Notes

The results associated with polymorphisms inside CYP2C19, ATP-binding cassette transporter B2, as well as paraoxonase-1 upon clopidogrel treatments for Uygur sufferers pursuing percutaneous heart involvement.
Given the longstanding inequities clarified by the pandemic, the time has come for nursing informatics to adopt the goals of social justice and equity as its primary focus. Social justice informatics (SJI) is an emerging field that leverages the power of data, information, and technology in pursuit of advancing equity through collaboration with diverse communities. We propose that an SJI orientation should be adopted to change the paradigms of power by placing communities at the center of the work and ensuring future informatics work is free from unintended consequences. However, to support this, legacy practices and policies will need to be replaced, which is discussed using the exemplar of academic systems. While this process will not be easy, it is hoped that by committing to and refining the vision presented here we will create a society that more accurately reflects our shared values of equity and prosperity.
It is predicted that approximately two billion tourist trips to foreign countries will be taken worldwide each year by 2030. Germany has long been among the most active countries in tourism. The frequency of illness among persons returning from developing and newly industrialized countries is 43-79%. The appropriate diagnosis of fever in returning travelers is a clinically important matter, as it can be a sign of a life-threatening illness.

This review is based on publications (2001-2022) retrieved by a selective search in PubMed for studies on the epidemiology, diagnosis, and treatment of febrile illnesses in returning travelers, or on specific tropical diseases.

Diarrhea, fever, and skin changes are the most common manifestations of disease after travel to tropical and sub - tropical areas. The diagnostic evaluation should be performed in a series of steps, beginning with a precise travel history and the identification of specific risk factors. Among travelers returning from sub-Saharan Africa, Plasmois can be narrowed by thorough history-taking with particular attention to the patient's travel route, combined with a good knowledge of the geographic spread and incubation times of the main tropical diseases. Algorithms help clinicians to focus the diagnostic work-up and select the appropriate further laboratory tests and diagnostic procedures.
Pre-exposure prophylaxis (PrEP) became available through the Australian Pharmaceutical Benefits Scheme (PBS) on 1 April 2018 for HIV infection prevention in patients ≥18years at medium-to-high HIV risk. The aims were to investigate PrEP utilisation in general practice since PBS listing, and factors associated with discontinuation.

This longitudinal study included patients aged 18-74years attending general practices participating in MedicineInsight, a large-scale national primary care database of deidentified electronic health records, between October 2017 and September 2019.

PrEP utilisation increased 10-fold following PBS listing. On average, patients had 9.7 PrEP prescriptions per year; a medication possession ratio of 80.8%. Of 1552 patients prescribed PrEP from April 2018, most were male (98.3%), aged 18-39years (59.3%), resided in major cities (86.7%) and in the two most socioeconomically advantaged quintiles (70.0%). Almost half (49.1%) of the patients were identified as new to PrEP. At study end, 65.1% were on active PrEP (16.5%, of whom had non-continuous use), 19.2% had discontinued PrEP and 15.7% were lost to follow up. Patients who discontinued were more likely to attend low rather than high PrEP caseload practices (adjusted odds ratio [aOR] 1.7; 95% CI 1.0-2.8; P=0.047). The odds of non-continuous therapy was 2.9-fold higher in patients with bipolar disorder (aOR 2.89; 95% CI 1.10-7.6; P=0.045).

Following PBS listing, PrEP utilisation increased and stopping therapy was associated with attending low caseload practices. General practice education, particularly among low caseload practices, could help address these disparities.
Following PBS listing, PrEP utilisation increased and stopping therapy was associated with attending low caseload practices. General practice education, particularly among low caseload practices, could help address these disparities.
Relationships between primary care providers (PCP) and trans patients remain important, necessitating discussions about gender identity, health and their intersections.

Using an online survey, we explored socio-demographic and psycho-social factors associated with (1) disclosing gender identity; (2) discussing gender identity-related health issues; and (3) comfort sharing gender identity with PCPs, among trans people (n=112) over 16years of age, sampled in Waterloo, Ontario, Canada. Bivariate and multivariate methods using modified Poisson regression generated effect estimates.

Age, birth presumed gender, employment status, family support, and transphobia were significantly associated with disclosing gender identity, discussing gender identity-related health issues, and comfortability sharing gender identity with PCPs.

Increasing PCPs' knowledge of trans-related health issues is stressed to improve access and quality for trans patients.
Increasing PCPs' knowledge of trans-related health issues is stressed to improve access and quality for trans patients.
Hypersexual behaviours could reflect psychopathology, in part, because they impair interactions with intimate partners.

Hypersexual concerns were measured as (1) concern about inability to control one's own sexual behaviours; and (2) sexual films viewed. The outcome, sexual arousal, was measured using two indicators (1) self-reported sexual arousal (before/after); and (2) skin conductance response from the person stimulated (continuously). Two-hundred and fifty participants completed Orgasmic Meditation (OM), a coupled, structured, 15-min manual-genital stroking.

Reported difficulty controlling their own sexual behaviours was not related to sexual arousal reports. Participants who viewed more sexual films reported more sexual arousal before starting OM than participants who viewed less sexual films. Strokers who viewed more sexual films were associated with a higher skin conductance response in the stroked partner.

Despite statistical power and pre-registration, hypersexual concerns did not predict sexual responses with a partner. Sex film viewing may increase sexual responsiveness in individuals and their partners.
Despite statistical power and pre-registration, hypersexual concerns did not predict sexual responses with a partner. Sex film viewing may increase sexual responsiveness in individuals and their partners.
Persons with multiple sclerosis (PwMS) are at increased risk for cognitive dysfunction. Considering the impact and potential ramifications of cognitive dysfunction, it is important that cognition is routinely assessed in PwMS. Thus, it is also important to identify a screener that is accurate and sensitive to MS-related cognitive difficulties, which can inform decisions for more resource-intensive neuropsychological testing. However, research focused on available self-report screeners has been mixed, such as with the Multiple Sclerosis Neuropsychological Screening Questionnaire (MSNQ). This study aims to clarify the relationship between subjective and objective assessment of cognitive functioning in MS by examining domain-specific performance and intraindividual variability (IIV).

87 PwMS (F = 65, M = 22) completed a comprehensive neuropsychological battery which included self- and informant-report measures of neurocognitive functioning. Scores were examined in relation to mean performance on five domains work should further examine the impact of mood disturbance with cognitive performance and IIV.
Obsessive-compulsive symptoms (OCS) are commonly associated with clozapine treatment but are frequently overlooked by clinicians despite their potential impact on patients' quality of life. Metabolism inhibitor In this study, we explored whether OCS severity impacted subjective wellbeing and general functioning, independently of depressive and psychotic symptoms.

We used anonymised electronic healthcare records from a large cohort of patients who were treated with clozapine and assessed annually for OCS, wellbeing, general functioning, and psychopathology using standardised scales as part of routine clinical practice. We used statistical mixed linear model techniques to evaluate the longitudinal influence of OCS severity on wellbeing and general functioning.

A total of 184 patients were included, with 527 face-to-face assessments and 64.7% evaluated three or more times. Different linear mixed models demonstrated that OCS in patients treated with clozapine were associated with significantly worse wellbeing scores, independently of depression and psychotic symptoms, but OCS did not impair general functioning. Obsessional thinking and hoarding behaviour, but not compulsions, were significantly associated with the impact on wellbeing, which may be attributable to the ego-syntonic nature of the compulsions.

Given the frequent occurrence of OCS and their negative impact on wellbeing, we encourage clinicians to routinely assess and treat OCS in patients who are taking clozapine.
Given the frequent occurrence of OCS and their negative impact on wellbeing, we encourage clinicians to routinely assess and treat OCS in patients who are taking clozapine.
To investigate the spiritual care needs and associated influencing factors among elderly inpatients with stroke, and to examine the correlations among spiritual care needs, spiritual well-being, self-perceived burden, self-transcendence, and social support.

A cross-sectional quantitative design was implemented, and the STROBE Checklist was used as the foundation of the study. A convenience sample of 458 elderly inpatients with stroke was selected from three hospitals in China. The sociodemographic characteristics questionnaire, the Nurse Spiritual Therapeutics Scale, the Functional Assessment of Chronic Illness Therapy-Spiritual Well-being, the Self-Perceived Burden Scale, the Chinese Self-Transcendence Scale, and the Perceived Social Support Scale were used. Descriptive statistics, correlation, Student's
-test, ANOVA, non-parametric, and multiple linear regression analyses were used to analyze the data.

The total score of spiritual care needs was 29.82 ± 7.65. Spiritual care needs were positively corte. It is suggested that nurses should enhance spiritual care knowledge and competence, take targeted spiritual care measures according to inpatients' individual personality traits or characteristics and differences of patients, reduce their self-perceived burden and improve their spiritual well-being, self-transcendence and social support in multiple ways and levels, so as to meet their spiritual care needs to the greatest extent and enhance their spiritual comfort.
Deficits in cognitive functions are observed in various diseases. The term "nootropics" refers to the compounds that increase mental functions including memory, motivation, concentration and attention. Given the complexity and vastness of the processes involved in cognition, developing an appropriate animal model for the screening of nootropic agents still remains a daunting task.

This review attempts to elicit the current trends in the animal models being used for screening of nootropic agents and to effectively use this knowledge in improving prospects embarking this area of research.

Electronic searches were carried out on PubMed using the keywords "nootropic agents"[MeSH Term] OR "nootropic drugs" [MeSH Term] AND "animal model"[MeSH Term] OR "animal model, experimental"[MeSH Term]. All relevant studies from 2016 to 31st August 2021 were then reviewed to meet the stated objective.

The most commonly used disease model for screening of nootropic agents was found to be the animal model of Alzheimer's disease.
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