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Our data suggest a direct embryotoxicity of NEFAs as well as impaired embryo development through a reduced oviductal ability to support and protect early embryo development.The objective of study was to compare effects of rapamycin-eluting single and double stenting on serum markers like high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), interleukin 8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) in patients with coronary bifurcation lesions. It was an experimental study carried out from April 2016 to July 2017. One hundred and twenty-six patients were divided into two equal groups according to different treatment regimens. Group A was treated with rapamycin-eluting single stenting and group B with rapamycin-eluting double stenting. Three months after operation, hs-CRP, TNF-α, IL-6, IL-8 and MCP-1 levels in group B were lower than those in group A (p=0.010, p less then 0.001, p less then 0.001, p less then 0.001 and p less then 0.001, respectively). After one year of follow-up, rate of intrasegmental restenosis of branch vessels was higher in group A than in group B (p=0.011). Compared with rapamycin-eluting single stenting, rapamycin-eluting double stenting may regulate more effectively the above serum markers levels, reduce the incidence of intrasegmental restenosis of branch vessels.Extra-anatomical cephalic to internal jugular venovenous bypass is a surgical method of improving the patency of arteriovenous access in patients with central venous stenosis (CVS), which is infrequently performed. It can be more durable compared to percutaneous venoplasty for CVS. We present a 60-year male who developed right subclavian vein stenosis after brachiocephalic arteriovenous fistula. He had two sessions of venoplasty, but had recurrence. Later, his CVS lesion was not amenable to venoplasty. He underwent cephalic to internal jugular venovenous bypass with externally supported polytetrafluoroethylene (PTFE) graft. This provided immediate symptomatic relief and also salvaged his fistula, which was patent at his last follow-up visit at six months. this website Venovenous bypass can be considered earlier in 'selected' patients to deal CVS not amenable to percutaneous interventions.Thrombosis or thrombophlebitis of the superficial dorsal vein of the penis is called penile Mondor's disease. Although many factors are suggested as the etiology, but it has not been clarified yet. Hypersensitivity reactions may predispose to this complication in some patients; and it results from the formation of antigen-antibody immune complexes in the circulation as a consequence of the penetration of antigenic debris into the circulation due to pruritus-related excoriations caused by parasitic infestations like scabies. Herein, we present a case of isolated superficial dorsal penile vein thrombosis developing due to scabies infestation without any additional thrombogenic factors. Conservative approach and medical treatment were sufficient in the successful treatment of scabietic penile Mondor's disease.Depending on which part of the physiological pathway is affected by the pathology, jaundice is classified into three categories pre-hepatic/hemolytic, hepatic/hepatocellular, and post-hepatic/cholestatic. With routine laboratory tests, most cases of jaundice can be etiologically diagnosed. However, exceptions do occur. Here, we present a case of a 14-year girl who presented with intermittent jaundice for one year that could not be diagnosed with a routine protocol. Her laboratory tests showed a moderate impairment of liver function and a positive osmotic fragility test. Computed tomography scan of her upper abdomen revealed multiple gallbladder stones and splenomegaly. With the help of liver pathological examination and exome sequencing, this patient was finally diagnosed as hereditary spherocytosis combined with Gilbert syndrome.Obturator hernia is a rare abdominal wall hernia and is one of the rare causes of intestinal obstruction. Due to lack of specific clinical symptoms in the early stage, and the deep position of hernia absence of surface swelling, few cases are diagnosed definitively before surgery. Therefore, obturator hernia is still a serious disease in clinical practice, with high mortality and morbidity. Herein, we report an 85-year female who was hospitalised with bowel obstruction. Preoperative computed tomography scan was performed, which revealed an incarcerated obturator hernia preoperatively; and it was treated successfully. This report reviews the diagnosis and treatment of obturator hernia by describing its anatomy, clinical manifestations and clinical signs. Increased awareness and proper management of the disease will lead to a decline in mortality and morbidity.Patients undergoing surgical resection and ionizing radiations for the treatment of head and cancer may lead a challenging life even after the cure of the disease; because these procedures can adversely affect the oral mucosa, salivary gland, bone, masticatory musculature, and the dentition. Especially, if major salivary glands are exposed to high dose radiation, an irreversible xerostomia may occur that can lead to rampant dental caries. Treatment of these complications demands high cost and time; and is often unaffordable for the patients in the resource constraint setting rendering them to compromise on their quality of life. The healthcare providers should work together in a team to prevent or manage these complications and improve the lives of the patients. This review paper focuses on the significance of low cost fluoride treatment for salvaging the dentition among patients who have had developed head and neck carcinoma and later got subjected to surgical resection and radiation therapy.OBJECTIVE To study the effects of age and duration of symptoms on the outcomes of scrotal explorations for acute scrotal pain at our institution. STUDY DESIGN Case series. PLACE AND DURATION OF STUDY Bradford Teaching Hospital NHS Trust, from January 2006 to December 2017. METHODOLOGY Retrospective data was collected from electronic case records of the patients who required scrotal exploration for suspected torsion of the testis. Group difference between continuous variables (age and duration of symptoms) were assessed by Kruskal Wallis and independent samples Mann-Whitney U-tests. The Fisher Exact and Chisquare tests were used to analyse relationships between categorical data. RESULTS In total, 502 patients required scrotal exploration. The median age (years) and duration of symptoms (hours) were 16.4 years (1.3 - 77) and 4 hours (1 - 336), respectively. Torsion of the testis was found in 231 (46%), torsion of the testicular appendix in 126 (25%), epididymal inflammation in 46 (9.2%), and no cause identified in 99 (19.
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