Notes

Histone deacetylase HDA-4-mediated epigenetic legislations in space-flown H. elegans.
Strength training increased the maximum strength in a similar magnitude to combined training in patients with T1DM (ES -0.114; P = .624).

Both combined training and strength training represent effective strategies for improving the maximum strength in individuals with T1DM.
Both combined training and strength training represent effective strategies for improving the maximum strength in individuals with T1DM.
Interrupting prolonged sitting can attenuate postprandial glucose responses in overweight adults. The dose-response effect in stroke survivors is unknown. The authors investigated the effects of interrupting 8hours of prolonged sitting with increasingly frequent bouts of light-intensity standing-based exercises on the postprandial glucose response in stroke survivors.

Within-participant, laboratory-based, dose-escalation trial. Participants completed three 8-hour conditions prolonged sitting and 2 experimental conditions. Experimental conditions involved light-intensity standing-based exercises of increasing frequency (2 × 5min to 6 × 5min bouts). Postprandial glucose is reported.

Twenty-nine stroke survivors (aged 66y) participated. Interrupting 8hours of prolonged sitting with light-intensity standing-based exercises every 90minutes significantly decreased postprandial glucose (positive incremental area under the curve; -1.1mmol/L·7h; 95% confidence interval, -2.0 to -0.1). In the morning (0800-1100), postprandial glucose decreased during the 4 × 5minutes and 6 × 5minutes conditions (positive incremental area under the curve; -0.8mmol/L·3h; 95% confidence interval, -1.3 to -0.3 and -0.8mmol/L·3h; 95% confidence interval, -1.5 to -0.2, respectively) compared with prolonged sitting.

Interrupting 8hours of prolonged sitting at least every 90minutes with light-intensity standing-based exercises attenuates postprandial glucose in stroke survivors. During the morning, postprandial glucose is attenuated when sitting is interrupted every 60 and 90minutes.
Interrupting 8 hours of prolonged sitting at least every 90 minutes with light-intensity standing-based exercises attenuates postprandial glucose in stroke survivors. During the morning, postprandial glucose is attenuated when sitting is interrupted every 60 and 90 minutes.
School-aged children in the Southeast, compared with other United States of America (US) regions, have significantly lower levels of active transportation to school (ATS). The purpose of this study was to contrast the parental correlates of ATS choice specific to the Southeast with other areas of the US.

This study utilized national data from 2952 households with school-aged children located within a 20-minute walk to a school. Parents reported their children's ATS behavior and their own ATS beliefs and perceptions. Logistic regression contrasted correlates of parents from the Southeast with other regions.

Parents in the Southeast, compared with parents across the US, were significantly less likely to allow their child to take ATS (12.9% vs 33.3%, respectively) (odds ratio [OR] = 0.46; 95% confidence interval [CI] = 0.36-0.59). Specific to the Southeast, parental correlates linked to increases in ATS were Black race/ethnicity (OR = 1.68; 95% CI, 1.31-2.60), being single, (OR = 1.71; 95% CI, 1.15-2.54), and any parental physical activity (P value for trend = .0053). The only correlate associated with a decrease in ATS in the Southeast was heightened safety concerns (eg,traffic speed, safe crossings) (OR = 0.44; 95% CI, 0.23-0.84).

Among households with children in the Southeast, ATS interventions that allay parental safety concerns and that promote physical activity among parents might lead to increases in ATS.
Among households with children in the Southeast, ATS interventions that allay parental safety concerns and that promote physical activity among parents might lead to increases in ATS.Most studies on offside decision making in soccer have not addressed rather simplistic situational probabilities like the number of players involved in an offside situation. In three studies (one observational and two experimental), the authors tried to assess whether the number of players close to the offside situation can predict the quality of offside decision making. In all three studies, they found that the presence of additional players negatively affected the percentage of correct decisions. The exact relationship between the number of players and the decrease in decision-making performance differed between the studies, though. Importantly, there was a negative influence of the number of players on decision-making quality in Studies 2 and 3, even though the authors tried to add players clearly farther away from the offside line than the relevant pair of players. This points to a crowding effect as a potential explanation for why decision-making quality decreases with an increasing number of players.The authors explored how sport structure predisposed a team to subgroup formation and influenced athlete interactions and team functioning. A season-long qualitative case study was undertaken with a nationally ranked Canadian track and field team. Semistructured interviews were conducted with coaches (n = 4) and athletes (n = 11) from different event groups (e.g., sprinters, jumpers) at the beginning and at the end of the season. The results highlighted constraints that directly impacted athlete interactions and predisposed the group to subgroup formation (e.g., sport/event type, facility/schedule limitations, team size/change over time). The constraints led to structural divides that impacted interactions but could be overcome through team building, engaging with leaders, and prioritizing communication. These findings underline how structure imposed by the design of sports impacts teammate interactions and how practitioners, coaches, and athletes can manage groups when facing such constraints. The authors describe theoretical and practical implications while also proposing potential future directions.A degraded, black-and-white image of an object, which appears meaningless on first presentation, is easily identified after a single exposure to the original, intact image. This striking example of perceptual learning reflects a rapid (one-trial) change in performance, but the kind of learning that is involved is not known. We asked whether this learning depends on conscious (hippocampus-dependent) memory for the images that have been presented or on an unconscious (hippocampus-independent) change in the perception of images, independently of the ability to remember them. We tested five memory-impaired patients with hippocampal lesions or larger medial temporal lobe (MTL) lesions. In comparison to volunteers, the patients were fully intact at perceptual learning, and their improvement persisted without decrement from 1 d to more than 5 mo. Yet, the patients were impaired at remembering the test format and, even after 1 d, were impaired at remembering the images themselves. To compare perceptual learning and remembering directly, at 7 d after seeing degraded images and their solutions, patients and volunteers took either a naming test or a recognition memory test with these images. The patients improved as much as the volunteers at identifying the degraded images but were severely impaired at remembering them. Notably, the patient with the most severe memory impairment and the largest MTL lesions performed worse than the other patients on the memory tests but was the best at perceptual learning. The findings show that one-trial, long-lasting perceptual learning relies on hippocampus-independent (nondeclarative) memory, independent of any requirement to consciously remember.To efficiently integrate cutting-edge terahertz technology into compact devices, the highly confined terahertz plasmons are attracting intensive attention. Compared to plasmons at visible frequencies in metals, terahertz plasmons, typically in lightly doped semiconductors or graphene, are sensitive to carrier density (n) and thus have an easy tunability, which leads to unstable or imprecise terahertz spectra. By deriving a simplified but universal form of plasmon frequencies, here, we reveal a unified mechanism for generating unusual n-independent plasmons (DIPs) in all topological states with different dimensions. Remarkably, we predict that terahertz DIPs can be excited in a two-dimensional nodal line and one-dimensional nodal point systems, confirmed by the first-principle calculations on almost all existing topological semimetals with diverse lattice symmetries. Besides n-independence, the feature of Fermi velocity and degeneracy factor dependencies in DIPs can be applied to design topological superlattice and multiwalled carbon nanotube metamaterials for broadband terahertz spectroscopy and quantized terahertz plasmons, respectively. Surprisingly, high spatial confinement and quality factor, also insensitive to n, can be simultaneously achieved in these terahertz DIPs. Our findings pave the way for developing topological plasmonic devices for stable terahertz applications.An aneuploid-immune paradox encompasses somatic copy-number alterations (SCNAs), unleashing a cytotoxic response in experimental precancer systems, while conversely being associated with immune suppression and cytotoxic-cell depletion in human tumors, especially head and neck cancer (HNSC). We present evidence from patient samples and cell lines that alterations in chromosome dosage contribute to an immune hot-to-cold switch during human papillomavirus-negative (HPV-) head and neck tumorigenesis. Overall SCNA (aneuploidy) level was associated with increased CD3+ and CD8+ T cell microenvironments in precancer (mostly CD3+, linked to trisomy and aneuploidy), but with T cell-deficient tumors. Early lesions with 9p21.3 loss were associated with depletion of cytotoxic T cell infiltration in TP53 mutant tumors; and with aneuploidy were associated with increased NK-cell infiltration. The strongest driver of cytotoxic T cell and Immune Score depletion in oral cancer was 9p-arm level loss, promoting profound decreases of pivotal IFN-γ-related chemokines (e.g., CXCL9) and pathway genes. Chromosome 9p21.3 deletion contributed mainly to cell-intrinsic senescence suppression, but deletion of the entire arm was necessary to diminish levels of cytokine, JAK-STAT, and Hallmark NF-κB pathways. Finally, 9p arm-level loss and JAK2-PD-L1 codeletion (at 9p24) were predictive markers of poor survival in recurrent HPV- HNSC after anti-PD-1 therapy; likely amplified by independent aneuploidy-induced immune-cold microenvironments observed here. learn more We hypothesize that 9p21.3 arm-loss expansion and epistatic interactions allow oral precancer cells to acquire properties to overcome a proimmunogenic aneuploid checkpoint, transform and invade. These findings enable distinct HNSC interception and precision-therapeutic approaches, concepts that may apply to other CN-driven neoplastic, immune or aneuploid diseases, and immunotherapies.Tau is a microtubule-associated protein, which promotes neuronal microtubule assembly and stability. Accumulation of tau into insoluble aggregates known as neurofibrillary tangles (NFTs) is a pathological hallmark of several neurodegenerative diseases. The current hypothesis is that small, soluble oligomeric tau species preceding NFT formation cause toxicity. However, thus far, visualizing the spatial distribution of tau monomers and oligomers inside cells under physiological or pathological conditions has not been possible. Here, using single-molecule localization microscopy, we show that tau forms small oligomers on microtubules ex vivo. These oligomers are distinct from those found in cells exhibiting tau aggregation and could be precursors of aggregated tau in pathology. Furthermore, using an unsupervised shape classification algorithm that we developed, we show that different tau phosphorylation states are associated with distinct tau aggregate species. Our work elucidates tau's nanoscale composition under nonaggregated and aggregated conditions ex vivo.
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