Notes

Basic safety assessment involving RhD-positive red mobile transfusion in RhD-negative liver-transplant recipients: Single-centre statement from Asia.
Fast calculation or simulation of the ablation zone induced by radiofrequency ablation (RFA) has a critical role in hepatic RFA planning and therapy. However, it remains challenging to approximate the ablation zone in real time, especially when more than one probe is involved in one ablation session. This paper presents a novel computational technique to calculate the 3D ablation zone of one probe RFA and two-probe switching RFA. The main idea is to get an approximate solution of the temperature distribution from a simplified Pennes bioheat equation, and further fit the solution to the coagulation measurements on ex vivo porcine liver. With a closed-form solution of temperature distribution, the calculation of the ablation zone is as simple as the commonly used ellipsoidal model, but it allows a more realistic prediction of combined ablation zones with different inter-probe spacing. selleck chemicals The new approximation technique could potentially replace the original ellipsoidal model in the intervention planning step.Due to the negative effects that injuries have on performance, club finances, and long-term player health (permanent disability after a severe injury), prevention strategies are an essential part of both sports medicine and performance. Purpose To summarize the current evidence regarding strength training for injury prevention in soccer and to inform its evidence-based implementation in research and applied settings. Conclusions The contemporary literature suggests that strength training, proposed as traditional resistance, eccentric, and flywheel training, may be a valid method to reduce injury risk in soccer players. Training strategies involving multiple components (eg, a combination of strength, balance, plyometrics) that include strength exercises are effective at reducing noncontact injuries in female soccer players. In addition, the body of research currently published supports the use of eccentric training in sports, which offers unique physiological responses compared with other resistance exercise modalities. It seems that the Nordic hamstring exercise, in particular, is a viable option for the reduction of hamstring injuries in soccer players. Moreover, flywheel training has specific training peculiarities and advantages that are related to the combination of both concentric and eccentric contraction, which may play an important role in injury prevention. It is the authors' opinion that strength and conditioning coaches should integrate the strength training methods proposed here in their weekly training routine to reduce the likelihood of injuries in their players; however, further research is needed to verify the advantages and disadvantages of these training methods to injury prevention using specific cohorts of soccer players.
Arthroscopic surgical repair of the shoulder is recommended when conservative treatment for shoulder instability (SI) fails. However, many patients undergoing this procedure do not return to same level of activity. Psychological factors and muscle strength have been shown to be associated with postoperative outcomes in other musculoskeletal conditions.

To investigate the association between fear avoidance, muscle strength, and short-term function in patients after surgical SI repair.

Twenty-five male patients who underwent shoulder surgery following at least one event of SI were included in this study. Evaluations of fear avoidance related to physical activity and disability were performed at baseline (during the first encounter with the physical therapist) and 7 to 8weeks postsurgery. Fear avoidance beliefs were assessed using the Fear Avoidance Beliefs Questionnaire. Disability was assessed using the Disabilities of Arm, Shoulder, and Hand questionnaire and the Western Ontario SI index. The follow-up ter explore and understand these relationships.
The results indicate a possible association between fear avoidance beliefs and short-term disability. Further studies are warranted to better explore and understand these relationships.
Individuals following anterior cruciate ligament reconstruction (ACLR) demonstrate altered postural stability and functional movement patterns. It is hypothesized that individuals following ACLR may compensate with sensory adaptations with greater reliance on visual mechanisms during activities. It is unknown if visual compensatory strategies are implemented to maintain postural stability during functional tasks.

To examine visual gaze accuracy during a single-leg balance task in individuals following ACLR compared with healthy, active controls.

Case control.

Controlled laboratory.

A total of 20 individuals (10 ACLR and 10 healthy controls) participated in the study.

Visual gaze patterns were obtained during 20-second single-leg balance trials while participants were instructed to look at presented targets. During the Stationary Target Task, the visual target was presented in a central location for the duration of the trial. The Moving Target Task included a visual target that randomly moved to 1 healthy individuals to maintain single-limb postural stability. This population may rely on visual input to compensate for the somatosensory changes following injury.The effects of walking speeds on lower-extremity muscle synergies (MSs) were investigated among 20 adults who walked 20 m at SLOW (0.6 ± 0.2 m/s), natural (NAT; 1.4 ± 0.1 m/s), and FAST (1.9 ± 0.1 m/s) speeds. Surface electromyography of eight lower-extremity muscles was recorded before extracting MSs using a nonnegative matrix factorization algorithm. Increasing walking speed tended to merge MSs associated with weight acceptance and limb deceleration, whereas reducing walking speed does not change the number and composition of MSs. Varying gait speed, particularly decreasing speed, may represent a gait training strategy needing additional attention given its effects on MSs.
Electrophysiological abnormalities, especially in the gamma frequency range, have been well documented in schizophrenia. This study was aimed to investigate the gamma spectral power of the brain in patients with first episode psychosis, using high-resolution electroencephalography.

Twenty-nine neuroleptic naïve/free male patients with non-affective psychosis as per ICD 10 DCR clinical criteria were compared with thirty age, sex, education and handedness matched healthy individuals as controls. All participants underwent 192-channel resting electroencephalography (EEG) recording. Gamma spectral power was calculated for low (31-50 Hz) and high-gamma (51-70 and 71-100 Hz) bands and compared between two groups using MANOVA and supplementary one-way ANOVA. Pearson correlation and linear regression analyses were conducted between spectral power parameters and various clinical variables.

The gamma spectral power in 31-50 Hz and 51-70 Hz frequency bands was found to be significantly higher in patients in most brain regions. Duration of illness predicted the gamma spectral power in both right and left frontal regions of the brain in the frequency range 31-50 Hz and 71-100 Hz, as well as in the right temporal region in 71-100 Hz range, where it was negatively correlated.

Patients with first episode psychosis have increased gamma spectral power, which might be indirectly related to the duration of illness.
Patients with first episode psychosis have increased gamma spectral power, which might be indirectly related to the duration of illness.
We conducted a systematic review and meta-analysis of all the randomized controlled trials (RCTs) with SGLT-2 inhibitors (SGLT-2i) in patients with known heart failure (HF) with or without type 2 diabetes (T2DM), that have studied the outcomes of cardiovascular (CV) death, hospitalization due to HF (HHF), and composite of CV death or HHF.

A systematic search in PubMed, Embase and Cochrane Library database were made up till November 20, 2020 using specific keywords. RCTs that qualified underwent a meta-analysis by applying the inverse variance-weighted averages of pooled logarithmic hazard ratio (HR) using both random- and fixed-effects model.

This meta-analysis of 9 RCTs (N=19,741) have found a significant 26% relative risk reduction in composite of CV death or HHF (HR 0.74; 95% CI, 0.69-0.79; p<0.001) with SGLT-2i in patients with HF. The meta-analysis of 8 RCTs (N=16,460) also showed a significant reduction in CV death (HR 0.86; 95% CI, 0.78-0.95; p=0.003) and HHF (HR 0.68; 95% CI, 0.62-0.74; p<0.001) outcomes with SGLT-2i in patients with HF. Subgroup analysis stratified on baseline ejection fraction (EF) showed a similar benefit in the composite of CV death or HHF in patients with HF with reduced EF (HFrEF) or preserved EF (HFpEF).

SGLT-2i significantly reduces the composite of CV death or HHF, CV death, and HHF in patients with HF. Although subgroup analysis suggested an insignificant P
for these outcomes irrespective of the types of HF, however, reduction in both CV death and HHF were more pronounced in patients with HFrEF.
SGLT-2i significantly reduces the composite of CV death or HHF, CV death, and HHF in patients with HF. Although subgroup analysis suggested an insignificant Pheterogenity for these outcomes irrespective of the types of HF, however, reduction in both CV death and HHF were more pronounced in patients with HFrEF.
Greater COVID-19 related mortality has been reported among persons with various non-communicable diseases (NCDs). We performed an ecological study to determine the association of state-level cases and deaths with NCD risk factors and healthcare and social indices.

We obtained cumulative national and state-level data on COVID-19 cases and deaths from publicly available database www.covid19india.org from February to end November 2020. To identify association with major NCD risk factors, NCDs, healthcare related and social variables we obtained data from public sources. Association was determined using univariate and multivariate statistics.

More than 9.5 million COVID-19 cases and 135,000 deaths have been reported in India towards end of November 2020. There is significant positive correlation (Pearson r) of state-level COVID-19 cases and deaths per million, respectively, with NCD risk factors- obesity (0.64, 0.52), hypertension (0.28, 0.16), diabetes (0.66, 0.46), NCD epidemiological transition index (0.58, 0.54) and ischemic heart disease mortality (0.22, 0.33). Correlation is also observed with indices of healthcare access and quality (0.71, 0.61), urbanization (0.75, 0.73) and human (0.61, 0.56) and sociodemographic (0.70, 0.69) development. Multivariate adjusted analyses shows strong correlation of COVID-19 burden and deaths with NCD risk factors (r
=0.51, 0.43), NCDs (r
=0.32, 0.16) and healthcare (r
=0.52, 0.38).

COVID-19 disease burden and mortality in India is ecologically associated with greater state-level burden of NCDs and risk factors, especially obesity and diabetes.
COVID-19 disease burden and mortality in India is ecologically associated with greater state-level burden of NCDs and risk factors, especially obesity and diabetes.
Although the Clinical Institute Withdrawal Assessment for Alcohol - Revised (CIWA-Ar) is a gold standard tool for the clinical evaluation of alcohol withdrawal syndrome (AWS), a systematic analysis using the total scores of the CIWA-Ar as a means of an objective follow-up of the course and treatment of AWS is missing. The aims of the present study were to systematically evaluate scientific data using the CIWA-Ar, to reveal whether the aggregated CIWA-Ar total scores follow the course of AWS and to compare benzodiazepine (BZD) and non-benzodiazepine (nBZD) therapies in AWS.

1054 findings were identified with the keyword "ciwa" from four databases (PubMed, ScienceDirect, Web of Science, Cochrane Registry). Articles using CIWA-Ar in patients treated with AWS were incorporated and two measurement intervals (cumulative mean data of day 1-3 and day 4-9) of the CIWA-Ar total scores were compared. Subgroup analysis based on pharmacotherapy regimen was conducted to compare the effectiveness of BZD and nBZD treatments.
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