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The effect of CoolClot hemostatic broker in skin color wound healing in rats.
Significant differences in length of stays, total hospitalization cost, outpatient visit cost, and emergency cost were shown between ASM groups and LTG, LEV, OXC, and PER showed relatively low utilization and cost.

Better adherence was observed in LTG, LEV, OXC, and PER groups than in CBZ, TPM, and VAL groups. Healthcare utilization and related costs showed significant difference between ASM groups.
Better adherence was observed in LTG, LEV, OXC, and PER groups than in CBZ, TPM, and VAL groups. Healthcare utilization and related costs showed significant difference between ASM groups.
Bipedal static posturography is widely used to assess postural control. However, standardized methods and evidence on the influence of footwear on balance in comparison to barefoot stance is sparse.

Is bipedal static posturography applied in a standardized way with respect to demographics and the experimental set-up (systematic review)? Does habitual footwear influence postural control in comparison to barefoot condition during bipedal static posturography in adult patients and healthy subjects (meta-analysis)?

For this systematic review and meta-analysis, a comprehensive follow-up literature search was conducted from March 2009 until January 2020 according to the PRISMA guidelines. Original, research articles reporting on bipedal, unsupported, static posturography in adults (≥18 years) were included according to inclusion criteria (age, sex, height, weight, duration, repetitions, visual/foot condition, sampling frequency). Studies comparing habitual footwear with barefoot condition during bipedal statiase knowledge whether habitual footwear decrease postural control in comparison to barefoot stance.
Methodical heterogeneity of bipedal static posturography hampers studies' comparability. Thus, we provide a standardized approach to increase knowledge whether habitual footwear decrease postural control in comparison to barefoot stance.
Pathological gait patterns are common in neurological and orthopedic patients. These put them at risk of falling and restrict their autonomy and social participation. Novel assistive walking devices are designed to actively support physiological gait patterns by means of motor guidance and mechanical support of the lower limbs.

Does a non-electric assistive walking device powered by a cam-spring mechanism (aLQ, Imasen) improve or otherwise affect pathological gait patterns in neurological and orthopedic patients?

A three-dimensional instrumented gait analysis was conducted on a treadmill (quasar, hp cosmos) using spatiotemporal, kinetic, and kinematic data obtained from synchronized motion capturing (Miqus M3, Qualisys), surface EMG (sEMG; Ultium, Noraxon), and pressure distribution measurements (FMD-T, Zebris). Participants with impaired walking were tested in a randomized repeated measures design (assisted/unassisted; at preferred/fast speed) and analyzed with regard to their medical condition (orthop to improve patients' functional health status and quality of life. Activities of daily living (ADLs) that involve extensive hip flexion like stairs or curb climbing are promising applications. We propose the implementation of an invertible cam-spring that provides an additional resistance training option.The ongoing process of climate change has shown that sustainable development of humankind is a necessity. Existing resources need to be used in a form of a circular economy, and no more in a linear economy as has been the case until now. Resources need to be better managed to meet the needs of future generations. Therefore, energy, water and environment systems need to be integrated in order to slow down their overexploitation. This paper discusses some of the latest developments in three main areas of sustainability, i.e., energy, water and environment, that emerged from the four "Sustainable Development of Energy, Water and Environment Systems" (SDEWES) Conferences that took place in 2020. The purpose of this review introduction article is to provide a brief introduction to the field and the articles included in this Virtual Special Issue. As such, it acts as an editorial paper for the virtual special issue of the Journal of Environmental Management, dedicated to the SDEWES 2020 conferences.Environmental monitoring of rivers is a cornerstone of the European Union's Water Framework Directive. It requires the estimation and reporting of environmental flows in rivers whose characteristics vary widely across the EU member states. This variability has resulted in a fragmentation of estimation and reporting methods for environmental flows and is exhibited by the myriad of regulatory guidelines and estimation procedures. To standardise and systematically evaluate environmental flows at the pan-European scale, we propose to formalise the estimation procedures through automation by reusing existing river monitoring resources. In this work, we explore how sensor-generated hydrological open government data can be repurposed to automate the estimation and monitoring of river environmental flows. In contrast to existing environmental flows estimation methods, we propose a scalable IoT-based architecture and implement its cloud-layer web service. The major contribution of this work is the demonstration of an automated environmental flows system based on open river monitoring data routinely collected by national authorities. Moreover, the proposed system adds value to existing environmental monitoring data, reduces development and operational costs, facilitates streamlining of environmental compliance and allows for any authority with similar data to reuse or scale it with new data and methods. We critically discuss the opportunities and challenges associated with open government data, including its quality. Finally, we demonstrate the proposed system using the Estonian national river monitoring network and define further research directions.The purpose of this study is to address the question of whether material flow cost accounting (MFCA) can contribute to the circular economy. Because MFCA is an environmental management accounting tool that simultaneously assesses company material and financial flows, it is expected to contribute to the circular economy by assisting companies to achieve both environmental and economic goals through resource efficiency. In short, the expected linkages between MFCA, company environmental and economic goals, and the circular economy are inputs, outputs, and outcomes. However, there is a lack of consensus regarding its potential, perhaps because of the scarcity of studies, with most being models and case studies without readily generalizable results. To address this gap, we analyze the triadic relationship between MFCA, environmental performance, and economic performance using a two-stage regression of data from Japanese listed companies. The main findings are as follows. Companies that implement MFCA more proactively are more likely to improve their environmental performance in terms of energy consumption, CO2 emissions, and waste produced. In turn, those that improve their environmental performance are also more likely to improve their productivity, while those that specifically improve environmental performance in terms of waste produced are also more likely to increase in profitability. Consequently, because MFCA can improve several aspects of environmental performance by saving resources, it can improve productivity by improving a range of environmental performance indicators. In particular, MFCA can improve company productivity and thereby profit, at least by reducing the amount of waste produced. This supports the view that MFCA is an effective tool to contribute to the circular economy.The high demand for plastic has led to plastic waste accumulation, improper disposal and environmental pollution. Even though some of this waste is recycled, most ends up in landfills or flows down rivers into the oceans. Therefore, researchers are now exploring better ways to solve the plastic waste management problem. From a socio-economic perspective, there is also a concerted effort to enable energy recovery from plastic waste and convert it into useful products to generate income for targeted segments of the population. In fact, this concept of waste-to-wealth has been adopted by the United Nations as part of its Sustainable Development Goals strategies. The current article begins by reviewing the strengths and weaknesses of plastic recycling before focusing specifically on microwave pyrolysis as an alternative to conventional technologies in plastic waste management, due to its benefit in providing fast and energy-efficient heating. The key parameters that are reviewed in this paper include different types of plastic, types of absorbent, temperatures, microwave power, residence time, and catalysts. The yield of the final product (oil, gaseous and char) varies depending on the main process parameters. Key challenges and limitations of microwave pyrolysis are also discussed in this paper.
Brucellosis is a neglected bacterial zoonotic disease with substantial economic impact on households. Pastoral communities are a potential risk group due to their way of life being closely interlinked with their large livestock herds.

A semi-structured questionnaire survey was conducted in households in the pastoral Afar and Somali (SRS) regions. Panobinostat price All households had people and animals serologically tested for brucellosis. Questions were related to husbandry, consumption habits, and knowledge-attitude-practice towards the disease and zoonoses. Descriptive statistics and logistic analysis were performed to assess potential risk factors for having households with positive humans and/or animals.

647 households were included in the survey. Herd brucellosis prevalence was 40.3 % (15.9-86.3 % in Afar; 4-72.2 % in SRS). Over half (56.3 %) of the households in Afar and 41.8 % in SRS had at least one human reactor. Nearly a quarter of the households (22.8 %), recalled abortions in goats in the last 12 months, whereas 52.5 % and 50.3 % recalled stillborn in all species and membrane retentions respectively. All respondents drank raw milk and discarded animal afterbirths in the direct surroundings with minimal protection. Risk factors for animal reactors were goat herd size, and goat abortion. There was no identified risk factor for having human reactors in households. None of the households knew about brucellosis.

Although being endemic in Afar and SRS, Brucellosis is not known by the pastoralists. Brucellosis control programs will have to be tailored to the pastoral context, accounting for their mobility, large, multi-species herds and habits.
Although being endemic in Afar and SRS, Brucellosis is not known by the pastoralists. Brucellosis control programs will have to be tailored to the pastoral context, accounting for their mobility, large, multi-species herds and habits.The CATIE schizophrenia trial was a very influential randomized controlled trial in patients with chronic schizophrenia. Patients were followed for up to 18 months under treatment with a randomly assigned antipsychotic. The primary endpoint, time to discontinuation of treatment for any reason, is influenced by individual patient characteristics, external factors as well as effects of drug treatment. New insight is obtained by applying an innovative survival analysis based on constrained confidence partitioning (SA-C2P). Through this data-driven approach we identify homogeneous collectives of patients with similar patient characteristics differing from the study population in the primary endpoint, enabling us to predict patient individual outcome more precisely. A subgroup of patients treated with olanzapine featuring neither an anxiety disorder in the past month, drug abuse in the past five years nor hospitalizations in the past year discontinued drug therapy substantially later compared to patients meeting at least one of the named parameters.
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