Notes

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BMSC-Exo combined with upregulated miR-193a reduced tumor volume and weight in mice with NSCLC. Functional studies report that BMSC-Exo shuffle miR-193a to suppress the colony formation, invasion, migration, and proliferation as well as advance apoptosis of NSCLC DDP-resistant cells via downregulating LRRC1.Huntington disease (HD) is a hereditary neurodegenerative disorder caused by mutant huntingtin (mHTT). Phosphorylation at serine-421 (pS421) of mHTT has been shown to be neuroprotective in cellular and rodent models. However, the genetic context of these models differs from that of HD patients. Here we employed human pluripotent stem cells (hiPSCs), which express endogenous full-length mHTT. Using genome editing, we generated isogenic hiPSC lines in which the S421 site in mHTT has been mutated into a phospho-mimetic aspartic acid (S421D) or phospho-resistant alanine (S421A). We observed that S421D, rather than S421A, confers neuroprotection in hiPSC-derived neural cells. Although we observed no effect of S421D on mHTT clearance or axonal transport, two aspects previously reported to be impacted by phosphorylation of mHTT at S421, our analysis revealed modulation of several aspects of mitochondrial form and function. These include mitochondrial surface area, volume, and counts, as well as improved mitochondrial membrane potential and oxidative phosphorylation. Our study validates the protective role of pS421 on mHTT and highlights a facet of the relationship between mHTT and mitochondrial changes in the context of human physiology with potential relevance to the pathogenesis of HD.Multiple myeloma (MM) is the second most common hematological malignancy, characterized by plasma cell bone marrow infiltration and end-organ involvement. Smoldering MM (SMM) is an intermediate clinical entity between MGUS and MM, with a risk of progression to symptomatic disease 10% per year. Bone disease is the most frequent symptom of MM, with ~90% of patients developing bone lesions throughout their disease course. Therefore, imaging plays a crucial role in diagnosis and management. Whole-body low-dose CT (WBLDCT) is widely available and has been incorporated in the latest diagnostic criteria of the IMWG. The purpose of this study was to evaluate the role of WBLDCT in the early identification of lesions in patients with SMM who progress solely with bone disease. In total, 100 asymptomatic patients were consecutively assessed with WBLDCT from July 2013 until March 2020 at baseline, 1-year after diagnosis and every 1 year thereafter. Ten percent of patients were identified as progressors with this single imaging modality. This is the first study to evaluate prospectively patients with SMM at different time points to identify early bone lesions related to MM evolution. Serial WBLDCT studies can identify early myeloma evolution and optimize disease monitoring and therapeutic strategies.BACKGROUND This case series describes 5 patients with SARS-CoV-2 infection and COVID-19 in Ecuador who had been treated with hydroxychloroquine for systemic lupus erythematosus (SLE) prior to their COVID-19 illness. CASE REPORT Case #1 reports a 29-year-old woman who had been treated with 200 mg of hydroxychloroquine per day for 1 year and presented with flu-like symptoms, chest pain, fever, odynophagia, asthenia, dry cough, and chills. Case #2 was a 34-year-old woman whose treatment for SLE included 200 mg of hydroxychloroquine per day since 2017. She arrived at the clinic with a dry cough, asthenia, and myalgias. Case #3 was a 24-year-old woman who had been using 200 mg of hydroxychloroquine per day since 2010. She presented with asthenia, myalgias, headaches, hypogeusia, and anosmia. Case #4 was a 39-year-old woman taking 200 mg of hydroxychloroquine every day for SLE who presented with dyspnea, chest pain, odynophagia, hypogeusia, anosmia, diarrhea, and fever. Case #5 was a 46-year-old woman who had been taking 200 mg of hydroxychloroquine since 2019. She came to our hospital complaining of chest pain, fever, and dyspnea. In all 5 patients, SARS-CoV-2 infection was confirmed with a nasopharyngeal SARS-CoV-2 reverse transcription-polymerase chain reaction (RT-PCR) test using the Cepheid/GeneXpert system. CONCLUSIONS All 5 of our patients with SLE who were taking hydroxychloroquine presented with SARS-CoV-2 infection and symptoms of COVID-19. This case series provides support for a lack of prevention of COVID-19 by hydroxychloroquine.BACKGROUND The aim of this study was to assess the diagnostic utility of iron homeostasis determinations for prediction of severity of COVID-19. MATERIAL AND METHODS This was a retrospective study enrolling a total of 50 patients diagnosed with the novel coronavirus disease-19 (COVID-19) from February 27, 2020 to March 30, 2020, including a severe group (12 patients) and a mild group (38 patients). For the control group, 50 healthy people were examined during the same period. We compared clinical laboratory data and iron homeostasis biomarkers among the 3 groups. ROC curve analysis was used to assess diagnoses. RESULTS Patients diagnosed with severe COVID-19 had higher hepcidin and serum ferritin levels than in other groups (p less then 0.001). A combination test of hepcidin and serum ferritin provided the best specificity and sensitivity in the prognosis of COVID-19 severity. Logistic regression analysis showed hepcidin and serum ferritin independently contributed to the severity of COVID-19. Hepcidin and serum ferritin tandem testing predicted COVID-19 severity with 94.6% specificity, while hepcidin and serum ferritin parallel testing had a sensitivity of 95.7%. CONCLUSIONS Iron homeostasis had a robust association with the occurrence of severe COVID-19. Iron homeostasis determinations were specific and sensitive for the early prediction of disease severity in COVID-19 patients and thus have clinical utility.
Traffic noise may contribute to depression and anxiety through higher noise annoyance (NA). However, little is known about noise sensitivity (NS) and mental health status as contextual factors.

We tested three hypotheses (1) Traffic noise is associated with mental ill-health through higher NA; (2) Mental ill-health and NS moderate the association between traffic noise and NA; and (3) NS moderates the indirect effect of traffic noise on mental ill-health.

We used a convenience sample of 437 undergraduate students from the Medical University in Plovdiv, Bulgaria (mean age 21 years; 35% male). Residential road traffic noise (L
; day equivalent noise level) was calculated using a land use regression model. Depression and anxiety symptoms were measured with the Patient Health Questionnaire 9-item (PHQ-9) and the Generalized Anxiety Disorder 7-item (GAD-7) scale, respectively. NA was measured using a 5-point verbal scale. The Noise Sensitivity Scale Short Form (NSS-SF) was used to measure NS. To investigate how these variables intertwine, we conducted mediation, moderation and moderated mediation analyses.

L
was indirectly associated with higher PHQ-9/GAD-7 scores through higher NA, but only in the low NS group. The relationship between L
and NA was stronger in students reporting depression/anxiety. While high NS was associated with high NA even at low noise levels, L
contributed to NA only in students low on NS.

We found complex conditional relationships between traffic noise, annoyance and mental ill-health. Understanding respective vulnerability profiles within the community could aid noise policy and increase efficacy of interventions.
We found complex conditional relationships between traffic noise, annoyance and mental ill-health. Understanding respective vulnerability profiles within the community could aid noise policy and increase efficacy of interventions.
This article discusses the correlation between sensory processing sensitivity (SPS) as a feature of personality and temperament and paramedics' subjective perception of noise inside an ambulance. Description of the theoretical basis of SPS has been strongly depicted.

Polish translation of SPS 12-item short scale and a survey concerning the subjective perception of noise inside an ambulance have been used in this research. Assessment of noise included its three sources emergency vehicle siren, resistance of rolling tires and noise produced by diesel engines. 46 paramedics from mobile emergency care units working in Poznan and the Poznan's district have taken part in the research. Paramedics with higher SPS results were selected, creating a highly sensitive people (HSP) group.

When non-HSP people were compared to paramedics from the HSP group, an emergency signal was considered more burdensome for HSP paramedics. The intensity of noise generated by the vehicle's suspension elements and tires was significantly higher in cars more than 3 years old. Older paramedics (≥30 years old) evaluated the intensity as well as burdensomeness of noise generated by suspension's elements and tires, higher than the younger (<30 years old) ones.

Both paramedics and drivers as occupational groups are liable to noise, which seems to be particularly harmful and burdensome to the HSP group. Further studies should be provided in this area. This may lead to an increase not only in their productivity but also in their quality of life.
Both paramedics and drivers as occupational groups are liable to noise, which seems to be particularly harmful and burdensome to the HSP group. Further studies should be provided in this area. This may lead to an increase not only in their productivity but also in their quality of life.
The sentence recognition score and quality of speech differ when hearing aid compression is set at different release times at different signal to noise ratios (SNRs) for the normal and compressed rate of sentences.

To investigate the effect of amplitude-compression release time of a hearing aid on sentence recognition and quality judgment (1) for normal rate and time-compressed sentences (2) in quiet and noisy conditions.

A post-test repeated measures design.

We recruited fifteen adult participants with bilateral sensorineural hearing loss in each group, the younger (35-45 years), and the older ones (60-70 years). A gap detection test assessed temporal processing ability. We used three compression settings, fast-acting, slow-acting, and linear. Sentence recognition and quality and envelope difference index in normal and altered rates were assessed in quiet and in noise at these three compression settings.

A repeated measure ANOVA.

We found a significant improvement in recognition of sentences at a normal rate in slow compression release time, compared to fast and linear gain settings at each SNR. Similar results were observed for sentences compressed at the rate of 35% in quiet and +10 dB SNR. Further, the participants preferred the quality of speech in quiet with the hearing aid set to slow compared to fast compression release time. selleck The benefit from the slow compression release time was higher than either linear or fast compression release time on sentence recognition. Further, we saw that there was a negative impact on sentence recognition at 3 dB SNR (normal-rate) and in quiet (35% compression rate) in older adults.

The slow compression release time in a hearing aid is superior to the fast one in noisy conditions and also with higher subjective ratings of speech quality in quiet.
The slow compression release time in a hearing aid is superior to the fast one in noisy conditions and also with higher subjective ratings of speech quality in quiet.
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