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Crack associated with ovarian endometriotic cyst complex along with endometriosis: In a situation record.
Reactive nitrogen (Nr) has far-reaching advantages and disadvantages on human beings. Nitrogen footprint (NF) is a tool to quantify the use of Nr in the environment. Food nitrogen footprint (FNF) accounts for the largest proportion of the total NF, and the differences between provinces in China exist objectively. In order to explore the spatial correlation and socio-economic driving factors of China's FNF, this paper uses N-calculator tool to calculate the FNF of 30 provinces in China from 2000 to 2018, and uses exploratory spatial data to analyze the spatial correlation and changes of provincial FNF, The driving factors and spatial effects of FNF change in the province were analyzed by using spatial Durbin panel model and spatial regression partial differential method. The results showed that (1) There is a significant and stable positive spatial dependence and heterogeneity in the FNF among provinces; (2) The direct effect factors of promoting the growth of FNF in the province are urban household Engel coefficient, per capita disposable income of rural residents and rural household Engel coefficient. The main factors of restraining the growth of FNF in the province are wastewater discharge per unit GDP and per capita GDP; (3) the spillover effect is mainly manifested as the negative effect of the increase of urban household Engel coefficient on neighboring provinces, and the spillover effect of per capita disposable income of urban residents and nitrogen fertilizer application rate per unit grain yield on the growth of FNF of neighboring provinces is significant. From the policy level, it is necessary to guide healthy and scientific eating habits, reduce the proportion of meat and fish in the diet structure, reduce the nitrogen fertilizer application per unit grain yield, and improve the efficiency of chemical fertilizer utilization. When formulating relevant policies, government departments should give consideration to the cooperation between provincial and regional governments.Lead is one of the highly toxic heavy metals causes various diseases even at very lower concentrations to human and affects eco-system. It is mainly released into the water through industrial activities. Phytoremediation is useful to degrade, reduce, metabolize and assimilate lead from wastewater. In this study, Turbinaria ornata was collected from the sea and dried biomass was used for biosorption of heavy metals. Adsorption of heavy metal was maximum after 100 min incubation with alga powder at acidic pH (4.5). The interactive effects of lead concentration, contact times, pH, biomass concentration and agitation speed was evaluated by a two-level full factorial design. Initial lead concentration, agitation speed and biomass concentration were the most important variables affecting lead removal (p 98.5% lead form the wastewater within 10 min in an optimized condition. The present study confirmed the potential application of T. ornata for the removal of lead from contaminated environment.Organophosphate esters (OPEs) are widely used around the world as flame retardants and plasticizers with a growing production in the last 15 years due to the phase-out of polybrominated diphenyl ethers. Multiple papers reported the occurrences of OPEs in various environmental matrices and elevated concentrations of OPEs (0.1-10,000 ng/g dry weight) were documented in different types of soils which were regarded as both the "sink" and "source" of OPEs. In this study, the source, transfer, and transformation mechanisms of OPEs are systematically reviewed from the perspective of the soil environment. The wet/dry deposition, air-soil exchange, sewage irrigation, sludge application, and indirect oxidization of organophosphate antioxidants are the possible sources of OPEs in soil. Meanwhile, the OPEs in the soil environment may also migrate into other environmental media via plant uptake, air-soil exchange, desorption, and infiltration to cause relevant ecological risk, which depends much on the chemical properties of these compounds. selleck chemicals llc The trimethylphenyl phosphate (TMPP) (mixture of isomers) and triphenyl phosphate (TPHP), which have strong hydrophobicity, pose a higher ecological risk for the soil environment than other OPEs. Further, the hydrolysis, indirect photolysis, and biodegradation of OPEs in the soil environment may be affected by the soil pH, organic acid, dissolved metals and metal oxides, active oxygen species, and microorganisms significantly. Besides that, the human exposure risks of OPEs from the soil are limited compared to those via indoor dust and food ingestion pathways. Finally, this study identifies the knowledge gaps and generated the future perspectives of the OPEs in soil.Antibiotics have been widely used to prevent or treat bacterial infections in aquaculture in the past decades. However, large proportions of these compounds are excreted unchanged in feces and urine of animals, given incomplete metabolism, leading to the residual of unmetabolized compounds, and posing a potential risk to the environment. This study investigated the occurrence and distribution of seven antibiotics in surface water, sediments, fish muscle, and fish feed by high-performance liquid chromatography from the aquaculture areas in Guilin, South of China. The highest concentrations of the target antibiotics in water, sediment, fish muscle, and fish feed were 2047.53 ng/L, 13.32 μg/kg, 35.90 μg/kg, and 2203.97 μg/kg, respectively. In contrast, the most abundant antibiotic was enrofloxacin (ENR), followed by ofloxacin (OFL), sulfadimidine (SMZ), and ciprofloxacin (CIP). In this work, the concentrations of antibiotics were lower than those in other breeding areas. Correlation analyses showed significant relationships between sulfadiazine (SDZ) and TP, TN, and CODCr in water. In sediment, the release of SDZ was significantly related to TN, TP, and organic matter. The risk quotient (RQ) results revealed that sulfamethoxazole (SMX), CIP, and ENR were at high risk to microorganisms in water; while, SMX and NOR were at high risk in sediments. The result from the estimated daily intakes (health risk quotient, HQ less then 1) suggested that the antibiotics might not pose a risk to human health by dietary exposure assessment; however, sediments may become an accumulation reservoir of antibiotics and cause secondary pollution, of which the local management should raise awareness.
Adiposity trajectories reflect dynamic process of growth and may predict later life health better than individual measures. Prenatal phthalate exposures may program later childhood adiposity, but findings from studies examining these associations are conflicting. We investigated associations between phthalate biomarker concentrations during pregnancy with child adiposity trajectories.

We followed 514 mother-child pairs from the Mexico City PROGRESS cohort from pregnancy through twelve years. We measured concentrations of nine phthalate biomarkers in 2nd and 3rd trimester maternal urine samples to create a pregnancy average using the geometric mean. We measured child BMI z-score, fat mass index (FMI), and waist-to-height ratio (WHtR) at three study visits between four and 12 years of age. We identified adiposity trajectories using multivariate latent class growth modeling, considering BMI z-score, FMI, and WHtR as joint indicators of latent adiposity. We estimated associations of phthalates biomarkers withiposity. The total phthalate mixture was not associated with early life child adiposity.
Prenatal concentrations of urinary DEHP metabolites, DiNP metabolites, and MCNP, a di-isodecyl phthalate metabolite, were associated with trajectories of child adiposity. The total phthalate mixture was not associated with early life child adiposity.In this study, we synthesized MnFe2O4 solid nanospheres (MSN) calcined at different temperatures (200-500 °C) and MSN-based materials mixed with carbon black, for their use as electrocatalysts in the oxygen reduction reaction (ORR) in alkaline medium (0.1 M KOH). It was demonstrated that the calcination temperature of MSN material determined its chemical surface composition and microstructure and it had an important effect on the electrocatalytic properties for ORR, which in turn was reflected in the performance of MSN/CB-based electrocatalysts. The study revealed that the presence of Mn species plays a key role in the ORR activity. Among tested, MSN200/CB and MSN350/CB exhibited the best electrochemical performances together with outstanding stability.Hereditary sensory neuropathy type 1 (HSAN1) is a rare axonopathy, characterized by a progressive loss of sensation (pain, temperature, and vibration), neuropathic pain and wound healing defects. HSAN1 is caused by several missense mutations in the SPTLC1 and SPTLC2 subunit of the enzyme serine-palmitoyltransferase (SPT) -the key enzyme for the synthesis of sphingolipids. The mutations change the substrate specificity of SPT, which then forms an atypical class of 1-deoxy-sphinglipids (1-deoxySL). Similarly, patients with type 2 diabetes (T2DM) also present with elevated 1-deoxySLs and a comparable clinical phenotype. The effect of 1-deoxySLs on neuronal cells was investigated in detail, but their impact on other cell types remains elusive. Here we investigated the consequences of externally added 1-deoxySLs on the migration of fibroblasts in a scratch assay as a simplified cellular wound-healing model. We showed that 1-deoxy-Sphinganine (1-deoxySA) inhibits the migration of NIH-3T3 fibroblasts in a dose- and time-dependent manner. This was not seen for a non-native, L-threo stereoisomer. Supplemented 1-deoxySA was metabolized to 1-deoxy-(dihydro)Ceramide and downstream to 1-deoxy-Sphingosine (1-deoxySO). Inhibiting downstream metabolism by blocking N-acylation rescued the migration phenotype. In contrast, adding 1-deoxySO had a lesser effect on cell migration but caused the massive formation of intracellular vacuoles. Further experiments showed, that the effect on cell migration was primarily mediated by 1-deoxy-dihydroceramides rather than by the free base or 1-deoxyceramides. Based on these findings, we suggest that limiting the N-acylation of 1-deoxySA could be a therapeutic approach to improve cell migration and wound healing in patients with HSAN1 and T2DM.Regulating dietary fat absorption may impact progression of nonalcoholic fatty liver disease (NAFLD). Here we asked if inducible inhibition of chylomicron assembly, as observed in intestine-specific microsomal triglyceride transfer protein knockout mice (Mttp-IKO), could retard NAFLD progression and/or reverse established fibrosis in two dietary models. Mttp-IKO mice fed a methionine/choline deficient (MCD) diet exhibited reduced hepatic triglycerides (TG), inflammation and fibrosis, associated with reduced oxidative stress and downstream activation of JNK and NFκB signaling pathways. However, when Mttpflox mice were fed a MCD for 5 weeks and then administered tamoxifen to induce Mttp-IKO, hepatic TG was reduced but inflammation and fibrosis were increased after 10 days reversal along with adaptive changes in hepatic lipogenic mRNAs. Extending the reversal time, following 5 weeks MCD feeding, to 30 days led to sustained reductions in hepatic TG but neither inflammation nor fibrosis were decreased and both intestinal permeability and hepatic lipogenesis were increased.
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