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Cyanobacteria blossoms possibly enhance unstable organic compound (VOC) pollution levels coming from a eutrophic river: Area along with new data.
Additionally, there were positive correlations between Hamilton Rating Scale for Depression-24 scores and bilateral ADCuh values in the SCP and cerebellar hemisphere. Conclusions The alteration of the ADCuh values in the cerebellum may reflect the changes of the AQP4, especially the abnormality of eDWI parameters in the SCP may be a key neurobiological feature of BD-II. The current results provide a novel insight to look into the pathophysiology mechanisms underlying BD-II.Background Exposure to severe Traumatic Events (TEs) has been associated with poor course and outcomes among individuals with Bipolar Disorder (BD). However, there is limited research on TEs among youth with BD, and few studies are longitudinal. This study prospectively followed a large sample of BD youth, examining the associations of lifetime TEs with their mood and functioning. Methods BD participants (n=375; mean age=17; range 8-25y) were assessed, on average, every 7 months for a median 8.7 years. Psychopathology and lifetime trauma history were prospectively evaluated using the Longitudinal Interval Follow-Up Evaluation, and a traumatic events screening. Results Accounting for covariates, participants with one or more lifetime TEs (84%) showed earlier BD onset, poorer psychosocial functioning, worse mood symptoms, and more suicidal ideation, comorbidities, and family psychopathology than those without TEs. TEs during recovery periods increased recurrence risk (p less then 0.02). More TEs were associated with poorer mood course, particularly among victims of violence/abuse (p less then 0.02). Abused participants (34% physical; 17% sexual) showed earlier onset of substance use disorders, more suicidality and comorbidities compared to those without abuse. Comparisons of mood course before and after abuse occurred, and with participants without abuse, showed worsening mood symptoms after, specifically hypo/mania (p less then 0.03). Limitations Prospective data was gathered longitudinally but assessed retrospectively at every follow-up; given approximate dates causality cannot be inferred; TEs severity was not assessed. Conclusions Severe TEs, particularly abuse, were associated with poorer course and outcomes among BD youth. Prompt screening of trauma and early intervention may be warranted to minimize TEs impact.Background Anxiety and depression are considered risk factors for cardiovascular diseases (CVDs), but their relationship to blood pressure (BP) is still uncertain. Lifestyle factors and age-related comorbidities may confound these relationships. Our study aimed to evaluate the associations between BP and anxiety and depression scores in a population aged ≥49 years. Methods Data on 8504 participants from The Irish Longitudinal Study on Ageing (TILDA) were analyzed for associations between BP and anxiety and depression questionnaire scores, accounting for relevant confounding factors. Results Multivariable analyses showed negative associations between systolic BP and anxiety and depression scores, independent of age, body mass index (BMI), marital status, education level, smoking status, alcohol consumption, level of physical activity, self-reported CVDs (≥2) and antihypertensive medication use in men (coefficient=-0.112, P=0.013; coefficient=-0.051, P=0.026) but not in women (coefficient=-0.001, P=0.855; coefficient=-0.005, P=0.556). Diastolic BP was not associated with anxiety or depression scores in either men (coefficient=-0.018, P=0.223; coefficient=-0.001, P=0.924) or women (coefficient=-0.007, P=0.338; coefficient=-0.015, P=0.293) after adjusting for these same confounding factors. After a follow-up of 4 years, lower BP in subjects not using antihypertensive medications was significantly associated with more anxiety and depression events. Limitation Time-varying confounding factors may have interfered with our results. Conclusion Our results show that systolic BP in a middle-aged and elderly population is negatively associated with anxiety and depression scores in men but not women after adjustment for a range of lifestyle factors. These results contrast with the predisposition of anxious or depressed participants to CVDs in later life when decades of unhealthy lifestyles have persisted.Background Concerns have been raised that synthetic oxytocin, a widely used obstetric tool for labor induction and augmentation, may have deleterious effects on the neuropsychological development of children. Few studies have examined the relationship between oxytocin-stimulated labor and emotional disorders. Methods We conducted a nationwide register-based cohort study including 677,629 singletons born in Denmark in the years 2000 to 2012 and followed through 2016 (median age = 10.6 years). Data on oxytocin-stimulation were obtained from the Danish Medical Birth Register. Cases of emotional disorders - anxiety, obsessive-compulsive disorder, mood or traumatic stress disorders or a redeemed prescription for a selective serotonin reuptake inhibitor - were identified using Danish patient and prescription registries. Results Oxytocin was used to stimulate 31% of births, and oxytocin-stimulated labor was not associated with childhood emotional disorders (HR = 1.05, 95% CI 0.99, 1.11) after adjustment for maternal history of psychopathology, antidepressants during pregnancy, cohabitation status, highest educational attainment, smoking status during pregnancy, birth year, and indications for labor stimulation. The crude cox model was also small and close to unity (HR = 1.09, 95% CI 1.03, 1.15). Limitations About 50% of our population had reached the age of 10 years, but the outcome included disorders with later average debut ages. Oxytocin dosage levels are not recorded in the registers. Conclusions Our small effect size estimates suggest that perinatal synthetic oxytocin does not contribute to the development of emotional disorders. Current evidence does not warrant revision of guidelines for the use of oxytocin in obstetrics.Background This study aimed to investigate the association between psychosocial variables and depression severity among Chinese patients with first-episode major depressive disorder (MDD). Methods This multicenter case-control study enrolled patients with first-episode MDD and healthy controls (HCs) from nine sites in China. Depressive symptoms, clinical features, and psychosocial variables were evaluated. Based on the total score of the Hamilton Rating Scale of Depression (HRSD-17), patients with MDD were classified into three subgroups of severity (mild, moderate and severe). The logistic regression analyses were conducted to investigate the independent risk factors of MDD and different severities of depression. Results Overall, 598 MDD patients and 467 HCs were included. The proportions of patients with mild, moderate, and severe depression were 260 (29.5%), 443 (50.2%), and 179 (20.3%), respectively. The logistic regression model revealed that the demographic and psychosocial factors could explain 50.6% of the total variance of occurrence of MDD in the whole sample with HCs. However, in the subsample of MDD patients, only older age [OR=1.03 (95%CI 1.02-1.05)], stressful social events [OR=1.04 (95%CI 1.02-1.06)], and melancholic feature [OR=2.68 (95%CI 1.91-3.74)] were independent risk factors for moderate and severe depression; these factors combined to explain only 10.2% of the total variance. Limitations Only patients with first-episode MDD were included in this study, leaving the associated factors for the severity of recurrent depression uninvestigated. Conclusion Demographic and psychosocial variables had satisfactory performance in predicting the occurrence of MDD, but showed inadequate value in predicting the depression severity of MDD patients.The aim of the study was to assess the effect of seaweed cultivation on the coastal environment. We analysed a multitude of environmental parameters using an asymmetrical before after control impact (BACI) design, comparing the seaweed farm (impact) with multiple unaffected locations (controls). The seaweed farm had a significant positive effect on benthic infauna (p less then 0.05) and was found to attract 17 mobile faunal and 7 other seaweed species, indicating that the farmed crop may provide habitat to mobile faunal species. A light attenuation of approximately 40% at 5m depth was noted at the peak of the seaweed biomass just before harvest. No changes were observed in benthic oxygen flux, dissolved nutrient concentrations, and benthic mobile fauna between farm and control sites. These results show that seaweed aquaculture has limited environmental effects, especially compared to other forms of aquaculture such as fish and bivalve farming.The nitrogen uptake kinetics and physiological growth of Karenia mikimotoi and Skeletonema costatum sensu lato grown on different N substrates and concentrations were compared in the laboratory. In the presence of three N substrates, both species preferred to take up NH4+. K. mikimotoi and S. costatum s.l. showed the highest substrate affinities for urea and NO3-, respectively. Both species grew well on three N substrates, and the growth parameters were comparable among the different N substrates. However, K. mikimotoi assimilated urea more efficiently than it assimilated either NO3- or NH4+. Different with S. costatum s.l., K. mikimotoi grew slowly and steady and the physiological and growth activities in N-depleted conditions were higher than those in N-replete conditions. Our results suggested that K. mikimotoi shows a greater readiness for uptake and assimilation of urea, and that this species is more competitive in an N-depleted environment when compared with S. costatum s.l.Globally, coral reefs have drastically degraded due to local and global environmental stressors. Concurrently, coral reef tourism is rapidly growing in developing economies, which is one of many anthropogenic stressors impacting reefs. At the Malvan Marine Sanctuary, a Marine Protected Area (MPA) on the West coast of India, we investigated the impact of recreational diving on the reef from 2016 to 2019. To evaluate the diver's underwater behavior, a novel approach was used, wherein the video-log broadcasting website www.youtube.com was perused. Evidential proof substantiates heavy physical damage to corals because of recreational diving activity, which may lead to the collapse of coral habitat if it continues unabated. This resource depletion ironically elevates the economy of dependents averting consequences due to lost corals, thus making this a 'tragedy' for corals which are not meant to be 'commons'. Puromycin aminonucleoside molecular weight The study asserts need for proactive conservation efforts with stringent implementation and restoration initiatives in this MPA.Consequences of a catastrophic flood on the habitat quality and the concurrent responses of the bentho-pelagic community were studied in Cochin estuary, a eutrophic estuary along the southwest coast of India. The episodic flood in 2018 led to a marked decline in the dissolved nutrients and heavy metal concentrations in water and sediments of the estuary. The pre-flood phytoplankton abundance dominated by a bloom-forming species Cerataulina bicornis experienced a significant drop after the flood. Contrarily, zooplankton and macrobenthos responded favorably towards the flood-imposed habitat alterations. Higher susceptibility to heavy metal pollution and increased grazing pressure from gelatinous carnivores restricted the abundance of Copepoda, the dominant zooplankton taxon during pre-flood. The lower heavy metal concentration in the sediment after the flood favored higher macrobenthic abundance and diversity with a conspicuous change in the community structure from opportunistic polychaetes, indicators of pollution to molluscans and crustaceans, indicators of the healthy benthic zones.
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