Notes

Integrating thermodynamics inside predator-prey online games predicts the actual diel foraging habits regarding poikilothermic predators.
Through simulation studies, the proposed test is found to retain nominal Type I error rates with considerable power in moderate sample size settings. Finally, we also evaluate the concordance between the proposed tests with the naive application of univariate tests by evaluating 44 systematic reviews with multiple outcomes from the Cochrane Database.Time-lapse confocal fluorescence microscopy images from mouse embryonic stem cells (ESCs) carrying reporter genes, histone H2B-mCherry and Mvh-Venus, have been used to monitor dynamic changes in cellular/differentiation characteristics of live ESCs. Accurate cell nucleus segmentation is required to analyse the ESC dynamics and differentiation at a single cell resolution. Several methods used concavities on nucleus contours to segment overlapping cell nuclei. Our proposed method evaluates not only the concavities but also the size and shape of every 2D nucleus region to determine if any of the strait, extrusion, convexity and large diameter criteria is satisfied to segment overlapping nuclei inside the region. We then use a 3D segmentation method to reconstruct simple, convex, and reasonably sized 3D nuclei along the image stacking direction using the radius and centre of every segmented region in respective microscopy images. Omecamtiv mecarbil To avoid false concavities on nucleus boundaries, fluorescence images of the H2B-mChpreprocessing method preserves the areas of mouse ESC nuclei and that the segmentation method effectively detects overlapping nuclei. All segmented nuclei in confocal images can be accessed using the dynamic data structures to be visualised and manipulated for quantitative analyses of the ESC differentiation behaviours. The manipulation can be tracking of segmented 3D cell nuclei in time-lapse images to calculate their dynamics of differentiation characteristics.
Targeting the Aetiology of Nocturia to Guide Outcomes (TANGO) is a validated English language questionnaire to identify underlying factors leading to nocturia. We set out to provide a culturally correct Arabic version of the TANGO questionnaire in Saudi Arabia.

The English version underwent forwarded and backward translation. The final version was administered to native Arabic speaking hospital employees and patients. Test-retest reliability and the clarity of questions were determined by Kappa and Cronbach's α statistics.

The translation The median Likert score for translated questions was ≥4 with a Cronbach's α .865. Test-retest reliability Thirty employees answered the questionnaire. The median, standard deviation (SD), and range were age 29.0 ± 11.0 years (20-55), and nocturia 1.0 ± 0.96 episodes per night (0-4). Three questions had identical constant answers and no Kappa values were computed. Based on prevalence-adjusted bias-adjusted Kappa (PABAK) values, 10 questions had a "very good" agreement, eight questions had a "good" agreement, and one item had a "moderate" agreement. The range of PABAK was 0.53 to 1, P < .01. Clarity of questions The employees had a median Likert score of 5.0 with a Cronbach's α .961. Thirty-two patients answered the questionnaire. The median, SD, and range were age 40.0 ± 15.4 years (17-79), and nocturia 1.0 ± 1.6 episodes per night (0-6). The median item score on the Likert scale was 5.0, with a Cronbach's α .909. A total of 29 (90.6%) patients stated that the questions were clear or needed no help to fill in the questionnaire.

The Arabic language translation of TANGO questionnaire is a valid tool in the dialect of Saudi Arabia.
The Arabic language translation of TANGO questionnaire is a valid tool in the dialect of Saudi Arabia.Human coronavirus OC43 (HCoV-OC43) is divided into genotypes A to H based on genetic recombination including the spike (S) gene. To investigate the longitudinal transition of the phylogenetic feature of the HCoV-OC43 S gene in a community, phylogenetic analysis of the S1 region of the S gene was conducted using 208 strains detected in Yamagata during 2010 to 2017 with reference strains of the genotype. The S1 sequences were divisible into four groups A to D. All Yamagata strains belonged to either group B or group D. In group B, 46 (90.2%) out of 51 Yamagata strains were clustered with those of genotype E reference strains (cluster E). In group D, 28 (17.8%) and 122 (77.7%) out of 157 Yamagata strains were clustered, respectively, with genotype F and genotype G reference strains. In cluster G, 28 strains formed a distinct cluster. Monthly distributions of HCoV-OC43 in Yamagata in 2010 to 2017 revealed that group B and group D appeared one after another. In group B, the cluster E strains were prevalent recurrently. In conclusion, epidemics of HCoV-OC43 in Yamagata, Japan might be attributable to two genetically different groups group B showed a recurrent epidemic of strains belonging to a single phylogenetic cluster and group D showed epidemic strains belonging to multiple clusters.The African wild dog is endemic to sub-Saharan Africa and belongs to the family Canidae which includes domestic dogs and their closest relatives (i.e., wolves, coyotes, jackals, dingoes, and foxes). The African wild dog is known for its highly social behavior, co-ordinated pack predation, and striking vocal repertoire, but little is known about its brain and whether it differs in any significant way from that of other canids. We employed gross anatomical observation, magnetic resonance imaging, and classical neuroanatomical staining to provide a broad overview of the structure of the African wild dog brain. Our results reveal a mean brain mass of 154.08 g, with an encephalization quotient of 1.73, indicating that the African wild dog has a relatively large brain size. Analysis of the various structures that comprise their brains and their topological inter-relationships, as well as the areas and volumes of the corpus callosum, ventricular system, hippocampus, amygdala, cerebellum and the gyrification index, all reveal that the African wild dog brain is, in general, similar to that of other mammals, and very similar to that of other carnivorans. While at this level of analysis we do not find any striking specializations within the brain of the African wild dog, apart from a relatively large brain size, the observations made indicate that more detailed analyses of specific neural systems, particularly those involved in sensorimotor processing, sociality or cognition, may reveal features that are either unique to this species or shared among the Canidae to the exclusion of other Carnivora.
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