Notes

Cancer dimensions and also period regarding breast cancers throughout Côte d'Ivoire as well as Republic associated with Congo : Is caused by population-based cancers registries.
Furthermore, the full ASSLMBs (Li|LiFePO4) enable decent capacity retention of 90% over 100 cycles at 0.5C and high Coulombic efficiency of nearly 100%. Therefore, constructing solid-state electrolytes with dual-interfacial compatibility may be an effective avenue to achieve high-performance ASSLMBs.This paper proposes a novel memristive synaptic Hopfield neural network (MHNN) with time delay by using a memristor synapse to simulate the electromagnetic induced current caused by the membrane potential difference between two adjacent neurons. First, some sufficient conditions of zero bifurcation and zero-Hopf bifurcation are obtained by choosing time delay and coupling strength of memristor as bifurcation parameters. Then, the third-order normal form of zero-Hopf bifurcation is obtained. By analyzing the obtained normal form, six dynamic regions are found on the plane with coupling strength of memristor and time delay as abscissa and ordinate. There are some interesting dynamics in these areas, i.e., the coupling strength of memristor can affect the number and dynamics of system equilibrium, time delay can contribute to both trivial equilibrium and non-trivial equilibrium losing stability and generating periodic solutions.This study deals with the finite-time synchronization problem of a class of switched complex dynamical networks (CDNs) with distributed coupling delays via sampled-data control. First, the dynamical model is studied with coupling delays in more detail. The sampling system is then converted to a continuous time-delay system using an input delay technique. We obtain some unique and less conservative criteria on exponential stability using the Lyapunov-Krasovskii functional (LKF), which is generated with a Kronecker product, linear matrix inequalities (LMIs), and integral inequality. Furthermore, some sufficient criteria are derived by an average dwell-time method and determine the finite-time boundedness of CDNs with switching signal. The proposed sufficient conditions can be represented in the form of LMIs. Finally, numerical examples are given to show that the suggested strategy is feasible.Aeration system is the main energy consumer in a wastewater treatment process. In this paper, the Naive Bayes classification (NBC) algorithm and response surface method (RSM) were firstly used to establish a methodology to improve the aeration efficiency and estimate effluent quality. Lab-scale experiments were conducted to verify the model. The errors between experimental values and predicted values were 3.36, -0.67 and -3.78% at operating temperatures of 20, 30 and 35 °C, indicating the applicability. To further elucidate the biological mechanisms of the experimental results, the microbial community composition was investigated under various operating conditions, the results shows that aerobic heterotrophic bacteria (HET) activity and COD removal efficiency were promoted at 30 °C. AOB and NOB activity and NH4+-N removal efficiency were promoted at 30-35 °C. These findings together suggest that operating temperature is crucial for activated sludge treatment, which should be considered when regulating DO content or aeration rate in practical application.Concentrated leachate (CL), characterized with high content salts and compositional complexity of dissolved organic matter (DOM), is difficult to degrade. Understanding the CL from molecular insight level is the requirement for further disposal based on their components. Here, typical CL samples were collected from the multi-stage membrane separation process in a large-scale leachate plant, including nanofiltration (NF), primary ultrafiltration (PUF), secondary nanofiltration (SNF), and reverse osmosis (RO). More than 95% of DOM was removed from raw CL, of which about 3/4 flowed into PUFCL and 1/5 flowed into SNFCL. DOM with macro-molecular weight (>500 Da, 30.46%) and highly unsaturated compounds (double-bond equivalents >15) were detected in PUFCL. Nearly half of DOM was CHO-only compounds (42.04%) in SNFCL. PUFCL was abundant in heteroatom species with higher-order oxygen (O ≥ 10), which was coincident with the trend of humic substance distribution (humic substance >1/2). Based on these properties results, advanced oxidation processes, such as ozonation, might be the right process for SNFCL rich in heteroatom species with low-order oxygen (O less then 10). Abundant disulfides (S2O2-6 classes, 20.19%) and monovalent salts existed in ROCL, which should be removed from the system. These findings might provide basic information for the treatment of CLs from different membranes.The ability of extracellular polymeric substances (EPS) recovered from aerobic granular sludge (AGS) to act as bioflocculant was tested in a pilot-scale sequencing batch reactor (SBR), fed with low-strength municipal wastewater. PIK-75 EPS were compared with the addition of Na-alginate as a standardized biopolymer. The optimal dosage of both biopolymers was determined through jar-test assays (400 mg L-1 of Na-alginate in a 250 mg Ca L-1 and 50 mg L-1 of EPS in pH of 2 ± 0.2). The addition of Na-alginate (Operational Period I- OP-I) and EPS (Operational Period II - OP-II) led to increased adhesion of particles with 2.9 ± 0.45 and 1.3 ± 0.3 g TSS L-1 during OP-I and OP-II, respectively, and fast settling biomass (SVI30 between 68 and 78 mL g-1). Granule predominance occurred at early stages of OP-I (day 37) and OP-II (day 44), presenting diameters mainly within the 212-600 μm range. The reactor showed removal efficiencies of 85% for biochemical oxygen demand (BOD) and above 50% for N-NH4 during the study periods. Furthermore, the addition of EPS as a bioflocculant promoted a substantial increase in polysaccharides (PS = 153.01 ± 121 mg gVSS-1) and proteins (PN = 121.96 ± 69 mg gVSS-1), while the addition of Na-alginate affected mostly the PS content (87 ± 24 mg gVSS-1). The microbial community shifted mainly from Betaproteobacteria (45%) during OP-I to Alphaproteobacteria (64%) in OP-II. Therefore, EPS affected both physical-chemical and microbial features of the AGS biomass without any change in treatment efficiencies. EPS is a promising resource to be recovered from aerobic granular sludge and to be used as an alternative and sustainable bioflocculant.Breast cancer has been identified as one of the most common cancers diagnosed in women. Various nanotechnology platforms offering unique features are considered in breast cancer treatment. Albumin is a versatile biodegradable, biocompatible, non-toxic and non-immunogenic protein nanocarrier. These characteristics attracted strong attention to fabricate albumin nanoparticles to deliver chemotherapeutic agents without major adverse effects. Albumin nanoparticles can undergo surface modifications using different ligands promoting tumor-targeted drug delivery. Moreover, multifunctional albumin nanoparticle is an upcoming strategy to attain efficient cancer therapy. This review gives an account of the potential albumin nanoparticles developed for chemotherapeutic drug delivery and its targeted approach for breast cancer. It also covers different multifunctional therapies available using albumin nanoparticles as breast cancer theranostics.Antibiotics, being critical antimicrobial agents, have been widely used for treating bacterial infections. However, prolonged use of antibiotics can induce drug resistance resulting in "superbug" that threatens human health. Therefore, developing antibiotic-free materials with intrinsic antibacterial properties is the key to the "superbug" challenge. In this study, two highly efficient metal-organic frameworks (MOFs) were successfully assembled through synergistic use of the antibacterial properties of reactive organic radicals and silver (Ag) cations. These hybrid Ag-based materials possessed radical-doped characteristics, continuously releasing Ag+, which significantly inhibited the growth of four common Gram-negative and Gram-positive human pathogens (Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, and Staphylococcus aureus), and particularly two multi-drug-resistance bacteria (MRSA and MDR-PA). Furthermore, in vivo assays indicated that the synergistic antibacterial effect of these compounds could significantly accelerate the healing rate of infected wounds in mice. Blood biochemistry and histological analyses of main organs in treated mice also exhibited negligible cytotoxicity. This study unveiled the promising potential of Ag-MOFs for anti-infective therapies and future clinical applications.Petroleum hydrocarbon-contaminated sites have been mainly remediated through the surfactant-enhanced soil leaching method. However, the commonly used chemical surfactants have poor biocompatibility and are prone to form residues in fields. Therefore, the purpose of this research is to establish an effective system of biosurfactant remediation in the field and provide instructions for common bioremediation challenges. First, wild-type Bacillus amyloliquefaciens A3, which produced lipopeptide biosurfactant, was used to improve the production of biosurfactant by atmosphere and room temperature plasma (ARTP) mutagenesis. Second, the mutant 1-24 was selected from a total of 174 mutants due to the outstanding yield. Subsequently, 1-24 was applied in the soil column leaching experiments and removed 45.44% of petroleum hydrocarbons by changing the relevant enzyme activities. Biosurfactant addition and 1-24 inoculation effectively activated a portion of the petroleum hydrocarbons in the soil columns, and 1-24 presented potential as a desired candidate for bioremediation. This is the first report of using ARTP mutagenesis to improve the production of biosurfactants. Simultaneously, we first propose a theoretical system in which the yield of biosurfactant was increased using ARTP mutagenesis for strains and applied the mutants in situ soil bioremediation. This research indicated that the theoretical system was useful in soil columns to simulate field remediation conditions, providing practical references for the bioremediation of contaminated soil.This work pledge to extend the therapeutic windows of hybrid nanoparticulate systems by engineering mannose-decorated hybrid nanoparticles based on poly lactic-co-glycolic acid (PLGA) and vegetable oil for efficient delivery of two lipophilic anti-inflammatory therapeutics (Celecoxib-CL and Indomethacin-IMC) to macrophages. The mannose surface modification of nanoparticles is achieved via O-palmitoyl-mannose spacer during the emulsification and nanoparticles assembly process. The impact of targeting motif on the hydrodynamic features (RH, PdI), stability (ζ-potential), drug encapsulation efficiency (DEE) is thoroughly investigated. Besides, the in vitro biocompatibility (MTT, LDH) and susceptibility of mannose-decorated formulations to macrophage as well their immunomodulatory activity (ELISA) are also evaluated. The monomodal distributed mannose-decorated nanoparticles are in the range of nanometric size (RH less then 115 nm) with PdI less then 0.20 and good encapsulation efficiency (DEE = 46.15% for CL and 76.20% for IMC). The quantitative investigation of macrophage uptake shows a 2-fold increase in fluorescence (RFU) of cells treated with mannose-decorated formulations as compared to non-decorated ones (p less then 0.001) suggesting an enhanced cell uptake respectively improved macrophage targeting while the results of ELISA experiments suggest the potential immunomodulatory properties of the designed mannose-decorated hybrid formulations.
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