Notes

Predictors of faculty students' leisure-time physical activity: A prolonged trans-contextual model utilizing Bayesian course investigation.
Tachycardia is an independent risk factor for mortality of patients with sepsis and multiple organ dysfunction syndrome (MODS), and has attracted extensive attention in recent years. Ivabradine, a specific blocker of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel in sinoatrial node, is capable of inducing heart rate reduction (HRR) via binding specific sites of the channel and promotes ventricular filling because of prolongation of the diastolic period. Ivabradine has no negative effect on inotropic contractility, conductivity, and systemic vascular resistance. While Ivabradine has recently shown its beneficial effects in diverse randomized controlled trials on heart failure, this medicine may be a potential option to treat tachycardia in patients with sepsis and septic cardiomyopathy (SCM). Preliminary findings demonstrate that Ivabradine can remarkably lower heart rate and improve hemodynamic stability in patients with sepsis. In addition, Ivabradine has been reported to ameliorate microcirculation perfusion and suppress the inflammatory response. This review discusses the effects of Ivabradine on heart rate control in patients with sepsis and SCM.Pre-hospital first aid can reduce the mortality and morbidity of critically ill patients, and first aid kit plays an important role in pre-hospital first aid. The first aid kit used in clinic is easy to cause the injection to be broken, and it is inconvenient to use at night. Thus, we have designed an "Owl" first aid kit and obtained a national utility model patent (ZL 2018 2 0727656.7) which includes an injection storage cover and a medicine storage box. A number of injection storage plates are arranged on the injection storage cover, which are used for clamping injections of different sizes, etc., and can effectively prevent injection drugs from being extruded, shedding and broken. There is a supporting rod on one side of the injection storage cover, which can improve the efficiency to take medicine from the first aid kit. There are several partitions in the drug storage box, which can be adjusted according to the size and type of articles placed. A number of symmetrical elastic buckles are arranged on the bottom plate for picking up medicine in bottles, which is convenient for emergency personnel to operate with one hand. There is an illuminating lamp at the edge of the injection storage cover, and a number of fluorescent strips are arranged on the inner wall of the medicine storage box. Based on the above device, it is convenient for medical personnel to pick up medicines at night, which can avoid potential errors effectively. The "Owl" first aid kit has a simple structure and low cost. It can prevent the injection from being broken and convenient to operate. At the same time, it is convenient to be used at night, so it is worthy of clinical application.
To explore the clinical characteristics of pneumonia infected by Chlamydophila psittaci (C. psittaci).

A retrospective analysis was performed on 3 cases of C. psittaci pneumonia admitted to People's Hospital of Tongling City from July 2019 to January 2020. The patients' contact history, clinical manifestations, laboratory examination, imaging characteristics and evolution, etiology, treatment process and outcome were analyzed, so as to provide experience for the diagnosis and prevention of C. find more psittaci pneumonia.

The 3 patients had been infected through pet or zoonotic exposures. link2 All symptoms included high fever (body temperature > 39 centigrade), cough, sputum, chest tightness and dyspnea. The disease progressed rapidly, with severe acute respiratory distress syndrome (ARDS) and shock as the main manifestations, but the damages to the heart, liver and kidney were mild. Laboratory tests showed that C-reactive protein (CRP, all > 200 mg/L) and neutrophil proportion (Neut%, > 0.90) were significanly diagnosis depends on mNGS, and reasonable treatment is important for prognosis.
The patients with C. psittaci pneumonia are critically ill, and clinical manifestations of moderate to severe ARDS and shock are common. Early diagnosis depends on mNGS, and reasonable treatment is important for prognosis.
To explore the application of human behavior recognition based on convolutional neural network (CNN) in the new generation of pre-hospital first aid.

Sixty videos were obtained from the Montreal Falling Video Data base, and divided into model training data and evaluation test data at a ratio of 51. (1) Data model training singular value decomposition was used to clarify the picture, the target boundary of the human body in the picture was identified through target detection and Fourier transform, then the human body curve was described; OpenCv computer vision and machine learning software library to estimate the body pose were used to mark the important parts of the human body (such as hips, knees), the angle between the line of important parts and the horizontal direction and the length and width ratio of the detection frame were calculated, and whether the human body had abnormal behavior was identified. link3 (2) Evaluation test 6 videos were randomly extracted from the model training data set, 10 frame were extracted from each video, each frame was treated as one picture, CNN behavior recognition was used on each frame, and calculated the recognition rate between normal behavior and abnormal behavior.

In the process of data model training, each frame was artificially labeled to train the CNN human behavior recognition model. The evaluation results showed that the recognition rate of normal behavior was (90.33±3.03)%, and the recognition rate of abnormal behavior was (87.74±2.88)%.

When passers-by have dangerous behaviors, the identification of human behaviors through CNN can determine whether they are in a critical state, and issue early warning in time, which plays a vital role in pre-hospital first aid.
When passers-by have dangerous behaviors, the identification of human behaviors through CNN can determine whether they are in a critical state, and issue early warning in time, which plays a vital role in pre-hospital first aid.
To investigate the antagonistic effect of ML355, the 12-lipoxygenase (12-LOX) inhibitor, on lipopolysaccharide (LPS)-induced inflammatory response in mice and its molecular mechanism.

(1) In vivo experiment 24 adult male C57BL/6 mice were randomly divided into control group [intraperitoneal injection of 100 μL dimethyl sulfoxide (DMSO) 1 hour in advance and then intraperitoneal injection of 0.9% normal saline], LPS group (intraperitoneal injection of LPS 20 mg/kg) and ML355 pretreatment groups (15 mg/kg, 30 mg/kg of ML355 intraperitoneal injection 1 hour in advance before LPS administration). The mice were euthanized 12 hours after the model was established, and the peripheral blood, peritoneal lavage fluid and peritoneal macrophages (PMs) were collected. The levels of plasma and peritoneal lavage fluid 12-hydroxyeicosatetraenoic acid (12-HETE), peritoneal lavage fluid interferon-γ (IFN-γ), interleukins (IL-1β, IL-6, IL-10), tumor necrosis factor-α (TNF-α) and serum IFN-γ, IL-1β were measured by enzyme liffect on LPS induced inflammatory response in mice, which may be associated with the suppression on 12/15-LOX, p-ERK and p-JNK proteins.
ML355 has antagonistic effect on LPS induced inflammatory response in mice, which may be associated with the suppression on 12/15-LOX, p-ERK and p-JNK proteins.
To investigate the protective effect of the hydrogen (H
) inhalation on intestinal injury in severe sepsis mice and its relationship with nuclear factor E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1)/high mobility group protein B1 (HMGB1) pathway.

The 280 male wild-type (WT) and Nrf2 knockout (Nrf2-KO) ICR mice (6-8 weeks old, 20-25 g weight) were assigned into 8 groups randomly (WT and Nrf2-KO mice, 4 groups respectively, n = 35) Sham group, H
inhalation group (Sham+H
group), sepsis model group which was induced by cecal ligation and puncture (CLP group) and H
treatment group (CLP+H
group). In Sham group, except cecal ligation and perforation, the same surgery was used. The mice in Sham group and CLP group inhaled only air for 1 hour and 6 hours, respectively, while the mice in Sham+H
group and CLP+H
group inhaled 2% H
for 60 minutes. After modeling, 20 mice randomly in each group were selected to measure 7-day natural survival rates; the remaining mice(15 mice) were killed in 24 hoursn) 0.148±0.004 vs. 0.164±0.043, HO-1 positive expression (A value) 0.109±0.020 vs. 0.113±0.025, HMGB1 protein expression (HMGB1/β-actin) 0.109±0.020 vs. 0.113±0.025, HMGB1 positive expression (A value) 39.570±12.660 vs. 42.790±9.680, all P > 0.05].

H
can inhibit the intestinal injury of mice with severe sepsis through Nrf2/HO-1/HMGB1 pathway, and Nrf2 plays an important role in the treatment of intestinal injury with H
.
H2 can inhibit the intestinal injury of mice with severe sepsis through Nrf2/HO-1/HMGB1 pathway, and Nrf2 plays an important role in the treatment of intestinal injury with H2.
To investigate whether the activation of NOD like receptor protein 3 (NLRP3) signaling pathway in vascular endothelial cells induced by heat stress (HS) could be inhibited by ethyl pyruvate (EP).

Human umbilical vein endothelial cells (HUVEC) were cultured in vitro, and the cells in logarithmic growth phase were taken to carry out experiment. Different temperatures gradients (39, 41, 43 centigrade for 4-hour HS) and different duration gradients (43 centigrade continuously HS respectively for 2, 3, 4 hours) were set up respectively. For HS group, HUVECs were placed in incubators with corresponding different conditions to carry out HS, then 43 centigrade persisting for 4-hour HS (43 centigrade, 4 hours) was selected as the final experimental condition; during HS, EP 10 mmol/L was added. For control group, the cells were synchronously cultured in 37 centigrade cell incubator. The protein expression of NLRP3 in HUVEC and activity of aspartate specific cysteine protease 1 (caspase-1) were detected with Western The activation of NLRP3 signaling pathway in vascular endothelial cells induced by HS could be significantly inhibited by EP, which helps to reduce the release of inflammatory cytokines from vascular endothelial cells induced by HS.
The activation of NLRP3 signaling pathway in vascular endothelial cells induced by HS could be significantly inhibited by EP, which helps to reduce the release of inflammatory cytokines from vascular endothelial cells induced by HS.
To evaluate the effect of distal perfusion catheter (DPC) on the incidence and prognosis of venous-arterial extracorporeal membrane pulmonary oxygenation (VA-ECMO) arterial catheter-related limb ischemia.

Literatures on the effect of DPC on catheter-related limb ischemia in VA-ECMO patients in Chinese and English databases such as CNKI, Wanfang Medical Database, PubMed, Embase, Scopus, Cochrane Library and Google Scholar were searched from building the database to February 2019. Keywords were extracorporeal membrane oxygenation, limb ischemia, extracorporeal membrane oxygenation, distal perfusion cannula. Outcome indicators included the incidence of limb ischemia and mortality. Two reviewers selected documents according to the inclusion and exclusion criteria, extracted data, and applied RevMan 5.3 software for Meta-analysis. Sensitivity analysis was used to test the stability of the Meta-analysis results, and funnel chart analysis was used to analyze publication bias.

There were totally 17 articles selected for review, including 11 series studies, 2 technical description studies and 4 retrospective cohort studies.
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