Notes

ICTV Virus Taxonomy Report: Herpesviridae 2021.
Integrating the present result with those from previous experimental investigations, it is shown that the hydrogen insertion in the THF hydrate is optimum for a pressure of ca. 55 bar at 270 K. Moreover, the co-inclusion of perchloric acid (with concentration as low as 1 acidic molecules per 136 water molecules) lead to promote the molecular hydrogen insertion within the hydrate structure. The hydrogen diffusion coefficient-measured at 270 K and 200 bar-is improved by a factor of 2 thanks to the acidic additive.The cyclic depsipeptide FR900359 (FR) isolated from the plant Ardisia crenata and produced by endosymbiotic bacteria acts as a selective Gq protein inhibitor. It is a powerful tool to study G protein-coupled receptor signaling, and has potential as a novel drug for the treatment of pulmonary diseases and cancer. For pharmacokinetic studies, sensitive quantitative measurements of drug levels are required. #link# In the present study we established an LC-MS/MS method to detect nanomolar concentrations of FR and the structurally related natural product YM-254890 (YM) in biological samples. HPLC separation coupled to ESI-QTOF-MS and UV-VIS detection was applied. For identification and quantification, the extract ion chromatogram (EIC) of M+1 was evaluated. Limits of detection (LOD) of 0.53-0.55 nM and limits of quantification (LOQ) of 1.6-1.7 nM were achieved for both FR and YM. This protocol was subsequently applied to determine FR concentrations in mouse organs and tissues after peroral application of the drug. A three-step liquid-liquid extraction protocol was established, which resulted in adequate recovery rates of typically around 50%. The results indicated low peroral absorption of FR. Besides the gut, highest concentrations were determined in eye and kidney. link2 The developed analytical method will be useful for preclinical studies to evaluate these potent Gq protein inhibitors, which may have potential as future drugs for complex diseases.The rare-earth nanocrystals containing Er3+ emitters offer very promising tools for imaging applications, as they can not only exhibit up-conversion luminescence but also down-conversion luminescence in the second near-infrared window (NIR II). Doping non-lanthanide cations into host matrix was demonstrated to be an effective measure for improving the luminescence efficiency of Er3+ ions, while still awaiting in-depth investigations on the effects of dopants especially those with high valence states on the optical properties of lanthanide nanocrystals. To address this issue, tetravalent Zr4+ doped hexagonal NaGdF4Yb,Er nanocrystals were prepared, and the enhancement effects of the Zr4+ doping level on both up-conversion luminescence in the visible window and down-conversion luminescence in NIR II window were investigated, with steady-state and transient luminescence spectroscopies. The key role of the local crystal field distortions around Er3+ emitters was elucidated in combination with the results based on both of Zr4+ and its lower valence counterparts, e.g., Sc3+, Mg2+, Mn2+. Univalent ions such as Li+ was utilized to substitute Na+ ion rather than Gd3+, and the synergistic effects of Zr4+ and Li+ ions by co-doping them into NaGdF4Yb,Er nanocrystals were investigated toward optimal enhancement. Upon optimization, the up-conversion emission of co-doped NaGdF4Yb,Er nanocrystals was enhanced by more than one order of magnitude compared with undoped nanocrystals. The current studies thus demonstrate that the local crystal field surrounding emitters is an effective parameter for manipulating the luminescence of lanthanide emitters.Much research has been carried out on nanoscale polymer microspheres (PMs) in laboratories in recent years. However, there are limited reports on the practical application of nanoscale PMs in ultralow permeability reservoirs. This paper reports a field application case of nanoscale PMs for in-depth profile control in the ultralow permeability oil reservoir. In the paper, the characteristics of the reservoir and the problems faced during development are analyzed in detail. Then, the PMs with calibration diameters of 300 nm and 800 nm are researched by evaluation experiments, and are selected for in-depth profile control in the ultralow permeability oil reservoir. Finally, according to the effect of the pilot application, the performance of PMs is evaluated, and a more suitable size for the pilot test reservoir is determined. The experiment's results show that the PMs have a good capacity for swelling and plugging. For the PMs with a calibration diameter of 300 nm, the final equilibrium swelling ratio is 56.2 nm·nm-1, and the maximum resistance coefficient and the blocking rate after swelling are 3.7 and 70.31%, respectively. For the PMs with a calibration diameter of 800 nm, the final equilibrium swelling ratio is 49.4 nm·nm-1, and the maximum resistance coefficient the blocking rate after swelling are 3.5 and 71.42%, respectively. The performance evaluation results show that nanoscale PMs can be used for in-depth profile control in the ultralow permeability oil reservoir. After the application of PMs in the pilot test area, the average water cut decreased by 10.4%, the average liquid production of single well-increased by 0.9 t/d, and the average thickness of the water-absorbing layer increased by 1.77 m. Comparing the dynamic data variation of well-groups using the PMs with the calibration diameter as 800 nm and the calibration diameter as 300 nm, it indicates that, for the pilot test area, PMs with a calibration diameter of 300 nm are more suitable than PMs with a calibration diameter of 800 nm.Zinc-based electrochemistry attracts significant attention for practical energy storage owing to its uniqueness in terms of low cost and high safety. In this work, we propose a 2.0-V high-voltage Zn-MnO2 battery with core@shell Co3O4@MnO2 on carbon cloth as a cathode, an optimized aqueous ZnSO4 electrolyte with Mn2+ additive, and a Zn metal anode. Benefitting from the architecture engineering of growing Co3O4 nanorods on carbon cloth and subsequently deposited MnO2 on Co3O4 with a two-step hydrothermal method, the binder-free zinc-ion battery delivers a high power of 2384.7 W kg-1, a high capacity of 245.6 mAh g-1 at 0.5 A g-1, and a high energy density of 212.8 Wh kg-1. It is found that the Mn2+ cations are in situ converted to Mn3O4 during electrochemical operations followed by a phase transition into electroactive MnO2 in our battery system. The charge-storage mechanism of the MnO2-based cathode is Zn2+/Zn and H+ insertion/extraction. This work shines light on designing multivalent cation-based battery devices with high output voltage, safety, and remarkable electrochemical performances.Ferroliquids are an example of a colloidal suspension of magnetic nanomaterials and regular liquids. These fluids have numerous applications in medical science such as cell separation, targeting of drugs, magnetic resonance imaging, etc. The hybrid nanofluid is composed by scattering the magnetic nanomaterial of more than one type nanoparticles suspended into the base fluid. It has different scientific applications such as heat dissipation, dynamic sealing, damping, etc. Owing to the vast ferrofluid applications, the time-dependent squeezed flow of hybrid ferroliquids under the impact of non-linear radiation and mixed convection within two disks was explored for the first time in this analysis. Here, the cobalt and magnetite ferrofluids are considered and scattered in a 50%50% mixture of water-EG (ethylene glycol). The similarity technique is used to reduce the leading PDEs into coupled non-linear ODEs. The transmuted equations together with recommended boundary restrictions are numerically solved via Matlab solver bvp4c. The opposing and assisting flows are considered. The impacts of an emerging parameter on fluid velocity and temperature field of hybrid ferroliquids are examined through the different graphical aids. The results showed that the opposite trend is scrutinized due to the magnetic influence on the temperature and velocity in the case of assisting and opposing flows. The velocity augments due to the volume fraction of nanoparticles in the assisting flow and declines in the opposing flow, while the opposite direction is noticed in the temperature field.Exploring catalysts with low cost and excellent performance for the hydrogen evolution reaction (HER) is still a significant challenge. In this work, zeolitic imidazolate framework 8 (ZIF-8), hybridized with polyvinylpyrrolidone, was used to prepare Zn, Ni co-loaded N-doped porous carbon (ZnNi/NPC) via a straightforward absorption and pyrolysis process. The as-prepared ZnNi/NPC was used as a catalyst for the HER. This experiment showed that the porous structure and Ni doping have a significant influence on the HER activity of the catalyst. Compared with Zn/NC and Zn/NPC, ZnNi/NPC exhibits superior HER activity with an overpotential of 198 mV and a Tafel slope of 69.2 mV dec-1. ZnNi/NPC also shows excellent physical and chemical stability during the HER process. Considering the lower cost and excellent HER performance of ZnNi/NPC, this work provides an attractive solution to fabricate non-precious materials and offers a possible new strategy to replace Pt-based electrocatalysts for HER.Metal-organic framework (MOF)-derived nanoporous carbons (NPCs) and porous metal oxide nanostructures or nanocomposites have gathered considerable interest due to their potential use in supercapacitor (SCs) applications, owing to their precise control over porous architectures, pore volumes, and surface area. Bimetallic MOFs could provide rich redox reactions deriving from improved charge transfer between different metal ions, so their supercapacitor performance could be further greatly enhanced. In this study, "One-for-All" strategy is adopted to synthesize both positive and negative electrodes for hybrid asymmetric SCs (ASCs) from a single bimetallic MOF. The bimetallic Zn/Co-MOF with cuboid-like structures were synthesized by a simple method. The MOF-derived nanoporous carbons (NPC) were then obtained by post-heat treatment of the as-synthesized Zn/Co-MOF and rinsing with HCl, and bimetallic oxides (ZnCo2O4) were achieved by sintering the Zn/Co-MOF in air. NF-κB inhibitor -prepared MOF-derived NPC and bimetallic oxides were utilized as negative and positive materials to assemble hybrid ASCs with 6 M KOH as an electrolyte. link3 Owing to the matchable voltage window and specific capacitance between the negative (NPC) and positive (ZnCo2O4), the as-assembled ASCs delivered high specific capacitance of 94.4 F/g (cell), excellent energy density of 28.6 Wh/kg at a power density of 100 W/kg, and high cycling stability of 87.2% after 5,000 charge-discharge cycles. This strategy is promising in producing high-energy-density electrode materials in supercapacitors.
At present, there are no validated biomarkers that can predict whether patients with advanced hepatocellular carcinoma (aHCC) are likely to benefit from anti-PD-1 therapy. We aimed to determine whether lung immune prognostic index (LIPI) is associated with outcomes in patients with aHCC treated with PD-1 inhibitors.

Patients undergoing initial treatment with PD-1 inhibitors for aHCC at a single center from January 1, 2015 to August 31, 2019 were included. The patients were stratified according to pretreatment LIPI based on a derived neutrophils/(leukocytes minus neutrophils) ratio (dNLR) ≥ 3 and a lactate dehydrogenase (LDH) level ≥ the upper limit of normal (ULN). Kaplan-Meier analysis and the Log rank test were used to calculate and compare survival between good LIPI and intermediate/poor LIPI scores. The prognostic values of LIPI for survival and disease control rate were evaluated using Cox proportional hazard and logistic regression models, respectively.

Of the 108 study patients, 53 (49%) had a good LIPI (dNLR < 3 and LDH normal) and 55 (51%) had intermediate/poor LIPI (dNLR ≥ 3 or/and LDH ≥ ULN).
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