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Influence associated with bacterial neighborhood structure involving seed debris for the attributes involving cardiovascular nitrifying granules.
The most active catalyst R-Cryptomelane reached a current density of 10 mA cm -2 at a potential 1.73 V without, and at 1.71 V in presence of carbon black. The improvement was significantly higher for catalyst with lower initial activity. However, the materials showed a disappointing catalytic stability during alkaline electrochemical OER, while the crystal structure was found to be stable at working conditions. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.To design high-performance mid-infrared (IR) nonlinear optical (NLO) materials, we have focused on the combination of a heavy metal lone pair cation, Pb 2+ and mixed oxyhalides. A systematic investigation in PbO-PbCl 2 -PbBr 2 system led us to discover the first examples of NLO lead mixed oxyhalides, namely, Pb 13 O 6 Cl 4 Br 10 , Pb 13 O 6 Cl 7 Br 7 , and Pb 13 O 6 Cl 9 Br 5 . All the reported materials have remarkably comprehensive properties including broad IR transparency (up to 14.0 μ m), qualified second harmonic generation (SHG) responses (0.6-0.9 × AgGaS 2 ), wide bandgaps (3.05-3.21 eV), and ease of crystal growth. Interestingly, a centimeter-sized single crystal (2.9 × 1.3 × 0.5 cm 3 ) of Pb 13 O 6 Cl 9 Br 5 revealing a wide transparent range (0.384-14.0 μ m) and high laser damage threshold (LDT) (14.6 × AgGaS 2 ) has been successfully grown in an open system. The study suggests that all the reported mixed oxyhalides are outstanding candidates for mid-IR NLO materials. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Esophageal squamous cell carcinoma (ESCC) belongs to one of the most common malignant tumors worldwide and possesses high mortality. Long non-coding RNAs (lncRNAs) have been demonstrated to be essential biological participants in the progression of ESCC. Based on bio-informatics prediction, forkhead box P4 antisense RNA 1 (FOXP4-AS1) and forkhead box P4 (FOXP4) were upregulated in esophageal carcinoma samples and were positively correlated with each other. Present study aimed to explore the function of FOXP4-AS1 and FOXP4 in ESCC cells. Function assays disclosed that knockdown of FOXP4-AS1 or FOXP4 efficiently suppressed cell proliferation and induced cell apoptosis. Moreover, FOXP4-AS1 positively regulated FOXP4 by interacting with insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) to stabilize FOXP4 mRNA. Additionally, FOXP4-AS1 could upregulate the expression of FOXP4 by sponging miR-3184-5p. Finally, we found that YY1 is a transcription factor that can transcriptionally activate both FOXP4-AS1 and FOXP4 in ESCC cells. In a word, YY1-induced upregulation of FOXP4-AS1 and FOXP4 promote the proliferation of ESCC cells This article is protected by copyright. All rights reserved. learn more This article is protected by copyright. All rights reserved.The preparation of an all supramolecular multi-chromophoric azaborondipyrromethene ( ABDP ) / zinc tetraphenylporphyrin ( ZnTPP ) / exfoliated graphene ( GR ) nanoensemble is accomplished. The ABDP derivative bears glycol chains for enhancing solubility and a pyridine functionality for allowing coordination with ZnTPP . The ABDP / ZnTPP/GR nanoensemble is characterized with regards to morphology and composition using complementary microscopy imaging, thermogravimetric analysis, Raman and steady state and time resolved absorption and emission spectroscopy. The photophysical and electrochemical assessment of ABDP / ZnTPP/GR as well as the binding properties of the ABDP / ZnTPP complex employed as reference are presented. Energy and electron transfer events were observed in ABDP / ZnTPP upon photoexcitation. However, in the case of ABDP / ZnTPP/GR , the graphene induced aggregation of the chromophores alters their electronic interactions, enhancing the energy/electron transfer process between them. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.There are few studies on heparan sulfate (HS) in the skin, during aging, when estrogen is suppressed. The enzyme heparanase-1 (HPSE-1), has its 17β-estrogen-regulated expression in pathological conditions such as cancer and chronic inflammatory diseases. HPSE-1 is correlated with the matrix metalloproteinase-9 (MMP-9), an endopeptidase that also undergoes estrogen action. We investigated the distribution of HS, expression HPSE-1 and MMP-9 in the skin of adult rats at different ages and in the age-matched ovariectomized rats to evaluate the influence of low estrogen on the distribution of HS. Thirty female Wistar rats were used. Rats underwent to a sham surgery (ctr, n = 15) or to a bilateral ovariectomy (ovx, n = 15) and were euthanized after 45, 75, and 90 days after ovariectomy. Morphological, morphometric, biochemical, and reverse transcriptase polymerase chain reaction (RT-PCR) methodologies were used. A significant decrease (P  less then  0.001) in total skin thickness was observed in the ctr and ovx animals, being higher in the older animals. The thickness of the epidermis and dermis decreased; however, the proportion in the total skin remained similar comparing ctr and ovx. An increase of HS with increasing age and ovariectomy was observed. The expression of the HPSE-1 and MMP-9 enzymes decreased, being higher in old animals. A correlation between the increase of HS and the decrease of the HPSE-1 was demonstrated in both groups. Overall, these data suggested that estrogen acts in the regulation of the expression of the HPSE-1, not only in pathological states, as already established, but also in aging. © 2020 International Federation for Cell Biology.BACKGROUND Head and neck squamous cell carcinoma (HNSCC) has attracted researchers' attention due to its high incidence around the world. This malignancy occurs in the oral cavity, pharynx, and larynx in most cases. Quite a few lncRNAs have been revealed to regulate the malignant neoplasia of several cancers. Nevertheless, effects of lncRNA LINC00467 in HNSCC have not yet been reported. METHODS The expression of LINC00467, miR-299-5p and ubiquitin specific protease-48 (USP48) in HNSCC cells were quantified by RT-qPCR. The influences of LINC00467 deficiency on HNSCC progression were reflected by CCK-8, colony formation, EdU, wound healing and western blot assays. RIP and luciferase reporter assays were conducted to confirm the interaction among LINC00467, miR-299-5p and USP48. RESULTS LINC00467 was considerably upregulated in HNSCC cells, and absence of LINC00467 suppressed cell growth, cell migration and EMT process in HNSCC. Furthermore, miR-299-5p expression was notably downregulated in HNSCC cells, and miR-299-5p could bind with LINC00467.
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