Notes

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Fermentation improves many food characteristics using microbes, such as lactic acid bacteria (LAB). Recent studies suggest fermentation may also enhance the health properties, but mechanistic evidence is lacking. The study aims to identify a metabolite pattern reproducibly produced during sourdough and in vitro colonic fermentation of various whole-grain rye products and how it affects the growth of bacterial species of potential importance to health and disease.

The study uses Lactiplantibacillus plantarum DSMZ 13890 strain, previously shown to favor rye as its substrate. Using LC-MS metabolomics, the study finds seven microbial metabolites commonly produced during the fermentations, including dihydroferulic acid, dihydrocaffeic acid, and five amino acid metabolites, and stronger inhibition is achieved when exposing the bacteria to a mixture of the metabolites in vitro compared to individual compound exposures.

The study suggests that metabolites produced by LAB may synergistically modulate the local microbial ecology, such as in the gut. This could provide new hypotheses on how fermented foods influence human health via diet-microbiota interactions.
The study suggests that metabolites produced by LAB may synergistically modulate the local microbial ecology, such as in the gut. This could provide new hypotheses on how fermented foods influence human health via diet-microbiota interactions.
Symptom checkers have been widely used during the COVID-19 pandemic to alleviate strain on health systems and offer patients a 24-7 self-service triage option. Although studies suggest that users may positively perceive web-based symptom checkers, no studies have quantified user feedback after use of an electronic health record-integrated COVID-19 symptom checker with self-scheduling functionality.

In this paper, we aimed to understand user experience, user satisfaction, and user-reported alternatives to the use of a COVID-19 symptom checker with self-triage and self-scheduling functionality.

We launched a patient-portal-based self-triage and self-scheduling tool in March 2020 for patients with COVID-19 symptoms, exposures, or questions. We made an optional, anonymous Qualtrics survey available to patients immediately after they completed the symptom checker.

Between December 16, 2021, and March 28, 2022, there were 395 unique responses to the survey. Overall, the respondents reported high satisfactiocians. Individual feedback suggested that the user experience for this type of tool is highly dependent on the organization's operational workflows for COVID-19 testing and care. This study provides insight for the implementation and improvement of COVID-19 symptom checkers to ensure high user satisfaction.
This analysis suggests that COVID-19 symptom checkers with self-triage and self-scheduling functionality may have high overall user satisfaction, regardless of user demographics. By allowing users to self-triage and self-schedule tests and visits, tools such as this may prevent unnecessary calls and messages to clinicians. Individual feedback suggested that the user experience for this type of tool is highly dependent on the organization's operational workflows for COVID-19 testing and care. This study provides insight for the implementation and improvement of COVID-19 symptom checkers to ensure high user satisfaction.This corrects the article DOI 10.1103/PhysRevLett.123.031601.Quantum pseudotelepathy is a strong form of nonlocality. Different from the conventional nonlocal games where quantum strategies win statistically, e.g., the Clauser-Horne-Shimony-Holt game, quantum pseudotelepathy in principle allows quantum players to with probability 1. In this Letter, we report a faithful experimental demonstration of quantum pseudotelepathy via playing the nonlocal version of Mermin-Peres magic square game, where Alice and Bob cooperatively fill in a 3×3 magic square. We adopt the hyperentanglement scheme and prepare photon pairs entangled in both the polarization and the orbital angular momentum degrees of freedom, such that the experiment is carried out in a resource-efficient manner. Under the locality and fair-sampling assumption, our results show that quantum players can simultaneously win all the queries over any classical strategy.Generating random numbers plays an important role in many scientific applications. Compared to pseudorandom number generators, a quantum device is capable of generating true random numbers by the laws of quantum mechanics. However, information-theoretical secure random numbers are regularly based on a perfect device model, which may deviate from a real-world device. To close this gap, we propose a quantum random number generation protocol and experimentally demonstrate it. In our protocol, we make no assumptions about the source. Some reasonable assumptions on the trusted two-dimensional measurement are needed, but we do not require a detailed characterization. Even if considering the most general quantum attack and using the general sources, we achieve a randomness generation rate of over 1 Mbps with a universal composable security parameter of 10^-10.We study particle transport through a chain of coupled sites connected to free-fermion reservoirs at both ends, subjected to a local particle loss. The transport is characterized by calculating the conductance and particle density in the steady state using the Keldysh formalism for open quantum systems. In addition to a reduction of conductance, we find that transport can remain (almost) unaffected by the loss for certain values of the chemical potential in the lattice. We show that this "protected" transport results from the spatial symmetry of single-particle eigenstates. find more At a finite voltage, the density profile develops a drop at the lossy site, connected to the onset of nonballistic transport.Intermediate-scale quantum technologies provide new opportunities for scientific discovery, yet they also pose the challenge of identifying suitable problems that can take advantage of such devices in spite of their present-day limitations. In solid-state materials, fractional quantum Hall phases continue to attract attention as hosts of emergent geometrical excitations analogous to gravitons, resulting from the nonperturbative interactions between the electrons. However, the direct observation of such excitations remains a challenge. Here, we identify a quasi-one-dimensional model that captures the geometric properties and graviton dynamics of fractional quantum Hall states. We then simulate geometric quench and the subsequent graviton dynamics on the IBM quantum computer using an optimally compiled Trotter circuit with bespoke error mitigation. Moreover, we develop an efficient, optimal-control-based variational quantum algorithm that can efficiently simulate graviton dynamics in larger systems. Our results open a new avenue for studying the emergence of gravitons in a new class of tractable models on the existing quantum hardware.We report a magnetic transition region in La_0.7Sr_0.3MnO_3 with gradually changing magnitude of magnetization, but no rotation, stable at all temperatures below T_C. Spatially resolved magnetization, composition and Mn valence data reveal that the magnetic transition region is induced by a subtle Mn composition change, leading to charge transfer at the interface due to carrier diffusion and drift. The electrostatic shaping of the magnetic transition region is mediated by the Mn valence, which affects both magnetization by Mn^3+-Mn^4+ double exchange interaction and free carrier concentration.We present a theory on the quantum phase diagram of AB-stacked MoTe_2/WSe_2 using a self-consistent Hartree-Fock calculation performed in the plane-wave basis, motivated by the observation of topological states in this system. At filling factor ν=2 (two holes per moiré unit cell), Coulomb interaction can stabilize a Z_2 topological insulator by opening a charge gap. At ν=1, the interaction induces three classes of competing states, spin density wave states, an in-plane ferromagnetic state, and a valley polarized state, which undergo first-order phase transitions tuned by an out-of-plane displacement field. The valley polarized state becomes a Chern insulator for certain displacement fields. Moreover, we predict a topological charge density wave forming a honeycomb lattice with ferromagnetism at ν=2/3. Future directions on this versatile system hosting a rich set of quantum phases are discussed.The security of quantum key distribution (QKD) usually relies on that the users' devices are well characterized according to the security models made in the security proofs. In contrast, device-independent QKD-an entanglement-based protocol-permits the security even without any knowledge of the underlying quantum devices. Despite its beauty in theory, device-independent QKD is elusive to realize with current technologies. Especially in photonic implementations, the requirements for detection efficiency are far beyond the performance of any reported device-independent experiments. In this Letter, we report a proof-of-principle experiment of device-independent QKD based on a photonic setup in the asymptotic limit. On the theoretical side, we enhance the loss tolerance for real device imperfections by combining different approaches, namely, random postselection, noisy preprocessing, and developed numerical methods to estimate the key rate via the von Neumann entropy. On the experimental side, we develop a high-quality polarization-entangled photon source achieving a state-of-the-art (heralded) detection efficiency about 87.5%. Although our experiment does not include random basis switching, the achieved efficiency outperforms previous photonic experiments involving loophole-free Bell tests. Together, we show that the measured quantum correlations are strong enough to ensure a positive key rate under the fiber length up to 220 m. Our photonic platform can generate entangled photons at a high rate and in the telecom wavelength, which is desirable for high-speed generation over long distances. The results present an important step toward a full demonstration of photonic device-independent QKD.High-order topological insulators (HOTIs), as generalized from topological crystalline insulators, are characterized with lower-dimensional metallic boundary states protected by spatial symmetries of a crystal, whose theoretical framework based on band inversion at special k points cannot be readily extended to quasicrystals because quasicrystals contain rotational symmetries that are not compatible with crystals, and momentum is no longer a good quantum number. Here, we develop a low-energy effective model underlying HOTI states in 2D quasicrystals for all possible rotational symmetries. By implementing a novel Fourier transform developed recently for quasicrystals and approximating the long-wavelength behavior by their large-scale average, we construct an effective k·p Hamiltonian to capture the band inversion at the center of a pseudo-Brillouin zone. We show that an in-plane Zeeman field can induce mass kinks at the intersection of adjacent edges of a 2D quasicrystal topological insulators and generate corner modes (CMs) with fractional charge, protected by rotational symmetries.
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