluated with VAS, PainDetect, TSS, NSS, NDS scores. The degree of polyneuropathy was verified by electroneuromyography. Serum levels of the growth factors and their receptors were studied using enzyme-linked immunosorbent assay.
Elevated expression of serum BDNF, VEGFA and TrkB was found in patients with DPN, regardless of the presence of symptoms. The severe stage of DPN is characterized by painless form of polyneuropathy, the deficiency of serum BDNF, VEGFA and VEGFR2 and the high serum level of TrkB. The high expression of BDNF affects the intensity of neuropathic pain, the severity of the clinical signs of DPN and is associated with the severity of axonal damage to sensory nerve fibers. The increase in the TrkB level is associated with the painless form of neuropathy and the degree of nerve fiber demyelination.
Enhanced serum expression of BDNF and VEGFA is proposed as a biomarker for the development of DPN, while different concentrations of TrkB and VEGFR2 receptors can be considered as predictors of DPN severity.
Enhanced serum expression of BDNF and VEGFA is proposed as a biomarker for the development of DPN, while different concentrations of TrkB and VEGFR2 receptors can be considered as predictors of DPN severity.
To clarify a role of distinct factors that form the morphological basis of the classical or primary Chiari type 1 malformation (CM1) in the development of its clinical manifestations and subtypes.
The main study group included 710 adult patients with cerebellar ectopia divided into subgroups according to the severity of cerebellar ectopia (less than 2 mm (CM0); 2-4 mm (CM0,5); 5 mm or more (CM1); 5 mm or more in combination with a pronounced prolapse of the brain stem below the foramen magnum (CM1,5)) as well as to the presence of «overcrowded» posterior cranial fossa (PF) and «small» PF. Clinical symptoms and bone phenotype of PF were analyzed.
With an increase of the degree of cerebellar tonsils ectopia, an increase in the proportion of patients with «overcrowded» PF, syringomyelia, otoneurological and lower cranial nerve, brain stem, cerebellar disturbances was revealed. The phenomenon of «small» PF was observed in 81% of the main group. «Small» PF was associated with a greater proportion of patientsmena in the diagnostic algorithm for patients with suspected Chiari malformation.
The study provided grounds for expanding the classification of CM1 in adults with the inclusion of CM0,5 form as well as for evaluation of the «small» and «overcrowded» PF phenomena in the diagnostic algorithm for patients with suspected Chiari malformation.
A search for accurate linear discriminant function (LDF) allowing the diagnosis of schizophrenia and estimation of treatment effectiveness according to EEG is an urgent problem.
To develop a methodology for discriminant EEG analysis for minimizing the overlearning effect, selection of optimal LDF model and evaluation of its generalizing ability.
Two hundred and twenty patients with schizophrenia and 1400 people without psychiatric diseases, who were comparable in basic characteristics, were enrolled. EEG was recorded using 16 leads, 10-20 system and aural reference electrodes. EEG was processed by spectral and coherent analysis.
After linear discriminant analysis, LDF was obtained to differentiate people with schizophrenia from healthy subjects and a formula was selected from LDF that included 8 predictors (spectral and coherent parameters of standard EEG ranges theta, alpha and beta) with 90% sensitivity and 80% specificity, significance level for Wilks' lambda
<3.9E-28 and the Mahalanobis distance between training set centroids 4,6.
A method for obtaining optimal LDF models and selection the best one with further LDF generalizing ability assessment is suggested.
A method for obtaining optimal LDF models and selection the best one with further LDF generalizing ability assessment is suggested.
To investigate the variations in
C-methionine uptake in the intact brain tissue and in glial brain tumors of different types.
Forty patients (21 men, 19 women) with gliomas, Grade I-IV, underwent
C-methionine PET-CT and contrast-enhanced MRI. Standardized uptake value (SUV), tumor-to-normal (T/N) ratios and tumor volume were analyzed.
The high inter-subject variability was detected in the intact brain tissue (SUV in the frontal lobe (FL) varies from 0.47 to 1.73). Amino acid metabolism was more active in women than in men (FL SUV 1.32±0.22 and 1.05±0.24, respectively). T/N ratio better differentiates gliomas by the degree of anaplasia compared to SUV. Gliomas of Grade III (T/N=2.64±0.98) were significantly different (
<0.05) from those of Grade IV (T/N=3.83±0.75). The lowest level of methionine uptake was detected in diffuse astrocytomas (T/N=1.52±0.57), which was lower than with anaplastic astrocytomas (T/N=2.34±0.77,
<0.05).
C-methionine PET-CT was informative in the high/low degree of malignancy differentiation (T/N 1.
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