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.4) compared with those with no rating (791.08±24.4, P<.001), in females (806.7±22.0) and geldings (812.2±22.4) compared with entires (792.7±26.2; P=.02) and in older horses (<2-year-old-763.7±24.8 vs 2- to 5-year-old-802.7±23.4, and 6- to 12-year-old-817.8±20.0; P=.002).
Data were cross-sectional.
Densification of the proximal sesamoid bones is associated with the commencement of racing in younger horses and the presence of bone fatigue-related pathology. Lower sesamoid BVTV was associated with longevity and better performance.
Densification of the proximal sesamoid bones is associated with the commencement of racing in younger horses and the presence of bone fatigue-related pathology. Lower sesamoid BVTV was associated with longevity and better performance.The aim of this study was to analyse the effect of pirfenidone against ischaemia-reperfusion injury occurring after detorsion in rats with induced testicular torsion model. Group 1 was assigned as the control group. Group 2 first had testis torsion performed, and then, testicular detorsion was performed. Group 3 had similar procedures to the rats in Group 2. Rats in Group 3 additionally had 325 mg/kg pirfenidone administered immediately after ischaemia. The blood samples were analysed spectrophotometrically. To determine the intensity of tissue injury, haemorrhage, oedema and congestion levels were evaluated with direct microscopic investigation of testis. Seminiferous tubule architecture, spermatogenesis processes and germ cell maturation were graded by Johnsen and Cosentino scoring systems. In Group 3, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities increased compared with Group 2 (p.03 and p.049 respectively). Additionally, the mean malondialdehyde (MDA) value was higher in Group 2 compared with the other groups (p.001). Histopathological investigation of rats in Group 3 identified positive changes in haemorrhage, oedema and congestion levels compared with Group 2 (p.031, p.048, p.044 respectively). Similarly, Johnsen and Cosentino scores were positively affected in Group 3 (p.033, p.032 respectively). Pirfenidone is protective against testicular oxidative damage.
To better characterise signalment, biologic behaviour, and treatment outcome in melanocytic tumours of the nasal planum in cats.
Retrospective study in cats diagnosed with histopathologically confirmed melanocytic tumours on the nasal planum.
Ten cats were identified with melanocytic tumours of the nasal planum. Pigmentation of the nasal planum seemed to be a predisposing factor. Seven cats were diagnosed histopathologically with a malignant melanoma, three with a benign melanocytoma. One of the cats developed a lymph node metastasis despite diagnosis of a well-differentiated melanocytic neoplasia. In four cases, a pigmented mass, which was initially stable over a long time, showed a sudden rapid progression suggesting malignant transformation. Treatments included hypofractionated radiation therapy (n=6) and surgical resection (n=1). In three cats no further treatment was pursued. Complete (n=3) and partial (n=3) remissions were observed in cats treated with radiation therapy; however, all experienced tumour progression or recurrence after a short period of time. Most of the cats (n=7) had to be euthanased due to tumour progression (median survival time 265 days).
The present case series provides insights in clinical presentation and clinical outcomes of cats with melanocytic tumours of the nasal planum.
The present case series provides insights in clinical presentation and clinical outcomes of cats with melanocytic tumours of the nasal planum.Spin waves are studied for data storage, communication, and logic circuits in the field of spintronics based on their potential to substitute electrons. The recent discovery of magnetism in 2D systems such as monolayer CrI3 and Cr2 Ge2 Te6 has led to a renewed interest in such applications of magnetism in the 2D limit. Here, direct evidence of standing spin waves is presented along with the uniform precessional resonance modes in the van der Waals magnetic material, CrCl3 . This is the first direct observation of standing spin-wave modes, set up along a thickness of 20 mm, in a van der Waals material. GM6001 nmr Standing spin waves are detected in the vicinity of both branches, optical and acoustic, of the antiferromagnetic resonance. Magnon-magnon coupling and softening of resonance modes with temperature enable extraction of interlayer exchange field as a function of temperature.This article combines the principal component analysis (PCA) with persistent homology for applications in biomolecular data analysis. We extend the technique of persistent homology to localized weighted persistent homology to fit the properties of molecules. We introduce this novel PCA in the study of the folding process of residues 1 to 28 of amyloid beta peptide in solution. We are able to determine seven metastable states of amyloid beta 1 to 28 using homology of dimension 2, corresponding to seven local minimums in the free energy landscape. We also give the transition information between the seven types and the disconnectivity graph. Our result is very robust under change of parameters. Furthermore persistent homology of dimension 1 also give consistent results. This method can be applied to different peptides and molecules.Dolichandrone serrulata flower (DSF) has been believed to reduce blood glucose in hyperglycaemic persons with sub-fertility but its effect on improvement of male reproductive impairment has never been elucidated scientifically. This study attempted to investigate the hypoglycaemic effects of DSF on male reproductive damages in type 2 diabetes mellitus (T2DM) rats. Adult Sprague Dawley rats were divided into four groups (control, T2DM, DSF200 + T2DM and DSF600 + T2DM; n = 10/each). Control rats received low-fat diet for 14 days before saline injection while streptozocin (50 mg/kg BW) induced T2DM groups received high-fat diet and were orally administered with DSF (200 and 600 mg/kg BW) for 28 days. At the end, fasted blood glucose (FBG), malondialdehyde (MDA), testosterone, sperm quality, histology and protein expressions were examined. The result showed that DSF decreased high FBG and testicular MDA and increased testosterone levels of T2DM-treated rats. Low-sperm quality and histological malfunction were ameliorated in DSF-treated group.
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