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The specific surface area of the hybrid nanosphere is 27.06 m2·g-1 and the average pore diameter of the sample is 3.84 nm, indicating the presence of mesoporous structure in the sample. This mesoporous structure can supply potential space for adsorption of anticancer drugs. Additionally, the surface charge of the nanoparticles was positive and the entrapment efficiency was 83.32%. The hybrid nanospheres have a capability of effective pH-sensitivity controlled drug release. All the drug loaded hybrid nanospheres successfully sustained the release of MET at pH 7.4, only about 44.58% of the drug released in 6 days. While under acidic condition (pH 5.0) drug release was significantly accelerated, being over 98.85% of the drug released. The hybrid nanospheres demonstrated an excellent smart drug delivery behavior.To eliminate nitrogen oxides (NOx), composite carrier-supported catalysts (Mn-Ce/MWCNT-W) and traditional catalysts (Mn-Ce/MWCNT and W-Mn-Ce/MWCNT) were prepared using an ultrasonic impregnation method that preformed low-temperature ammonia-selective catalytic reduction (SCR) removal of NOx. The promotion effects of MWCNT-W composite carriers for low temperature SCR activities and SO2 tolerance of the catalysts were systematically investigated. Compared to traditional catalyst, Mn-Ce/MWCNT-W catalyst, with a 30% WOx/MWCNT mass ratio, demonstrated improved SCR activity and high N2-selectivity from 100°C to 200°C. A series of characterizations were carried out and it was found that there were more redox sites and the stronger the NH3 adsorption capacity over the composite carrier-supported catalysts than traditional catalysts. Also, with this composite carrier-supported catalyst, the improvement of SCR reaction was considered to be from the abundance of high valence state Mn and well dispersed active components. Notably, compared to traditional catalyst, the composite carrier-supported catalyst exhibited the stronger sulfur resistance. Thus, using MWCNT-W composite carriers to prepare Mn-Ce/MWCNT-W catalysts resulted in excellent NOx conversion and SO2 resistance at low temperatures.Implications LT NH3-SCR of NOx is an effective way to remove NOx from stationary sources. The physicochemical properties of the support not only affect a catalyst's LT SCR activity but also affect the catalyst's anti-poisoning performance. The modified carriers could promote active component dispersion, which is conducive to SCR reaction. However, for LT SCR reactions, few reports have addressed the design and preparation of composite carrier-supported catalysts. The goal of this study was to design and synthesize Mn-Ce/MWCNT-W catalysts and to observe the influence of composite support in Mn-based catalysts on LT SCR activity and sulfur resistance.The aim of this study was threefold (a) to compare the maximal lactate steady state (MLSS) with critical power (CP); (b) to describe the relationship of MLSS with rowing performances; and (c) to verify the agreement of MLSS with several exercise intensity thresholds in rowers. Fourteen male rowers (mean [SD] age = 26 [13] years; height = 1.82 [0.05] m; body mass = 81.0 [7.6] kg) performed on a rowing ergometer (I) discontinuous incremental test with 3 min stages and 30-s recovery intervals (INC3min); (II) continuous incremental test with 60-s stages (INC1min); (III) two to four constant workload tests to determine MLSS; and (IV) performance tests of 500, 1000, 2000 and 6000 m to determine CP. Twenty-seven exercise intensity thresholds based on blood lactate, heart rate and ventilatory responses were determined by incremental tests, and then compared with MLSS. CP (257 [38] W) was higher than MLSS (187 [25] W; p  5%), with a lower bias found between MLSS and the first intensity thresholds (-12.5% to 4.1%). MLSS was correlated with mean power during 500 m (r = 0.65), 1000 m (r = 0.86) and 2000 m (r = 0.78). In conclusion, MLSS intensity is substantially lower than CP and presented low agreement with 27 incremental-derived thresholds, questioning their use to estimate MLSS during rowing ergometer exercise.Highlights MLSS was substantially lower than CP in rowing exercise with a mean difference of 37%, much larger than the difference commonly found in running and cycling exercise (i.e., ?10%).A clear disagreement was reported between MLSS and 27 physiological thresholds determined in different incremental tests.There is a positive association of MLSS with 500, 1000 and 2000 m rowing ergometer performance tests.Reproductive coercion and abuse is defined as behaviour that deliberately interferes with a person's reproductive autonomy. It is typically perpetrated by men against women in a context of fear and control and includes forcing a woman to become pregnant or to terminate a pregnancy. There is a dearth of qualitative research investigating experiences of reproductive coercion and abuse, particularly for women from minority ethnic backgrounds. In this study, we address this gap through qualitative analysis of data from six focus groups with service providers in Australia. Three main themes were developed 1) exploiting structural inequalities; 2) women as reproductive property; and 3) pregnancy as a form of control. Findings confirm the complex interplay between reproductive coercion and abuse, intimate partner and sexual violence, and suggest that community attitudes towards women's role in sex and reproduction and structural risk factors may complicate this nexus even further for minority ethnic women. It is important for service providers supporting minority ethnic women - particularly in antenatal and abortion care - to be aware of reproductive coercion and abuse. Similarly, policies concerning access to financial support for minority ethnic women should acknowledge the critical role this could play in facilitating or preventing abuse.Barefoot running has been increasing in popularity, yet there is a gap in understanding concerning the biomechanics of mid-distance barefoot running, especially between genders and runners of different running-experience levels. This study examines the effects of running-experience, gender, and their interaction on running biomechanics following 5 km barefoot running. Before and after a 5 km run, three-dimensional kinematics and kinetics of the lower limb joints and plantar pressure during barefoot running were collected from 20 participants. Participants were stratified by their running-experience levels (novice and marathon-experienced) and gender. This study revealed significant gender effects on lower limb biomechanics following a 5 km barefoot run. Increased plantar pressure under the lateral aspect of the foot was observed in the female cohort, while the male cohort exhibited reduced plantar pressure under the lateral heel. This study suggests that modified lower limb running biomechanics and modified lateral foot loading after 5 km barefoot running may create a different foot loading environment for female and male runners that should be accommodated in barefoot runningand minimalist shoe design.Research has produced conflicting evidence regarding whether performance of an on-going visual task is disrupted more by an interruption from a visual or an auditory alert. Tasks and alerts studied to date have been complex or idiosyncratic. This experiment examined how the modality of simple alerts-visual icons or auditory tones-affected performance of an on-going visual task. Participants (58 females and 4 males) tracked a visual target while performing a choice reaction time task in response to alerts. Visual alerts were more harmful to performance of the tracking task. Dual task workload was lowest with an auditory alert, provided there was not noise present. Interruptions affected tracking task performance for around 1500 ms. Results supported the predictions of Multiple Resources Theory and showed no evidence of auditory preemption. In practical applications for which an on-going visual task is interrupted, auditory alerts may be less disruptive and may reduce perceived workload. Practitioner Summary Many practical scenarios involve on-going visual tasks that are interrupted by simple alerts requiring a simple response. Auditory alerts may be less disruptive than visual alerts and may reduce perceived workload. A conservative estimate is that the effects of even simple interruptions will last a minimum of 1500 ms. Abbreviations ANOVA analysis of variance; LSD least significant difference; TLX task load index.An electrochemiluminescence (ECL) aptasensor was prepared to detect Pb2+ with nitrogen-doped carbon quantum dots (NCQDs) as ECL materials. selleck chemical To prepare the working electrode, NCQDs with carboxyl groups were loaded on a glassy carbon electrode (GCE) and then Pb2+ aptamers were covalently bound to the NCQDs to form a stable GCE/NCQDs/aptamers. On addition of Pb2+, the chain aptamers change to a pb2+ G-quadruplex conformation, which lead to a large decrease in the ECL intensity. The variation of intensity and the logarithm of the Pb2+ concentration had a good linear relationship (R2 = 0.998). The detection range was wide (50 pM to 387.9 nM) with a low detection limit (18.9 pM). link2 In interference experiments, the ECL Pb2+ aptasensor did not suffer from interference and it had good stability. The NCQDs ECL aptasensor can detect Pb2+ quickly and accurately, and provides a fast and efficient method for detection of Pb2+. Compared with literatures, the Pb2+ aptasensor has simpler preparation process, lower cost; furthermore, it is more environmentally friendly.Cancer is a worldwide problem that threatens human health. Radiotherapy plays an important role in a variety of cancer treatment methods. link3 The administration of radiotherapy can alter the differentiation pathways and functions of T cells, which in turn improves the immune response of T cells. Radiotherapy can also induce up-regulation of PD-L1 expression, which means that it has great potential for enhancing the therapeutic effect of anti-PD-1/PD-L1 inhibitors and reducing the risk of drug resistance toward them. At present, the combination of radiotherapy and anti-PD-1/PD-L1 inhibitors has shown significant therapeutic effects in clinical tumor research. This review focuses on the mechanism of radiotherapy on T cells reported in recent years, as well as related research progress in the application of PD-1/PD-L1 blockers. It will provide a theoretical basis for the rational clinical application of radiotherapy combined with PD-1/PD-L1 inhibitors.Background Younger women with chronic disease ( less then 60 years of age), especially women with stereotypically "men's" heart disease (HD), are understudied. Unique difficulties may occur with HD, which is less commonly associated with women, compared with breast cancer (BC). Similarities may also exist across younger women, as chronic disease is less normative in younger people. Intersections of gender, age, and the specific disease experience require greater attention for improving women's health. This exploratory qualitative study compared younger women's experiences of HD or BC. Methods Semistructured interviews with 20 women (n = 10 per disease) were analyzed using applied thematic analysis. Results Amidst building careers, intimate relationships, and families, women felt thwarted by disease-related functional problems. Cognitive-behavioral coping strategies spurred resilience, including integrating the illness experience with self-identity. Barriers arose when medical professionals used representativeness heuristics (e.
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