Notes

Influences regarding frosty plasma televisions treatment method on physicochemical, functional, bioactive, textural, along with nerve organs attributes of foodstuff: An extensive assessment.
Accreditation of simulation programs is relatively new, and entails a rigorous process of planning, development and evaluation of all aspects of the simulation experience for students and/or health care professionals. The purpose of this paper is to describe the experience of a Nursing Simulation Program in achieving designation as a fully accredited program. The process of developing a formal simulation program, strategic plan, policies and procedures, and an evaluation plan are included, as well as the benefits to achieving accreditation.
A relation between cardiovascular diseases and bone health is increasingly reported. However, the association between osteoporosis and incident heart failure (HF) has not been yet determined.

We aimed to summarize available evidence to evaluate whether osteoporosis was associated with an increased risk of incident HF.

Major databases, including PubMed, Embase, the Cochrane library, Web of Science, and ClinicalTrials, were searched for cohort studies reporting the hazard ratio (HR) for incident HF in patients with osteoporosis. The pooled hazard ratios (HRs) and 95% CIs were estimated by using a random‑effects model. Heterogeneity was evaluated by the I2 statistics and the χ2 test.

Three studies with a total of 70 697 patients were included, with the mean (SD) age of 62.9 (13.3) years. Osteoporosis was associated with an increased overall risk of incident HF (pooled HR, 1.17; 95% CI, 1.08-1.26; P <0.001; heterogeneity I2 = 13.28%, P = 0.32). The risk of incident HF was elevated in osteoporotic men (HR, 1.3; 95% CI, 1.05-1.62; P = 0.02; I2 = 71.57%, P = 0.03); however, no significant association was found for women (HR, 1.14; 95% CI, 0.94-1.37; P = 0.19; I2 = 64.66%, P = 0.06). The association between osteoporosis and incident HF risk was positive among individuals of Asian ethnicity (HR, 1.18; 95% CI, 1.06-1.3; P = 0.002; I2 = 52.61%, P = 0.15).

Osteoporosis was associated with a modest but significantly increased risk of incident HF. Considering the limited number and quality of available studies, future high‑quality data are required to further demonstrate the association between osteoporosis and incident HF.
Osteoporosis was associated with a modest but significantly increased risk of incident HF. Considering the limited number and quality of available studies, future high‑quality data are required to further demonstrate the association between osteoporosis and incident HF.The ten chapters of this volume exploit the potentials of stem cells biology in translational medicine in a very clear way also thanks to nice color illustrations together with tricks and suggestions useful to get reproducible results...The hypoglycemic drug GLP-1 receptor agonist can ameliorate hepatic steatosis but the mechanism is not clear. Intake of high fructose leads to non-alcoholic fatty liver disease by stimulating lipid synthesis, and β-catenin is the key molecule for realizing GLP-1 function in extrahepatic tissues; with the discovery of GLP-1 receptor in liver, we speculate that β-catenin might mediate GLP-1 receptor agonist on ameliorating hepatic steatosis induced by high fructose. Wistar rats were fed with high fructose diet for 8 weeks and then treated with GLP-1 receptor agonist exenatide for 4 weeks; the changes of lipid synthesis pathway factors, the expression and nuclear translocation of β-catenin, and the hepatic steatosis of the rats were observed. see more After the intervention of exenatide, the hepatic steatosis induced by high fructose was improved, the nuclear translocation and expression of β-catenin were facilitated, and the mRNA and protein expression of the upstream regulator SREBP-1 and the downstream key enzymes ACC, FAS and SCD-1 of de novo lipogenesis were down-regulated. link2 GLP-1 receptor agonist may ameliorate hepatic steatosis induced by high fructose by β-catenin regulating de novo lipogenesis pathway. GLP-1 receptor agonist may be a potential new drug for the treatment of non-alcoholic fatty liver disease, and the β-catenin may be an important target for the drug therapy.Bullets without a metal core are almost the only ones currently produced for the OSA complex. In the available forensic literature there are small number of cases of the description of injuries using this cartridge. The article presents a case from practice when, in the course of forensic medical research, not only the type of cartridge used was established, but also the conclusion was drawn about the use of barrelless firearms of limited destruction, equipped with two cartridges at the same time - the PB-2 Egida pistol. This allowed police authorities to quickly identify the criminal person.Currently, there is a constant expansion of the range of narcotic substances that differ from each other by a small structural fragment. The option of determining narcotic substances using test panels is widespread due to its rapidity and high specificity through the use of immunochemical reactions. The purpose of the study was to optimize the determination of morphine and amphetamine in bioobjects (synthetic and natural urine) using immunochromatographic analysis with new test panels and to select the optimal conditions for mass analysis. Test panels were used to detect the presence of amphetamine and morphine. For color recording of the results of analysis, colloidal gold nanoparticles were used. link3 The principle of operation of these test panels is described. The sensitivity of the test panels is such that it is possible to avoid false-positive results. It was found that with the help of test panels it is possible to determine narcotic substances in a concentration lower than stated in the instructions (300 ng/ml). The actual detection limit for amphetamine was 75 ng/ml and morphine 100 ng/ml. The analytical characteristics of the developed metho-dology were determined detection limit, precision, truth and specificity. The specificity was proved by conducting ICA to detect the presence of cross-reactions of test systems to amphetamine and morphine using structural analogues - adrenaline 1000 and codeine 300, respectively. The study did not receive false positive results for these molecules using the proposed test panels. Immunochromatographic test systems are optimal for drug detection, especially when conducting mass studies.The purpose of work was to study the activity of collagenase biosynthesis by bacilli and clostridia isolated from the bone microflora in a pure culture at different periods of bone decomposition and at different values of acidity of the medium and the temperature of cultivation. The comparative collagenase activity of the strains of Bacillus mycoides, Bacillus subtilis, Clostridium putrificum, Clostridium sporogenes found in microflora of bone tissue was determined. The catalytic activity of collagenases was evaluated according to the modified method of agar blocks by the diameter of precipitation zone as a result of diffusion of enzyme into an agar medium with collagen. Within 6 months of experiment, the dynamics of changes in the number of collagenolytic strains was monitored. For all isolated Bacillus and Clostridium isolates, a steady increase in collagenase synthesis was observed throughout the study period, with the exception of Bac. subtilis, which is probably due to the acidity of medium, which did not correspond to the optimal pH range for this species. The optimum temperature for manifestation of the maximum collagenolytic activity of bacilli was 40 °C, and for clostridia - 30 °C. The study of proteolytically active species involved in the destruction of bone collagen is promising for the purposes of forensic examination. The use of bacterial enzymes in forensic practice remains a difficult task, however, the use of their substrate specificity can significantly expand the evidence base of the examinations.Special scientific directions are developing in the world - pediatric pathology and pediatric (perinatal) forensic medicine. The article presents eleven important features of the autopsy of fetuses and newborns that must be observed for a high-quality diagnosis of diseases and causes of death of children. The reasons for the importance of observing these features both in pathoanatomical and forensic autopsies are indicated. A proposal has been made to include the considered features in the standard protocol of the pathological and anatomical autopsy of the fetus and newborns.The purpose of the work is to study the possibilities and options for assessing the degree of bilateral symmetry of dermatoglyphic signs of the right and left palms in solving the practical task of forensic medicine in establishing the belonging of body parts to one or different persons. The material of study was fingerprints of 600 palms of 300 people. It was found that the dermatoglyphic signs of the palms are characterized by a high degree of bilateral symmetry. The most consistent with each other on the right and left palms are the rudiments of papillary ridges, ridge counting and the distance between the finger triradiuses. In practical terms, the most informative are the coincidence of values of the characters having an average frequency of occurrence; coincidence of frequent signs have reliable, but low diagnostic significance. It is shown that, using the recommended set of dermatoglyphic signs of the palms, a forensic expert can, with a high degree of certainty, solve the question of whether the parts of body with the palms belong to one or different dead persons. The prospects of further research aimed at improving the technique are considered.The aim of study was to develop a comprehensive assessment of the central and peripheral parts of the nervous system with a determination of degree of severity of alterative changes in comparison with the condition of myocardial contractile apparatus. Own observations on modern methods of morphological study of the cardiac conduction system in the sudden death of young people are presented. Particular attention is paid to the technique of isolating and coloring the nervous structures of sympathetic and parasympathetic parts of the autonomic nervous system, including the medulla oblongata, sinus-atrial and atrial-ventricular nodes, atrioventricular bundle (the His bundle), Purkinje fibers. The features of morphological changes in the nerve structures of the heart, due to various etiological factors are highlighted.An analysis of the mortality of children and adolescents as a result of road injuries in Nizhny Novgorod, Volgograd, Krasnoyarsk, Yaroslavl regions over the past 5 years is presented. The relevance of the topic is due to the large number of deaths of minors as a result of road traffic accidents on the roads of the Russian Federation. The impact of qualitative factors (gender, age, season, type of motor vehicle accident) on the number of deaths was evaluated. We used the mathematical-statistical method - the Pearson criterion. We revealed similar general patterns of mortality from road injuries, despite some differences in the territorial distribution of this indicator. We established the need to create a unified information and analytical center, which will concentrate information on cases of traffic accidents throughout the region, including information from units of the forensic medical examination service.
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