Notes

Common iliac abnormal vein stenting regarding May-Thurner syndrome and up coming pregnancy.
Overcoming the FLT3-ITD mutant has been a promising drug design strategy for treating acute myeloid leukemia (AML). Herein, we discovered a novel FLT3 inhibitor 17, which displayed potent inhibitory activity against the FLT3-ITD mutant (IC50 = 0.8 nM) and achieved good selectivity over c-KIT kinase (over 500-fold). Compound 17 selectively inhibited the proliferation of FLT3-ITD-positive AML cell lines MV4-11 (IC50 = 23.5 nM) and MOLM-13 (IC50 = 35.5 nM) and exhibited potent inhibitory effects against associated acquired resistance mutations. In cellular mechanism studies, compound 17 strongly inhibited FLT3-mediated signaling pathways and induced apoptosis by arresting the cell cycle in the sub-G1 phase. In in vivo studies, compound 17 demonstrated a good bioavailability (73.6%) and significantly suppressed tumor growth in MV4-11 (10 mg/kg, TGI 93.4%) and MOLM-13 (20 mg/kg, TGI 98.0%) xenograft models without exhibiting obvious toxicity. These results suggested that compound 17 may be a promising drug candidate for treating FLT3-ITD-positive AML.The requirement for increased resolution has created the concept of displays with nanoscale pixels; that is, each subpixel consists of multiple or even a single nanolight source, which is considered the ultimate light source for light field, near-eye, and implantable displays. However, related research is still at an early stage, and further insights into this future display concept should be provided. In this Perspective, we provide our proposed term for this future display, namely, nanopixel light-emitting display (NLED). We present an overview of nanolight-emitting diodes, which are considered the core component of NLEDs. Then, a roadmap to realize NLEDs from the view of material design is provided. Finally, we introduce our proposed operation mode (nonelectrical contact and noncarrier injection mode) for NLEDs and recommend possible nanopixel-level drive approaches. We hope that this Perspective will be helpful in designing innovative display technologies.We present an implementation of the GW space-time approach that allows cubic-scaling all-electron calculations with standard Gaussian basis sets without exploiting any localization or sparsity considerations. The independent-electron susceptibility is constructed in a time representation over a nonuniform distribution of real-space locations rk optimized within a separable resolution-of-the-identity framework to reproduce standard Coulomb-fitting calculations with meV accuracy. The compactness of the obtained rk distribution leads to a crossover with the standard Coulomb-fitting scheme for system sizes below a few hundred electrons. The needed analytic continuation follows a recent approach that requires the continuation of the screened Coulomb potential rather than the much more structured self-energy. The present scheme is benchmarked over large molecular sets, and scaling properties are demonstrated on a family of defected hexagonal boron-nitride flakes containing up to 6000 electrons.Manipulation of cells, droplets, and particles via ultrasound within microfluidic chips is a rapidly growing field, with applications in cell and particle sorting, blood fractionation, droplet transport, and enrichment of rare or cancerous cells, among others. However, current methods with a single ultrasonic transducer offer limited control of the position of single particles. In this paper, we demonstrate closed-loop two-dimensional manipulation of particles inside closed-channel microfluidic chips, by controlling the frequency of a single ultrasound transducer, based on machine-vision-measured positions of the particles. For the control task, we propose using algorithms derived from the family of multi-armed bandit algorithms. We show that these algorithms can achieve controlled manipulation with no prior information on the acoustic field shapes. The method learns as it goes there is no need to restart the experiment at any point. Starting with no knowledge of the field shapes, the algorithms can (eventually) move a particle from one position inside the chamber to another. This makes the method very robust to changes in chip and particle properties. We demonstrate that the method can be used to manipulate a single particle, three particles simultaneously, and also a single particle in the presence of a bubble in the chip. GC7 Finally, we demonstrate the practical applications of this method in active sorting of particles, by guiding each particle to exit the chip through one of three different outlets at will. Because the method requires no model or calibration, the work paves the way toward the acoustic manipulation of microparticles inside unstructured environments.Hydrophobically modified polyhedral oligomeric silsesquioxanes (XPOSS) are linked to one end of water-soluble poly(ethylene oxide) (PEO) to synthesize giant amphiphiles (XPOSS-PEO). XPOSS-PEO exhibit an interesting surface activation capacity owing to the synergy of the soft PEO segment and hydrophobic XPOSS when they are spread on the water surface and compressed by the barrier. The monolayers of XPOSS-PEO at the air-water interface are transferred onto the silicon substrate at different surface pressures using the Langmuir-Blodgett (LB) film deposition protocol. The modification of the POSS head significantly changes the crystallinity of the PEO tail, which affects the LB film morphologies of the giant amphiphiles. When the POSS are modified with fluorinated agents, the assembled LB films show a fractal growth pattern, but when the POSS are decorated with a pure alkane chain, the fractal growth pattern does not present in the resulting LB film.Finger-like radial hierarchical micropillars with folded tips are observed on the surface of the rose pistil stigma (RPS). Impressively, a water droplet on the surface of the RPS presents a spherical shape and it still hangs on the surface even when the RPS is turned over. Superhydrophobicity and high adhesion to water are demonstrated on the RPS, which is beneficial for the RPS to remain clean and fresh. The special wetting behavior of the RPS is highly related to its hierarchical microstructures and surface chemistry. Finger-like hierarchical micropillars with a high aspect ratio are capable of retaining air to support superhydrophobicity while the microgap between the micropillars and on the hydrophilic tips enables the RPS to retain a high adhesion to water. These findings about the unique wetting behaviors of the RPS may provide inspiration for the design and fabrication of functional wetting surfaces for diverse applications such as microdroplet manipulation, three-dimensional cell culture, and microfluidics.Assembling p orbital ferromagnetic half-metallicity and a topological element, such as a Dirac point at the Fermi level, in a single nanomaterial is of particular interest for long-distance, high-speed, and spin-coherent transportation in nanoscale spintronic devices. On the basis of the tight-binding model, we present an orbital design of a two-dimensional (2D) anionogenic Dirac half-metal (ADHM) by patterning cations with empty d orbitals and anions with partially filled p-type orbitals into a kagome lattice. Our first-principles calculations show that 2D transition-metal peroxides h-TM2(O2)3 (TMO3, TM = Ti, Zr, Hf), containing group IVB transition-metal cations [TM]4+ bridged with dioxygen anions [O2]8/3- in a kagome structure, are stable ADHMs with a Curie temperature over 103 K. The 2/3 filled π* orbitals of dioxygen anions are ferromagnetically coupled, leading to p orbital ferromagnetism and a half-metallic Dirac point right at the Fermi level with a Fermi velocity reaching 2.84 × 105 m/s. We proposed that 2D h-TM2(O2)3 crystals may be extracted from ABO3 bulk materials containing 2D TMO3 layers.Even though the first docking procedures were developed almost 40 years ago, they are still under intense development, alongside with their validation. In this article, we are proposing the use of the quantum free-orbital AlteQ method in evaluating the correctness of ligand binding poses and their ranking. The AlteQ method calculates the electron density in the interspace between the ligand and the receptor, and since their interactions follow the maximum complementarity principle, an equation can be obtained, which describes these interactions. In this way, the AlteQ method evaluates the quality of contacts between the ligand and the receptor, bypasses the drawbacks of using ligand RMSD as a measure of docking quality, and can be considered as an improvement of the "fraction of recovered ligand-receptor contacts" method. Free Windows and Linux versions of the AlteQ program for assessing complementarity between the ligand and the receptor are available for download at www.chemosophia.com.Poly(aspartic acid) (PASP) is an anionic polypeptide that is a highly versatile, biocompatible, and biodegradable polymer that fulfils key requirements for use in a wide variety of biomedical applications. The derivatives of PASP can be readily tailored via the amine-reactive precursor, poly(succinimide) (PSI), which opens up a large window of opportunity for the design and development of novel biomaterials. PASP also has a strong affinity with calcium ions, resulting in complexation, which has been exploited for bone targeting and biomineralization. In addition, recent studies have further verified the biocompatibility and biodegradability of PASP-based polymers, which is attributed to their protein-like structure. In light of growing interest in PASP and its derivatives, this paper presents a comprehensive review on their synthesis, characterization, modification, biodegradation, biocompatibility, and applications in biomedical areas.We quantified per- and polyfluoroalkyl substance (PFAS) transport from groundwater to five tributaries of the Cape Fear River near a PFAS manufacturing facility in North Carolina (USA). Hydrologic and PFAS data were coupled to quantify PFAS fluxes from groundwater to the tributaries. Up to 29 PFAS were analyzed, including perfluoroalkyl acids and recently identified fluoroethers. Total quantified PFAS (ΣPFAS) in groundwater was 20-4773 ng/L (mean = 1863 ng/L); the range for stream water was 426-3617 ng/L (mean = 1717 ng/L). Eight PFAS constituted 98% of ΣPFAS; perfluoro-2-(perfluoromethoxy)propanoic acid (PMPA) and hexafluoropropylene oxide dimer acid (GenX) accounted for 61%. For PFAS discharge from groundwater to one tributary, values estimated from stream water measurements (18 ± 4 kg/yr) were similar to those from groundwater measurements in streambeds (22-25 ± 5 kg/yr). At baseflow, 32 ± 7 kg/yr of PFAS discharged from groundwater to the five tributaries, eventually reaching the Cape Fear River. Given the PFAS emission timeline at the site, groundwater data suggest the abundant fluoroethers moved through the subsurface to streams in ≪50 yr. Discharge of contaminated groundwater may lead to long-term contamination of surface water and impacts on downstream drinking water supplies. This work addresses a gap in the PFAS literature quantifying PFAS mass transfer between groundwater and surface water using field data.Liquid chromatography tandem mass spectrometry (LC/MS) and other mass spectrometric technologies have been widely applied for triacylglycerol profiling. One challenge for targeted identification of fatty acyl moieties that constitute triacylglycerol species in biological samples is the numerous combinations of 3 fatty acyl groups that can form a triacylglycerol molecule. Manual determination of triacylglycerol structures based on peak intensities and retention time can be highly inefficient and error-prone. To resolve this, we have developed TAILOR-MS, a Python (programming language) package that aims at assisting (1) the generation of targeted LC/MS methods for triacylglycerol detection and (2) automating triacylglycerol structural determination and prediction. To assess the performance of TAILOR-MS, we conducted LC/MS triacylglycerol profiling of bovine milk and two infant formulas. Our results confirmed dissimilarities between bovine milk and infant formula triacylglycerol composition. Furthermore, we identified 247 triacylglycerol species and predicted the possible existence of another 317 in the bovine milk sample, representing one of the most comprehensive reports on the triacylglycerol composition of bovine milk thus far.
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