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Effect of Vincristine, Scientifically Utilized in Cancers Treatments and Resistant Thrombocytopenia, on the Purpose of Human Platelets.
Together, results underscored appearance-relevant content in online peer interactions as influences on body image and emotional status and provided psychometric support for a brief self-report measure of these factors. Research has demonstrated that mothers transmit body-related attitudes and eating behaviors to their daughters, but little is known about the role of self-compassion-treating oneself with kindness and being mindful about one's experiences-in this transmission. This research examined the intrapersonal and interpersonal associations between mothers' and daughters' self-compassion, body esteem (i.e., positive self-evaluations about one's appearance), and emotional eating (i.e., the tendency to eat in response to negative affect). Dyads (N = 191) of Canadian mothers (mean age 57.37) and daughters (mean age 28.76) completed self-report questionnaires. Dyadic, structural equation modeling and bootstrapping analyses were conducted to examine relationships among the study variables. Controlling for mothers' and daughters' body mass index, self-compassionate mothers and daughters reported higher body esteem. Additionally, daughters of self-compassionate mothers were more self-compassionate and had higher body esteem, which in turn predicted lower emotional eating. Adding to the literature on the intergenerational transmission of eating-related attitudes and behaviors, results suggest a relation between mother and daughter self-compassion, body esteem, and eating behaviors. Results also showed that attitudes toward oneself were related to eating behaviors. Mothers' self-compassion might provide a model for daughters, which in turn is associated with daughters' improved body esteem and eating behaviors. Social media content can negatively influence body esteem in young women by reinforcing beliefs that to be considered attractive, people must look a certain way. The current study examines how text associated with attractive social media images impacts on female users' mood and feelings about their own body. Female participants (N = 109) aged between 18 and 25 years were randomly allocated to one of three conditions in which they viewed the same fitspiration-style images from Instagram. However, the captions associated with each image were experimentally manipulated to reflect either a fitspiration, body positive, or neutral theme. Images associated with fitspiration captions encouraging observers to improve their personal fitness led to increased negative mood. When body-positive captions encouraging the self-acceptance of appearance or highlighting the unrealistic nature of social media content were viewed with the same images, no increase in negative affect was observed, and participants reported greater body esteem post exposure. The findings provide partial support for the idea that body positive comments accompanying images on Instagram may have some protective value for female body esteem. Captions may play an important part in observers' reactions to social media images, beyond the influence of the images alone. OBJECTIVE Phrenic nerve conduction study is a marker of hypoventilation in amyotrophic lateral sclerosis. We aimed to evaluate its intra-rater reliability in healthy subjects and in a cohort of Primary Lateral Sclerosis (PLS) patients. METHODS Eighteen healthy subjects and 16 PLS patients were included. All subjects underwent three phrenic nerve conduction evaluations (time interval 1 week for healthy controls; 1 year for PLS patients). We analyzed intra-rater reliability for five parameters of the diaphragmatic motor response latency; negative-peak duration, area and amplitude; peak-to-peak amplitude. RESULTS Healthy subjects showed excellent inter-test reliability for most parameters (coefficients of variation 0.9] and good for negative-peak amplitude and area (ICC 0.75 ≥ 0.9); duration was not reliable (ICC = 0.383). Negative peak and peak-to-peak amplitude had the least random error (respectively ±0.136 mV and ± 0.177 mV). All parameters showed homoscedasticity (R2 less then 0.1). CONCLUSIONS Intra-rater reliability is high for phrenic nerve study, especially for latency, peak-to-peak and negative-peak amplitude. SIGNIFICANCE Phrenic nerve conduction study is a reliable method to monitor respiratory function. OBJECTIVE Writer's cramp (WC) is a focal task-specific dystonia characterized by abnormal posturing of the hand muscles during handwriting, but not during other tasks that involve the same set of muscles and objects such as sharpening a pencil. Our objective was to investigate the pathophysiology underlying the task specificity of this disorder using EEG. We hypothesized that premotor-parietal connectivity will be lower in WC patients specifically during handwriting and motor imagery of handwriting. METHODS We recruited 15 WC patients and 15 healthy controls. EEG was recorded while participants performed 4 tasks - writing with a pencil, sharpening a pencil, imagining writing and imagining sharpening. We determined the connectivity changes between relevant brain regions during these tasks. RESULTS We found reduced interhemispheric alpha coherence in the sensorimotor areas in WC patients exclusively during handwriting. WC patients also showed less reduction of task-related beta spectral power and a trend for reduced premotor-parietal coherence during motor tasks. CONCLUSION We could not confirm an abnormality in premotor-parietal connectivity specific to handwriting by this method. However, there was a task-specific reduction in interhemispheric alpha connectivity in WC patients, whose behavioral correlate remains unknown. SIGNIFICANCE Interhemispheric alpha connectivity can be a potential interventional target in WC. V.OBJECTIVE Recent findings suggested that subclinical epileptiform activity is prevalent during sleep in a significant proportion of Alzheimer's Disease (AD) patients. THE AIMS OF OUR STUDY WERE (A) comparing the frequency of subclinical epileptiform activity during the sleep in a sample diagnosed with 'probable' AD and Mild Cognitive Impairment (MCI) due to AD, and in healthy subjects; (B) evaluating epileptiform EEG activity as a function of different sleep stages within a well-controlled polysomnographic setting. METHODS We prospectively enrolled 50 'probable' AD patients (73 ± 7.0 years) and 50 subjects with MCI due to AD (72 ± 6.7 years) without history of seizures, comparing them with 50 controls (69 ± 6.7 years). Patients underwent to a full-night video-PSG. RESULTS Subclinical epileptiform activity was detected in 6.38% of 'probable' AD patients, 11.63% of MCI due to AD subjects and 4.54% of controls (p = 0.43). The comparisons between the three groups for the frequency of epileptiform activity did not reach statistically significant differences neither for total sleep nor for any sleep period considered. CONCLUSIONS Our study shows that, when controlling for sleep stages and the influence of psychoactive drugs, AD patients and MCI due to AD subjects do not exhibit a higher frequency of epileptiform discharges during sleep compared to healthy subjects. SIGNIFICANCE Subclinical epileptiform activity during sleep does not discriminate 'probable' AD from MCI due to AD and healthy controls. OBJECTIVE Recruitment of interneuronal circuits generating later indirect (I) waves seem to be important in short-interval intracortical inhibition (SICI) and facilitation (SICF) development. This study assessed whether individual variations in intracortical inhibition and facilitation could be explained by variation in recruitment of interneuronal networks. METHODS Cortical excitability was assessed using a figure of eight coil, with motor evoked responses recorded over the contralateral abductor pollicis brevis (APB) muscle. I-wave recruitment was inferred from the measurement of motor evoked potential (MEP) onset latencies, with coil positioned in posterior-to-anterior (early I waves) and anterior-to-posterior (later I waves) directions. RESULTS Subtle variability in the recruitment of later I-waves (I3) was evident across subjects. Importantly, mean SICI (P less then 0.05) was significantly greater in subjects recruiting I3 waves, as were the two SICI peaks at interstimulus intervals of 1 ms (P less then 0.05) and 3 ms (P less then 0.05). In addition, mean SICF was significantly greater in participants exhibiting an AP-to-LM latency differences of less then 4 ms (P less then 0.01). There was no significant correlation between I-wave recruitment and intracortical facilitation, motor evoked potential amplitude or cortical silent period duration. CONCLUSIONS Differential recruitment of interneuronal networks appears to underlie the generation and individual variations in intracortical inhibition and facilitation. SIGNIFICANCE Investigating cortical interneuronal networks in human diseases may yield novel pathophysiological insights. Real-time detection of nitroaromatic explosives is a pressing problem for public security and environmental monitoring. Although many efforts have been devoted, sensing of explosives still suffers limitations of complicated and time-consuming sensing procedure. In this work, we develop a fluorescent film for rapid and visual detection of 2,4,6-trinitrophenol (TNP) by using polyethyleneimine-capped quantum dots (QDs-PEI) as fluorescent sensing probe and electrospun membrane as matrix. Fluorescent sensing is mainly based on effective reaction between amino groups of PEI and nitro groups, phenol hydroxyl groups of TNP. It also benefits from the rapid absorption of TNP in aqueous solution by PA6 nanofiber membranes with high hydrophilicity and porosity. As a result, visual sensing could be realized when TNP is >100 ng·mL-1 by obvious fluorescent change with a thirty-second response time. We believe this fluorescent membrane sensor holds a promising prospect for real time and visual detection of TNP in environmental science and analytical fields. Dye-sensitized solar cells (DSSCs) have attracted great interest due to their simple fabrication process and low cost. However, most organic dyes with D-π-A configuration usually exhibit narrow absorption band, leading to poor light harvesting ability and great loss on photon conversion efficiency. find more In this research, a series of excellent light-absorbing dyes (CC202-I - CC202-III) with different N-substituents at phenothiazine entities based on the champion dye CC202 were designed and investigated by density functional theory (DFT) and time-dependent DFT (TD- DFT). According to the analysis of absorption property, the results demonstrated that different N-substituents (12-crown-4-substituted phenyl, 4-hexoxyphenyl, and bare phenyl) at phenothiazine entities lead to stronger and broader absorption band as well as red-shifted spectra; moreover, larger electronic injection driving force (ΔGinject), regeneration driving force (ΔGreg), capability of light harvested (ηLHE(λstrong)/η-LHEλ) and maximal photon generated current (Jph) in CC202-I - CC202-III are observed compared to that of CC202, which further increase JSC. Additionally, a larger VOC can be obtained in CC202-I - CC202-III due to larger dipole moment (unormal) and slow electron recombination rate. Considering the all calculated characteristics related to JSC and VOC, dyes with 12-crown-4-substituted phenyl, 4-hexoxyphenyl, and bare phenyl substituent on phenothiazine can effectively enhance the photoelectric conversion efficiency of DSSCs. V.
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