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Background & Aims Epilepsy affects nearly 70 million people worldwide. selleck chemicals llc Vitamin D deficiency may influence the balance of certain epilepsies. The purpose of this study was to determine the vitamin D status and anthropometric measurements of people with epilepsy (PWE), according to their pharmacosensitivity. Methods Forty-six PWE, with or without drug resistance, underwent nutritional assessment after giving consent. Weight, body mass index (BMI), triceps skinfold thickness (TSF), fat mass (FM) and free fat mass (FFM) by bioelectrical impedance analysis were measured. Serum vitamin D was determined without supplementation. Deficiency was defined as a level less then 30 ng/mL. Statistical analysis involved Student t test, ANOVA and Chi2. Results Patients were aged 44.5 ± 14.3 years, with 60.9% of drug-resistance. BMI was 28.7 ± 7.0, 2.2% were malnourished and 30.4% obese according to the BMI. The average vitamin D level was 15.3 ± 9.9 ng/mL, with 87.0% of deficiency, and 40.0% of severe deficiency ( less then 10 ng/mL). The TSF was higher in drug-resistant cases (p = 0.03). There was no link between drug resistance and anthropometric measurements, FM, FFM or vitamin D concentration. Conclusions Although limited in size, this study showed that PWE are more often obese. Vitamin D deficiency is more common than in the general population, with a much higher prevalence of severe deficiency.We report herein a fatal case of acute human orthopneumovirus (formerly respiratory syncytial virus) infection in a captive white-handed gibbon (Hylobates lar). Other members of the housing group had mild respiratory signs. Gross examination revealed bilateral pulmonary congestion and froth in the bronchi. Microscopically, the lungs had lymphocytic, neutrophilic infiltration of the interstitium and alveolar walls. There was necrosis of terminal bronchiolar epithelium and terminal bronchioles, and surrounding alveoli contained necrotic and exfoliated epithelial cells admixed with histiocytes and syncytial cells. Additional lesions included nonsuppurative meningoencephalitis, and epidermal hyperkeratosis and hyperplasia with syncytial cell formation. PCR screening for 12 human respiratory viruses was positive for orthopneumovirus in multiple tissues, including lung, and immunohistochemical staining for human orthopneumovirus detected viral antigen within bronchial epithelial cells. IHC and PCR for measles virus on preserved sections were negative. White-handed gibbons have not been previously reported as hosts for human orthopneumovirus, an important respiratory pathogen of both primates and humans.Introduction Guillain-Barré Syndrome usually presents with ascending symmetric polyneuropathy, typically preceded by a viral infection. Despite the low incidence, physicians will often include Guillain-Barré Syndrome in their differential diagnosis. However, another underlying cause of polyneuropathy known as ANCA-associated vasculitis (AAV) is even more rare than Guillain-Barré Syndrome and therefore is usually overlooked. AAV has a broad spectrum of symptomatology and sometimes presents only with neurological complaints. If treated inappropriately, AAV can be lethal.Case report In this case report, we describe a 72-year-old man presenting with complaints of symmetric polyneuropathy and paresis of both legs, initially diagnosed as Guillain-Barré Syndrome. During his treatment with intravenous immunoglobulins, he developed acute renal failure. Further investigations showed ANCA positive pauci-immune acute glomerulonephritis. This, in combination with eosinophilia and sinusitis, led to a final diagnosis of Eosinophilic Granulomatosis with Polyangiitis EGPA (Churg-Strauss disease). Induction therapy was initiated using glucocorticoids, cyclophosphamide and temporary plasmapheresis, followed by maintenance therapy with azathioprine complicated by bone marrow suppression. Azathioprine was discontinued and monotherapy with low-dose glucocorticoids was continued with the recovery of bone marrow function, good clinical condition and no relapse of vasculitis at 14 months follow-up.Conclusion Physicians should be aware of the possible presentations of AAV. When suspected, indirect immunofluorescence assay for ANCA should be performed. When AAV is diagnosed, induction therapy should be administered as soon as possible, followed by maintenance therapy and careful follow-up, as patients are at risk for opportunistic infections, bone marrow toxicity or relapse.Circles of Support and Accountability (CoSA) are comprised of approximately five trained Circle volunteers who provide support during reentry to one core member previously convicted of a sexual offense. In 2008, the Minnesota Department of Corrections implemented the Minnesota Circles of Support and Accountability (MnCoSA). In-depth interviews were conducted with 33 MnCoSA volunteers and 10 core members to gain an understanding of (a) what makes volunteers desirable to core members, as well as (b) what makes CoSA desirable to volunteers. The study finds core members express a desire for the availability and consistency of volunteers, a preference for certain types of volunteers, and consistent with volunteers' perceptions, a belief that CoSAs offer particular benefits for volunteers. Implications for recruitment of volunteers and optimal structuring of CoSAs are discussed.In this study, rice straw was used as the raw materials of biomass carbon to prepare biochar at different temperatures (400°C, 500°C, 600°C, 700°C, and 800°C). In addition, cetyl trimethyl ammonium bromide (CTAB) modified biochar was used to treat 2,4-dichlorophenol (2,4-DCP) in water. The influences of adsorbent dosage, solution pH, adsorption time, and initial solubility of the 2,4-DCP solution on the adsorption properties were investigated. The physicochemical properties of biochar were investigated using SEM, FT-IR, BET surface area, and pore size analysis. The results showed that the pyrolysis temperature had a great influence on the biochar structure. CTAB provided hydrophilic and hydrophobic groups to the modified biochar, which had increased adsorption capacity comparing to unmodified biochar. The pH also had a significant effect on the adsorption performance of biochar, and the adsorption performance of biochar decreased significantly under alkaline conditions. The maximum adsorption capacities of modified biochar and unmodified biochar were 59.
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