Notes

Study of the Solid-State Synthesis of Nickel Ferrite (NiFe2O4) by simply X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM) along with Raman Spectroscopy.
[
F]-fluorodeoxyglucose (FDG) positron emission tomography with computed tomography (PET-CT) is a well-established modality in the work-up of patients with suspected or confirmed diagnosis of lung cancer. Recent research efforts have focused on extracting theragnostic and textural information from manually indicated lung lesions. Both semi-automatic and fully automatic use of artificial intelligence (AI) to localise and classify FDG-avid foci has been demonstrated. To fully harness AI's usefulness, we have developed a method which both automatically detects abnormal lung lesions and calculates the total lesion glycolysis (TLG) on FDG PET-CT.

One hundred twelve patients (59 females and 53 males) who underwent FDG PET-CT due to suspected or for the management of known lung cancer were studied retrospectively. These patients were divided into a training group (59%; n = 66), a validation group (20.5%; n = 23) and a test group (20.5%; n = 23). A nuclear medicine physician manually segmented abnormal lung lesints with potentially malignant lesions.
The AI-based method is suitable for the detection of lung lesions and automatic calculation of TLG in small- to medium-sized tumours. In a clinical setting, it will have an added value due to its capability to sort out negative examinations resulting in prioritised and focused care on patients with potentially malignant lesions.This study aimed to determine the influence of sorghum ensiled with unsalable pumpkin at 20 or 40% dry matter (DM) basis on rumen fermentation characteristics and rumen microbial communities using the rumen simulation technique (RUSITEC). The experiment used a completely randomised design including silages comprising (1) 100% sorghum; (2) 80% sorghum + 20% DM pumpkin; or (3) 60% sorghum + 40% DM pumpkin. Each RUSITEC run (n = 2) was 15 d long, including 6 d of adaptation and 9 d of sampling. Dry matter digestibility (DMD) was measured on d 8 and 10-13. Gas production was measured daily, whereas methane and volatile fatty acids (VFA) production were measured from d 7-15. Solid-associated microbes (SAM) were collected on d 5, 10 and 15, whereas liquid-associated microbes (LAM) were collected after 15-d incubation. The V4 region of the 16S rRNA gene and the ITS1 region were sequenced to identify archaeal, bacterial and fungal communities. Ensiling 40% DM pumpkin with sorghum increased DMD and decreased the ratio of acetate to propionate (P ≤ 0.01). Both bacterial SAM and LAM communities were dominated by Megasphaera, and had the highest relative abundance (P = 0.03) with 40% DM pumpkin after 5 d incubation in the SAM community, while species of the Aspergillus genus dominated fungal SAM and LAM communities with 20 or 40% DM unsalable pumpkin. Therefore, ensiling up to 40% DM unsalable pumpkin with sorghum produces a high-quality ruminant feed with minimal influence on the rumen microbial population. KEY POINTS • Including 40% DM unsalable pumpkin decreased acetatepropionate • Ensiling unsalable pumpkin with sorghum increases digestibility in a RUSITEC • Rumen microbial communities were slightly influenced by unsalable pumpkin inclusion.
Patients can experience recurrence following curative-intent resection of non-functional pancreatic neuroendocrine tumors (NF-pNETs). We sought to develop a nomogram to risk stratify patients relative to recurrence following resection of NF-pNETs.

Patients who underwent curative-intent resection for NF-pNETs between 1997 and 2016 were identified from a multi-institutional database. The impact of clinicopathologic factors, including tumor burden score (TBS) (TBS
 = (maximum tumor diameter)
 + (number of tumors)
), was assessed relative to recurrence-free survival (RFS), and a nomogram was developed and internally validated.

With a median follow-up of 31.0months (IQR 11.3-56.6months), 66 (15.8%) out of 416 patients in the cohort experienced tumor recurrence. Overall, 3-, 5-, and 10-year RFS following curative-intent resection was 83.2%, 74.0%, and 44.7%, respectively. Several factors were associated with risk of recurrence including tumor grade (referent G1 G2, HR 4.07, 95% CI 2.29-7.26, p < 0.001; hed that had good discrimination and calibration. The nomogram may be an effective tool to stratify patients relative to recurrence risk following resection of NF-pNETs.
The treatment strategy for pancreatic metastasis (PM) from renal cell carcinoma (RCC) is unclear due to its rarity. The aim of this study was to reveal the role of surgery for PM from RCC.

A systematic literature search was conducted using PubMed and the Cochrane Library. The effectiveness of surgery for PM was evaluated based on the primary outcome of overall survival (OS), which was investigated in relation to surgical procedures and metastatic sites via subgroup analyses.

There was no significant difference in the rate of 2-year OS between the surgery and control group (OR 0.43, 95% CI 0.14-1.26, P = 0.12). However, the rate of 5-year OS was significantly higher in the surgery group than the control group (OR = 0.41, 95% CI 0.18-0.93, P = 0.03). The rates of the complications and OS were not significantly different between radical and conservative pancreatectomies. The rate of 5-year OS of the patients with PM was higher than that with other metastases (OR 0.38, 95% CI 0.20-0.74, P = 0.004).

Surgical resection for PM from RCC is associated with good prognosis. Limited surgery may be a useful option depending on the location of the lesion.
Surgical resection for PM from RCC is associated with good prognosis. Limited surgery may be a useful option depending on the location of the lesion.Dysmorphophobia is the phobia that arises from the distorted view that one has of one's external appearance, caused by the excessive concern for one's body image, in most cases not justified. The role of the plastic surgeon is to recognize the dysmorphophobic patient, make him aware of the non-existence of the defect and direct him towards a path that can help him. The body is a living organism that has its own characteristics and with its own uniqueness. Performing a cosmetic surgery means improving an imperfection by enhancing the positive traits of each patient. For this reason, the ultimate goal of surgery is to seek a positive aesthetic improvement and never a transformation. A dysmorphophobic patient is a dissatisfied person who is constantly looking for a mutation by entering a loop from which he will not be able to get out easily. When the patient suffers from dysmorphophobia, he generally complains of a blemish that cannot be objectified and must be an alarm bell for the specialist who is visiting him. The visit serves to analyze the patient as a whole. Relying on a specialist in plastic, reconstructive and aesthetic surgery means that you are faced with a professional trained in this branch of medicine, who can guide the patient towards the most suitable path and with the safest and most predictable results, or is a capable professional. To recognize a psychological weakness of the patient, blocking from the beginning a process that would not be indicated.
Drug protocols in intensive care units may require the concomitant administration of many drugs as patients' venous accesses are often limited. A major challenge for clinicians is to limit the risk of simultaneously infusing incompatible drugs. Incompatibilities can lead to the formation of particles and inactivation of drugs, whose consequences on the body have already been indicated. Our objective was to assess current strategies to counter the risk of incompatible infusions and control the resulting clinical consequences.

This review was independently conducted by three investigators in respect of the PRISMA statement. Three online databases were consulted. Full-text articles, notes, or letters written in English or French, published or in press between the 1990s and the end of February 2020, with clinical study design, were eligible. Parameters of interest were mainly number and size of particles, and a number of observed/avoided incompatibilities.

All in all, 382 articles were screened, 17 meeting all the acceptance criteria. The strategies outlined and assessed were filtration, the use of multi-lumen devices, the purging of infusion lines, incompatibility tables and databases, and the use of standard operating procedures.

Although many strategies have been developed in recent years to address drug incompatibility risks, clinical data is still lacking. All studies with in vitro design were excluded although some current innovative strategies, like niosomes, should be considered and studied by means of clinical data in the future.
Although many strategies have been developed in recent years to address drug incompatibility risks, clinical data is still lacking. All studies with in vitro design were excluded although some current innovative strategies, like niosomes, should be considered and studied by means of clinical data in the future.To enhance milk quantity and quality which have continued to decrease in Kenya, various stakeholders have intervened through promotion of technical dairy innovations at the farm level including improved cow feeding, health management, promotion of exotic breeds, and milking hygiene. At the milkshed level, stakeholders' focus has been on organizational innovations, specifically milk sale by farmers through groups. This study sought to characterize dairy innovations that have been adopted by farmers in the milkshed of three milk processors including New Kenya Co-operative Creameries Sotik (NKCC Sotik), Happy Cow Limited (HCL), and Mukurweini Wakulima Dairy Limited (MWDL), representing one state, private, and farmer-owned processor, respectively. Data were collected using a structured questionnaire from a sample of 1146 farmers (410, 382, and 354 in MWDL, HCL, and NKCC Sotik, respectively). check details A categorical principal components analysis was used to reduce 32 variables into four sets of uncorrelated components. Four categories were identified including principal component (PC) 1 (technical capacity), PC 2 (animal health management), PC 3 (organizational capacity), and PC 4 (milk hygiene). More farmers in the milkshed of MWDL adopted technical and organizational dairy innovations such as use of artificial insemination and milk sale through groups, respectively, than farmers in milkshed of NKCC and HCL. The county governments in the milkshed of HCL and NKCC Sotik need to strengthen cooperative societies to boost adoption of artificial insemination through arrangement in which milk is sold and payment of services offered on credit is settled from milk sale and ensure milk market availability throughout the year.The introduction of novel targeted therapies during the last 2 decades has led to a significant improvement in patients' clinical outcomes with renal cell carcinoma. However, this improvement came at the price of a whole new spectrum of adverse events, including renal toxicity. Systemic treatment of patients with kidney neoplasms who often present with impairment of kidney function, even prior to treatment, poses an increasing diagnostic and therapeutic challenge for clinicians. Common lifestyle-related comorbidities, i.e., hypertension and diabetes, may contribute to further impairment of kidney function. The lack of official guidelines and the exclusion of patients with reduced kidney function from the clinical trials of recently approved drugs complicate the issue even further. Early detection and correct management of renal toxic effects are crucial to preserve kidney function and ensure the optimal administration of life-prolonging therapies. This review presents detailed information on the renal toxicities of three groups of drugs commonly used in renal cell carcinoma treatment tyrosine kinase inhibitors, mammalian target of rapamycin inhibitors, and immune checkpoint inhibitors.
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