Notes

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Therefore, along one month, approximately 8% of seronegative individuals became infected, even after almost half of the population was already seropositive. Nevertheless, a smaller proportion of incident cases were symptomatic (21% versus 77% of the earlier cases), and no deaths were recorded. Whether this decreased clinical expression resulted from a lower viral load in new infections cannot be determined. Increased seroconversion in individuals using latrines is consistent with a contributory role of fecal-oral transmission, although we cannot rule out the possibility that latrines are acting as a proxy for poverty or other unknown interacting variables.The cell-type-specific response of neural cells to oxidative stress, a crucial mechanism for accelerating aging and cognitive dysfunction in Alzheimer's disease (AD), is still far from understood. Here, we employed human-induced pluripotent stem cells (hiPSCs)-derived neural stem cells (hiPSC-NSCs), neurons (hiPSC-Neurons), and microglia-like cells (hiPSC-MGLs) from sporadic AD (sAD) patients, age-matched cognitive normal controls (CNCs), and young subjects to observe human neural cell-type response to H2O2 stimulation. Without H2O2 exposure, reactive oxygen species (ROS) cannot be detected in hiPSC-NSCs from all three groups, but the viability of hiPSC-NSCs from AD patients was significantly lower than those of CNCs and young subjects. There were no significant differences in ROS, viabilities, neurite length, and neurite branch points in hiPSC-Neurons among three groups. No significant differences in viabilities, phagocytosis, and secretion of cytokines were observed in hiPSC-MGLs among three groups, but higher ROS levels in sAD hiPSC-MGLs. Under H2O2 exposure, the viability, neurite length, and neurite branch points of hiPSC-Neurons from AD patients reduced more significantly accompanied by more ROS release. H2O2 exposure caused hiPSC-MGLs from AD patients to release more ROS, cytokines, and stronger phagocytosis. Nevertheless, H2O2 exposure had no effect on viability of hiPSC-NSCs. Our results showed hiPSC-Neurons and hiPSC-MGLs were more sensitive to H2O2 than hiPSC-NSCs, which indicated the different response styles of hiPSC-NSCs, hiPSC-Neurons, and hiPSC-MGLs to oxidative stress. HiPSC-derived neural cells from AD patients suffered more severe injury from H2O2 than those of CNCs and young subjects, indicating that the vulnerability to oxidative stress of AD patients can be recapitulated in hiPSCs.In this study, biocompatible titanium-niobium (Ti-Nb) alloys were fabricated by using powder metallurgy methods. Physical, morphological, thermal, and mechanical analyses were performed and their in vivo compatibility was evaluated. Besides α, β, and α″ martensitic phases, α+β Widmanstätten phase due to increasing sintering temperature was seen in the microstructure of the alloys. Phase transformation temperatures of the samples decreased as Nb content increased. The ratio of Nb in the samples affected their mechanical properties. No toxic effect was observed on implanted sites. This study shows that Ti-Nb alloys can be potentially used for orthopedic applications without any toxic effects.This study examined the release characteristics of malodorous ammonia (NH3) and hydrogen sulphide (H2S) gases in different areas of a full-capacity operational landfill in Hangzhou, China. Gas samples were collected using static boxes from exposed working areas (EWAs), temporarily covered areas (TCAs), and final closure areas (FCAs), and were analysed using spectrophotometric methods. Gas release increased in the following order TCA > EWA > FCA. The average concentrations of released NH3 in these areas were 2763, 1171, and 27 mg m-3, respectively, and those of H2S were 2481, 631, and 10 mg m-3, respectively. The concentrations of gases released from holes in the film in the temporarily covered and EWAs were significantly higher than the AEGL-3 level values specified by the Acute Exposure Guideline Levels (AEGL) Advisory Committee. EWAs were identified as key for odour control, where the highest NH3 release was recorded at approximately 1200. The diurnal variation in H2S release was insignificant (p > 0.05). Therefore, the study shows that working in EWAs should be avoided at approximately noon. Adverse impacts on human health can be reduced by standardising procedures, using higher-quality films, and improving film installation procedures. The results of this study serve as a valuable reference for odour control in operational landfills.This study aims to improve understanding of how distracting information and target task demands influence the strength of gaze and non-biological (arrow and moving line) cuing effects. Using known non-predictive central cues, we manipulated the degree of distraction from additional information presented on the other side of the target, and target task difficulty. In Experiment 1, we used the traditional unilateral cuing task, where participants state the location of an asterisk and the non-target location is empty (no distraction). Experiment 2 comprised a harder localisation task (which side contains an embedded oddball item) and presented distracting target-related information on the other side. In Experiment 3, we used a discrimination task (upright or inverted embedded T) with distracter information that was unrelated or related to the target (low vs. high distraction, respectively). We found that the magnitude of cuing scaled with the degree of combined distraction and task demands, increasing up to six-fold from Experiments 1 and 2 to the high-distraction condition in Experiment 3. Thus, depleting attentional resources in this manner appears to weaken the ability to ignore uninformative directional cues. Findings are discussed within the framework of a resource-limited account of cue inhibition.National, state, and local actors seem ready to address the long-neglected mental health crisis system in the United States. Elements of an organized system of crisis care are in place in some states, including regional or statewide call centers, mobile crisis teams, and crisis care facilities. These necessary advances are not sufficient to address the urgent problems of increasing suicide rates, the inappropriate use of emergency departments to hold people in psychiatric distress, and the problematic reliance on inadequately trained law enforcement who frequently respond to mental health crises. This article describes the immediate challenges and opportunities that can launch nationwide reform in systems of care for individuals in psychiatric crisis. Five action recommendations describe clear, feasible next steps that can be taken to move these systems forward and meaningfully improve access and quality of care for people in crisis. The recommendations include a central coordinating role for Congress, an increase in federal authorization and appropriation of funds, enactment of a 5% Mental Health Block Grant set-aside, expanded funding for research and evaluation, and the pursuit of additional payment mechanisms by states and counties.Because of limited intermediate-care services, patients with autism spectrum disorders (ASDs) are increasingly being treated in emergency departments (EDs) and psychiatric hospitals. To address this growing problem, the authors developed a mobile outreach program, called Access to Psychiatry through Intermediate Care (APIC), for young (≤26 years) patients with ASD at risk for involvement with emergency medical services or the legal system. In its initial year, the average program duration per patient was 264.5 days. Clinical and Family Distress Scale scores indicated significant improvements for participating patients and caretakers. In the first year, among 40 patients with sufficient data for comparison, 13 (33%) went to the ED, and lengths of stay decreased up to 77% from pre- to postintervention. Given a cost per APIC-enrolled patient of $1,700, the net saving for the cost of ED treatment was $2,260-$2,559 per patient. The feasibility and cost-effectiveness of the APIC model has attracted additional state and county funding.Interpreters improve access to care for patients with limited English proficiency (LEP), but some studies have reported poorer cultural understanding, relationship quality, and patient satisfaction than with language-concordant care. Use of interpreter roles beyond linguistic conversion (clarifier, cultural broker, or advocate/mediator) may enhance interpreter-mediated care by improving cultural understanding and the therapeutic alliance. As reported in this column, pilot data on interpreter-mediated evaluations of 25 psychiatric outpatients with LEP support this position. The authors found that clarification of the interpreter's role and the session structure improved provider-interpreter collaboration, with two perceived benefits improved assessment through elicitation of clinically relevant information and stronger therapeutic alliance through "emotion work." Strategies for effectively enhancing provider-interpreter collaboration are discussed.
Homelessness is associated with increased risk of suicide attempts. This study examined whether suicide attempts typically precede or occur during episodes of homelessness in a representative national sample.

Data from 36,127 adults in the National Epidemiologic Survey on Alcohol and Related Conditions-III were used to identify 1,992 respondents who reported a lifetime suicide attempt. Bivariate analyses compared attempt histories between adults who reported past-year homelessness, homelessness prior to the past year, and no history of homelessness. Measures included years since most recent attempt and first attempt and proportion attempting suicide in the past year. Multivariable analyses adjusted for potentially confounding effects of age and identified independent factors associated with past-year attempts along with past-year homelessness.

Among respondents who experienced homelessness in the past year, 21.0% reported a past-year suicide attempt, compared with 5.8% among those experiencing homelessn behavior began decades ago and likely preceded homelessness.
Air pollution is a major environmental risk to health. Ambient (outdoor) air pollution in both cities and rural areas was estimated to cause 4.2 million premature deaths worldwide in 2016. Selleck MGCD0103 In this review, the authors sought to briefly summarize original research investigating the short-term effects of air pollution exposure on mental health.

A systematic search of the electronic databases PubMed, Scopus, and Web of Science was conducted (from any time until March 4, 2019) to identify research studies reporting associations between daily levels of air pollutants and daily admissions to hospitals or emergency departments (EDs) for psychiatric disorders and symptoms. A final set of 19 articles was reviewed.

The results of all selected studies showed statistically significant associations between daily hospital admissions and ED visits for mental disorders and daily levels of some or all air pollutants considered, including particulate matter (PM) of variable sizes (in micrometers given in subscripts; PM
and PM
), sulfur dioxide, carbon monoxide, nitrogen oxide, and ozone. The strongest and more consistent evidence across studies was found for PM
and PM


The results summarized in this review extend the evidence that air pollution may contribute either to worsening of psychiatric symptoms or to the decision to seek treatment for a large group of mental diseases and conditions, including severe psychiatric disorders such as schizophrenia and depression.
The results summarized in this review extend the evidence that air pollution may contribute either to worsening of psychiatric symptoms or to the decision to seek treatment for a large group of mental diseases and conditions, including severe psychiatric disorders such as schizophrenia and depression.
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