Notes

Patient-reported final results soon after major rotating joint total joint arthroplasty: the multi-centre clinical cohort research.
5 mg/kg AuNPs group was significantly reduced compared to that in the PBS control group, accompanied by the decreased expression of 17α-hydroxylase in the testes. In addition, AuNPs treatment significantly increased the rate of epididymal sperm malformation, but without affecting fertility.

Our results suggest that AuNPs can accumulate in the testes and reduce testosterone production in Leydig cells by down-regulating the expression of 17α-hydroxylase, thus affecting the quality of epididymal sperm.
Our results suggest that AuNPs can accumulate in the testes and reduce testosterone production in Leydig cells by down-regulating the expression of 17α-hydroxylase, thus affecting the quality of epididymal sperm.[This corrects the article DOI 10.2147/IJN.S207852.].Graphene, a wonder material, has made far-reaching developments in many different fields such as materials science, electronics, condensed physics, quantum physics, energy systems, etc. Since its discovery in 2004, extensive studies have been done for understanding its physical and chemical properties. Owing to its unique characteristics, it has rapidly became a potential candidate for nano-bio researchers to explore its usage in biomedical applications. In the last decade, remarkable efforts have been devoted to investigating the biomedical utilization of graphene and graphene-based materials, especially in smart drug and gene delivery as well as cancer therapy. Inspired by a great number of successful graphene-based materials integrations into the biomedical area, here we summarize the most recent developments made about graphene applications in biomedicine. In this paper, we review the up-to-date advances of graphene-based materials in drug delivery applications, specifically targeted drug/ gene delivery, delivery of antitumor drugs, controlled and stimuli-responsive drug release, photodynamic therapy applications and optical imaging and theranostics, as well as investigating the future trends and succeeding challenges in this topic to provide an outlook for future researches.[This corrects the article DOI 10.2147/CIA.S268140.].Reporting of a single nucleotide variant (SNV) follows the Sequence Variant Nomenclature (http//varnomen.hgvs.org/), using an unambiguous numbering scheme specific for coding and noncoding DNA. However, the corresponding sequence neighborhood of a given SNV, which is required to assess its impact on splicing regulation, is not easily accessible from this nomenclature. Providing fast and easy access to this neighborhood just from a given SNV reference, the novel tool VarCon combines information of the Ensembl human reference genome and the corresponding transcript table for accurate retrieval. selleck inhibitor VarCon also displays splice site scores (HBond and MaxEnt scores) and HEXplorer profiles of an SNV neighborhood, reflecting position-dependent splice enhancing and silencing properties.Childhood obesity is a serious public health problem worldwide. Perturbations in the gut microbiota composition have been associated with the development of obesity in both children and adults. Probiotics, on the other hand, are proven to restore the composition of the gut microbiome which helps reduce the development of obesity. However, data on the effect of probiotics on gut microbiota and its association with childhood obesity is limited. This study aims to determine the effect of probiotics supplement intervention on gut microbiota profiles in obese and normal-weight children. A total of 37 children, 17 normal weight, and 20 overweight school children from a government school in Selangor were selected to participate in this study. Participants were further divided into intervention and control groups. The intervention groups received daily probiotic drinks while the control groups continued eating their typical diet. Fecal samples were collected from the participants for DNA extraction. The hypervariableobiome dysbiosis in an underrepresented population.This study examined associations between body habitus and functions of aggression, in a sample of 474 college students from the Midwestern region of the United States (age range = 18-25y; 73% Caucasian). Two instruments of aggression, the Reactive-Proactive Aggression Questionnaire from Dodge & Coie 1987 (DC) and Raine et al. 2006 (RPQ) were given as self-assessments. Body habitus measures standardized by age and gender specific weight and height were collected. Subjects considered to have a large body habitus in our study had both weight and height measures above the 75th percentile. Large body habitus was positively correlated with both proactive and reactive functions of aggression among adult males but not females; however, regression analyses indicated that body habitus was most strongly and robustly associated with proactive aggression. Findings suggest that even in a healthy homogeneous population, large body size in males is associated with aggression, particularly proactive aggression including bullying rather than retaliatory aggression. The presence of a large body physique may reinforce aggressive behavioral traits acquired through life experiences and activities evoking physical dominance. Alternatively, the relationship may reflect neurological processes related to size influenced by genetic factors and hormones leading to antisocial behaviors requiring future research on the role of genes for aggression.[This corrects the article DOI 10.1007/s11366-020-09695-3.].Our previous study [R. Bhardwaj and A. Agrawal, "Likelihood of survival of coronavirus in a respiratory droplet deposited on a solid surface," Phys. Fluids 32, 061704 (2020)] showed that the drying time of typical respiratory droplets is on the order of seconds, while the survival time of the coronavirus on different surfaces was reported to be on the order of hours in recent experiments. We attribute the long survival time of the coronavirus on a surface to the slow evaporation of a thin nanometer liquid film remaining after the evaporation of the bulk droplet. Accordingly, we employ a computational model for a thin film in which the evaporating mass rate is a function of disjoining and Laplace pressures inside the film. The model shows a strong dependence on the initial thickness of the film and suggests that the drying time of this nanometric film is on the order of hours, consistent with the survival time of the coronavirus on a surface, seen in published experiments. We briefly examine the change in the drying time as a function of the contact angle and type of surface. The computed time-varying film thickness or volume qualitatively agrees with the measured decay of the coronavirus titer on different surfaces. The present work provides insights on why coronavirus survival is on the order of hours or days on a solid surface under ambient conditions.In the unfortunate event of the current ongoing pandemic COVID-19, where vaccination development is still in the trial phase, several preventive control measures such as social distancing, hand-hygiene, and personal protective equipment have been recommended by health professionals and organizations. Among them, the safe wearing of facemasks has played a vital role in reducing the likelihood and severity of infectious respiratory disease transmission. The reported research in facemasks has covered many of their material types, fabrication techniques, mechanism characterization, and application aspects. However, in more recent times, the focus has shifted toward the theoretical investigations of fluid flow mechanisms involved in the virus-laden particles' prevention by using facemasks. This exciting research domain aims to address the complex fluid transport that led to designing a facemask with a better performance. This Review discusses the recent updates on fluid flow dynamics through the facemasks. Key design aspects such as thermal comfort and flow resistance are discussed. Furthermore, the recent progress in the investigations on the efficacy of facemasks for the prevention of COVID-19 spread and the impact of wearing facemasks is presented.
Role reversal or boundary dissolution (BD) refers to the breakdown of expected parent-child roles and poses risk to development. Although retrospective reports in adulthood demonstrates that the emotional aspects of BD negatively influence self-concept, examination of BD in early childhood typically focuses on BD broadly as a reversal of parent-child roles rather than isolating the emotional aspects of BD. In addition, empirical work has yet to distinguish between mother and child engagement in BD despite the strong theoretical emphasis on this distinction.

We coded (N = 110 mother-child dyads) mother and child (age 3-6 years) engagement in role reversal during play and in emotional BD during mother-child reminiscing discussions to isolate emotional BD.

Child engagement in BD was associated across the contexts of play and mother-child emotional conversations whereas there was no association between maternal engagement in BD across these contexts. We examined associations between mother and child engagement in emotional BD and the extent to which child self-concept was consistent. Maternal engagement in emotional BD during reminiscing emerged as a significant predictor of less consistency in child self-concept in regression models including child engagement in emotional BD, role reversal in play, and child age.

Results provide empirical support for critical components of BD theory (e.g., salience of emotional BD, distinguishing parent versus child engagement in BD, impact on self-concept) and the measurement of these aspects of BD in future studies.
Results provide empirical support for critical components of BD theory (e.g., salience of emotional BD, distinguishing parent versus child engagement in BD, impact on self-concept) and the measurement of these aspects of BD in future studies.Investigators from multiple institutions (Cleveland Clinic, University Hospital Leuven, ZOL Genk, Kempenhaeghe and Maastricht UMC+, and Children's Hospitals and Clinics of Minnesota) used the Tuberous Sclerosis Complex Natural History Database (TSCNHD) to evaluate the relationship between epilepsy and neuropsychiatric disorders in individuals with TSC, along with any potential influence of genotype.Investigators from the Hospital Dona Estefânia, Escola Superior de Tecnologias e Saúde de Lisboa and Centro Hospitalar Psiquiátrico de Lisboa investigated 38 patients with continuous spike-wave of sleep (CSWS) syndrome.Researchers from the University of Strasbourg investigated whether defective transcription of ATF3 responsive genes is a marker for Cockayne Syndrome (CS).This paper is in response to the manuscript titled "Ethical oversight of student data in learning analytics A typology derived from a cross-continental, cross-institutional perspective" (Willis et al. in Educ Technol Res Dev 66(4)1029-1049, 2016). The response is from a K-12 educational environment perspective. Willis, Slade, and Prinsloo's typology of different ethical approaches to learning analytics adds value to the special issue topic of shifting to digital as it provides different ways to view learning analytics as well as the type of approval(s) possibly needed for each view. K-12 educational institutions can utilize the manuscript as a starting place for review of their ethical oversights when analyzing student data as more schools are shifting to digital. A limitation of Willis, Slade, and Prinsloo's manuscript in supporting the shift to digital is that the manuscript was published before the overwhelming shift to digital was mandated as a result of Covid-19. Future work related to the manuscript and with a focus on the K-12 educational environment could include K-12 education agencies deriving a K-12 specific typology from a review of ethical oversight protocols or analyzing the effects of the shift to digital in K-12 on the original typology.
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