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A comparison between on-demand using of rFVIIa versus prophylaxis usage of emicizumab inside high titer inhibitory hemophilia A new individuals inside Iran: The cost-utility examination.
Tendrils are clasping structures used by climbing plants to anchor and support their vines that coil around suitable hosts to achieve the greatest exposure to sunlight. Although recent evidence suggests that climbing plants are able to sense the presence of a potential stimulus in the environment and to plan the tendrils' movements depending on properties such as its thickness, the mechanisms underlying thickness sensing in climbing plants have yet to be uncovered. The current research set out to use three-dimensional kinematical analysis to investigate if and in what way the root system contributed to thickness sensing. Experiment 1 was designed to confirm that the movement of the tendrils of pea plants (Pisum sativum L.) is planned and controlled on the basis of stimulus thickness when the stimulus is inserted into the substrate. Experiment 2 was designed to investigate what happens when the stimulus is lifted to the ground so as to impede the root system from sensing it. The results confirmed that tendrils' kinematics depend on thickness when the stimulus is available to the root system but not when it is unavailable to it. These findings suggest that the root system plays a pivotal role in sensing the presence and the thickness of a stimulus and that the information perceived affects the planning and the execution of the climbing plants' reach-to-grasp movements. (PsycInfo Database Record (c) 2021 APA, all rights reserved).The health, economic, and social challenges associated with coronavirus disease 2019 (COVID-19) present a range of threats to students' well-being, psychoeducational experiences, and outcomes, spurring fears for a "lost generation." In this article, we present COVID-19 as a large-scale multisystemic disaster causing massive disruptions and losses, with adversities moderated by the intersectional nature of systemic inequity. https://www.selleckchem.com/products/cariprazine-rgh-188.html We first synthesize the broad effects of COVID-19 as they relate to equity and social justice, followed by the major implications for students and schools, with a focus on intersectional systemic issues. We then propose foundational considerations and resources intended to usher a paradigm shift in how school psychologists' roles and activities are conceptualized in the years to come, ending with key imperatives for practice and graduate education in school psychology. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Children who exhibit inattention (IA) and hyperactivity-impulsivity (HI), symptoms often indicative of attention-deficit/hyperactivity disorder (ADHD), have notable social impairments. We investigated whether IA and HI are directly connected to peer difficulties or indirectly connected through their known association with other problem behaviors. Quadratic assignment procedures (QAP) were employed to address the main study questions Is the relation between a child reporting not wanting to play with a peer who they perceive as HI and/or IA mediated by the child's perception of that same peer as reactively aggressive, instrumentally aggressive, and/or anxiously withdrawn? Participants were 387 fourth and fifth graders nested in 21 classroom-based peer networks. Participants nominated classroom peers as IA, HI, aggressive, anxiously withdrawn, and as liked-least. Analyses were conducted separately for each classroom-based peer network, and meta-analytic procedures were used to compile results and calculate effect sizes across networks. Controlling for gender homophily between nominators and nominees, logistic regression QAPs indicated that reactive and instrumental aggression do not mediate the relation between IA/HI and peer dislike but, rather, add unique information beyond IA/HI. In contrast, nominating a peer as anxious-withdrawn was not tied to nominating that same peer as IA, HI, or disliked. The results suggest that children find IA and HI aversive enough to contribute to their disliking of peers who exhibit these behaviors, even when accounting for co-occurring aggressive behaviors. (PsycInfo Database Record (c) 2021 APA, all rights reserved).In social groups, such as school-based peer networks, youth often vie for power and dominance over others. Different strategies may be used to gain power (i.e., coercive and/or cooperative strategies), and with varying levels of success. Using a social networks approach, we examined whether and how social network centrality and social network prestige were associated with social strategies, social power, and peer reputation. Participants were fifth- to eighth-grade elementary school students (N = 466, 51% girls, 63% White) in southern Ontario, Canada. Peer nominations were used to assess social network centrality and prestige (via friendship nominations), social power strategies (coercive and cooperative strategies), social power, and peer reputation (popularity and likeability). Results indicated that coercive and cooperative strategies were used by youth high in both centrality and prestige, but that only high prestige related to power, popularity, and likeability. Results have implications for the usefulness of a social networks approach to understanding the structure of youths' social relationships and power in school settings, as well as practical implications for teachers and other school staff. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Self-medication of pain with alcohol is prevalent, and expectancies for alcohol analgesia (EAA) likely influence pain relief and alcohol consumption. Hazardous alcohol use has been associated with greater delay discounting rates; however, little is known about the relationship between delay discounting and EAA. Therefore, the present study examined sex differences in associations between delay discounting and EAA. Healthy drinkers without chronic pain (N = 53) completed measures of EAA, alcohol use, and alcohol outcome expectancies. A five-trial adjusting-delay discounting task (DDT) for monetary outcomes was also administered. Regression analyses revealed that sex moderated the relationship between delay discounting and EAA. Steeper delay discounting rates were associated with weaker EAA among men when adjusting for average alcohol consumption. Among women, nonsignificant associations between delay discounting rates and EAA were observed. These findings provide initial evidence of sex differences in associations between delay discounting and EAA. The directionality of these associations was unexpected and may have implications for patterns of self-medication with alcohol. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Simultaneous co-ingestion of prescription medication (e.g., opioid, tranquilizer/sedative, stimulant) and alcohol is associated with overdose and elevated substance use, but no studies have examined prescription drug misuse (PDM) and alcohol co-ingestion in U.S. young adults (18-25 years), despite the high rates of PDM in this age group. We used the 2015-19 National Survey on Drug Use and Health (young adult N = 69,916) to examine prevalence of past-month PDM-alcohol co-ingestion, PDM characteristics, and sociodemographic, physical health, mental health, and substance use correlates. Logistic regression examined correlates, comparing those without past-year PDM, those with past-year but not past-month PDM, those with past-month PDM without alcohol co-ingestion, and those with past-month PDM and alcohol co-ingestion. An estimated 585,000 young adults engaged in any past-month PDM-alcohol co-ingestion, or between 32.7% (opioids) and 44.6% (tranquilizer/sedatives) of those who were engaged in past-month PDM. Co-ingestion varied by educational status and was more common in males and white or multiracial young adults. All PDM-involved groups had elevated odds of suicidal ideation and other psychopathology, but substance use and substance use disorder (SUD) odds were significantly higher in young adults with co-ingestion, versus all other groups. To illustrate, 41.1% with opioid-alcohol co-ingestion had multiple past-year SUDs, versus 2.0% in those without past-year PDM. Young adults with co-ingestion are particularly likely to have problematic alcohol use and higher rates of SUD. Counseling about the risks of PDM-alcohol co-ingestion and screening for co-ingestion among those at risk are warranted to limit poor outcomes. (PsycInfo Database Record (c) 2021 APA, all rights reserved).Black drinkers experience more alcohol problems compared to White drinkers at comparable levels of alcohol use (Mulia et al., 2009; Witbrodt et al., 2014; Zapolski et al., 2014). Research has found that Black compared to White drinkers endorse drinking to cope more frequently via retrospective report (Bradizza et al., 1999; Cooper et al., 2008). Additional research is needed to understand contributors to these racial differences. The primary aim of the present study was to examine how quality and frequency of cross-group contact at work and/or school relates to experiencing discrimination and, in turn, drinking to cope. Seventy-two young adult drinkers (Mage = 25, 72% female, 28% male; 64% Black, 36% White) completed baseline questionnaires and a subset (n = 50) completed a 17-day ecological momentary assessment (EMA) protocol. Cross-group contact frequency and quality was assessed at baseline while discrimination and coping motives were assessed via retrospective report at baseline and acutely via EMA. Accounting for sociodemographic covariates, path analyses utilizing retrospective measures revealed a significant indirect pathway from race to coping motives through quality of work/school cross-group contact and discrimination experiences related to assumptions of inferiority. Identical path analyses utilizing the acute EMA data revealed a significant indirect pathway from race to coping motives through quality of work/school cross-group contact. link2 Improving cross-group contact at work and school may reduce drinking to cope. Additional research examining multiple domains of discrimination, quality of cross-group contact, and alcohol problems over time is needed to further understanding of social determinants of health inequities in alcohol problems. (PsycInfo Database Record (c) 2021 APA, all rights reserved).The occurrence of sexual behavior that poses heightened risk for negative outcomes (e.g., condomless sex, sex with new or unfamiliar partners) often involves drinking alcohol for social and enhancement purposes, with female college students being particularly at-risk for resulting consequences. This study examined whether alcohol use, drinking motives, and sex-related impelling cues (i.e., cues that may impel one toward engaging in sexual activity) could predict sexual behaviors that pose heightened risk for negative consequences among female undergraduates. link3 A total of 251 drinking episodes from 56 female college students (M age = 19.66) were obtained via surveys assessing alcohol use, drinking motives, sex-related impelling cues, and sexual behaviors at the event level. Relationships between variables were examined via main effect and factorial generalized estimating equations for social, enhancement, coping, and conformity drinking motives. In each main effects model, sex-related impelling cues were the only significant predictor.
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