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Gene set enrichment analysis (GSEA) revealed that DCBLD2 overexpression induces epithelial-mesenchymal transition (EMT) and activates the JAK/STAT3 pathway. CONCLUSIONS We found that high DCBLD2 expression correlated with a poor clinical outcome, as well as tumorigenesis, invasion and metastasis of CRC cells. DCBLD2 may serve as a prognostic biomarker and a novel therapeutic target for CRC.BACKGROUND 44Sc has been increasingly investigated as a potential alternative to 68Ga in the development of tracers for positron emission tomography (PET). The lower mean positron energy of 44Sc (0.63 MeV) compared to 68Ga (0.83 MeV) can result in better spatial image resolutions. However, high-energy γ-rays (1157 keV) are emitted at high rates (99.9%) during 44Sc decay, which can reduce image quality. Therefore, we investigated the impact of these physical properties and performed an unbiased performance evaluation of 44Sc and 68Ga with different imaging phantoms (image quality phantom, Derenzo phantom, and three-rod phantom) on two preclinical PET scanners (Mediso nanoScan PET/MRI, Siemens microPET Focus 120). RESULTS Despite the presence of high-energy γ-rays in 44Sc decay, a higher image resolution of small structures was observed with 44Sc when compared to 68Ga. Myricetin price Structures as small as 1.3 mm using the Mediso system, and as small as 1.0 mm using the Siemens system, could be visualized and analyzed by calcoises and can effect an overestimation of scatter correction, depending on the PET system and phantom.PURPOSE Our purpose is to describe a safe and easy technique for the removal of the BrightOcular cosmetic iris implants. Our technique involves cutting the implant into five parts rather than removal as a whole with less intraocular manipulation and no rotation of the implant. METHODS We have used this technique in two eyes of a 28-year-old patient who presented to us with progressive drop of vision and acute attacks of ocular pain. Best-corrected distance visual acuity (BCVA) was found to be 6/18 and 6/9 on Snellen chart in her right and left eyes, respectively. Intraocular pressure was 40 mmHg and 20 mmHg in the right and left eyes, respectively, with visual field and retinal nerve fiber layer changes in the right eye. RESULTS After removal of both implants, 1-week post-operative BCVA improved to 6/6 bilaterally. After 3 months of regular follow-ups, IOP remains uncontrolled in the right eye despite medical treatment, and surgical intervention is planned. CONCLUSION Our five-slice technique for removal of iris implants can be done effectively through a small corneal wound thus avoiding most wound-related problems. Our technique also includes no rotation or excessive manipulation inside the anterior chamber and can be carried out easily and safely with both the NewColorIris and BrightOcular implant designs.OBJECTIVES To evaluate whether ERAS is feasible and beneficial in elderly patients undergoing VATS lobectomy for lung cancer. METHODS From February 2016 to March 2019, 182 patients were included into a 17-items ERAS pathway. Patients were divided into two groups according to age Group A ( less then  75 years) 138 patients and Group B (≥ 75 years) 44 patients. End points were length of stay (LoS), 30-day morbidity, 90-day mortality, 30-day re-admittance rate, and ERAS-score (number of ERAS objectives achieved). RESULTS Elderly patients had significantly more chronic renal failure (p = 0.039) and a worse pulmonary function. Mean FEV1% was 101.6% (± 21.0% SD) and 90.8% (± 19.1% SD) and mean FEV1/FVC was 0.75 (± 0.10 SD) and 0.68 (± 0.12 SD) for group A and B, respectively (p  = 0.02 and p  = 0.01). Median LoS was longer in Group B (6 days) than in Group A (5 days; p  = 0.006). Morbidity was higher for elderly patients (A 32.6% vs B 56.8%; p  = 0.007), major complication rates were similar (p  = 0.782). No post-operative mortality was observed, re-admittance rates were similar (A 7.8% vs B 11.5%; p  = 0.548). Mean ERAS-scores were 13.8 (± 1.83 SD) for Group A and 13.4 (± 1.98 SD) for Group B (p  = 0.240). Multivariable analysis showed previous major surgery (p  = 0.028), COPD (p  = 0.027), history of arrhythmic disease (p  = 0.015), post-operative complications (p   less then  0.001), and ERAS-score (p   less then  0.001) as independent predictive factors of LoS, age did not significantly influence LoS. CONCLUSIONS Elderly patients adhere to an ERAS protocol similarly to younger ones. ERAS pathway in VATS lobectomy patients seems to be beneficial regardless the age.Two women in their sixties were diagnosed with inoperable locally advanced epithelioid malignant pleural mesothelioma, c-stage IIIB. Post-chemotherapy, the tumors down-staged to yc-stage IA, and pleurectomy/decortication were performed. The pathological diagnoses were p-stages II and IA. One patient had tumor recurrence 6 months after surgery; she is currently undergoing fourth-line chemotherapy and is alive 30 months postoperatively. The second patient had tumor recurrence 4 months after surgery and died 2 months later. Conversion surgery for advanced malignant mesothelioma does not improve progression-free survival but might have a chance to extend overall survival in selected patients without deteriorating performance status.PURPOSE Survivors of multiple primary cancers make up a sizable proportion of all cancer survivors, yet little is known about the health of this population. We examined the prevalence of medical conditions and physical function deficits among multiple primary survivors compared with single primary survivors and individuals without a cancer history. METHODS Participants were enrolled in the Cancer Prevention Study (CPS)-II Nutrition Cohort in 1992/1993. Prevalent medical conditions (diabetes, heart conditions, cerebrovascular conditions, emphysema/chronic bronchitis, osteoporosis, osteoarthritis), physical function limitations, use of a cane or walker, balance difficulties, and falls within the past year were assessed on a follow-up survey completed in 2011. We estimated age- and sex-adjusted prevalence ratios (PRs), comparing multiple primary survivors (N = 1003) to single primary survivors (N = 12,849) and participants without cancer (N = 63,578). RESULTS The prevalence of medical conditions did not differ substantially between multiple primary survivors and either comparison group.
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