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The results show that the solution of the optimization problem for combination therapy is the dosing schedule that leads to tumor eradication at the end of the treatment period. The results also investigate the tumor dynamics for all mutation types when undergoing treatment, showing that single drug therapies can fail to combat the emergence of resistance, while optimized combination therapies can reduce the amount of all mutation types during the course of treatment, thereby combating resistance.We propose a point-mass biomechanical model to estimate the forces and moments supported by the upper extremity during Lofstrand crutch-assisted gait. This model is based on the Newtonian classical mechanics and the angular momentum theorem. The system arm-crutch is divided into three segments 1) crutch, 2) wrist-elbow, and 3) elbow-shoulder. The theoretical model was experimentally validated with a disabled person with spinal cord injury. Two crutch-assisted gait patterns have been chosen to carry out the experimental validation two-point reciprocal gait and swing-through gait. Six position markers (three placed on the arm and three placed on the crutch) and two force sensors (placed on the crutch) were used in experiments for testing the model. The results were compared with a distributed-mass model based on studies previously published, concluding that the relative mean difference between models is less than 3% Body Weight and 1% Body Weight times Height when forces and moments are estimated, respectively. Some advantages of using a point-mass model are summarized simple formulation, easy to understand; require less numerical calculation reducing the computational cost; requires less position markers placed on the subject, increasing therefore the comfort of the subject.The recent definition of fractional Brownian motions on surfaces has raised the statistical issue of estimating the Hurst index characterizing these models. To deal with this open issue, we propose a method which is based on a spectral representation of surfaces built upon their Laplace-Beltrami operator. This method includes a first step where the surface supporting the motion is recovered using a mean curvature flow, and a second one where the Hurst index is estimated by linear regression on the motion spectrum. The method is evaluated on synthetic surfaces. The interest of the method is further illustrated on some fetal cortical surfaces extracted from magnetic resonance images as a means to quantify the brain complexity during the gestational age.Long-Term visual localization under changing environments is a challenging problem in autonomous driving and mobile robotics due to season, illumination variance, etc. Image retrieval for localization is an efficient and effective solution to the problem. In this paper, we propose a novel multi-task architecture to fuse the geometric and semantic information into the multi-scale latent embedding representation for visual place recognition. To use the high-quality ground truths without any human effort, the effective multi-scale feature discriminator is proposed for adversarial training to achieve the domain adaptation from synthetic virtual KITTI dataset to real-world KITTI dataset. The proposed approach is validated on the Extended CMU-Seasons dataset and Oxford RobotCar dataset through a series of crucial comparison experiments, where our performance outperforms state-of-the-art baselines for retrieval-based localization and large-scale place recognition under the challenging environment.Laparoscopic Ultrasound (LUS) is recommended as a standard-of-care when performing laparoscopic liver resections as it images sub-surface structures such as tumours and major vessels. Given that LUS probes are difficult to handle and some tumours are iso-echoic, registration of LUS images to a pre-operative CT has been proposed as an image-guidance method. This registration problem is particularly challenging due to the small field of view of LUS, and usually depends on both a manual initialisation and tracking to compose a volume, hindering clinical translation. In this paper, we extend a proposed registration approach using Content-Based Image Retrieval (CBIR), removing the requirement for tracking or manual initialisation. Pre-operatively, a set of possible LUS planes is simulated from CT and a descriptor generated for each image. Then, a Bayesian framework is employed to estimate the most likely sequence of CT simulations that matches a series of LUS images. We extend our CBIR formulation to use multiple labelled objects and constrain the registration by separating liver vessels into portal vein and hepatic vein branches. The value of this new labeled approach is demonstrated in retrospective data from 5 patients. Results show that, by including a series of 5 untracked images in time, a single LUS image can be registered with accuracies ranging from 5.7 to 16.4 mm with a success rate of 78%. Initialisation of the LUS to CT registration with the proposed framework could potentially enable the clinical translation of these image fusion techniques.A spatial resolution metric is presented for tomosynthesis. The Fourier spectral distortion metric (FSD) was developed to evaluate specific resolution properties of different imaging techniques for digital tomosynthesis using a star pattern image to plot modulation in the frequency domain. The FSD samples the spatial resolution of a star-pattern image tangentially over an acute angle and for a range of spatial frequencies in a 2D image or 3D image reconstruction slice. The FSD graph portrays all frequencies present in a star pattern quadrant. In addition to the fundamental input frequency of the star pattern, the FSD graph shows spectral leakage, square wave harmonics, and residual noise. The contrast transfer function (CTF) is obtained using the FSD graph. The CTF is analogous to the modulation transfer function (MTF), but it is not normalized to unity at zero spatial frequency. click here Unlike the MTF, this metric separates the fundamental input-frequency from the other signals in the Fourier domain. This metric helps determine optimal image reconstruction parameters, the in-plane limit of spatial resolution with respect to aliased signals, and a threshold criterion for an image to support super resolution and reduce aliasing artifacts.
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