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Efficiency and safety associated with electroacupuncture along with Suanzaoren decoction pertaining to sleep loss subsequent cerebrovascular accident: review protocol for any randomized manipulated tryout.
Objectives Opioid analgesics have been used for a long time in the treatment of acute and chronic pain. However, they have many side effects including tolerance development to a significant extent. Agomelatine, an atypical antidepressant, has been demonstrated to be effective in experimental studies on pain. However, the effect of agomelatine on morphine tolerance development and its mechanism of action are unknown. The antinociceptive effects of agomelatine, morphine and their combination were assessed in a mice model for painful diabetic neuropathy. The roles of glutamate ionotropic receptor N-methyl-D-aspartate (NMDA) type subunit-1 (GluN1) in raphe nucleus and periaqueductal gray (PAG) in the effect of agomelatine on neuropathic pain were also investigated in diabetic mice.Methods Agomelatine (10 mg/kg), morphine (10 mg/kg) and agomelatine + morphine were administered intraperitoneally for 15 consecutive days (twice per day), and the analgesic responses were assessed at days 1, 3, 6, 9, 12 and 15 in healtPeriaqueductal grey; PKCγ Protein kinase C gamma; RT-PCR Real time polymerase chain reaction; STZ Streptozotocin.The relationship between abusive supervision and newcomers' turnover intention was explored from the perspective of perceived workplace ostracism. Findings from three-wave data (n = 300) showed that (1) abusive supervision was positively associated with newcomers' perceived coworker ostracism, perceived supervisor ostracism, and turnover intention; (2) rather than perceived coworker ostracism, perceived supervisor ostracism was positively associated with newcomers' turnover intention; and (3) the relationship between abusive supervision and newcomers' turnover intention was mediated by perceived supervisor ostracism but not by perceived coworker ostracism. Thus, the hypotheses were partially confirmed. Results underscore the importance of perceived supervisor ostracism in accounting for the relationship between abusive supervision and newcomers' turnover intention. Implications and directions for future research are also discussed.Fluorescent-activated cell sorting (FACS) remains a powerful tool to enrich for blood-derived progenitor cells for the establishment of highly-proliferative endothelial colony forming cells (ECFC). Further investigation remains necessary to determine whether the retention of progenitor cell phenotypes after expansion can identify ECFC with enhanced proangiogenic and regenerative functions. This study employed FACS purification to segregate umbilical cord blood derived (UCB) ECFC using conserved pro-vascular progenitor cell markers CD34 or aldehyde dehydrogenase (ALDH) activity. ECFC FACS-purified for high versus low ALDH-activity formed single cell-derived colonies and demonstrated tubule formation in Matrigel at comparable rates. Surprisingly, FACS purification of ECFC for CD34 enriched for cells with enhanced colony forming capabilities and tubule formation within the CD34- population. CD34 expression was enriched on early ECFC populations, however steady-state expression of CD34 rapidly declined and stabiled to CD34- counterparts. The knowledge will support future studies aiming to identify ECFC subsets with enhanced vessel forming functions for applications of regenerative medicine.Introduction The role of nutritional factors in MS etiology is a matter of debate. Employing dietary antioxidant index (DAI) as well as index of nutritional quality (INQ) we aimed to investigate the possible link between diet and MS risk.Methods This was a large population-based case-control study recruiting 547 incident cases and 1057 population controls between August 2013 and February 2015. DAI and INQ were calculated based on the adolescence dietary intake of the participants. Logistic regression was employed for estimating adjusted odds ratios (OR) and their 95% confidence interval in 2018.Results Participants with less than median DAI values had two-fold increased risk of MS onset (adjusted OR 2.05, 95% CI 1.64-2.58, P  less then  0.001). A significant dose-response pattern for DAI (adjusted OR 1.35, 95% CI 1.18-1.55, P for trend less then 0.001) was also detected. In the case of INQ, the strongest decreased risk were detected for vitamin D (OR = 0.09) and Zinc (OR = 0.34), followed by vitamin A (OR = 0.49), Calcium (OR = 0.49) and vitamin B6 (OR = 0.51) (All P-values  less then  0.05).Conclusion Considering the inherent limitation of case-control designs, an appropriate intake of nutrient antioxidants may have a role in decreasing the likelihood of MS risk. Moreover, those with healthier diet assessed by index of nutritional quality were at decreased risk for MS.Objectives To characterize the inclusion of cognition in definitions of successful aging (SA) according to empirical studies published in peer-reviewed journals.Methods A systematic review across ISI Web of Knowledge.Results Of the 74 included studies, there were 65 studies (87.8%) analyzing cognition as one component of multicomponent SA model (cognitive component studies), and 9 studies (12.2%) focusing solely on successful cognitive aging (SCA studies). Most of the studies operationalized cognition in SA by defining SA group and analyzing single SA indicators. A minority of the studies calculated the SA index. Finally, emergent techniques to operationalize SA as a latent variable and emergent field of cognition in SA in pathology were identified.Conclusions The results highlight that cognition is being included in SA using different levels of complexity. Even though research investigating SA in pathology is emerging, there is currently a lack of utilization of the concept in pathological and at-risk populations.Clinical implications The current research of cognition in SA provides several valid options to evaluate if a person is aging successfully. The emerging research indicates that people from at-risk and pathological populations can age successfully.Little research has examined factors that might weaken or strengthen commitment effects on relationship outcomes. The current research integrates attitude strength and investment model perspectives to identify uncertainty as a new moderator of commitment's predictive ability. Consistent with an attitude strength perspective, having doubt associated with commitment undermines commitment's predictive power. However, uncertainty can motivate uncertainty reduction achieved by acting in line with commitment. Therefore, uncertainty amplifies commitment effects on relationship maintenance, but only when behaviors are perceived to have implications for uncertainty. Across studies, certainty was found to moderate the link between commitment and relationship outcomes. Whether uncertainty weakened or strengthened commitment's predictive power depends on an individual's focus (implication-focused or not) when making relationship judgments.Traditional sets can be fatiguing, but redistributing rest periods to be shorter and more frequent may help maintain peak vertical barbell displacement (DISP) and reduce concentric repetition duration (CRDI), peak velocity decline (PVD) and perceptual exertion (RPE) across multiple repetitions, sets and loads during clean pulls. Fifteen strength-trained men performed 3 traditional sets of 6 clean pulls using 80% (TS80), 100% (TS100) and 120% (TS120) of power clean 1RM with 180 seconds of inter-set rest; and 3 'rest redistribution' protocols of 9 sets of 2 clean pulls using 80% (RR80), 100% (RR100) and 120% (RR120) of power clean 1RM with 45 seconds of inter-set rest. DISP was greater during RR100 (g = 0.39) and RR120 (g = 0.56) compared to TS100 and TS120, respectively. In addition, PVD was less during RR120 than TS120 (g = 1.18), while CRDI was greater during TS100 (g = 0.98) and TS120 (g = 0.89) compared to RR100 and RR120, respectively. Also, RR protocols resulted in lower RPE across the sets at all loads (g = 1.11-1.24). Therefore, RR generally resulted in lower perceptual and mechanical fatigue, evidenced by lower RPE, PVD, CRDI and greater DISP than TS, and these differences became even more exaggerated as the barbell load and the number of sets performed increased.KRAS mutation-induced Ras activation plays an important role in the pathogenesis of pancreatic cancer, but the role of wild-type Ras and Ras GTPase-activating proteins remains unclear. The present study was designed to determine the expression spectra of Ras GTPase-activating proteins genes in pancreatic cancer cells, and the role of DAB2IP, a Ras GTPase-activating proteins gene, in the development and progression of pancreatic cancer. Following the analyses of the expression profiles of 16 Ras GTPase-activating proteins in 6 pancreatic cancer cell lines including Bxpc-3 (with wild-type KRAS), Capan-2, Sw1990, Aspc-1, CFPAC-1, and Panc-1 (with mutant KRAS) and 1 normal human pancreatic ductal epithelial cell line, H6C7, the expression of DAB2IP messenger RNA was further analyzed by quantitative real-time polymerase chain reaction. The role of DAB2IP in pancreatic cancer was further investigated in vitro and in vivo by upregulating DAB2IP in Bxpc-3 cells through transfection of DAB2IP into Bxpc-3 cells with recombinant lentivirus. The DAB2IP expression in pancreatic cancer cells and tissues with wild-type KRAS was significantly lower than that in cells and tissues with mutant KRAS (P less then .05). In Bxpc-3 cells with wild-type KRAS, overexpression of DAB2IP decreased the expression of P-AKT and P-ERK and the Ras activity; increased the expression of P-JNK and caspase 3; inhibited cell proliferation, invasiveness, and migration; and increased the cell sensitivity to cetuximab. Overexpression of DAB2IP inhibited tumor progression in a mouse model. In conclusion, DAB2IP downregulates Ras activity in wild-type pancreatic cancer cells. Overexpression of DAB2IP decreases the Ras activity, inhibits cell proliferation, and increases sensitivity to cetuximab in wild-type pancreatic cancer cells. In conclusion, DAB2IP may serve as a potential molecular therapeutic target for the treatment of pancreatic cancer.BACKGROUND In New Caledonia, a South Pacific archipelago whose inhabitants comprise Melanesians, Europeans/whites, Wallisians, Futunans, Polynesians, and Asians, the prevalence of rheumatic heart disease (RHD) is 0.9% to 1% at ages 9 and 10. It could be higher at the age of 16, but this remains to be verified. METHODS AND RESULTS A total of 1530 Melanesian, Métis, white, Wallisian, Futunan, Polynesian, and Asian adolescents benefited from a transthoracic echocardiogram. LGK-974 purchase Definite or borderline RHD, nonrheumatic valve lesions, congenital heart defects, family and personal history of acute rheumatic fever, and socioeconomic factors were collected. The prevalence of cardiac abnormalities was 8.1%, made up of 4.1% RHD including 2.4% definite and 1.7% borderline RHD, 1.7% nonrheumatic valve lesions, and 2.3% congenital anomalies. In whites and Asians, there were no cases of RHD. RHD was higher in the Wallisian, Futunan, and Polynesian group (7.6%) when compared with Melanesians (5.3%) and Métis (2.9%). The number of nonrheumatic valve lesions was not statistically different in the different ethnicities. The prevalence of RHD was higher in adolescents with a personal history of acute rheumatic fever, in those living in overcrowded conditions, and in those whose parents were unemployed or had low-income occupations, such as the farmers or manual workers. CONCLUSIONS RHD was 4 times higher in adolescents at age 16 than at ages 9 and 10 (4.1% versus 0.9%-1%). No cases of RHD were observed in whites and Asians. The determining factors were history of acute rheumatic fever and socioeconomic factors.
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