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Endothelial-Myocardial Angiocrine Signaling throughout Coronary heart Improvement.
IL4RPep-1-KLA was internalized in the cells and colocalized with mitochondria. Whole-body fluorescence imaging and immunohistochemical analysis of tumor tissues showed the homing of IL4RPep-1-KLA as well as IL4RPep-1 to KKU-213 tumor in mice. Systemic administration of IL4RPep-1-KLA efficiently inhibited KKU-213 tumor growth, whereas treatment with 5-FU alone did not significantly inhibit tumor growth in mice. No significant systemic side effects including liver toxicity and immunotoxicity were observed in mice during peptide treatments. These findings suggest that IL4RPep-1-KLA holds potential as a targeted therapeutic agent against chemoresistant CCA.The integration of high-k gate dielectrics with two-dimensional (2D) semiconducting channel materials is essential for high-performance and low-power electronics. However, the conformal deposition of a uniform high-k dielectric with sub-1 nm equivalent oxide thickness (EOT) and high interface quality on high-mobility 2D semiconductors is still challenging. Here, we report a facile approach to synthesize a uniform high-k (εr ∼ 22) amorphous native oxide Bi2SeO x on the high-mobility 2D semiconducting Bi2O2Se using O2 plasma at room temperature. The conformal native oxide can directly serve as gate dielectrics with EOT of ∼0.9 nm, while the original properties of underlying 2D Bi2O2Se is preserved. Furthermore, high-resolution area-selective oxidation of Bi2O2Se is achieved to fabricate discrete electronic components. This facile integration of a high-mobility 2D semiconductor and its high-k native oxide holds high promise for next-generation nanoelectronics.The manipulation of ferrofluidic droplets by magnetic fields is a popular technique for controlling fluid transport in open microfluidic systems. We examine the effect of gravity and shear flow external forces on the adhesion properties of sessile ferrofluidic droplets in the presence of a uniform magnetic field. The magnetic field was found to enhance the critical Bond number at which sliding begins on a tilting substrate but suppress the critical Weber number at which sliding begins in a moderate Reynolds number channel flow. The divergent adhesion trends are explained in terms of the shape deformation induced in the ferrofluidic droplet, the substrate wettability, and the apparent contact angle variation induced by the droplet deformation.Recently, smaller-size electron-beam (EB) accelerators have offered EB irradiation in laboratory systems. Therefore, polymer surface treatments with low-energy EB have been developed in the past years. For high adhesion strength, low-energy EB treatment is also a promising method in comparison to plasma surface treatment. In the plasma treatment, the mechanism of the effect on the adhesion properties has been proved and the excess treatments led to the formation of a weak boundary layer and reduction of adhesion strength. In contrast, the low-energy EB possesses high penetration ability. In this work, we focused on the surface treatments of isotactic polypropylene (it.PP) with low-energy EB irradiation for adhesion. The dependence of adhesion strength on the absorbed dose of electron beam was evaluated, and the mechanism of electron beam on the adhesion properties was investigated from various perspectives of surface properties and morphology. Compared to that of plasma-treated it.PP, the adhesion strength of it.PP with electron-beam irradiation increased drastically. We proved that the radical was generated in the substrates after electron-beam treatments and would form covalent bonds between adhesives and substrates, which achieved higher adhesion than plasma treatments. In addition, the electron beam reached effectively a deep region from the top surface of the substrates and provided larger adhesion strength.Adsorbing DNA oligonucleotides onto nanoparticles is the first step in developing DNA-based biosensors, drug delivery systems, and smart materials. Since DNA is a polyanion, it is repelled by negatively charged nanoparticles, which constitute the majority of commonly used nanomaterials. Adding salt such as NaCl to screen charge repulsion is a standard method of promoting DNA adsorption. However, Na+ does not supply additional attractive forces. In addition, adding a high concentration of NaCl can cause the aggregation of nanomaterials. In this feature article, we mainly summarize the methods developed in our laboratory to promote DNA adsorption by lowering the pH and by adding polyvalent metal ions, especially transition-metal ions. Various materials including noble metals (gold, silver, and platinum), 2D materials (graphene oxide, MoS2, WS2, and MXene), polydopamine, and several metal oxides are discussed. In general, low pH can protonate DNA bases and nanoparticle surfaces, reducing charge repulsion and even leading to attraction, although DNA folding at low pH can sometimes be detrimental to adsorption. Bexotegrast Polyvalent metal ions can bridge additional interactions to achieve otherwise impossible adsorption. On the basis of the current understanding, a few future research directions are proposed to further improve DNA adsorption.The ability to restrict the shuttle of lithium polysulfide (LiPS n ) and improve the utilization efficiency of sulfur represents an important endeavor toward practical application of lithium-sulfur (Li-S) batteries. Herein, we report the crafting of a robust 3D graphene-wrapped, nitrogen-doped, highly mesoporous carbon/sulfur (G-NHMC/S) hierarchical aerogel as an effective polysulfide confinement matrix for a highly stable Li-S battery. Rich polar sites of NHMC firmly anchor LiPS n on the matrix surface. Porous NHMC provides ample space for accommodating sulfur and cushioning its volume expansion. Moreover, graphene wrapped on NHMC/S not only physically hinders the LiPS n shuttle but also interconnects the isolated NHMC/S, thus increasing electron transfer rate. Taken together, triple confinement of G-NHMC/S aerogel synergistically retains the soluble LiPS n and displays a specific capacity of 1322 mAh g-1 and 1000-cycle life. As such, rationally designed 3D carbon/sulfur aerogel affords a unique platform to impart high energy density and stable electrodes for energy storage devices.
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