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Dual-luciferase reporter gene assay showed that miR-621 could bind circ_0000064 and SYF2 3'UTR; in addition, miR-621 overexpression or SYF2 knockdown could partially weaken the cancer-promoting effect of circ_0000064 on GC cells. Circ_0000064 expression was negatively correlated with miR-621 expression in GC tissues while positively with SYF2 expression. Circ_0000064 can participate in the GC progression via modulating miR-621/SYF2 axis. This implies that circ_0000064 may be a new diagnosed biomarker or a new therapeutic target of GC.Supercapacitors with high power density and an ultralong cyclic lifetime have been intensively investigated. However, the crucial challenge of their rapid self-discharge process is often neglected in most cases. A heterogeneous interface formed between two layers of polymer electrolytes is designed, in which a polyanion and a polycation are added into a common matrix of polymer electrolyte, respectively. By using the heterogeneous polymer electrolyte (HPE) as the separator simultaneously, the resultant supercapacitors exhibit comparable electrochemical performance to that of devices based on traditional polymer electrolytes. The HPE-based supercapacitors using both electric double-layer capacitive and pseudocapacitive electrodes show at least one time longer self-discharge time than that of devices based on homogenous polymer electrolyte, especially for the electrode in an electrolyte containing polyanion served as a positive pole during the charging process. Because of the same polymer matrix used, the heterojunction structure of the HPE exhibits excellent stability without obvious phase separation during thousands of charge/discharge and repeated bending cycles. This novel strategy by interface engineering of electrolyte to suppress the self-discharge behavior of supercapacitors is very meaningful to promote their practical applications.Spinel oxides are considered as promising low-cost non-precious metal electrocatalysts for oxygen evolution reaction (OER) due to their desirable catalytic activities and fast kinetics. However, as a result of the structural complexity of spinel oxides, systematic and in-depth studies on enhancing the OER performance of spinel oxides remain inadequate. In particular, the construction of active sites regarding the large number of unoccupied octahedral interstices has not yet been explored. Herein, more octahedral sites with high OER activities are constructed on the surface of spinel oxides via a cationic misalignment, which is induced by the defects in the spinel oxide solutions, i.e., MoFe2 O4 and CoFe2 O4 nanosheets supported on an iron foam (MCFO NS/IF). With increased active sites and modified electronic structure, the state-of-the-art electrocatalyst exhibits the excellent OER catalytic activity with an onset potential of 1.41 V versus RHE and an overpotential of 290 mV to achieve a current density of 500 mA cm-2 . Moreover, such an electrocatalyst also demonstrates fast kinetics with the Tafel slope of 38 mV dec-1 and superior durability by maintaining the OER activity at 250 mA cm-2 for 1000 h.We have synthesized the tetrabutylammonium ([Bu4 N]+ ), tetraethylammonium ([Et4 N]+ ), guanidinium ([C(NH2 )3 ]+ ), and methylguanidinium ([C(N3 H5 CH3 )]+ ) salts of the [BH3 (NH2 BH2 )2 H]- anion, a five-membered B/N anionic chain, in high yields by the metathesis reactions of Na[BH3 (NH2 BH2 )2 H] with the corresponding halides and characterized them by NMR (11 B, 11 B1 H, 1 H, 1 H11 B, 13 C), IR, elemental analysis, TGA-DSC, and TGA-MS. These complexes behave like ionic liquids (ILs), in which the melting point of the [Bu4 N][BH3 (NH2 BH2 )2 H] is the lowest (-51 °C). The dehydrogenation of these ILs have been studied through the thermal decomposition and catalytic hydrolysis in aqueous solution using the noble or non-noble metals or their salts as catalysts, and the results indicate that these ILs of five-membered B/N anionic chain are promising hydrogen storage materials.Enamel, once formed, loses the ability to regenerate due to the loss of the formative ameloblasts. It is subjected to constant damaging events due to exposure to external agents and oral microbiomes. An enamel remineralization process targets to replenish the lost ionic component of the enamel through a multitude of methods. Enamel remineralization is highly challenging as it has a complex organized hierarchical microstructure. Hydroxyapatite nanocrystals of the enamel vary in size and orientation along alignment planes inside the enamel rod. The inability of the enamel to remodel unlike other mineralized tissues is another substantial deterrent. One of the well-known biomaterials, bioglass (BG) induces apatite formation on the external surface of the enamel in the presence of saliva or other physiological fluids. Calcium, sodium, phosphate, and silicate ions in BG become responsive in the presence of body fluids, leading to the precipitation of calcium phosphate. Studies have also demonstrated the bactericidal potential of BG against Streptococcus mutans biofilms. The anticariogenicity and antibacterial activity were found to be enhanced when BG was doped with inorganic ions such as F, Ag, Mg, Sr, and Zn. Due to the versatility of BG, it has been combined with a variety of agents such as chitosan, triclosan, and amelogenin to biomimic remineralization process. Key strategies that can aid in the development of contemporary enamel remineralization agents are also included in this review.The diagnostic yield of standard tissue-sampling modalities of suspected lung cancers, whether by bronchoscopy or interventional radiology, can be nonoptimal, varying with the size and location of lesions. What is needed is an insitu sensor, integrated in the biopsy tool, to objectively distinguish among tissue types in real time, not to replace biopsy with an optical diagnostic, but to verify that the sampling tool is properly located within the target lesion. Veliparib in vitro We investigated the feasibility of elastic scattering spectroscopy (ESS), coupled with machine learning, to distinguish lung lesions from the various nearby tissue types, in a study with freshly-excised lung tissues from surgical resections. Optical spectra were recorded with an ESS fiberoptic probe in different areas of the resected pulmonary tissues, including benign-margin tissue sites as well as the periphery and core of the lesion. An artificial-intelligence model was used to analyze, retrospectively, 2032 measurements from excised tissues of 35 patients.
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