Notes

Substance Suggesting: Polypharmacy and also Deprescribing.
These effects were more pronounced in male mice than that in females. The promoting-effects of Cd on fibrosis and angiogenesis were further validated in hepatic stellate cells and liver sinusoidal endothelial cells. PPAR and ERBB signaling pathways were identified as the potential pathways to promote the toxicity of chronic Cd exposure. These findings provide a better understanding about the long-term influence of environmental Cd spanning the entire precancerous lesions-to-cancer formation cycle.Wastewater treatment plants are particularly challenging with the treatment and disposal of sewage sludge produced from the treatment units due to its high costs and environmental hazards. In this study, a biogas recirculation-driven anaerobic digestion (AD) system was developed with upward shear force being provided by biogas recirculation coupled with the alkali addition strategy, targeting biogas upgrading, sludge stabilization, and sludge flocculation simultaneously, thus reducing the sludge management costs. Compared to the conventional AD system, the novel biogas recirculation-driven AD system could achieve biogas upgrading with 10% higher CH4 content. Besides, the combination of NaOH and Ca(OH)2 addition strategy obviously improved sludge settleability and dewaterability compared to the single NaOH addition strategy. Owing to the attraction between negatively charged sludge particles and Ca2+ ions, the available Ca2+ in the former AD system may facilitate the re-flocculation and P immobilization in solid digestate, fix partial CO2 with less CO2 emission, and bridge with some sludge flocs. Moreover, 12.6% lower net cost for sludge management was achieved by this biogas recirculation-driven AD system together with the combination alkali addition strategy, which is regarded as a promising integrated multi-purpose system for sludge treatment.Monitoring and management of drinking water distribution networks (DWDNs), including possible leaching from materials in contact with drinking water, have been stressed as crucial to avoid re-contamination of drinking water leading to a potential increase of human health risk. Recent scientific studies and regulations clearly highlighted the leaching of bisphenol A (BPA) from plastic materials used to renovate DWDNs pipelines as one of the major hazardous source, resulting in severe consequences for human health. In this study, lab migration tests were performed on three commercial epoxy resins, designed with the Design of Experiments (DoE) method in order to build a BPA migration model as a function of water chemical stability, evaluated as aggressivity index (AI), and residual chlorine concentration. Tests lasted about 170 days to account for both short and long-term leaching. BPA migration over time was well described by a combination of two 1st-order kinetic models with an initial peak of leaching, a decrease and, then, a second increase due to resins' deterioration. Initial BPA concentration in the contact water and BPA integral migration over time showed inverse proportionality with both chlorine concentration and AI values. However, measurements of free BPA content in epoxy resins proved that this is due to BPA transformation, not to a reduced leaching. The validated BPA migration model was combined with the hydraulic model of the DWDN in an urban area, through EPANET-MSX software. The model allowed to simulate the propagation of BPA in the DWDN, after the execution of a relining intervention, identifying the most vulnerable areas and permitting to customize a site-specific monitoring and intervention plan to minimize the health risk for final consumers.This study investigates water quality along the river Liffey in Dublin city with the help of citizen scientists, including the community of river users such as paddle boarders and those accessing the river from the bank. The primary objective was to evaluate water quality near sources of pollution observed by citizens, while filling data gaps for the United Nations (UN) Sustainable Development Goal (SDG) 6, Indicator 6.3.2. Belvarafenib cost The participants used field chemistry kits to measure nitrate (NO₃-N) and phosphate (PO₄-P) at 19 locations on a monthly basis over the course of nine months, recording the results on a smartphone app. 10% of nitrate samples were indicative of low quality water values while 35.6% of phosphate samples were indicative of low quality water. Rainfall over the study period was analysed to investigate the impact of run-off from rainwater on the river. Results indicated that excessive rainfall was not a factor in lower water quality in this area. Citizen scientists' observational notes and photographs entered onto the database, with accompanying test results were key to highlighting pollution sources at specific locations which correlated with high levels of nitrate and phosphate resulting in low quality water. Land use was a factor in these areas of recent housing development indicating possible domestic misconnections. Citizen scientist data has the potential to fulfil UN SDG 6, in contributing to Indicator 6.3.2 while detecting contamination.As climate issues gradually attract public attention worldwide, the operation and construction of oil product pipelines have been attached with new energy-saving and emission-reduction targets. Though previous studies concerning Life Cycle Assessment of oil and gas pipelines have estimated the carbon footprint to some extent, there is a lack of researches that take the characteristics of oil products pipelines into consideration. Oil products pipelines undertake the task of delivering various products to downstream demand locations, which differs greatly from other pipeline transportation systems as back-to-back sequential delivery is adopted. In this paper, a detailed Life Cycle Assessment model is established to analyze carbon emissions of oil products pipeline system from construction to disposal as well as its impact on soil environment. Data from practical pipes is adopted as the case study to reflect emissions produced in different stages, and the amount of total and unified emissions of different pipes provided through the proposed model is within the range of 2.78 to 4.70 tCO2e/t·km. Then, sensitivity analysis is carried out to identify the driving factors of emissions. According to the calculation results, pipe length, diameter and throughput turn out to be the dominating factors, and an empirical formula is derived for future planned pipes. Relevant recommendations are put forward based on the results to help reduce emissions from oil product pipe transportation.The fate of nanoparticles (NPs) in soil under relevant environmental conditions is still poorly understood. In this study, the mobility of two metal-oxide nanoparticles (CuO and TiO2) in contrasting agricultural soils was investigated in water-saturated soil columns. The transport of TiO2 and CuO-NPs were assessed in six soils with three different textures (from sand to clay) and two contrasted organic matter (OM) contents for each texture. TiO2 mobility was very low in all soils, regardless of texture and OM content. Mass recoveries were always less than 5%, probably in relation with the strong homo-aggregation of TiO2-NPs observed in all soil solutions, with apparent sizes 3-6 times larger than their nominal size. This low mobility suggests that TiO2-NPs present a low risk of direct groundwater contamination in contrasted surface soils. Although their retention was also generally high (more than 86%), CuO nanoparticles were found to be mobile in all soils. This is probably related to their smaller apparent size and low capacity of homo-aggregation of CuO-NPs in all soil solutions. No clear influence of neither soil texture or soil total organic matter content could be observed on CuO transport. However, this study shows that in contrasted agricultural soils, CuO-NPs transport is mainly controlled by the solutes dissolved in soil solution (DOC and PO4 species), rather than by the properties of the soil solid phase.The impact of calcium on the solubility and redox behavior of the Pu(IV)-EDTA system was investigated using a combination of undersaturation solubility studies and advanced spectroscopic techniques. Batch solubility experiments were conducted in 0.1 M NaCl-NaOH-HCl-EDTA-CaCl2 solutions at constant [EDTA] = 1∙10-3 M, 1 ≤ pHm ≤ 11, and 1∙10-3 M ≤ [CaCl2] ≤ 2∙10-2 M. Additional samples targeted brine systems represented by 3.5 M CaCl2 and WIPP simulated brine. Redox conditions were buffered with hydroquinone (pe + pH ≈ 9.5) with selected samples prepared in the absence of any redox buffer. All experiments were performed at T = 22 °C under Ar atmosphere. In-situ X-ray absorption spectroscopy indicated that PuO2(ncr,hyd) was the solubility-controlling phase during the lifetime of all experiments and that aqueous plutonium was present in the +IV oxidation state across all experimental conditions except at pHm ≈ 1, where a small fraction of Pu(III) was also identified. Current thermodynamic models overestimate Pu(IVa pronounced impact on plutonium predominance diagrams over a broad range of pH, pe, and calcium concentrations that are relevant to nuclear waste disposal.Lawns have long been a primary feature of residential landscapes in the United States. However, as population growth in urban areas continues to rise, water conservation is becoming a key priority for many municipalities. In recent years, some municipalities have begun to offer rebate programs which incentivize removal of turfgrass areas and conversion to alternative 'water-efficient' landscapes, with the goal of reducing outdoor water use. The environmental impacts and changes to ecosystem services associated with such landscape alterations are not well understood. Therefore, a 2-year continuous research project was conducted at the Urban Landscape Runoff Research Facility at Texas A&M University to evaluate rainfall capture and runoff volumes associated with several commonly used residential landscape types (including, St. Augustine grass Lawn, Xeriscaping, Mulch, Artificial Turf, and Sand-capped Lawn) and to characterize the flow dynamics of surface runoff in relation to rainfall intensity for each landscape. The results demonstrate that runoff dynamics differ between landscapes, but also change over time as the newly converted landscapes become established. Following the initial months of establishment, the effects of landscape type on runoff volumes were significant, with Artificial Turf and Xeriscaping generating greater runoff volumes than Mulch and St. Augustine grass Lawns for most runoff events, which is partially due to the low infiltration rate of such landscapes. Overall, Artificial Turf and Xeriscaping showed the greatest cumulative runoff volumes (>400 L m-2), whereas Water Efficient- Mulch, Sand-capped Lawn and St. Augustine grass Lawn had a significantly lower cumulative runoff volumes, ranging from 180 to 290 L m-2. Information from this research should be useful to municipalities, water purveyors, and homeowner associations as they weigh the long-term hydrological impacts of lawn removal and landscape conversion programs.Iron/copper bimetallic nanoparticles based sludge biochar (Fe/Cu-SBC) was prepared by using a modified co-precipitation route. The Fe/Cu-SBC system prepared was subsequently applied to activate periodate (IO4-) to degrade diclofenac sodium (DCF) by using UV light at room temperature (25 °C). The physicochemical properties of both SBC and Fe/Cu-SBC such as morphology, physical properties, crystal structures and functional groups were examined. The type and number of surface functional groups were found to be increased and the catalytic performance was improved by the modification of Fe/Cu bimetallic nanoparticles. The influence of various parameters to evaluate the catalytic efficiency such as periodate (PI) concentration, dosage of catalysts, UV power, initial pH and coexisting anions were investigated. Under the optimized conditions (pH 6.9, UV-power 60 W, PI concentration of 5 mM and 0.1 g Fe/Cu-SBC), it was observed that 99.7% of DCF was degraded with a pseudo-first-order kinetics reaction constant 9.39 × 10-2 min-1.
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