Notes

Language translation of the poly(GR) body throughout C9ORF72-ALS/FTD can be governed by cis-elements associated with choice splicing.
In bears, reproduction is dependent on the body reserves accumulated during hyperphagia. The Cantabrian brown bear mainly feeds on nuts during the hyperphagia period. Understanding how landscape heterogeneity and vegetation productivity in human-dominated landscapes influence the feeding habits of bears may therefore be important for disentangling species-habitat relationships of conservation interest. We determined the spatial patterns of nut consumption by brown bears during the hyperphagia period in relation to landscape structure, characteristics of fruit-producing patches and vegetation productivity. For this purpose, we constructed foraging models based on nut consumption data (obtained by scat analysis), by combining vegetation productivity data, topographical variables and landscape metrics to identify nut foraging patterns during this critical period for bears. The average wooded area of patches where scats were collected and where the nuts that the bears had consumed were produced was larger than that of the corresponding patches where nuts were not produced. For scats collected outside of nut-producing patches, the distance between the scats and the patches was greatest for chestnut-producing patches. Elevation, Gross Primary Production (GPP) and the Aggregation Index (AI) were good predictors of acorn consumption in the models. Good model fits were not obtained for data on chestnut consumption in bears. The findings confirm that brown bears feeding on nuts show a preference for relatively large, highly aggregated patches with a high degree of diversity in the landscape pattern, which may help the bears to remain undetected. The nut prediction model highlights areas of particular importance for brown bears during hyperphagia. The human presence associated with sweet chestnut forest stands or orchards may make bears feel more vulnerable when feeding.Environmental pollution and biological invasions are key drivers of biodiversity change. However, the effects of invasion and pollution on food webs remain largely unexplored. Here, we used stable isotopes to examine the effects of common carp Cyprinus carpio and pollution on trophic dynamics in six small reservoirs. Our results revealed that the trophic niche widths of invertebrates, vertebrates, and invasive carp did not significantly differ among reservoirs with different pollution statuses. However, we found low niche conservatism among reservoirs, suggesting that while niche width may remain consistent, there is a shift in the position of the niches in isotopic space under both pollution and invasion scenarios. Niche conservatism among reservoirs was generally higher in invertebrates, but this was also regardless of reservoir condition (i.e. presence or absence of pollution and invasion). These results suggest that invasion by species coupled with organic pollution may cause subtle yet differing effects on components of a food web (basal end-members, invertebrates and vertebrates). Our findings provide a baseline measure of the potential in the development of detection and response strategies for carp invasions and organic pollution.Geographic origin is directly linked to the quality and commercial value of bivalves. The globalization of the seafood trade and the increasing number of fraudulent practices in the bivalves industry has prompted consumers to become increasingly aware on the geographic origin of the seafood they consume. To enhance consumers' confidence and allow authorities to effectively enforce regulations and contain risks that threaten public health, fast and accurate tools must be made available to confirm claims along the trade chain on the geographic origin of bivalves. In the present study the efficiency of using the elemental fingerprints of a small-homogenized subsample of the shell of common cockles (Cerastoderma edule) to confirm their harvesting location is evaluated at different spatial scales i) regional (along the Galician coast (Spain) - Espasante, Barallobre, Rio Anllóns, Camariñas, Muros, Noia, Carril, Grove, Combarro, Placeres, Moaña, and Baiona), ii) national (along the Portuguese coast - Ria de Aveiro, Óbidos lagoon, Tagus estuary, Sado estuary and Ria Formosa), and iii) international (along the Northeast Atlantic coast - Hejeltefjorden (Norway), Nykobing Mors (Denmark), Sylt (Germany), Slikken van Viane (Netherlands), Roscoff (France), Plymouth (England), Swansea (Wales), Ria de Aveiro (Portugal) and Oualidia (Morocco). Results confirm that elemental fingerprints of bivalve shells are significantly different among locations and that they can be successfully used with high accuracy to discriminate the geographic origin of cockles at all spatial scales surveyed (97.2% at regional scale, 99.3% at national scale and 100% at international scale). Overall, elemental fingerprints of a small-homogenized subsample of the shell showed to be a replicable, low cost and fast tool to reliably trace the place of origin of cockles sampled at different spatial scales, with success rate of discrimination directly increasing with distance between collection sites.At present, the improvement of nitrate and mixed heavy metals removal in wastewater by microorganism are urgently needed. Previous studies have shown that Pseudomonas hibiscicola strain L1 exhibited Ni(II) removal ability under aerobic denitrification. In this study, the characteristics of the free strain L1, peanut shell biochar (PBC) and further the co-system of strain L1 immobilized on PBC were investigated for the removal of Ni(II), Cr(VI), Cu(II) and nitrate in mix-wastewater. The results illustrated that strain L1 could remove 15.51% - 32.55% of Ni(II) (20-100 mg·L-1), and removal ratios by co-system were ranked as Ni(II) (81.17%) > Cu(II) (45.84%) > Cr(VI) (38.21%). Scanning Electron Microscope (SEM), X-ray Diffractometer (XRD) and Fourier Transform Infrared Spectroscopy (FTIR) images indicated that the strain L1 immobilized well on PBC and had vigorous biological activity; the crystals of Ni(OH)2, Cu(OH)2 and CrO(OH) etc. were formed on surface of co-system with various functional groups participated in. In Sequential Batch Reactor (SBR), the pollutant removal ratios by co-system were higher than that by free strain L1. This study illustrated that the co-system of strain L1 immobilized on PBC was qualified to be applied for practical scenarios of effective heavy metal removal of electroplating mix-wastewater.Pyrolytic biochar is a good material for remediating soils contaminated with heavy metals; however, it exhibits strong alkalinity, which easily causes soil alkalization and fertility reduction. Herein, a series of novel biochar materials (BPBCs) were prepared by combined ball milling and phosphorus (P)-loading. The optimized BPBC were fabricated in the basis of Cd and Pb adsorption capacities of the biochar, with pyrolysis at 700 °C, ball milling for 12 h and the addition of 5% red P (BPBC700). Ball milling could effectively grind pristine biochar into submicron particles and nanoscale P particles could be uniformly loaded on BPBC700. Moreover, the oxidative conversion of red P into phosphorus oxides, phosphoric acid and (hydro)phosphates was promoted due to reactions with the carbonates, alkaline minerals and O-containing functional groups of biochar. These reactions also decreased the biochar and soil pH to nearly neutral by acid-base neutralization. Pot experiments showed that BPBC700 had better effects than the pristine or ball-milled biochar in improving soil properties (e.g., cation exchange capacity and organic carbon), increasing the concentrations of soil nutrients (e.g., N and P), promoting alkaline phosphatase, catalase and urease activities, decreasing soil mobility and plant accumulation of Cd and Pb, and alleviating Cd and Pb stress on maize plants. Thus, BPBC is a promising and ecofriendly amendment to enhance its adsorption ability on Cd and Pb, soil quality and plant productivity in contaminated soil.The analysis of community structure in studies of freshwater ecology often requires the application of dimensionality reduction to process multivariate data. A high number of dimensions (number of taxa/environmental parameters × number of samples), nonlinear relationships, outliers, and high variability usually hinder the visualization and interpretation of multivariate datasets. Here, we proposed a new statistical design using Uniform Manifold Approximation and Projection (UMAP), and community partitioning using Louvain algorithms, to ordinate and classify the structure of aquatic biota in two-dimensional space. We present this approach with a demonstration of five previously published datasets for diatoms, macrophytes, chironomids (larval and subfossil), and fish. Principal Component Analysis (PCA) and Ward's clustering were also used to assess the comparability of the UMAP approach compared to traditional approaches for ordination and classification. selleck chemicals llc The ordination of sampling sites in 2-dimensional space showed a much denser, and easier to interpret, grouping using the UMAP approach in comparison to PCA. The classification of community structure using the Louvain algorithm in UMAP ordinal space showed a high classification strength for data with a high number of dimensions than the cluster patterns obtained with the use of a Ward's algorithm in PCA. Environmental gradients, presented via heat maps, were overlayed with the ordination patterns of aquatic communities, confirming that the ordinations obtained by UMAP were ecologically meaningful. This is the first study that has applied a UMAP approach with classification using Louvain algorithms on ecological datasets. We show that the performance of local and global structures, as well as the number of clusters determined by the algorithm, make this approach more powerful than traditional approaches.The chemical composition and redox conditions of the Precambrian ocean are key factors for reconstructing the temporal evolution of atmospheric oxygen through time. In particular, the isotopic composition of iron are useful proxies for reconstructing paleo-ocean environments. Yet, respective processes and related signatures are poorly constrained, hindering the reconstruction of iron redox mechanisms in the Archean ocean. This study centers on Sihailongwan Lake, a stratified water body with a euxinic lower water column considered as an Archean ocean analogue. Results show that the anaerobic oxidation layer is so different from other similar lakes in which dissolved Fe oxidation is present in redoxcline layer. And the fractionation factor between ferrous Fe and iron hydroxide observed in nature water body of Sihailongwan Lake reaches to 2.6‰, which would benefit the production of the oxidations of BIF in sediment. By the spatial distribution of Fe isotope, the benthic water in autumn and the hypolimnetic anoxic water in spring has been identified as iron sulfide zone, where iron isotopic fractionation factor during iron sulfide formation is 1.16‰, accounting for partial scavenging of dissolved Fe(II) with an associated isotopic fractionation. However, pyrite in the sediment records the iron isotopic signal from the redoxcline but not in the iron sulfide or oxide zones of the water column. Above findings indicate that neither the iron isotope fractionation during partial transfer of ferrous iron to iron sulfide nor the partial oxidation of ferrous iron are recorded as pyrite in sedimentary rock. Importantly, the signal of Fe isotopic fractionation in water was archived in the suspended particulate matter and transferred into the sediment, rather than via ferrous iron directly deposited in the sediment. This study reveals that Fe isotopes from modern natural environments are useful proxies for reconstructing iron oxidation-reduction process during Earth's early history.
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