Notes

Facile and Powerful Inside Situ Polymerization Technique of Sulfur-Based All-Solid Plastic Electrolytes in Lithium Power packs.
etency.
Effects of the COVID-19 pandemic on residency training are multi-dimensional. The majority of surgical and anesthesia residents perceived that their technical ability diminished as a result of skill decay, whereas other skillsets improved. Longitudinal surveillance of trainees is warranted to evaluate the effect of reduced operative volume and redeployment on professional competency.
Recent evidence suggests that many adults with intellectual and developmental disabilities (IDD) do not adequately manage hypertension (HTN) medication. Known risk factors for insufficient prescription filling include age, residential placement, and lack of caregiver support. This is a first report of a randomized intervention trial designed to analyze the relationship of a brief educational intervention with increased knowledge about HTN and improvement in prescription filling for anti-hypertensive medication.

The objective was to test whether an educational flyer and regular messages about HTN and the importance of refilling medication would improve scores on knowledge surveys. Participants were Medicaid members with HTN and IDD (Member) or caregivers (Helpers) who chose to participate on behalf of a Member.

Recruitment letters explained that either the Member or their Helper could participate (not both). Participants were randomly assigned to the Case or Comparison group, and both were comprised of Members and Helpers. Only Case participants received a flyer and monthly HTN education messages for one year, but all participants completed knowledge surveys at baseline, six, and 12 months. Linear regression and log-binomial models were used to compare responses between groups.

Case Helpers had statistically significant improvements on HTN knowledge from baseline through the first year, compared to Comparison Members and Comparison Helpers. Regardless of group assignment, Helpers scored better on surveys than did Members.

This study suggests that it is beneficial to explicitly include Helpers in health care instruction and in management of chronic disease for adults with IDD.
This study suggests that it is beneficial to explicitly include Helpers in health care instruction and in management of chronic disease for adults with IDD.
The purpose of this study was to assess the impact of advanced modeled iterative reconstruction (ADMIRE) algorithm and dose levels on the accuracy of Hounsfield unit (HU) measurement, image noise and contrast-to-noise ratio (CNR) in virtual monochromatic images (VMIs) with low iodine concentrations, and the accuracy of iodine quantification.

A CT phantom was scanned with dual-source CT using abdomen-pelvis examination parameters at four dose levels 5, 8, 11 and 20 mGy. Images were reconstructed using filtered-back projection (FBP) and ADMIRE levels 3 and 5 (A3-A5). HU accuracy was assessed calculating the root-mean-square deviation (RMSD
). Image noise and CNR were computed on VMIs at 40/50/60/70keV for 4 iodine inserts with 0.5, 1, 2 and 5mg/mL concentrations. Accuracy of iodine quantification was assessed by the RMSD
and iodine bias (IB).

The RMSD
decreased significantly as the dose levels increased compared to 5 mGy, except for 8 mGy with A3 (P=0.380) and with A5 level (P=0.945). Noise increased by 63.0±3.0 (standard deviation [SD])% from 20 mGy to 5 mGy. Noise decreased significantly by -53.8±0.9 (SD) % with A5 compared to FBP. The CNR decreased by -43.1±6.5 (SD)% from 20 mGy to 5 mGy. It increased using ADMIRE, and as the ADMIRE levels increased. The RMSD
and IB decreased as the dose level increased, and this was similar for all reconstruction types.

ADMIRE strongly improves image quality in VMIs and slightly improves HU accuracy but does not affect the accuracy of iodine quantification.
ADMIRE strongly improves image quality in VMIs and slightly improves HU accuracy but does not affect the accuracy of iodine quantification.
There is limited information on the role of fatigue on retirement, either independently or in association with poor sleep. The aim of this study was to examine the prospective association between daytime fatigue, measured as feeling tired or feeling worn out, independently and in relation to dissatisfaction with sleep, and subsequent retirement among 960 older workers in New Zealand.

Data from 2 consecutive surveys (2008 and 2010) of the New Zealand Health, Work, and Retirement Longitudinal Study were used. Poisson regression was used to investigate whether feeling tired and feeling worn out in 2008, along with dissatisfaction with sleep, were associated with self-reported retirement either due to health reasons or other reasons by 2010.

The risk for retirement due to health reasons during a 2-year follow-up was 1.80-fold (95% confidence interval [CI] 1.16-2.45) among those who felt tired and 1.99-fold (95% CI 1.34-2.64) among those who felt worn out when compared to those not tired or not feeling worn out after adjusting for several sociodemographic, work characteristics and self-rated health. The risk for retirement due to health reasons was even higher when participant experienced both tiredness and feeling worn out. Dissatisfaction with sleep did not predict retirement due to health or other reasons.

Our results highlight that workers at risk of subsequent retirement due to health reasons may be identified with rather simple questions on tiredness and feeling worn out even among generally healthy older workers.
Our results highlight that workers at risk of subsequent retirement due to health reasons may be identified with rather simple questions on tiredness and feeling worn out even among generally healthy older workers.
To examine the role of adolescents' and their parents' sleep quality as mediators of family-level processes and family members' psychological distress (ie, anxiety/depressive symptoms).

Short-term prospective design with an initial survey followed by a 7-day twice-daily (morning and evening) diary.

Online survey for high school students and their parents across the United States.

A total of 193 adolescent (M
=15.7 years old, standard deviation=0.94; 54.4% female) and parent (M
=47.6 years old, standard deviation=5.4; 80% female) dyads.

In the initial survey, adolescents reported on family dysfunction, parent-child relationship quality, and parents reported on their own romantic relationship satisfaction. Both adolescents and parents reported their daily levels of sleep quality (morning diaries) and their psychological distress (evening diaries) for 7 days.

At the level of between-family differences, parents' sleep quality mediated the association between their baseline reports of romantic relationship satisfaction and daily levels of psychological distress. In addition, adolescents' sleep quality mediated the association between family-level dysfunction and their own psychological distress. After controlling for between-family associations, spikes in parents' and/or adolescents' sleep quality on specific mornings predicted corresponding drops in parents' evening reports of psychological distress on those same days. Finally, parents' and adolescents' sleep quality demonstrated significant levels of concordance across the 7 days of the daily diary.

Findings underscore the dynamic and tightly related processes within the family system and the important role that sleep plays in linking them with family members' psychological distress.
Findings underscore the dynamic and tightly related processes within the family system and the important role that sleep plays in linking them with family members' psychological distress.
Renal medullary carcinoma (RMC) is a rare and lethal renal cell carcinoma characterized by the loss of tumor suppressor SMARCB1. Molecular profiling studies have suggested that RMC cells may be vulnerable to therapies that generate DNA damage, such as the combination of the nucleoside analog gemcitabine, and topoisomerase inhibitor doxorubicin.

We retrospectively analyzed the records of patients with RMC treated with gemcitabine plus doxorubicin at our institution between January 2005 and September 2020. Best radiographic response and disease progression (RECIST v1.1) were assessed by a blinded radiologist.

Sixteen patients were included in the study. All but 1 patient (93.8%) received prior platinum-based chemotherapy. E6446 ic50 Gemcitabine was given intravenously at 900-1200 mg/m
and doxorubicin at 40-50 mg/m
intravenously every 2 weeks. Three patients (18.8%) achieved partial response and 7 (43.8%) patients achieved stable disease. The median progression-free survival was 2.8 months (95% CI, 0-6.0). Medianmechanisms of resistance.The microbiome assisted tumor microenvironment (TME) supports the tumors by modulating multiple mechanisms. Recent studies reported that microbiome dysbiosis is the main culprit of immune suppressive phenotypes of TME. Further, it has been documented that immune suppressive stimulate metastatic phenotype in TME via modulating signaling pathways, cell differentiation, and innate immune response. This review aims at providing comprehensive developments in microbiome and breast TME interface. The combination of microbiome and breast cancer, breast TME and microbiome or microbial dysbiosis, microbiome and risk of breast cancer, microbiome and phytochemicals or anticancer drugs were as used keywords to retrieve literature from PubMed, Google scholar, Scopus, Web of Science from 2015 onwards. Based on the literature, we presented the impact of TME assisted microbiome dysbiosis and estrobolome in breast cancer risk, drug resistance, and antitumor immunity. We have discussed the influence of antibiotics on the breast microbiome. we also presented the possible dietary phytochemicals that target microbiome dysbiosis to restore the tumor suppression immune environment in breast TME. We presented the microbiome as a possible marker for breast cancer diagnosis. This study will help in the identification of microbiome as a novel target and diagnostic markers and phytochemicals and microbiome metabolites for breast cancer treatment.
To evaluate accuracy of tooth movements with in-house clear aligners.

This prospective clinical study included 30 participants for anterior clear aligners with crowding not exceeding 4 mm. per arch, non-extraction cases with no changes in posterior relationship. Aligners were created with OrthoAnalyzer
software, attachments were placed as needed and IPR was performed in required areas. The final stage of tooth movement was compared with predicted tooth movement by superimposition of the two STL models. Maxillary arch was superimposed on stable posterior teeth and best fit on palatal rugae while mandibular arch was superimposed on unmoved posterior teeth. The amount of differences in predicted and achieved tooth movements were compared. Six types of tooth movement were included in the comparison which were labial, lingual, mesiodistal, intrusion, extrusion and rotation.

Total sample consisted of 259 anterior teeth (126 maxillary, 133 mandibular). The achieved tooth movements were significantly lesser than the predicted tooth movements in all the six types of tooth movement. Overall accuracy of tooth movement with clear aligner was 56.18%. The most accurate tooth movement was mesiodistal (72.33%). The least accurate movement was intrusion (43.28%). While mesiodistal, labial, rotation and lingual tooth movements were more predictable than intrusion and extrusion.

Understanding the accuracy of different tooth movements might help in case selection, treatment plan and development or increase accuracy and predictability of in-house clear aligners.
Understanding the accuracy of different tooth movements might help in case selection, treatment plan and development or increase accuracy and predictability of in-house clear aligners.
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