Notes

Statin utilize as well as occurrence as well as mortality regarding breast as well as gynecology cancers: Any cohort study with all the Nationwide Health care insurance promises data source.
(celery) seed has been used for hypertension treatment. To provide a pharmacological basis, the vasorelaxant effect of celery seed extract was investigated in isolated rat aorta.

Wistar male rats (200-250 g) were divided into 15 groups (n=7 for each group). The vasorelaxant response of different concentrations of celery seed extract (0.05, 0.1, 0.25, 0.5, 1, and 2 mg/ml) on isolated aorta precontracted with phenylephrine (PE) or KCl was evaluated by organ bath technique. The role of endothelium, extracellular calcium influx, intracellular sources of calcium, and potassium channels in vasorelaxant effect of celery seed extract was investigated.

The extract showed a concentration-dependent relaxation in the isolated aorta contracted with PE and KCl that was endothelium-dependent at lower concentrations. Pretreatment of aortic rings with indomethacin or L-NAME, did not affect the vasorelaxation induced by celery seed extract. The extract inhibited KCl and PE-induced contractions in cumulative calcium concentrations as well as after incubation with diltiazem in denuded aortic rings of endothelium. The relaxation induced by celery seed extract was inhibited by 4-aminopyridine.

This relaxation was mediated by inhibiting calcium influx into vascular smooth muscle cells. Also, voltage-dependent potassium channels were involved in inducing the vasorelaxant effect of celery seed extract.
This relaxation was mediated by inhibiting calcium influx into vascular smooth muscle cells. Also, voltage-dependent potassium channels were involved in inducing the vasorelaxant effect of celery seed extract.
This study was done to evaluate the
and
effects of the essential oil (OE-CL) and nanoemulsion (N-CL) of
against


assays were done with 10
parasites and OE-CL and N-CL in the concentrations 110, 220, 330, 440, 550, 660, 770 and 880 µg/ml and four controls CN (culture medium and trophozoites), MTZ (trophozoites plus 800 µg/ml of metronidazole), TW (trophozoites plus vehicles used for solubilization of derivatives (0.01% Tween) and NB (blank nanoemulsion 880 µg/ml). The
assay was done in 35 quails (
) infected experimentally 4x10
mg/kg, were divided in seven groups (n=5) A (control-healthy), B (control infected), C (control TW 0.01%), D (NB 0.88 mg/kg), E (drug MTZ 25 mg/kg, F (OE-CL at 0.55 mg/kg) and G (N-CL at 0.44 mg/kg), during 7 consecutive days.

The
test showed that the OE-CL (550 μg/ml) and N-CL (440 μg/ml) concentrations reduced the trophozoites viability in 100%. In the
test, the treatment with OE-CL was efficient on the 4
treatment day and the N-CL after the 3
day, and the MTZ in the therapeutic concentration was efficient on the 7
day.

It can be observed in this study that the lemon grass has natural potential antitrichomonal activity against
and
.
It can be observed in this study that the lemon grass has natural potential antitrichomonal activity against T. gallinae in vitro and in vivo.
The aims of this study was to determine the effect of Propolis (resinousmixture thathoney beesproduce by mixing saliva andbeeswax) on clinical and physiological findings of moderate persistent asthma.

Fifty-two subjects aged 44.6±18.5 years old with moderate asthma and Forced expiratory volume in 1 second (FEV1) 60-79% of predicted, were enrolled in this clinical trial. We randomly allocated subjects to receive either propolis (75 mg three times a day) or a matched placebo for one month. Primary outcome was Asthma control test (ACT) score and secondary outcomes included dyspnea, spirometry, fractional exhaled nitric oxide (FENO) and sputum cytology including inflammatory cell. Sputum induction was done by hypertonic saline and cytology slides were stained by Papanicolaou stain.

Clinical findings significantly improved after the treatment. ACT scores significantly increased by using propolis (12.8±5.5 before and 18.1±4.99 after the trial), which was significantly higher than the placebo group (14.4±6.6 after the trial). The most significant physiological improvements were significant increases in FEV1, FV1/Forced vital capacity and expiratory flows. FENO showed significant decreases in the propolis group but increases in the placebo group. Cytological examination of sputum showed that the pattern of inflammation was eosinophilic in 44% subjects with an average eosinophil of 7.2±1.01%. Eosinophilia significantly decreased (p<0.05) by using propolis (7.2±1.01 and 4.3±3.1%, before and after treatment, respectively), but it significantly increased (p<0.04) in the placebo group (5.5±2.8, and 11.1±6.6%, before and after treatment, respectively).

Propolis improved the clinical and physiological findings of moderate persistent asthma, and it was able to suppress eosinophilic inflammation.
Propolis improved the clinical and physiological findings of moderate persistent asthma, and it was able to suppress eosinophilic inflammation.
Many pharmaceutical factories have dramatically improved the quality of herbal remedies in cancer treatment. Escin The results of somestudies have shown anticancer effect of
genus
Therefore, the aim of this article was to review the chemical ingredients and biological effects of
genus especially
from the family Apiaceae (Umbelliferae).

Online databases ScienceDirect, PubMed, Scopus, and Google Scholar were searched using the keywords
, Apiaceae, Biologic, Phytochemistry, and Benzodioxole to retrieve studies published between 1970 and 2020.

The
genus has two species,
(Boiss.) Drude and
(L.) Drude. In this genus, 5 new biologically active phytochemicals with benzodioxole structure were introduced and their biological effects were assessed.

Since many of the most commonly used anticancer drugs such as etoposide, teniposide, podophyllotoxin and sanguinarine have benzodioxole structureand according to the results of biological tests, it seems that more researchwith these perspectives should be done on this genus.
Since many of the most commonly used anticancer drugs such as etoposide, teniposide, podophyllotoxin and sanguinarine have benzodioxole structureand according to the results of biological tests, it seems that more researchwith these perspectives should be done on this genus.
Traditional medicines have been widely used to prevent and treat diseases for thousands of years. This study was designed to evaluate the effect of ginger feed on cardiac biomarker in isoproterenol (ISO)-induced myocardial toxicity.

Thirty male Wistar rats were grouped into six groups of five Control; ISO-induced toxicity; ginger fed; ginger fed before; ginger fed+ ISO simultaneously and ginger fed after. Freshly prepared solution of ISO was injected through intraperitoneal route at a dosage of 20 mg/kg, while the control received distilled water. Blood was collected via cardiac puncture after two weeks of administration, the serum was used to evaluate biomarkers.

The CK-MB and CK of ginger-fed groups were significantly lower compared to ISO group- 8.2±0.5 U/L and 39.36±5.28 U/L respectively, P <0.05. link2 The CK-MB and CK levels of all ginger-fed groups showed no significant difference compared to the control- 2.2±0.3 U/L and 17. 07±3.4.90 U/L, respectively p>0.05, except ginger fed after group where they were significantly higher compared to the control. The mean value of LDH in all ginger-fed groups was lower than the ISO group (67.17±0.88 U/L; p<0.05), but significantly higher (p<0.05) than the control (26.45±2.52 U/L). The mean value of ALT in all ginger fed groups was lower than the ISO group (83.11±4.88U/L; p≤0.05).

Ginger feed hindered toxic effects of isoproterenol.
Ginger feed hindered toxic effects of isoproterenol.
End-stage kidney disease (ESKD) patients on maintenance renal replacement therapy (RRT) have far lower life spans than those of the general population. No previous studies have been performed to assess the mortality of dialysis patients in the State of Qatar. We designed this study to assessthe mortality of dialysis patientsin Qatarandthe impact of dialysis modality.

All chronic ambulatory dialysis patients (both on hemodialysis(HD)and peritonealdialysis (PD)between 2014 and 2016) were included in the study, whereas patients undergoing dialysis for less than 3 months were excluded. We reviewedpatients' demographics, comorbidities, and general laboratory investigations through our electronic record system and collected and analyzed them. We identified patients who died during that period andcompared them to those who survived. We performeda subanalysisforHD versus PDpatients who died.

The total number of deceased dialysis patients was 164, with an overall crude mortality rate of 6.4%. They were significaHD than PD patients. This is the first study to look at these outcomes in Qatar. link3 We identified multiple mortality associated factors, such as comorbid conditions and old age. We believe that improving treatment and close monitoring for comorbid conditions in the dialysis population might improve survival.
Our study found that the high-risk population had a significant mortality, which was higher in HD than PD patients. This is the first study to look at these outcomes in Qatar. We identified multiple mortality associated factors, such as comorbid conditions and old age. We believe that improving treatment and close monitoring for comorbid conditions in the dialysis population might improve survival.
The spread of the SARS-CoV-2 virus has caused chaos around the world. At the onset of the virus' detection in the State of Qatar, a free-testing system was rapidly established to invite individuals who had recently returned from countries with a COVID-19 disease travel warning to avoid putting other people at risk. The testing site needed to be accessible to individuals without requiring them to enter the hospital and congregate in a waiting area. The aim of this article is to share our experience with the early implementation of a drive-through testing clinic using the invited person's vehicle as an isolation compartment during screening to minimize person-to-person contamination.

A Hamad Medical Corporation site was selected to stage a drive-through testing facility to avoid congestion and offer space to facilitate the process. A process was rapidly agreed upon, and staff received the required training regarding infection control measures and documentation. At the testing site, individuals were subjectehe initial call to the travelers who had recently returned from a country with a newly instituted travel warning and concluded by them leaving with their sick leave certificate and an information flyer with reminders about preventative infection control measures and encouraging them to self-quarantine after having been swabbed.Multiorgan dysfunction syndrome (MODS) remains a major complication and challenge to treat patients with critical illness in different intensive care unit settings. The exact mechanism and pathophysiology of MODS is complex and remains unexplored. We reviewed the literature from January 2011 to August 2019 to analyze the underlying mechanisms, prognostic factors, MODS scoring systems, organ systems dysfunctions, and the management of MODS. We used the search engines PubMed, MEDLINE, Scopus, and Google Scholar with the keywords "multiple organ dysfunction syndrome," "intensive care units," "multiorgan failure," "MODS scoring system," and "MODS management." The initial search yielded 3550 abstracts, of which 91 articles were relevant to the scope of the present article. A better understanding of a disease course will help differentiate the signs of an intense inflammatory response from the early onset of sepsis and minimize the inappropriate use of medications. This, in turn, will promote organtargeted therapy and prevent occurrence and progression of MODS.
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