Notes

Crataegus aronia prevents high-fat diet-induced hepatic steatosis inside test subjects by simply activating AMPK-induced suppression involving SREBP1 along with account activation of PPARα.
The current Covid-19 pandemic makes necessary to identify people affected by SARS-CoV-2. To do this, the most reliable method is the use of the molecular test that is the gold standard to detect positive peoples.Here, we provide a comprehensive review on the diagnostic processes through molecular tests for SARS-CoV-2 infection. First, we have obtained information about the testing technologies in the Liguria region's hospitals to find and describe the most common technologies used and to calculate the molecular test's average cost. Second, we have evaluated the sensitivity, the specificity, the safety with respect to the data reported on scientific literature (Real Word Data VS Registrative Studies) and the organizational aspects of the molecular tests.Clinical Relevance- This study aims to provide support to the decision makers on clinical, economic, organizational, social and ethical issues related to the use of molecular test for SARS-CoV-2.Blood pressure (BP) is one of the most crucial vital signs of the human body that can be assessed as a critical risk factor for severe health conditions such as cardiovascular diseases (CVD) and hypertension. An accurate, continuous, and cuff-less BP monitoring technique could help clinicians improve the prevention, detection, and diagnosis of hypertension and manage related treatment plans. Notably, the complex and dynamic nature of the cardiovascular system necessitates that any BP monitoring system could benefit from an intelligent technology that can extract and analyze compelling BP features. In this study, a support vector regression (SVR) model was developed to estimate systolic blood pressure (SBP) and diastolic blood pressure (DBP) continuously. We selected a set of features commonly used in previous studies to train the proposed SVR model. A total of 120 patients with available ECG, PPG, DBP and SBP data were chosen from the Medical Information Mart for Intensive Care (MIMIC III) dataset to validate the proposed model. The results showed that the average root mean square error (RMSE) of 2.37 mmHg and 4.18 mmHg were achieved for SBP and DBP, respectively.Seizure episodes are frequently observed for adults and children suffering from medically refractory epilepsy and the events remain debilitating unless treated with a more comprehensive approach. Ictal perfusion studies with single-photon emission computed tomography (SPECT) is one of the non invasive imaging modality that has been extensively used to adequately localize the seizure focus. Current practices include the tracer injection within a short time interval at the onset of seizure to generate desirable SPECT scan quality with accurate information on foci region. However, the onset of a seizure is a highly unpredictable event and also with added subclinical events, the overall procedure makes it difficult to administer the tracer manually within the ideal time frame.Hence a complete autonomous injection of radioactive tracer element without manual intervention is expected to offer a highly accurate epileptical focus region and aids in further management of the patient. Electroencephalogram (EEG) physiols. The EEG signal based early prediction of seizure ensures adequate time for radioactive tracer element to reach the brain cells and eventually helps to accurately localize the onset region of seizure in the brain. The EEG driven automated injection system for the noninvasive Ictal SPECT method is clinically important as a pre-surgical evaluation in MRI negative or discordant cases for further surgical actions.Non-invasive means of monitoring mild cognitive impairments (MCI) is recently gaining popularity. With the advent of easy to use physiological sensors, there have been an outburst of studies from the last decade which aim at detecting a target's mental health condition. However, not many studies present the experience or insights gained from carrying out such in-situ research work, particularly when working with older adults. Such insights could not only assist researchers in related areas when designing their study but also avoid potential pitfalls. Clinical trials were conducted by our organization in collaboration with the Geriatric Educational Research Institute, Singapore (GERI) and Singapore Management University (SMU) for detecting mild cognitive impairments in a geriatric population. Digitized versions of the standard pen & paper psychological tests were used along with gaze tracking technologies for MCI detection. Details of our user study and it's outcomes are discussed as well as a generic approach of digitizing any given psychological test battery is highlighted.One of the benefits of Do-it-yourself Artificial Pancreas Systems (DIYAPS) over commercially available systems is the high degree of customization possible through various features developed by the community. This paper investigates the impact of thirteen commonly used custom features on the glycemic outcomes of users with type 1 diabetes. Significant differences were observed in the group using the Automated Microbolus, Autotune (automatic), and the Superbolus feature. As many of the features aim to improve not only glycemic outcomes but also reduce the burden of managing diabetes on the user, future studies should investigate the impact of these features on the quality of life of their users.Clinical Relevance-This paper expands the existing knowledge on the DIYAPS for people with type 1 diabetes which have been gaining popularity among the patient population in recent years.Thermography can contribute to the early diagnosis of tumors by identifying nodules that need to be analyzed. The objective of this paper was to verify possible semivariogram curves to identify the possible spatial behavior centered in the region with the nodule and capture the thermal behavioral information surroundings of this point. For this, we used the resources of R-Studio and theoretical basis in semivariogram models. As results we verified that the spatial technique indicates Gaussian behavior in both healthy and tumor areas, but the thermal averages differ from each other. Based on the cases analyzed, all tumors evaluated were thermally significantly different in relation to the healthy point, even when presenting the same model for the semivariogramClinical Relevance-Thermographic is a non-invasive technique and has been widely studied to aid in the early diagnosis of neoplasms by identifying nodules that need to be evaluated. Without this early identification, only larger (palpable) tumors would be evaluated, and thus many patients are at risk of developing metastasis before treatment begins.
Arc welding is generally considered very safe electrically. There have been electrocution cases with welders in high humidity environments. When dry, the flux coatings tend to have sufficient electrical resistance to limit the current below that required for the induction of VF (ventricular fibrillation).

We tested 4 welding electrodes for resistance in both dry and wet conditions. To estimate the cardiac current density - in a worst-case scenario - we used a 20k element finite-element bioimpedance model with 1 cm of skin and fat along with 1 cm of muscle before the heart of 5 cm dimensions. Between the heart and a metal plate we assumed 5 cm of lung and 1 cm of skin and fat.

Welding electrode flux is highly resistive when dry. However, when saturated with moisture the resistance is almost negligible as far as dangerous currents in a human. The FEM model calculated a current density of > 7 mA/cm
on the ventricular epicardium with a source of 80 V at the welding rod.

In conditions of high humidity, a supine operator, in contact with a coated welding electrode to the precordial region of the body can be fibrillated with the AC open-circuit voltage. Most reported DC fatalities were probably due to pseudo-DC outputs that were merely rectified AC without smoothing.
In conditions of high humidity, a supine operator, in contact with a coated welding electrode to the precordial region of the body can be fibrillated with the AC open-circuit voltage. Most reported DC fatalities were probably due to pseudo-DC outputs that were merely rectified AC without smoothing.Irreversible electroporation (IRE) is a non-thermal tumor ablation method where strong electrical fields between at least two electrodes are used and can be seen as an alternative to thermal ablation techniques. The therapy outcome directly dependents on the position of the electrodes. Real-time monitoring of the IRE by magnetic resonance imaging (MRI) would allow to detect unwanted electrode displacement and to apply visualization methods for the ablation area. This requires that the IRE generator does not significantly interfere with the MRI. Currently, there is no IRE generator available designed for MRI-guided IRE.This paper presents an IRE system specifically developed for use in an MRI environment. The system is initially tested with a standard IRE sequence and then the interference between a clinical 3 T MRI device and the IRE system is investigated using a noise measurement and the signal-to-noise ratio (SNR) of images acquired with a gradient echo (GRE) sequence. The results show, that although the SNR of the images decrease by maximal 36 % when the IRE system is switched on, image quality does not visibly degrade. Hence, MRI-guided IRE is feasible with the proposed system.Clinical relevance- This paper demonstrates the possibility of MRI-guided IRE with only minor image degradation when the IRE system is used in parallel with MRI imaging.Fine needle aspiration cytology requires accurate needle insertion into a tumor and sufficient amount collection of samples, which highly depends on the skill of the physician. The advantage of the diagnosis is to minimize the tissue damage with the fine needle, while, when the amount of the sample sucked from the lesion is not enough for the definite diagnosis, the procedure has to be repeated until satisfying them. Although numerous research reported a robot-assisted insertion method to improve the accuracy of needle placement with fine needles, there was less research to address the efficient tissue collection. Ideally, the amount of the samples can be satisfied for the diagnosis even if an extra-fine needle (e.g. 25-gauge) is used. This paper proposes a novel needle insertion method for increasing the amount of the tissue sample with the extra-fine needle. The proposed insertion method comprises the round-trip insertion motion and trajectory rerouting with the nature of the bevel-tipped needle. The phantom study's result showed the equivalency of the aspiration amount between a physician's manual procedure with a 22-gauge needle and the proposed method with a 25-gauge needle (4.5 ± 1.0 mg vs 5.1 ± 0.7 mg). The results suggested that the proposed robotic aspiration method can increase the sampling amount with the extra-fine needle in the fine needle aspiration cytology.The pressure and force line trajectory of the distal femoral prosthesis relative to the prosthesis gasket are key factors in judging the appropriate position of implants in unicondylar knee arthroplasty (UKA) surgeries, which is critical to the success of UKA surgeries. In this paper, we propose a portable pressure and force line trajectory measurement system, which includes a pressure sensors array, an analog-to-digital converter (ADC), and a microcontroller unit (MCU). TVB-3166 cell line Data from twenty sensors is obtained through time-sharing scanning and transmitted to the host computer through the USB interface. We put forward an algorithm to calculate pressure value and fit the force line trajectory for better accuracy. Both the pressure value and force line trajectory are calculated and displayed on the screen of the host computer by developed software in real-time. The experiments results show that the root mean square error of fitting force line trajectory in the experiments is ±0.342mm, which has 63% reduction compared with that in the previous work, and the average pressure value measurement error is 10.
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